Hideki Ebihara

Summary

Affiliation: Public Health Agency of Canada
Country: Canada

Publications

  1. ncbi request reprint In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein
    Hideki Ebihara
    Department of Special Pathogens, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Infect Dis 196:S313-22. 2007
  2. pmc Molecular determinants of Ebola virus virulence in mice
    Hideki Ebihara
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Pathog 2:e73. 2006
  3. pmc Tyro3 family-mediated cell entry of Ebola and Marburg viruses
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 80:10109-16. 2006
  4. pmc Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 86:2067-78. 2012
  5. ncbi request reprint The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
  6. pmc Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport
    Seiya Yamayoshi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Cell Host Microbe 3:168-77. 2008
  7. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
  8. ncbi request reprint In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 196:S382-9. 2007
  9. ncbi request reprint Epitopes required for antibody-dependent enhancement of Ebola virus infection
    Ayato Takada
    Department of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 060 0818, Japan
    J Infect Dis 196:S347-56. 2007
  10. pmc The multimerization of hantavirus nucleocapsid protein depends on type-specific epitopes
    Kumiko Yoshimatsu
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    J Virol 77:943-52. 2003

Collaborators

Detail Information

Publications17

  1. ncbi request reprint In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein
    Hideki Ebihara
    Department of Special Pathogens, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Infect Dis 196:S313-22. 2007
    ..These findings demonstrate that the incorporation of a foreign gene will attenuate ZEBOV in vivo but that these viruses still have potential for in vitro and in vivo research applications...
  2. pmc Molecular determinants of Ebola virus virulence in mice
    Hideki Ebihara
    Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Pathog 2:e73. 2006
    ..These findings suggest a critical role for overcoming the interferon-induced antiviral state in the pathogenicity of EBOV and offer new insights into the pathogenesis of EBOV infection...
  3. pmc Tyro3 family-mediated cell entry of Ebola and Marburg viruses
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 80:10109-16. 2006
    ..Antibody to Axl inhibited infection of pseudotype viruses in a number of Axl-positive cell lines. These results implicate each Tyro3 family member as a cell entry factor in filovirus infection...
  4. pmc Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry
    Masayuki Shimojima
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Virol 86:2067-78. 2012
    ..The identification of these four molecules as Lassa virus receptors advances our understanding of Lassa virus cell entry...
  5. ncbi request reprint The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
    ..Here we review the existing reverse genetics systems for VHF causing viruses and discuss their use in studying viral replication, pathogenesis, and the development of antivirals and vaccines...
  6. pmc Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport
    Seiya Yamayoshi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Cell Host Microbe 3:168-77. 2008
    ..These findings identify a conserved intersection between a host pathway and filovirus replication, an intersection that can be targeted in the development of new antiviral drugs...
  7. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
    ..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
  8. ncbi request reprint In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 196:S382-9. 2007
    ..Therefore, we explored the application of minigenomes as screening tools to identify functional siRNA targets under biosafety level 2 conditions...
  9. ncbi request reprint Epitopes required for antibody-dependent enhancement of Ebola virus infection
    Ayato Takada
    Department of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 060 0818, Japan
    J Infect Dis 196:S347-56. 2007
    ..These data suggest that GP lacking the ADE-inducing epitopes may increase the potential of GP as a vaccine antigen...
  10. pmc The multimerization of hantavirus nucleocapsid protein depends on type-specific epitopes
    Kumiko Yoshimatsu
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    J Virol 77:943-52. 2003
    ..Combined, the results indicate that several steps and regions are involved in multimerization of hantavirus NP...
  11. pmc Use of vesicular stomatitis virus pseudotypes bearing hantaan or seoul virus envelope proteins in a rapid and safe neutralization test
    Michiko Ogino
    Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Clin Diagn Lab Immunol 10:154-60. 2003
    ..The stability of the pseudotype viruses allows distribution of the material to remote areas by using conventional cooling boxes for use as a diagnostic reagent...
  12. ncbi request reprint Protective efficacy of neutralizing antibodies against Ebola virus infection
    Ayato Takada
    Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 060 0818, Japan
    Vaccine 25:993-9. 2007
    ..These results underscore the potential therapeutic utility of monoclonal antibodies for postexposure treatment of Ebola virus infections...
  13. ncbi request reprint Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification
    Yohei Kurosaki
    National Research Institute of Police Science, Kashiwa 277 0882, Japan
    J Virol Methods 141:78-83. 2007
    ..Furthermore, as this technique does not require sophisticated instrumentation, it seems very suitable for diagnosis in the field or laboratories in Ebola outbreak areas such as Central Africa...
  14. pmc Infection of naive target cells with virus-like particles: implications for the function of ebola virus VP24
    Thomas Hoenen
    Institut fur Virologie, Philipps Universitat Marburg, Marburg, Germany
    J Virol 80:7260-4. 2006
    ..Here we describe a ZEBOV iVLP system which overcomes this limitation and show that VP24 is essential for the formation of a functional ribonucleoprotein complex...
  15. pmc Cell fusion activities of Hantaan virus envelope glycoproteins
    Michiko Ogino
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Virol 78:10776-82. 2004
    ..This variability in fusion induction suggests the involvement of host cell factors in the process of cell membrane fusion...
  16. pmc Generation of biologically contained Ebola viruses
    Peter Halfmann
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 105:1129-33. 2008
    ....
  17. pmc Assembly and budding of Ebolavirus
    Takeshi Noda
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    PLoS Pathog 2:e99. 2006
    ..These data form a foundation for the identification and development of potential antiviral agents to combat the devastating disease caused by this virus...