Research Topics
| J PepinSummaryCountry: Canada Publications
| Collaborators
|
Detail Information
Publications
The expansion of HIV-1 in colonial Leopoldville, 1950s: driven by STDs or STD control?Jacques Pepin
CHUS, Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec J1H 5N4, Canada
Sex Transm Infect 88:307-12. 2012..To understand the factors that drove the exponential spread of HIV-1 in Léopoldville (Kinshasa) in the 1950s...- Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infectionMilagros Gonzales
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, 3001 12eme Avenue Nord, Sherbrooke, Quebec, Canada
BMC Infect Dis 10:363. 2010..We wished to determine to what extent faecal levels of vancomycin vary according to diarrhoea severity and dosage, and whether it is rational to administer high-dose vancomycin to selected patients... - From the Old World to the New World: an ecologic study of population susceptibility to HIV infectionJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Canada
Trop Med Int Health 10:627-39. 2005.... - Risk factors for mortality following emergency colectomy for fulminant Clostridium difficile infectionJacques Pepin
University of Sherbrooke, Sherbrooke, Quebec, Canada
Dis Colon Rectum 52:400-5. 2009..This study evaluated risk factors for mortality after emergency colectomy for fulminant Clostridium difficile infection... - Chronic antiplatelet therapy and mortality among patients with infective endocarditisJ Pepin
University of Sherbrooke, Sherbrooke, QC, Canada
Clin Microbiol Infect 15:193-9. 2009..Whether or not a beneficial effect could be replicated by initiating antiplatelet therapy at the time of diagnosis remains unproven... - Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in QuebecJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 173:1037-42. 2005..The effects of this epidemic on mortality and duration of hospital stay remain unknown. We measured these effects among patients admitted to a hospital in Quebec during 2003 and 2004... - Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in QuebecJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 41:1254-60. 2005..In 2003, a total of 55% of patients with CDAD at our hospital had received fluoroquinolones in the preceding 2 months. It has been suggested that massive use of proton pump inhibitors might have facilitated this epidemic... - Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, CanadaJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
Clin Infect Dis 42:758-64. 2006.... - Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasisJacques Pepin
Department of Microbiology and Infectious Diseases and Centre for International Health, University of Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
Trans R Soc Trop Med Hyg 100:437-41. 2006..Graded dosing, which was associated with a much lower efficacy and more frequent convulsions, should be abandoned... - Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African womenJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 42:490-3. 2006..Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them... - Vancomycin for the treatment of Clostridium difficile Infection: for whom is this expensive bullet really magic?Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 46:1493-8. 2008..In practice, because it is not yet possible to rapidly type the strains, all patients with severe CDI should be treated with vancomycin. Future trials should use complicated CDI and recurrences as their primary outcomes... - Noble goals, unforeseen consequences: control of tropical diseases in colonial Central Africa and the iatrogenic transmission of blood-borne virusesJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Canada
Trop Med Int Health 13:744-53. 2008.... - Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, CanadaJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 40:1591-7. 2005..Clinicians who treat patients with Clostridium difficile-associated diarrhea (CDAD) in Quebec, Canada, have noted an apparent increase in the proportion of patients who experience relapse... - Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workersJ Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Canada
Sex Transm Infect 81:67-72. 2005..To identify the contribution of Mycoplasma genitalium to the aetiology of cervicitis in sub-Saharan Africa and its relative importance in the overall burden of sexually transmitted infections among female sex workers (FSW)... - The complex vaginal flora of West African women with bacterial vaginosisJacques Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Canada
PLoS ONE 6:e25082. 2011..These methods have yet to be used in large-scale epidemiological studies in Africa where BV is highly prevalent... - Risk factors for hepatitis C virus transmission in colonial CameroonJacques Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 51:768-76. 2010.... - The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West AfricaJacques Pepin
Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
Bull World Health Organ 84:729-38. 2006..To evaluate whether single-dose treatments are as effective as standard therapy in the syndromic management of vaginal discharge... - Iatrogenic transmission of human T cell lymphotropic virus type 1 and hepatitis C virus through parenteral treatment and chemoprophylaxis of sleeping sickness in colonial Equatorial AfricaJacques Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 51:777-84. 2010.... - Low prevalence of cervical infections in women with vaginal discharge in west Africa: implications for syndromic managementJ Pepin
Centre for International Health, University of Sherbrooke, Canada
Sex Transm Infect 80:230-5. 2004..To measure prevalence and risk factors for cervical infections among a large sample of women consulting for vaginal discharge in west Africa and to evaluate its syndromic management through a two visit algorithm... - Klebsiella pneumoniae bacteraemia in a region of CanadaJ Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, QC, Canada
Clin Microbiol Infect 16:141-6. 2010..pneumoniae bacteraemia who were diabetic increased from 26% (1997-2004) to 42% (2005-2007). The rising incidence of K. pneumoniae bacteraemia may represent an unexpected consequence of the expanding population of adult diabetics... - Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severityJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 171:466-72. 2004..difficile-associated diarrhea (CDAD) in our institution. We describe cases of CDAD at our institution over a 13-year period and investigate changes in illness severity... - Etiology of urethral discharge in West Africa: the role of Mycoplasma genitalium and Trichomonas vaginalisJ Pepin
Centre de santé internationale, Universite de Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
Bull World Health Organ 79:118-26. 2001..To determine the etiological role of pathogens other than Neisseria gonorrhoeae and Chlamydia trachomatis in urethral discharge in West African men... - Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Am J Gastroenterol 102:2781-8. 2007..To reassess the comparative efficacy of vancomycin versus metronidazole in the treatment of Clostridium difficile-associated disease (CDAD) after the emergence in 2003 of the hypervirulent NAP1/027 strain... - Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-BissauA C Labbe
Centre for International Health, University of Sherbrooke, Canada
Sex Transm Infect 78:289-91. 2002..To evaluate the impact of Mycoplasma genitalium on the outcome of pregnancy... - Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strainAlex Carignan
Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 46:1838-43. 2008..The purpose of this study was to determine the risk of PAP-induced CDI after selected surgical procedures and to compare such risk before with such risk after the emergence of the hypervirulent strain of C. difficile... - Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strainFrancois Lamontagne
University of Sherbrooke, Sherbrooke, Canada
Ann Surg 245:267-72. 2007..To determine whether emergency colectomy reduces mortality in patients with fulminant Clostridium difficile-associated disease (CDAD), and to identify subgroups of patients more likely to benefit from the procedure... - Fatal Clostridium difficile enteritis caused by the BI/NAP1/027 strain: a case series of ileal C. difficile infectionsC Lavallee
Departement de Microbiologie, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
Clin Microbiol Infect 15:1093-9. 2009..This case series suggests that small bowel involvement in C. difficile infections may be more frequent than previously thought... - Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trialJ Pepin
Centre de santé internationale, Universite de Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
Bull World Health Organ 78:1284-95. 2000.... - Parenteral transmission during excision and treatment of tuberculosis and trypanosomiasis may be responsible for the HIV-2 epidemic in Guinea-BissauJacques Pepin
Department of Microbiology and Infectious Diseases and Center for International Health, Centre Hospitalier Universitaire 3001, University of Sherbrooke, 12th Avenue North, Sherbrooke, Quebec, Canada
AIDS 20:1303-11. 2006..We sought to verify the hypothesis that parenteral transmission was the key factor in the building-up of the HIV-2 epidemic... - The epidemiology and control of human African trypanosomiasisJ Pepin
Infectious Diseases Division, Centre for International Health, University of Sherbrooke, Quebec, Canada
Adv Parasitol 49:71-132. 2001..The various methods and strategies for the surveillance and control of both diseases are reviewed... - Satisfaction with health services for STIs, HIV, AIDS among a high-risk population in West AfricaD Morin
Faculty of Nursing Sciences, Universite Laval, Quebec, Canada
AIDS Care 20:388-94. 2008.... - Secular changes in incidence and mortality associated with Staphylococcus aureus bacteraemia in Quebec, Canada, 1991-2005C Allard
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
Clin Microbiol Infect 14:421-8. 2008..MRSA did not replace, but added to, an existing stable incidence of MSSA bacteraemia... - Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strainLouis Valiquette
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 45:S112-21. 2007..The inefficacy of infection control measures targeting transmission through hospital personnel might be a result of their implementation late in the epidemic, when the environment was heavily contaminated with spores... - Prediction of complicated Clostridium difficile infection by pleural effusion and increased wall thickness on computed tomographyLouis Valiquette
Department of Microbiology and Infectious Diseases, University of Sherbrooke, 3001, 12ème AveNord, Sherbrooke, Quebec J1H 5N4, Canada
Clin Infect Dis 49:554-60. 2009..difficile. We sought to describe and correlate abdominal CT findings with complicated CDI and to compare them before and after the emergence of the epidemic strain... - Fluoroquinolones and risk for methicillin-resistant Staphylococcus aureus, CanadaLouiselle Leblanc
University of Sherbrooke, Sherbrooke, Quebec, Canada
Emerg Infect Dis 12:1398-405. 2006..84-3.60) and infection (AHR 2.49, 95% CI 1.02-6.07). Effect of antimicrobial drugs on MRSA colonization and infection was similar to effect on CDAD and should be considered when selecting antimicrobial drugs to treat common infections... - Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001Jacques Pepin
Centre for International Health and Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Emerg Infect Dis 11:921-7. 2005.... - A tale of two countries: HIV among core groups in TogoFrancois Sobela
Centre de Santé Internationale de l Université de Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 51:216-23. 2009..To describe the epidemiology of HIV among core groups in Togo... - The Indian Ocean paradox revisited: HIV and sexually transmitted infections in the ComorosYasmina Dada
Center for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
Int J STD AIDS 18:596-600. 2007..Only 1/70 (1.4%) and 0/83 sex workers sampled in 2004 and 2005 were HIV-infected. The Comoros have been protected by their insular status, male circumcision and paucity of syphilis. HIV control should focus on sex workers... - Hepatitis C virus infection in Guinea-Bissau: a sexually transmitted genotype 2 with parenteral amplification?Mireille Plamondon
Department of Microbiology and Infectious Diseases and Centre for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
PLoS ONE 2:e372. 2007..Genotype 2 HCV is thought to have originated from West Africa several hundred years ago. Mechanisms of transmission remain poorly understood... - Trypanosoma brucei gambiense African trypanosomiasis: differences between men and women in severity of disease and response to treatmentJacques Pepin
Centre for International Health, University of Sherbrooke, Quebec, Canada
Trans R Soc Trop Med Hyg 96:421-6. 2002..8%) (P = 0.004), even after adjustment for other independent risk factors in multivariate analysis. The cause of this higher risk of treatment failure among men treated with melarsoprol remains unclear... - The impact of syphilis, HIV-1, and HIV-2 on pregnancy outcome in Bissau, Guinea-BissauAnne Claude Labbé
Centre for International Health, University of Sherbrooke, Quebec, Canada
Sex Transm Dis 29:157-67. 2002..Syphilis remains a major cause of fetal loss and neonatal mortality in sub-Saharan Africa. Guinea-Bissau is the epicenter of the HIV-2 epidemic, and little is known about the impact of HIV-2 on pregnancy... - Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patientMireille Plamondon
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Canada
Clin Infect Dis 51:e1-3. 2010.... - High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantationAnnie Claude Labbe
Department of Microbiology and Infectious Diseases, Hôpital Maisonneuve Rosemont and Université de Montréal, Montreal, Canada
Biol Blood Marrow Transplant 13:1192-200. 2007..Because there is currently no surrogate in vitro markers of immunocompetence following NMA HSCT, this clinical finding is of particular importance to identify a population at higher risk who should be targeted for antimold prophylaxis... - Nocardiosis in Quebec, Canada, 1988-2008J Tremblay
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Canada
Clin Microbiol Infect 17:690-6. 2011.... - Transactional sex is the driving force in the dynamics of HIV in Accra, GhanaAnne Marie Côté
Centre for International Health, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
AIDS 18:917-25. 2004..To delineate the population attributable fraction (PAF) of transactional sex in prevalent cases of HIV infection in the male adult population of Accra, Ghana... - Cost-effectiveness of a 3-dose pneumococcal conjugate vaccine program in the province of Quebec, CanadaBéatrice Poirier
Department of Community Health Sciences, University of Sherbrooke, Sherbrooke, Canada
Vaccine 27:7105-9. 2009..The incremental cost-effectiveness ratio was $18,000 per QALY gained for the health system and the program was close to the break-even threshold in a societal perspective... - The price of development: HIV infection in a semiurban community of GhanaNadine Sauve
Centre for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 29:402-8. 2002..To describe the epidemiology of HIV infection in the Manya Krobo District, Ghana, and its potential link to the building of the Akosombo dam... - Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and EuropeMichel Warny
Acambis Inc, Cambridge, MA, USA
Lancet 366:1079-84. 2005..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains... - A Gambian infant with fever and an unexpected blood filmStephen Howie
Medical Research Council Laboratories, Banjul, Gambia
PLoS Med 3:e355. 2006 - Combination therapy for sleeping sickness: a wake-up callJacques Pepin
J Infect Dis 195:311-3. 2007 - Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat anGeorge Killgore
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 46:431-7. 2008..All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks... - Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and womenKathryn Chu
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Int J STD AIDS 17:681-6. 2006..5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions... - Absence of Mycoplasma genitalium in eye samples from a trachoma-endemic area of TanzaniaJacques Pepin
Br J Ophthalmol 92:435. 2008 - Performance of HerpeSelect and Kalon assays in detection of antibodies to herpes simplex virus type 2Jerome Legoff
Universite Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743, Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Hopital Europeen Georges Pompidou, Paris, France
J Clin Microbiol 46:1914-8. 2008..Low index values obtained with the HerpeSelect assay may correspond to true HSV-2 infection, in particular to nonprimary first episodes of genital HSV-2 infection, and need to be interpreted in the context of clinical history... - Improving the treatment of Clostridium difficile-associated disease: where should we start?Jacques Pepin
Clin Infect Dis 43:553-5. 2006 - A randomized placebo-controlled trial of the impact of multiple micronutrient supplementation on HIV-1 genital shedding among Thai subjectsSukhum Jiamto
J Acquir Immune Defic Syndr 37:1216-8. 2004 - A randomized trial of the impact of multiple micronutrient supplementation on mortality among HIV-infected individuals living in BangkokSukhum Jiamton
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
AIDS 17:2461-9. 2003..The clinical findings need to be reproduced in other settings and the mechanism, which appears to be independent of change in CD4 cell count, merits further investigation...