L Perusse

Summary

Country: Canada

Publications

  1. pmc Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Chicoutimi, and Lipid Research Center, Laval University, Quebec, Canada ca
    Am J Hum Genet 66:1558-68. 2000
  2. doi request reprint Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks
    Annie Chamberland
    Department of Fundamental Sciences, Universite du Quebec a Chicoutimi, Que, Canada
    Public Health Genomics 12:253-8. 2009
  3. doi request reprint Risk factors for adult overweight and obesity in the Quebec Family Study: have we been barking up the wrong tree?
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, and Quebec Heart Institute, Hôpital Laval Research Center, Quebec City, Quebec, Canada
    Obesity (Silver Spring) 17:1964-70. 2009
  4. doi request reprint Sex differences in inflammatory markers: what is the contribution of visceral adiposity?
    Amélie Cartier
    Quebec Heart Institute, Hôpital Laval Research Centre, Hopital Laval, Quebec, Canada
    Am J Clin Nutr 89:1307-14. 2009
  5. pmc LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study
    Christophe Garenc
    Departement de Medecine, Universite Laval, QC, Canada
    Hum Genomics 3:157-68. 2009
  6. pmc Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels
    Véronique Garneau
    Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Nutr J 11:46. 2012
  7. pmc Comparison of the dipeptidyl peptidase-4 gene methylation levels between severely obese subjects with and without the metabolic syndrome
    Valérie Turcot
    Institute of Nutraceuticals and Functional Foods INAF, Pavillon des Services, Universite Laval, 2440 Hochelaga Blvd, G1V 0A6, Quebec, Canada
    Diabetol Metab Syndr 5:4. 2013
  8. pmc LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes
    Valérie Turcot
    Institute of Nutraceuticals and Functional Foods, 2440 Hochelaga Blvd, Quebec City, G1V 0A6, Canada
    Clin Epigenetics 4:10. 2012
  9. pmc Validity of a self-reported measure of familial history of obesity
    Ann Marie Paradis
    Department of Food Science and Nutrition, Institute of Nutraceuticals and Functional Food Laval University, Quebec, Canada
    Nutr J 7:27. 2008
  10. pmc Moderators of the intention-behaviour and perceived behavioural control-behaviour relationships for leisure-time physical activity
    Steve Amireault
    Research Group on Behaviour in the Field of Health, Laval University, Québec Québec, Canada
    Int J Behav Nutr Phys Act 5:7. 2008

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Chicoutimi, and Lipid Research Center, Laval University, Quebec, Canada ca
    Am J Hum Genet 66:1558-68. 2000
    ....
  2. doi request reprint Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks
    Annie Chamberland
    Department of Fundamental Sciences, Universite du Quebec a Chicoutimi, Que, Canada
    Public Health Genomics 12:253-8. 2009
    ..The aim of this study was to investigate associations between candidate genes and obesity-related phenotypes using a sample of 252 lumberjacks issued from a founder population and sharing a common and circumscribed environment...
  3. doi request reprint Risk factors for adult overweight and obesity in the Quebec Family Study: have we been barking up the wrong tree?
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, and Quebec Heart Institute, Hôpital Laval Research Center, Quebec City, Quebec, Canada
    Obesity (Silver Spring) 17:1964-70. 2009
    ..They also indicate that the four factors, which have the best predictive potential of variations in BMI, be it in a cross-sectional or a longitudinal analytical design, do not have a "caloric value" per se...
  4. doi request reprint Sex differences in inflammatory markers: what is the contribution of visceral adiposity?
    Amélie Cartier
    Quebec Heart Institute, Hôpital Laval Research Centre, Hopital Laval, Quebec, Canada
    Am J Clin Nutr 89:1307-14. 2009
    ....
  5. pmc LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study
    Christophe Garenc
    Departement de Medecine, Universite Laval, QC, Canada
    Hum Genomics 3:157-68. 2009
    ....
  6. pmc Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels
    Véronique Garneau
    Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Nutr J 11:46. 2012
    ..The aim of this study was to verify whether intakes of n-3 FA estimated from a food frequency questionnaire (FFQ) correlate with n-3 FA levels measured in plasma phospholipids (PL)...
  7. pmc Comparison of the dipeptidyl peptidase-4 gene methylation levels between severely obese subjects with and without the metabolic syndrome
    Valérie Turcot
    Institute of Nutraceuticals and Functional Foods INAF, Pavillon des Services, Universite Laval, 2440 Hochelaga Blvd, G1V 0A6, Quebec, Canada
    Diabetol Metab Syndr 5:4. 2013
    ....
  8. pmc LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes
    Valérie Turcot
    Institute of Nutraceuticals and Functional Foods, 2440 Hochelaga Blvd, Quebec City, G1V 0A6, Canada
    Clin Epigenetics 4:10. 2012
    ..abstract:..
  9. pmc Validity of a self-reported measure of familial history of obesity
    Ann Marie Paradis
    Department of Food Science and Nutrition, Institute of Nutraceuticals and Functional Food Laval University, Quebec, Canada
    Nutr J 7:27. 2008
    ..Familial history information could be useful in clinical practice. However, little is known about the accuracy of self-reported familial history, particularly self-reported familial history of obesity (FHO)...
  10. pmc Moderators of the intention-behaviour and perceived behavioural control-behaviour relationships for leisure-time physical activity
    Steve Amireault
    Research Group on Behaviour in the Field of Health, Laval University, Québec Québec, Canada
    Int J Behav Nutr Phys Act 5:7. 2008
    ..Therefore, the aim of this study was to identify moderators of the intention-behaviour and perceived behavioural control (PBC)- behaviour relationships for leisure-time physical activity...
  11. pmc The effect of mere-measurement of cognitions on physical activity behavior: a randomized controlled trial among overweight and obese individuals
    Gaston Godin
    Canada Research Chair on Behavior and Health, Faculty of Nursing, Laval University, Quebec city Quebec, Canada
    Int J Behav Nutr Phys Act 8:2. 2011
    ..Thus, the aim of the present study was to test the effect of completing a questionnaire based on the Theory of Planned Behavior (TPB) on the level of physical activity...
  12. ncbi request reprint [Genetics of human obesity: results from genetic epidemiology studies]
    L Perusse
    Division de kinesiologie, Departement de Medecine sociale et preventive, PEPS, Universite Laval, Sainte Foy, PQ, G1K 7P4 Canada
    Ann Endocrinol (Paris) 61:24-30. 2000
    ..This genetic covariation is however moderate and accounts for a smaller percentage of the variance compared to the genetic effects reported for each of the phenotypes studied independently...
  13. ncbi request reprint Gene-diet interactions in obesity
    L Perusse
    Division of Kinesiology, the Department of Social and Preventive Medicine, The Faculty of Medicine, Laval University, Ste Foy, Canada
    Am J Clin Nutr 72:1285S-1290S. 2000
    ..In addition, gene-diet interactions in children need to be investigated to determine whether the genes involved are the same as those found in adults...
  14. ncbi request reprint A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  15. ncbi request reprint Familial aggregation of submaximal aerobic performance in the HERITAGE Family study
    L Perusse
    Division of Kinesiology, School of Medicine, Laval University, Quebec, Canada
    Med Sci Sports Exerc 33:597-604. 2001
    ..This study examines the contribution of genetic factors to submaximal aerobic performance phenotypes measured before and after 20 wk of endurance training...
  16. ncbi request reprint The human obesity gene map: the 2000 update
    L Perusse
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 9:135-69. 2001
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  17. ncbi request reprint Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study
    L Perusse
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Obes Res 8:140-50. 2000
    ..Investigate the familial aggregation of amount and distribution of subcutaneous fat and their changes in response to endurance training...
  18. ncbi request reprint [Genetics of obesity and metabolic complications in the Quebec Family Study]
    Louis Perusse
    Division de kinesiologie, PEPS, Departement de Medecine sociale et preventive, Faculte de Medecine, Universite Laval, Sainte Foy, Quebec G1K 7P4, Canada
    Med Sci (Paris) 19:937-42. 2003
    ..This review summarizes the evidence accumulated so for regarding the contribution of genetic factors in obesity and the number of gene and loci linked to obesity in the Quebec Family Study...
  19. ncbi request reprint Role of genetic factors in childhood obesity and in susceptibility to dietary variations
    L Perusse
    Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    Ann Med 31:19-25. 1999
    ..Finally, there is increasing evidence that responsiveness to dietary intervention is genetically determined...
  20. ncbi request reprint Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study
    L Perusse
    Division of Kinesiology, Laval University School of Medicine, Ste Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3270-7. 1997
    ....
  21. ncbi request reprint Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 90:1777-87. 2001
    ..This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss...
  22. ncbi request reprint Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
    ....
  23. ncbi request reprint Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
    ..0001), SF8 (+30 mm, P = 0.01), FM (+7 kg, P = 0.0004), %FAT (+5%, P = 0.0002), and leptin (+4 ng/mL, P = 0.0006). These results indicate a significant effect of leptin receptor on adiposity in middle-aged Caucasian males...
  24. pmc Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
    ..Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity...
  25. ncbi request reprint Familial resemblance for VO2max in the sedentary state: the HERITAGE family study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 30:252-8. 1998
    ..These results suggest that genetic and nongenetic factors as well as maternal influences contribute to the familial aggregation of VO2max in sedentary individuals...
  26. pmc Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, PEPS Laval University, 2300 rue de Terrasse, Quebec, QC, Canada G1V 0A6
    Diabetologia 53:679-89. 2010
    ....
  27. ncbi request reprint High normal 2-hour plasma glucose is associated with insulin sensitivity and secretion that may predispose to type 2 diabetes
    M E Piché
    Department of Food Science and Nutrition, Laval University, Quebec City, QC, Canada
    Diabetologia 48:732-40. 2005
    ..We also aimed to determine the respective contributions made by 2hPG and fasting plasma glucose to the metabolic risk profile...
  28. ncbi request reprint The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  29. doi request reprint Evidence for interaction between PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms in determining type 2 diabetes intermediate phenotypes in overweight subjects
    S M Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Exp Clin Endocrinol Diabetes 117:455-9. 2009
    ..We hypothesized that independent and interactive effects of the PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms influence T2DM intermediate phenotypes...
  30. ncbi request reprint Acute and chronic effects of exercise on leptin levels in humans
    L Perusse
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada G1K 7P4
    J Appl Physiol 83:5-10. 1997
    ..We conclude that there are no meaningful acute or chronic effects of exercise, independent of the amount of body fat, on leptin levels in humans...
  31. ncbi request reprint Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
    S J Weisnagel
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:697-702. 2001
    ....
  32. ncbi request reprint Associations between USF1 gene variants and cardiovascular risk factors in the Quebec Family Study
    A C Choquette
    Lipid Research Center, CHUQ, CHUL, Quebec, Canada
    Clin Genet 71:245-53. 2007
    ..561-100 A/A and c.*187 T/T genotypes had more favorable adiposity indices (<0.04). In summary, significant associations between relatively common USF1 genetic variants and CVD risk factors were observed in French Canadians...
  33. doi request reprint Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada
    Diabet Med 25:400-6. 2008
    ....
  34. ncbi request reprint Haplotypes in the phospholipid transfer protein gene are associated with obesity-related phenotypes: the Québec Family Study
    Y Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec, Canada
    Int J Obes (Lond) 29:1338-45. 2005
    ..The phospholipid transfer protein (PLTP) may play a role in body fat regulation...
  35. ncbi request reprint Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  36. ncbi request reprint Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Québec Family Study
    L Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec
    J Endocrinol Invest 27:1003-9. 2004
    ..These results suggest that in men, the human resistin gene is associated with reduced amount of visceral obesity and lower insulin secretory responses to a glucose load...
  37. ncbi request reprint Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 87:1003-8. 1999
    ..We conclude that the trainability of VO(2max) is highly familial and includes a significant genetic component...
  38. ncbi request reprint Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians
    J Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, Ste Foy, Quebec, Canada
    Int J Obes (Lond) 31:411-7. 2007
    ..We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the -87T>C polymorphism...
  39. ncbi request reprint Muscle adiposity and body fat distribution in type 1 and type 2 diabetes: varying relationships according to diabetes type
    M C Dubé
    Faculty of Medicine, Department of Physiology and Endocrinology, Laval University, QC, Canada
    Int J Obes (Lond) 30:1721-8. 2006
    ....
  40. doi request reprint Investigation of LRP8 gene in 1p31 QTL linked to LDL peak particle diameter in the Quebec family study
    G Dolley
    Department of Food Science and Nutrition, Laval University, Quebec City, Canada
    Mol Genet Metab 102:448-52. 2011
    ..005, p=0.004 and p=0.01, respectively) but not with LDL size-related variables. These results suggest that LRP8 gene polymorphisms influence plasma cholesterol levels as well as size and composition of LDL particles...
  41. ncbi request reprint Spousal resemblance and risk of 7-year increases in obesity and central adiposity in the Canadian population
    P T Katzmarzyk
    Physical Activity Sciences Laboratory, Laval University Ste Foy, Quebec, Canada
    Obes Res 7:545-51. 1999
    ....
  42. ncbi request reprint Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Québec Family Study
    L Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes (Lond) 31:891-9. 2007
    ..Several candidate genes have been associated with obesity, but very few studies have tested more than one gene simultaneously...
  43. ncbi request reprint Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size
    G Dolley
    CRML, CHUL Research Centre, 2705 Boul Laurier, Ste Foy, Canada
    Atherosclerosis 195:297-302. 2007
    ..In the liver, phosphatidylcholine transfer protein binds specifically phosphatidylcholine suggesting a role for this protein in the formation of HDL and possibly VLDL phospholipid membranes...
  44. doi request reprint A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals
    V Turcot
    Institute of Nutraceuticals and Functional Foods, Pavillon des Services, Laval University, Local 2729K, Quebec G1V 0A6, Canada
    Hum Genet 131:57-66. 2012
    ..This study showed a novel association between rs11554159 (p.R76Q) polymorphism at the IFI30 locus and the risk of hyperglycemia/diabetes in severely obese individuals...
  45. ncbi request reprint The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study
    J Robitaille
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    Clin Genet 63:109-16. 2003
    ..These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome...
  46. ncbi request reprint Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men
    J Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, Ste Foy, Que, Canada G1V 4G2
    Mol Genet Metab 82:296-303. 2004
    ..These findings reinforce the importance to take into account gene-diet interactions in the prevention and management of the metabolic syndrome...
  47. ncbi request reprint Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997
    ..The evidence is strong enough to warrant a search for DNA sequence variation in the gene itself...
  48. doi request reprint Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter
    G Dolley
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:137-45. 2011
    ..FASN may play a role in the regulation of feeding and may be a potential therapeutic target for obesity and insulin resistance...
  49. ncbi request reprint Linkage and association of the sodium potassium-adenosine triphosphatase alpha2 and beta1 genes with respiratory quotient and resting metabolic rate in the Québec Family Study
    P T Katzmarzyk
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 84:2093-7. 1999
    ..1% and 0.3% of the variance in RQ in younger and older adults, respectively. The results suggest that the sodium potassium adenosine triphosphatase alpha2 gene may play a role in fuel oxidation, particularly in younger individuals...
  50. pmc A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence
    N Boucher
    Laval Hospital Research Center and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:158-65. 2002
    ....
  51. doi request reprint The Three-Factor Eating Questionnaire and BMI in adolescents: results from the Québec family study
    A R Gallant
    Division of Kinesiology, Department of Preventive Medicine, Universite Laval, Quebec, QC, Canada
    Br J Nutr 104:1074-9. 2010
    ..These results show that the eating behaviour traits of disinhibition and rigid control are independently related to BMI z-scores in this group of adolescents...
  52. ncbi request reprint DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
    J M Oppert
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 18:526-31. 1994
    ..3-kb allele was found in individuals who gained more body fat over time...
  53. ncbi request reprint A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status
    B Wolfarth
    Physical Activity Sciences Laboratory, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 32:1709-12. 2000
    ....
  54. ncbi request reprint Summary of human linkage and association studies
    L Perusse
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Behav Genet 27:359-72. 1997
    ..With genomewide searches for obesity genes actually under way, together with the 16,000 genes and transcripts included in the recent human gene map, this number is likely to increase rapidly in the next few years...
  55. doi request reprint Associations between dietary patterns and obesity phenotypes
    A M Paradis
    Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Int J Obes (Lond) 33:1419-26. 2009
    ..To examine whether dietary patterns are associated with obesity phenotypes...
  56. pmc Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Mol Med 3:663-73. 1997
    ....
  57. ncbi request reprint The human obesity gene map: the 1999 update
    Y C Chagnon
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 8:89-117. 2000
    ..The number of genes, markers, and chromosomal regions that have been associated or linked with human obesity phenotypes continues to increase and is now well above 200...
  58. doi request reprint Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS)
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    J Hum Genet 53:629-36. 2008
    ..No evidence of linkage was found for TNF-alpha plasma levels. These results suggest that several QTLs can influence plasma levels of adiponectin and CRP, partly via their effects on adiposity...
  59. ncbi request reprint Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity
    Luigi Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Lipid Research Centre, Canada
    Am J Clin Nutr 80:1478-86. 2004
    ..Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. However, little is known about the genes influencing eating behaviors...
  60. ncbi request reprint Dietary intakes and familial history of obesity
    Ann Marie Paradis
    Department of Food Science and Nutrition, and Lipid Research Center, CHUQ CHUL Pavilion, Laval University, Quebec, QC, Canada
    Can J Diet Pract Res 69:97-100. 2008
    ..To compare dietary intakes of individuals with and without familial history of obesity (FHO) with recommendations from Canada's Food Guide to Healthy Eating (CFGHE)...
  61. ncbi request reprint The human obesity gene map: the 2004 update
    Louis Perusse
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 13:381-490. 2005
    ..The electronic version of the map with links to useful publications and genomic and other relevant sites can be found at http://obesitygene.pbrc.edu...
  62. ncbi request reprint Evidence of a quantitative trait locus for energy and macronutrient intakes on chromosome 3q27.3: the Quebec Family Study
    Anne C Choquette
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Am J Clin Nutr 88:1142-8. 2008
    ..Little is known about the genes influencing dietary energy and nutrient intakes, despite evidence that these intakes are influenced by genetic factors...
  63. doi request reprint Prediction of daily fruit and vegetable consumption among overweight and obese individuals
    Gaston Godin
    Canada Research Chair on Behaviour and Health, Faculty of Nursing, Laval University, Quebec, Canada G1V 0A6
    Appetite 54:480-4. 2010
    ..Interventions should encourage the development of habit and PBC. However, the age and level of anticipated regret of the targeted population should be considered when designing interventions...
  64. ncbi request reprint Energy balance and body-weight stability: impact of gene-environment interactions
    Angelo Tremblay
    Division of Kinesiology, Institute of Nutraceuticals and Functional Foods, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    Br J Nutr 92:S63-6. 2004
    ....
  65. doi request reprint Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women
    Benoit J Arsenault
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Quebec, Canada
    Am J Cardiol 104:240-6. 2009
    ....
  66. doi request reprint Prediction of leisure-time physical activity among obese individuals
    Gaston Godin
    Laval University, Quebec, Canada
    Obesity (Silver Spring) 17:706-12. 2009
    ..Nonetheless, both cognitions and aspects of the built environment should be given consideration in the promotion of leisure-time physical activity among obese individuals...
  67. ncbi request reprint A simple method to assess fruit and vegetable intake among obese and non-obese individuals
    Gaston Godin
    Canada Research Chair on Behaviour and Health, Laval University, Quebec, QC
    Can J Public Health 99:494-8. 2008
    ..The aim of the present study was to validate a brief one-page self-administered fruit and vegetable questionnaire (FV-Q) for obese and non-obese populations...
  68. doi request reprint Low cardiorespiratory fitness levels and elevated blood pressure: what is the contribution of visceral adiposity?
    Caroline Rheaume
    Department of Family and Emergency Medicine, Universite Laval, Quebec, Canada
    Hypertension 54:91-7. 2009
    ..Individuals with high visceral adipose tissue levels have higher blood pressure, independent of their fitness. Visceral adipose tissue may represent an important clinical target in the management of elevated blood pressure...
  69. ncbi request reprint Plasminogen-activator inhibitor-1 polymorphisms are associated with obesity and fat distribution in the Quebec Family Study: evidence of interactions with menopause
    Luigi Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Menopause 12:136-43. 2005
    ..PAI1 levels are also increased at menopause, a condition that is associated with fat mass gain, especially in the abdominal area...
  70. doi request reprint Contributions of cardiorespiratory fitness and visceral adiposity to six-year changes in cardiometabolic risk markers in apparently healthy men and women
    Caroline Rheaume
    Department of Family and Emergency Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada G1V 0A6
    J Clin Endocrinol Metab 96:1462-8. 2011
    ..Both excess visceral adipose tissue (VAT) and low cardiorespiratory fitness (CRF) levels are associated with a deteriorated cardiometabolic risk profile...
  71. ncbi request reprint Effect of implementation intentions to change behaviour: moderation by intention stability
    Gaston Godin
    Canada Research Chair on Behaviour and Health, FSI Vandry, 3rd Floor, Laval University, Quebec, Canada G1V 0A6
    Psychol Rep 106:147-59. 2010
    ..Intention stability thus moderated the effect of the intervention, i.e., the intervention was more successful among individuals who needed support to change (unstable intenders)...
  72. ncbi request reprint Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome
    Benoit J Arsenault
    Hôpital Laval Research Centre, Hopital Laval, Quebec, Canada
    Arch Intern Med 167:1518-25. 2007
    ..It has been suggested that overweight and obese individuals with an adequate level of cardiorespiratory fitness (CRF), the so-called fat and fit, are at reduced risk of coronary heart disease and type 2 diabetes mellitus...
  73. ncbi request reprint The human obesity gene map: the 2002 update
    Yvon C Chagnon
    Psychiatric Genetic Unit, Laval University Robert Giffard Research Center, Beauport, Quebec, Canada
    Obes Res 11:313-67. 2003
    ..More than 300 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  74. ncbi request reprint Long-term adiposity changes are related to a glucocorticoid receptor polymorphism in young females
    Angelo Tremblay
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada, G1K 7P4
    J Clin Endocrinol Metab 88:3141-5. 2003
    ..Further research will, however, be necessary to characterize the lifestyle factors promoting fat accumulation, over time, among genetically susceptible individuals...
  75. ncbi request reprint Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome
    Julie Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, 2705 Laurier Blvd, TR 93, G1V 4G2, Ste Foy, QC, Canada
    J Hum Genet 49:482-9. 2004
    ..05). In conclusion, the PPARalpha-L162V polymorphism alone or in interaction with dietary fat intake is associated with components of the metabolic syndrome...
  76. ncbi request reprint Familial resemblance in eating behaviors in men and women from the Quebec Family Study
    Véronique Provencher
    Department of Food Sciences and Nutrition, Laval University, Quebec, Canada
    Obes Res 13:1624-9. 2005
    ..The purpose of this study was to estimate the degree of familial resemblance in eating behavioral traits (cognitive dietary restraint, disinhibition, and susceptibility to hunger)...
  77. ncbi request reprint The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-Canadians
    Julie Robitaille
    Lipid Research Center, CHUQ CHUL, Ste Foy, Quebec, Canada
    Br J Nutr 97:11-8. 2007
    ..Similar results were observed for c.-840C>A and c.-1830T>C. These results suggest that cholesterol intake interacts with LXRalpha variants to modulate the plasma lipid profile...
  78. doi request reprint Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, 2300 rue de la Terrasse, Quebec, Canada
    Ann Med 42:196-206. 2010
    ....
  79. ncbi request reprint The peroxisome proliferator-activated receptor alpha L162V mutation is associated with reduced adiposity
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Sainte Foy, Quebec, Canada
    Obes Res 11:809-16. 2003
    ..To determine the contribution of the peroxisome proliferator-activated receptor alpha (PPARalpha) L162V mutation to the variation of several indexes of body fatness obtained from healthy adults who participated in the Quebec Family Study...
  80. doi request reprint Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 2:225-34. 2009
    ..The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake...
  81. ncbi request reprint Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study
    Christophe Garenc
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Obes Res 11:612-8. 2003
    ....
  82. doi request reprint Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec City, QC, Canada
    Acta Diabetol 46:217-26. 2009
    ..These variants were found to account for 2.0-8.5% of the variance of T2DM-related traits...
  83. doi request reprint GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study
    Anne C Choquette
    Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    Physiol Behav 98:505-10. 2009
    ..61450 C>A (p=0.038) and 4.9kg (vs 2.5kg in non-carriers) in C-allele carriers of c. 8473 A>C (p=0.013). The results suggest a role for the GAD2 gene in determining food intake, eating behaviors and weight gain over time in women...
  84. doi request reprint Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1147-50. 2008
    ..The present study investigated the role of two FTO SNPs (rs17817449 and rs1421085) in adiposity, insulin sensitivity, and body weight regulation, including energy intake and expenditure...
  85. doi request reprint Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity
    Luigi Bouchard
    Montreal University Community Genomics Medicine Center, Chicoutimi Hospital, Universite de Montreal, Chicoutimi, Quebec, Canada
    Obesity (Silver Spring) 17:1466-72. 2009
    ..63; P < 0.001), hyperglycemia/diabetes (OR = 1.48; P < 0.004) as well as with MetS per se (OR = 1.56; P < 0.01). These results suggest that the OSBPL11 gene is involved in cholesterol and glucose metabolism in obese individuals...
  86. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2002 update
    Louis Perusse
    Department of Preventive Medicine Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 35:1248-64. 2003
    ..To all these loci, one must add 14 mitochondrial genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes...
  87. ncbi request reprint Quantitative trait locus on 15q for a metabolic syndrome variable derived from factor analysis
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec G1V 4G2, Canada
    Obesity (Silver Spring) 15:544-50. 2007
    ..75) was also observed on chromosomes 1p, 3p, 3q, 6q, 7p, 19q, and 21q. These quantitative trait loci may harbor genes contributing to the clustering of the metabolic syndrome-related phenotypes...
  88. ncbi request reprint What is a normal glucose value? Differences in indexes of plasma glucose homeostasis in subjects with normal fasting glucose
    Marie Eve Piché
    Nutraceuticals and Functional Foods Institute, Laval University, Quebec, Canada
    Diabetes Care 27:2470-7. 2004
    ..4 mmol/l but < 6.1 mmol/l have been shown to have an increased risk of developing type 2 diabetes over 5 years, little is known about glucose metabolism abnormalities in this population...
  89. pmc The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study
    Christophe Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:88-94. 2002
    ..A C-1291G polymorphism is located in the alpha2-adrenergic receptor gene (ADRA2A) but no association with body fat accumulation has been reported yet...
  90. ncbi request reprint Heritability of LDL peak particle diameter in the Quebec Family Study
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec City, Quebec, Canada
    Genet Epidemiol 25:375-81. 2003
    ..These results suggest that LDL-PPD strongly aggregates in families, and that the familial resemblance appears to be primarily attributable to genetic factors. Genes responsible for this genetic contribution remain to be identified...
  91. ncbi request reprint Combined effects of PPARgamma2 P12A and PPARalpha L162V polymorphisms on glucose and insulin homeostasis: the Québec Family Study
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, TR 93, 2705 Laurier Blvd, Sainte Foy, Quebec, G1V 4G2 Canada
    J Hum Genet 48:614-21. 2003
    ....
  92. doi request reprint Interaction between HNF4A polymorphisms and physical activity in relation to type 2 diabetes-related traits: results from the Quebec Family Study
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Diabetes Res Clin Pract 84:211-8. 2009
    ....
  93. doi request reprint Association between mu-opioid receptor-1 102T>C polymorphism and intermediate type 2 diabetes phenotypes: results from the Quebec Family Study (QFS)
    Stephanie May Ruchat
    Department of Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada
    Clin Exp Pharmacol Physiol 35:1018-22. 2008
    ..The results of the present study reveal that the 102T/C OPRM1 gene polymorphism is associated with a better glucose tolerance and improved IS, both of which suggest a potential protective effect of this variant on T2DM risk...
  94. doi request reprint Eating behaviours of non-obese individuals with and without familial history of obesity
    Ann Marie Paradis
    Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Br J Nutr 101:1103-9. 2009
    ..More specifically, having an obese mother is associated with a higher dietary restraint score in women...
  95. ncbi request reprint Genetics of LDL particle heterogeneity: from genetic epidemiology to DNA-based variations
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Laval University, Quebec, Canada
    J Lipid Res 45:1008-26. 2004
    ..This work is an attempt to summarize the growing evidence of genetic control on LDL particle heterogeneity with the aim of providing a concise overview in one read...
  96. doi request reprint Interaction between familial history of obesity and fat intakes on obesity phenotypes
    Ann Marie Paradis
    Department of Food Science and Nutrition, Laval University, Quebec City, Que, Canada
    J Nutrigenet Nutrigenomics 2:37-42. 2009
    ..To evaluate whether familial history of obesity (FHO) interacts with dietary fat intake (DFI) on obesity-related phenotypes...
  97. ncbi request reprint Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate
    Charles Brouillette
    Lipid Research Center, CHUL Research Center, 2705 Laurier Blvd, TR93, G1V 4G2, Sainte Foy, QC, Canada
    J Hum Genet 49:424-32. 2004
    ..03). These results suggest that the LFABP T94A missense mutation could influence obesity indices as well as the risk to exhibit residual hypertriglyceridmia following a lipid-lowering therapy with fenofibrate...
  98. ncbi request reprint Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Sainte Foy, Quebec, G1V 4G2, Canada
    Circulation 107:2361-8. 2003
    ..However, association and linkage analyses have thus far been inconclusive in identifying the underlying gene(s)...
  99. ncbi request reprint Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians
    Julie Robitaille
    Lipid Research Center, CHUQ CHUL, 2705 Laurier Blvd, TR 93, Ste Foy, Quebec G1V 4G2, Canada
    J Mol Med (Berl) 85:129-37. 2007
    ..In conclusion, this finding suggests that indices of obesity might be modulated by an interaction between CPT1 variants and fat intake...
  100. ncbi request reprint Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Quebec, Canada
    J Lipid Res 45:2174-84. 2004
    ..However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage...
  101. ncbi request reprint Health-related quality of life in morbid obesity
    Karine Duval
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Obes Surg 16:574-9. 2006
    ..In order to evaluate the impact of severe obesity and its treatment on quality of life (QoL), it would be important to first identify the areas of QoL most likely to be affected by the disease...