Mélanie Plourde

Summary

Country: Canada

Publications

  1. pmc Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?
    Valérie Conway
    Centre de recherche sur le vieillissement, Institut Universitaire de Geriatrie de Sherbrooke, Universite de Sherbrooke, 1036 Belvedere Sud, Sherbrooke J1H 4C4, Canada
    Lipids Health Dis 13:148. 2014
  2. pmc Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly
    Mélanie Plourde
    Research Center on Aging, Health and Social Sciences Center Sherbrooke University Geriatrics Institute, Department of Medicine, Universite de Sherbrooke, Canada
    Nutr Metab (Lond) 8:5. 2011
  3. doi request reprint Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly
    Mélanie Plourde
    Research Center on Aging, Sherbrooke, Quebec, Canada
    Nutrition 25:289-94. 2009
  4. doi request reprint Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men
    Mélanie Plourde
    Research Centre on Aging, Universite de Sherbrooke, Sherbrooke, Canada
    Br J Nutr 102:1121-4. 2009
  5. doi request reprint Conjugated linoleic acids: why the discrepancy between animal and human studies?
    Mélanie Plourde
    Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nutr Rev 66:415-21. 2008
  6. ncbi request reprint Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease
    Mélanie Plourde
    Research Center on Aging, 1036 Belvedere South, Sherbrooke, Quebec, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:301-8. 2007
  7. ncbi request reprint Conjugated alpha-linolenic acid isomers in bovine milk and muscle
    M Plourde
    Department of Food Science and Nutrition, Institut des Nutraceutiques et des Aliments Fonctionnels Centre de Recherche en Sciences et Technologie du Lait, Universite Laval, Quebec, Canada G1K 7P4
    J Dairy Sci 90:5269-75. 2007
  8. doi request reprint Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly
    Milène Vandal
    Research Center on Aging, Health and Social Sciences Center, Sherbrooke University Geriatrics Institute, 1036 Belvédère St South, Sherbrooke, QC, J1H 4C4, Canada
    Lipids 43:1085-9. 2008
  9. doi request reprint Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals
    Mélanie Plourde
    From the Research Center on Aging, Health and Social Services Centre University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada MP, RC W, CR P, MF, MTMD, M JA, JT M, DL, and SCC the Departments of Medicine MP, PP, and SCC, Physiology RC W and MTMD, and Psychology DL, Universite de Sherbrooke, Sherbrooke, Canada the, Division of Nutritional Sciences, Cornell University, Ithaca, NY YZ, PL, and JTB and the Institute of Nutrition and Functional Foods MP, RC W, MTMD, M CV, and SCC and Department of Food Science and Nutrition M CV, Universite Laval, Quebec, Canada
    Am J Clin Nutr 100:105-12. 2014
  10. doi request reprint Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects
    Jennifer Tremblay-Mercier
    Research Center on Aging, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada
    J Pharmacol Exp Ther 334:341-6. 2010

Collaborators

Detail Information

Publications27

  1. pmc Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?
    Valérie Conway
    Centre de recherche sur le vieillissement, Institut Universitaire de Geriatrie de Sherbrooke, Universite de Sherbrooke, 1036 Belvedere Sud, Sherbrooke J1H 4C4, Canada
    Lipids Health Dis 13:148. 2014
    ....
  2. pmc Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly
    Mélanie Plourde
    Research Center on Aging, Health and Social Sciences Center Sherbrooke University Geriatrics Institute, Department of Medicine, Universite de Sherbrooke, Canada
    Nutr Metab (Lond) 8:5. 2011
    ....
  3. doi request reprint Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly
    Mélanie Plourde
    Research Center on Aging, Sherbrooke, Quebec, Canada
    Nutrition 25:289-94. 2009
    ..We investigated whether a dietary supplement rich in eicosapentaenoic acid (EPA) increases fasting plasma ketones or postprandial ketone responses in healthy young and elderly subjects...
  4. doi request reprint Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men
    Mélanie Plourde
    Research Centre on Aging, Universite de Sherbrooke, Sherbrooke, Canada
    Br J Nutr 102:1121-4. 2009
    ..After the supplementation, there were significant gene x diet interactions in which only non-carriers had increased EPA and DHA in plasma NEFA and TAG, respectively...
  5. doi request reprint Conjugated linoleic acids: why the discrepancy between animal and human studies?
    Mélanie Plourde
    Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nutr Rev 66:415-21. 2008
    ..The relatively unknown metabolic fate of CLA in humans may also be a contributing factor that helps explain the lack of consistency for CLA efficacy across studies...
  6. ncbi request reprint Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease
    Mélanie Plourde
    Research Center on Aging, 1036 Belvedere South, Sherbrooke, Quebec, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:301-8. 2007
    ..Studies reporting DHA intake and plasma levels while also undertaking a DHA intervention in AD would presumably help resolve these issues...
  7. ncbi request reprint Conjugated alpha-linolenic acid isomers in bovine milk and muscle
    M Plourde
    Department of Food Science and Nutrition, Institut des Nutraceutiques et des Aliments Fonctionnels Centre de Recherche en Sciences et Technologie du Lait, Universite Laval, Quebec, Canada G1K 7P4
    J Dairy Sci 90:5269-75. 2007
    ..This study appears to be the first to identify 2 CLnA isomers in bovine muscle lipid extract...
  8. doi request reprint Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly
    Milène Vandal
    Research Center on Aging, Health and Social Sciences Center, Sherbrooke University Geriatrics Institute, 1036 Belvédère St South, Sherbrooke, QC, J1H 4C4, Canada
    Lipids 43:1085-9. 2008
    ..We conclude that healthy aging is accompanied by subtle but significant changes in DHA incorporation into plasma lipids...
  9. doi request reprint Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals
    Mélanie Plourde
    From the Research Center on Aging, Health and Social Services Centre University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada MP, RC W, CR P, MF, MTMD, M JA, JT M, DL, and SCC the Departments of Medicine MP, PP, and SCC, Physiology RC W and MTMD, and Psychology DL, Universite de Sherbrooke, Sherbrooke, Canada the, Division of Nutritional Sciences, Cornell University, Ithaca, NY YZ, PL, and JTB and the Institute of Nutrition and Functional Foods MP, RC W, MTMD, M CV, and SCC and Department of Food Science and Nutrition M CV, Universite Laval, Quebec, Canada
    Am J Clin Nutr 100:105-12. 2014
    ..Docosahexaenoic acid (DHA) kinetics appear to change with intake, which is an effect that we studied in an older population by using uniformly carbon-13-labeled DHA ((13)C-DHA)...
  10. doi request reprint Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects
    Jennifer Tremblay-Mercier
    Research Center on Aging, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada
    J Pharmacol Exp Ther 334:341-6. 2010
    ..Thus, in hypertriglyceridemic individuals, bezafibrate is mildly ketogenic and significantly changes fatty acid metabolism, effects that may be linked to PPARalpha stimulation and to moderately improved glucose metabolism...
  11. doi request reprint A variant in the LRRFIP1 gene is associated with adiposity and inflammation
    Mélanie Plourde
    Institute of Nutraceuticals and Functional Foods INAF, Quebec City, Quebec, Canada
    Obesity (Silver Spring) 21:185-92. 2013
    ..6 × 10(-6))...
  12. doi request reprint n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations
    Michel Lucas
    Lucie and André Chagnon Chair for the Teaching of an Integrated Approach in Prevention, Laval University, Saint François d Assise Hospital CHUQ, Quebec, QC, Canada
    Public Health Nutr 13:63-70. 2010
    ..To quantify marine food product consumption and EPA + DHA intake among Quebecers, and to compare the results with the most recent recommendations...
  13. ncbi request reprint Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements
    Mélanie Plourde
    Research Center on Aging, Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, 1036 Belvedere St, South, Sherbrooke, QC J1H 4C4, Canada
    Appl Physiol Nutr Metab 32:619-34. 2007
    ..Despite this inefficient conversion, there are potential roles in human health for ALA and EPA that could be independent of their metabolism to DHA through the desaturation - chain elongation pathway...
  14. doi request reprint Interaction between BMI and APOE genotype is associated with changes in the plasma long-chain-PUFA response to a fish-oil supplement in healthy participants
    Raphaël Chouinard-Watkins
    Research Center on Aging, Health and Social Services Centre University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada Departments of Physiology and
    Am J Clin Nutr 102:505-13. 2015
    ..This effect could be exacerbated in overweight individuals because DHA metabolism changes according to body mass index (BMI; in kg/m²)...
  15. doi request reprint Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2
    Milène Vandal
    Centre de Recherche du Centre Hospitalier de l Université Laval CHUL, Quebec City, Quebec, Canada Institut des Nutraceutiques et des Aliments Fonctionnels, Universite Laval, Quebec City, Quebec, Canada
    J Neurochem 129:516-26. 2014
    ..These data provide a mechanistic explanation for the lack of benefit of DHA in APOE4 carriers on cognitive function and the risk of Alzheimer's disease (AD)...
  16. doi request reprint Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice
    Valérie Conway
    Research Center on Aging, Health and Social Services Center, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada J1H 4C4 Departement of Medicine, Universite de Sherbrooke, Sherbrooke, Canada Institute of Nutrition and Functional Foods, Universite Laval, Quebec, Canada
    Prostaglandins Leukot Essent Fatty Acids 91:261-7. 2014
    ..Therefore, since APOE-isoform differences were not always in line with the unbalanced n-3 PUFA profiles in organs, other proteins may be involved in maintaining n-3 PUFA homeostasis in mice with different APOE-isoforms. ..
  17. doi request reprint Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants
    Isabelle Marc
    Departement de Pediatrie, Centre Hosipitalier de l Université Laval, Quebec, Canada
    J Nutr 141:231-6. 2011
    ..001). Early supplementation with DHA to lactating mothers with low dietary DHA intake successfully increased the plasma DHA status in very preterm infants...
  18. doi request reprint Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate
    Fabien Pifferi
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Epilepsia 49:76-9. 2008
    ..In rats and humans, paired PET scans ((11)C-AcAc followed immediately by(18)fluorodeoxyglucose) will be conducted to assess the uptake of AcAc and glucose by the brain while on the KD and in neurological disorders associated with aging...
  19. doi request reprint Fish, docosahexaenoic acid and Alzheimer's disease
    S C Cunnane
    Department of Medicine and Research Center on Aging, CSSS IUGS, Universite de Sherbrooke, QC, Canada
    Prog Lipid Res 48:239-56. 2009
    ..We draw attention to some of the methodological issues that need resolution as well as an emerging mechanism that may explain how DHA could be linked to protecting brain function in the elderly...
  20. doi request reprint Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice
    Anthony Pinçon
    Research Center on Aging, Department of Physiology, Universite de Sherbrooke, 1036 Belvedere Sud, Sherbrooke, Quebec, Canada, J1H 4C4 Institute of Nutrition and Functional Foods, 2440 Boulevard Hochelaga, Quebec City, Quebec, Canada, G1V 0A6
    J Nutr Biochem 34:83-8. 2016
    ..These findings suggest that plasma and liver cholesterol homeostasis and the receptors regulating uptake of cholesterol in the liver are modulated differently and independently by APOE allele and DHA intake. ..
  21. doi request reprint Disrupted fatty acid distribution in HDL and LDL according to apolipoprotein E allele
    Thuy Mai Dang
    Department of Physiology, Universite de Sherbrooke, Sherbrooke, Canada Research Center on Aging, Health and Social Sciences Center, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada
    Nutrition 31:807-12. 2015
    ..The objective of this study was to investigate whether the ω-3 PUFA distribution in the high and low density lipoproteins is APOE-genotype dependant before and after supplementation with ω-3 PUFAs...
  22. doi request reprint Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline
    Marie Hennebelle
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Proc Nutr Soc 73:80-6. 2014
    ..In conclusion, recent development of new tools such as isotopically labelled DHA to study DHA metabolism in human subjects highlights some promising avenues to evaluate how and why DHA metabolism changes during ageing and AD. ..
  23. doi request reprint A Diet Rich in Docosahexaenoic Acid Restores Liver Arachidonic Acid and Docosahexaenoic Acid Concentrations in Mice Homozygous for the Human Apolipoprotein E ε4 Allele
    Raphaël Chouinard-Watkins
    Research Center on Aging, Health and Social Services Centre, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Canada and Department of Pharmacology Physiology and
    J Nutr 146:1315-21. 2016
    ..However, high doses of dietary docosahexaenoic acid (DHA) seem to restore DHA homeostasis in APOE4 carriers, but the contribution of hepatic fatty acid (FA) transporters is unknown...
  24. pmc Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher risk of cognitive decline and coronary heart disease?
    Raphaël Chouinard-Watkins
    Research Center on Aging, Health and Social Services Centre University Institute of Geriatrics of Sherbrooke, Department of Medicine, Universite de Sherbrooke, 1036 Belvedere Sud, Sherbrooke, J1H 4C4, Canada
    Nutrients 6:4452-71. 2014
    ..Therefore, there is a potential shift in fatty acid selection for β-oxidation towards LC omega-3 which are usually highly preserved for incorporation into cell membranes. ..
  25. doi request reprint Dietary conjugated α-linolenic acid did not improve glucose tolerance in a neonatal pig model
    Christian Alexandre Castellano
    Research Center on Aging, Health and Social Sciences Center, Geriatrics Institute, Sherbrooke, QC, Canada
    Eur J Nutr 53:761-8. 2014
    ..The aim of the study was to investigate whether a 1% dietary supplementation of mono-CLNA isomers (c9-t11-c15-18:3 + c9-t13-c15-18:3) improved glucose and lipid metabolism in neonatal pigs...
  26. doi request reprint Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men
    Shama V Joseph
    Department of Food Science and Nutrition, and Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada
    J Nutr 141:1286-91. 2011
    ..In conclusion, although no detrimental effects were caused by supplementation, these results do not confirm a role for CLA in either body weight or blood lipid regulation in humans...
  27. ncbi request reprint Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal
    Stephen C Cunnane
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Hum Biol 19:578-81. 2007
    ..Hence, we reject Carlson and Kingston's position and reiterate support for the concept that access to shore-based diets containing docosahexaenoic acid was necessary for hominin encephalization beyond the level seen in the great apes...