G Pelletier

Summary

Country: Canada

Publications

  1. ncbi Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
    M El-Alfy
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Canada
    Endocrinology 140:1481-91. 1999
  2. ncbi Flanking sequence tags in Arabidopsis thaliana T-DNA insertion lines: a pilot study
    Dominique Ortega
    , UMR 5096, , 52, Av. de Villeneuve, 66860 Perpignan, France
    C R Biol 325:773-80. 2002
  3. ncbi Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 109:247-53. 2008
  4. ncbi Effects of ovariectomy and dehydroepiandrosterone (DHEA) on vaginal wall thickness and innervation
    Georges Pelletier
    Research Center in Molecular Endocrinology, Oncology and Human Genomics, Laval University, Quebec, QC, Canada
    J Sex Med 9:2525-33. 2012
  5. ncbi Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
    Hong Liu
    Oncology and Molecular Endocrinology Laboratory, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, GlV 4G2, Canada
    BMC Biochem 8:2. 2007
  6. ncbi Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada GIV 4G2
    J Steroid Biochem Mol Biol 93:49-57. 2005
  7. ncbi Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, 2705, Laurier Boulevard, Quebec, Québec GIV 4G2, Canada
    J Mol Endocrinol 33:459-65. 2004
  8. ncbi Cellular localization of mRNA expression of enzymes involved in the formation and inactivation of hormonal steroids in the mouse prostate
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, 2705, Laurier Boulevard, Quebec, G1V 4G2, Canada
    J Histochem Cytochem 52:1351-6. 2004
  9. ncbi Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, Quebec, G1V 4G2, Canada
    J Mol Endocrinol 26:11-9. 2001
  10. ncbi Role of extra-ovarian oestrogens in the regulation of gonadotropin releasing hormone mRNA expression in the rat brain
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, Canada
    J Neuroendocrinol 13:678-82. 2001

Collaborators

Detail Information

Publications83

  1. ncbi Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
    M El-Alfy
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Canada
    Endocrinology 140:1481-91. 1999
    ..The potential role of androgen formation and action in blood vessels is unknown and opens new avenues of investigation for a better understanding of the multiple roles of androgens...
  2. ncbi Flanking sequence tags in Arabidopsis thaliana T-DNA insertion lines: a pilot study
    Dominique Ortega
    , UMR 5096, , 52, Av. de Villeneuve, 66860 Perpignan, France
    C R Biol 325:773-80. 2002
    ..The distribution of the T-DNA insertions along the chromosomes shows that they are essentially absent from the centrometric and pericentrometric regions...
  3. ncbi Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 109:247-53. 2008
    ..It is also postulated that UGT enzymes protect the tissue from deleteriously high concentrations of active androgen...
  4. ncbi Effects of ovariectomy and dehydroepiandrosterone (DHEA) on vaginal wall thickness and innervation
    Georges Pelletier
    Research Center in Molecular Endocrinology, Oncology and Human Genomics, Laval University, Quebec, QC, Canada
    J Sex Med 9:2525-33. 2012
    ..Recently, it has been shown that intravaginal administration of dehydroepiandrosterone (DHEA) could produce beneficial effects on sexual dysfunction in postmenopausal women...
  5. ncbi Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
    Hong Liu
    Oncology and Molecular Endocrinology Laboratory, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, GlV 4G2, Canada
    BMC Biochem 8:2. 2007
    ....
  6. ncbi Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada GIV 4G2
    J Steroid Biochem Mol Biol 93:49-57. 2005
    ....
  7. ncbi Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, 2705, Laurier Boulevard, Quebec, Québec GIV 4G2, Canada
    J Mol Endocrinol 33:459-65. 2004
    ..In the testes and peripheral tissues, the action of E2 is probably limited to the cells involved in its formation in an intracrine fashion...
  8. ncbi Cellular localization of mRNA expression of enzymes involved in the formation and inactivation of hormonal steroids in the mouse prostate
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, 2705, Laurier Boulevard, Quebec, G1V 4G2, Canada
    J Histochem Cytochem 52:1351-6. 2004
    ..The present results indicate that both epithelial and stromal cells in the mouse prostate play a role in local formation and inactivation of hormonal steroids...
  9. ncbi Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, Quebec, G1V 4G2, Canada
    J Mol Endocrinol 26:11-9. 2001
    ..The absence of any association of the enzymes with membrane-bound organelles appears as a common finding in the reactive cell types of two peripheral tissues...
  10. ncbi Role of extra-ovarian oestrogens in the regulation of gonadotropin releasing hormone mRNA expression in the rat brain
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, Canada
    J Neuroendocrinol 13:678-82. 2001
    ....
  11. ncbi Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada G1V 4G2
    J Endocrinol 171:373-83. 2001
    ....
  12. ncbi Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, and Laval University, Quebec, Canada G1V 4G2
    J Clin Endocrinol Metab 85:4835-40. 2000
    ..Moreover, they contribute to establish the exact sites of action of estrogens in male and female human reproductive systems...
  13. ncbi Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, 2705, Laurier Boulevard, Canada G1V 4G2
    Brain Res Mol Brain Res 125:143-6. 2004
    ..In the hippocampus, the labelling was mostly located over pyramidal cells of the CA1 layer. These results suggest that progesterone can be inactivated by 20alpha-HSD in some specific brain areas...
  14. ncbi Effect of long-term treatment with the antiestrogen EM-652.HCl on pituitary estrogen receptor alpha and prolactin mRNA expression in intact, ovariectomized and gonadotropin-releasing hormone-treated female rats
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada
    Neuroendocrinology 74:367-74. 2001
    ..It is suggested that estrogens can positively regulate pituitary ERalpha gene transcription and that the antiestrogen EM-652.HCl can downregulate by itself pituitary ERalpha gene transcription...
  15. ncbi Localization of sex steroid receptors in human skin
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, Quebec, Quebec, Canada
    Histol Histopathol 19:629-36. 2004
    ..This information on the differential localization of sex steroid receptors in human skin should be of great help for future investigation on the specific role of each steroid on skin and its appendages...
  16. ncbi Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina
    G Pelletier
    Atlas Project, Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Québec G1 V 4 G2, Canada
    J Endocrinol 180:77-85. 2004
    ..The data obtained indicated that, in adult mice, estrogens exert a positive regulation of AR mRNA expression in the different compartments of both the uterus and the vagina...
  17. ncbi Sex-related expression of 20alpha-hydroxysteroid dehydrogenase mRNA in the adult mouse
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, 2705 Laurier Boulevard, Québec PQ G1V 4G2, Canada
    J Histochem Cytochem 51:1425-36. 2003
    ....
  18. ncbi Effects of estradiol on prostate epithelial cells in the castrated rat
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada
    J Histochem Cytochem 50:1517-24. 2002
    ..These results suggest that E(2) can influence the activity of rat prostate epithelial cells by mechanisms that remain to be fully clarified...
  19. ncbi Role of androgens in the regulation of urotensin II precursor mRNA expression in the rat brainstem and spinal cord
    G Pelletier
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, QC, Canada G1V 4G2
    Neuroscience 115:525-32. 2002
    ..The physiological relevance of these new findings remains to be fully explored...
  20. ncbi Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Quebec, Canada GIV 4G2
    Neuroscience 132:689-96. 2005
    ....
  21. ncbi Localization of androgen and estrogen receptors in rat and primate tissues
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital and Laval University, Quebec, Canada
    Histol Histopathol 15:1261-70. 2000
    ..Altogether, the recent results on the cellular localization of sex steroid receptors will certainly contribute to a better understanding of the specific role of these steroids in different target organs...
  22. ncbi Morphological studies of prolactin-secreting cells in estrogen receptor alpha and estrogen receptor beta knockout mice
    Georges Pelletier
    Oncology and Molecular Endocrinology Research Center and Quebec Genome Center, Le Centre Hospitalier de l Université Laval CHUL, Quebec, Que, Canada
    Neuroendocrinology 77:324-33. 2003
    ..The present data strongly suggest that the positive regulation of PRL expression at the pituitary level by estrogens is mediated by ERalpha and does not involve ERbeta activation...
  23. ncbi Localization of type 5 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Le Centre Hospitalier de l Université Laval CHUL, 2705, Laurier Boulevard, Quebec, G1V 4G2, Canada
    Cell Tissue Res 320:393-8. 2005
    ..The data indicate that androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney...
  24. ncbi Steroidogenic enzymes in the brain: morphological aspects
    Georges Pelletier
    Oncology, Molecular Endocrinology and Human Genomics Research Center CHUL, Quebec, Canada
    Prog Brain Res 181:193-207. 2010
    ..More work is required to fully establish the migration of precursors and active steroids in the brain...
  25. ncbi Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
    Georges Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, Quebec, Canada
    J Histochem Cytochem 53:1257-71. 2005
    ..In the lung, type 8 17beta-HSD mRNA was detected in bronchial epithelial cells and walls of pulmonary arteries. The present data suggest that type 8 17beta-HSD can exert its action to downregulate E2 levels in a large variety of tissues...
  26. ncbi Expression of steroidogenic enzymes and sex-steroid receptors in human prostate
    Georges Pelletier
    Oncology and Molecular Endocrinology Laboratory Research Center, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, Canada
    Best Pract Res Clin Endocrinol Metab 22:223-8. 2008
    ..Androgen receptor (AR) has been localized in luminal cell nuclei of alveoli and a large number of stromal cells, while estrogen receptor beta has been detected in both basal and luminal cells in alveoli and also in stromal cells...
  27. ncbi Oestrogenic regulation of pro-opiomelanocortin, neuropeptide Y and corticotrophin-releasing hormone mRNAs in mouse hypothalamus
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, Quebec, Quebec, Canada
    J Neuroendocrinol 19:426-31. 2007
    ..The present data suggest that oestrogen might exert an anorexigenic action by stimulating POMC and CRH mRNA expression and decreasing NPY mRNA expression in the hypothalamus...
  28. ncbi Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology
    G Pelletier
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada
    J Steroid Biochem Mol Biol 108:102-8. 2008
    ..As in the monkey, the histology of the female rat mammary gland remained unchanged following long-term treatment with any of the two doses of DHEA...
  29. ncbi Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues
    H F Zhao
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 266:583-93. 1991
    ..The present data indicate the existence of two mRNAs encoding rat 3 beta-HSD and their differential tissular distribution in both steroidogenic and peripheral tissues.(ABSTRACT TRUNCATED AT 400 WORDS)..
  30. ncbi Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, Quebec, Canada G1V 4G2
    J Mol Endocrinol 25:1-16. 2000
    ..To date, seven human 17 beta-HSDs have been cloned, sequenced and characterized. The 17 beta-HSDs provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs...
  31. ncbi Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters
    B Han
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center, 2705 Laurier Blvd, Quebec City, QC, G1V 4G2, Canada
    J Steroid Biochem Mol Biol 112:194-200. 2008
    ..The decrease in 17beta-HSD type 2 and 17beta-HSD type 5 expressions in breast cancer may play a predominant role in the development and/or progression of the cancer by modifying the intratumoral levels of estrogens and androgens...
  32. ncbi Cellular localization of estrogen receptor beta messenger ribonucleic acid in cynomolgus monkey reproductive organs
    G Pelletier
    Laboratory of Molecular Endocrinology, Laval University Medical Research Center and Laval University, Quebec, Canada G1V 4G2
    Biol Reprod 61:1249-55. 1999
    ..In the male testis and prostate, ER-beta has been found in cells that contain very little or no ER-alpha. The role of circulating or locally produced estrogens in the male reproductive system remains to be clarified...
  33. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization
    C Juneau
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biol Reprod 48:226-34. 1993
    ..Similar results were obtained in 40-day-old and adult animals. The present data indicate a progressive expression of 3 beta-HSD in different morphological structures during ovarian development in the rat...
  34. ncbi Intracrinology and the skin
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec City, Canada
    Horm Res 54:218-29. 2000
    ....
  35. ncbi Is dehydroepiandrosterone a hormone?
    F Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec G1V4G2, Canada
    J Endocrinol 187:169-96. 2005
    ....
  36. ncbi Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate
    C Labrie
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Center, Quebec, Canada
    Mol Cell Endocrinol 68:169-79. 1990
    ..Consequently, as indicated by this sensitive and androgen-specific in vivo rat model, such compounds are not recommended for the treatment of conditions requiring an optimal blockade of androgens, especially prostate cancer...
  37. ncbi DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, , , , Canada
    Nucleic Acids Res 29:3241-7. 2001
    ..We use this and previous data to refine the existing enhancesome model and show that HMG boxes 1 and 2 of UBF lie head-to-head along the DNA...
  38. ncbi Role of glucocorticoids in the modulation of corticotropin-releasing hormone mRNA level by the endogenous benzodiazepine receptor ligand octadecaneuropeptide in rat brain
    L Givalois
    Molecular Endocrinology Laboratory, CHUL Research Center of Laval University, Quebec, Canada
    Neuroendocrinology 68:98-104. 1998
    ..Together with previous findings, these results suggest that adrenal and/or gonadal factor(s) other than glucocorticoids are involved in ODN modulation of the HPA axis...
  39. ncbi Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, 2705 Laurier Boulevard, G1V 4G2, Quebec, Canada
    Mol Cell Endocrinol 171:77-82. 2001
    ..The double activity of type 5 17beta-HSD in the female reproductive tissues is probably necessary to the control of the optimal level of progesterone and sex steroids...
  40. ncbi Age-related decrease in the hypothalamic CRH mRNA expression is reduced by dehydroepiandrosterone (DHEA) treatment in male and female rats
    L Givalois
    MRC Group in Molecular Endocrinology, CHUL Research Center of Laval University, Sainte Foy, Que, Canada
    Brain Res Mol Brain Res 48:107-14. 1997
    ....
  41. ncbi Unique features of the basal cells of human prostate epithelium
    M El-Alfy
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, and Laval University, Quebec, G1V 4G2, Canada
    Microsc Res Tech 51:436-46. 2000
    ..Human basal cells could thus regulate functions of the luminal cells by being part of a two-cell mechanism somewhat analogous to thecal and granulosa cells in the ovary...
  42. ncbi Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas
    E L Calvo
    Dept Médecine, Fac Médecine, Univ Sherbrooke, Quebec, Canada
    Biochem Biophys Res Commun 229:257-63. 1996
    ..These new data demonstrate that HGF and its receptor may be implicated in normal pancreas development and maturation...
  43. ncbi Localization and glucocorticoid regulation of 11beta-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Quebec, Quebec, Canada G1V 4G2
    Neuroscience 145:110-5. 2007
    ..This downregulation might contribute to maintain low intracellular corticosterone levels in central regions and then prevent the deleterious effects induced by high glucocorticoid levels...
  44. ncbi Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study
    D Poisson Paré
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center, 2705 Laurier Blvd, Quebec City, QC, Canada, G1V 4G2
    Breast Cancer (Auckl) 3:9-21. 2009
    ..The significance of the association between EST1E1 and ER-β or PR-B should be further studied since these two receptors are transcription activators and may regulate the expression of protective enzymes like EST1E1...
  45. ncbi Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry
    Y Takase
    Oncology and Molecular Endocrinology Laboratory, CHUL Research Center, Quebec, Canada
    Prostate 67:405-9. 2007
    ..We have recently shown that EST 1E1 is highly expressed in male mouse reproductive organs, including prostate. It appeared of interest to study the expression of EST 1E1 in human prostate...
  46. ncbi Autoradiographic localization of beta-adrenoreceptors in rat uterus
    M Tolszczuk
    MRC Group in Molecular Endocrinology, Le Centre Hospitalier de l Université Laval, Ste Foy, Quebec, Canada
    J Histochem Cytochem 36:1475-9. 1988
    ..Specific labeling was also observed in glandular elements. These results suggest that beta-adrenoreceptors might be involved in different functions in the uterus...
  47. ncbi Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin
    M Dumont
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Invest Dermatol 99:415-21. 1992
    ..38 microM, 1.3 microM, and 1.2 microM, respectively. Immunohistochemical localization of 3 beta-HSD, illustrated by using an antibody raised against human placental 3 beta-HSD, shows that the enzyme is localized in sebaceous glands...
  48. ncbi Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH2) in growing pigs
    P Dubreuil
    Department of Biology, University of Sherbrooke, QC, Canada
    Domest Anim Endocrinol 4:299-307. 1987
    ....
  49. ncbi Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells
    Jenny Kaeding
    Molecular Endocrinology and Oncology Research Center, CHUL Research Center, Quebec, QC, Canada G1V 4G2
    Biochem J 410:245-53. 2008
    ..In conclusion, the present study identifies for the first time the activators of FXR as important regulators of androgen metabolism in human prostate cancer cells...
  50. ncbi Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization
    E Dupont
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Endocrinology 129:2687-92. 1991
    ..The present data suggest that 3 beta-HSD expression could well play a major role in regulating adrenal function during foetal and postnatal development...
  51. ncbi Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs
    G Pelletier
    Molecular Endrocrinology Laboratory, CHUL Research Center of Laval University, Quebec G1V 4G2, Canada
    J Endocrinol 165:359-70. 2000
    ..By establishing the precise sites of action of oestrogens and androgens they contribute to a better understanding of the respective role of these steroids in reproduction function...
  52. ncbi Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase
    Van Luu-The
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL, Laval University, Que, Canada G1V 4G2
    J Steroid Biochem Mol Biol 93:269-76. 2005
    ..On the other hand estrogen sulfotransferase, the enzyme that inactivates estrogen, has been found selectively expressed in male tissues, thus suggesting a role for this enzyme to protect male-specific tissues against estrogenic activity...
  53. ncbi Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center Centre Hospitalier de l Université Laval and Laval University, Quebec City, Quebec G1V 4G2, Canada
    Endocr Rev 24:152-82. 2003
    ....
  54. ncbi Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization
    Zhuo Li
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Centre CRCHUL and Laval University, Quebec City, Quebec, Canada
    Histol Histopathol 24:273-82. 2009
    ..The present results indicate the enzymes which play a role in the synthesis and metabolism of E2 are expressed in both epithelial and stromal cells in human breast...
  55. ncbi The combination of a novel selective estrogen receptor modulator with an estrogen protects the mammary gland and uterus in a rodent model: the future of postmenopausal women's health?
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    Endocrinology 144:4700-6. 2003
    ....
  56. ncbi Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
    Alain Belanger
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center, Laval University, G1V 4G2, Quebec, Canada
    Trends Endocrinol Metab 14:473-9. 2003
    ..It is postulated that the conjugating activity of UGT enzymes is the main mechanism for modulating the action of steroids and protecting the androgen-sensitive tissues from deleteriously high concentrations of DHT, ADT and 3alpha-DIOL...
  57. ncbi Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium
    Sarah Chouinard
    Faculty of Medicine, Laval University, Quebec, Canada
    Endocr Res 30:717-25. 2004
    ..This reinforces the hypothesis that UGT enzymes catalyze an important mechanism for modulating the action of steroids and protecting the steroid-sensitive tissues from deleteriously high steroid concentrations...
  58. ncbi Expression of enzymes involved in estrogen metabolism in human prostate
    Yasukazu Takase
    Oncology and Molecular Endocrinology Laboratory, CHUL Research Center, 2705 Laurier Boulevard, , G1V 4G2, Canada
    J Histochem Cytochem 54:911-21. 2006
    ....
  59. ncbi Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone
    Jean Thibaudeau
    Oncology and Molecular Endocrinology Research Center, Faculty of Pharmacy, Laval University, Quebec, Canada
    Cancer Res 66:125-33. 2006
    ....
  60. ncbi Isolation of IFAPa-400 cDNAs: evidence for a transient cytostructural gene activity common to the precursor cells of the myogenic and the neurogenic cell lineages
    J L Simard
    Centre de Recherche du CHUL, Ste Foy, Que, Canada
    Brain Res Dev Brain Res 70:173-80. 1992
    ..These results further confirm that IFAPa-400 mRNA transcripts are limited to the early precursor cells of both neurogenic and myogenic lineages...
  61. ncbi Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus
    Mahine Ivanga
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center, CHUQ, Department of Anatomy and Physiology, Laval University, Quebec, Canada
    Mol Reprod Dev 76:278-88. 2009
    ....
  62. ncbi Intravenous diltiazem in acute myocardial infarction. Diltiazem as adjunctive therapy to activase (DATA) trial
    P Theroux
    Department of Medicine, Montreal Heart Institute and University of Montreal, Quebec, Canada
    J Am Coll Cardiol 32:620-8. 1998
    ..This study was defined as a pilot investigation of the usefulness and safety of intravenous diltiazem as adjunctive therapy to tissue plasminogen activator in acute myocardial infarction, followed by oral therapy for 4 weeks...
  63. ncbi An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6, Quebec, Canada
    Mol Cell 8:1063-73. 2001
    ..Thus, growth factor regulation of ribosomal transcription likely acts by a cyclic modulation of DNA architecture. The data suggest a central role for ribosome biogenesis in growth regulation...
  64. ncbi Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center, 2705 Laurier Boulevard Bloc T3-67, , Canada G1V 4G2
    Endocrinology 147:5431-42. 2006
    ..These differential effects of androgens, IL-1alpha, and EGF on lipid metabolism likely constitute an additional mechanism by which these endogenous factors promote prostate cancer development...
  65. ncbi Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle
    Z Wang
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 98:2422-8. 1998
    ..The present study was designed to define the relative levels of mRNA for various IRKs in human atrium and in failing and nonfailing ventricle...
  66. ncbi Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
    G Pelletier
    Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
    Mol Cell 6:1059-66. 2000
    ..quot; Thus, PolI transcription is regulated by protein acetylation, and the competitive recruitment of CBP and Rb...
  67. ncbi Immunocytochemical localization of sex steroid hormone receptors in normal human mammary gland
    Sijie Li
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    J Histochem Cytochem 58:509-15. 2010
    ..Estrogens and androgens can also indirectly influence epithelial cell activity by an action on stromal cells...
  68. ncbi Neuropeptide Y inhibits the biosynthesis of sulfated neurosteroids in the hypothalamus through activation of Y(1) receptors
    Delphine Beaujean
    European Institute for Peptide Research (IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U-413, UA Centre National de la Recherche Scientifique, University of Rouen, 76821 Mont-Saint-Aignan, France
    Endocrinology 143:1950-63. 2002
    ..Our data also demonstrate that NPY, acting via Y(1) receptors, exerts an inhibitory effect on the biosynthesis of sulfated neurosteroids...
  69. ncbi Central nitric oxide regulation of the hypothalamic-pituitary-adrenocortical axis in adult male rats
    Laurent Givalois
    Cerebral Plasticity Laboratory, UMR 5102 CNRS, Montpellier II University, , Montpellier, France
    Brain Res Mol Brain Res 102:1-8. 2002
    ..These results suggest that the central NO system exerts a tonic negative influence on the activity of the HPA axis in the presence or absence of circulating glucocorticoids...
  70. ncbi Biochemical characterization and immunocytochemical localization of EM66, a novel peptide derived from secretogranin II, in the rat pituitary and adrenal glands
    Maite Montero-Hadjadje
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    J Histochem Cytochem 51:1083-95. 2003
    ....
  71. ncbi Structure-activity relationships of a series of analogs of the endozepine octadecaneuropeptide (ODN(11)(-)(18)) on neurosteroid biosynthesis by hypothalamic explants
    Jean Luc Do Rego
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP 23, University of Rouen, 76821 Mont Saint Aignan, France
    J Med Chem 50:3070-6. 2007
    ..The present study indicates that the C-terminal hexapeptide of ODN/OP is the minimal sequence retaining full biological activity on steroid-producing neurons...
  72. ncbi Vasotocin and mesotocin stimulate the biosynthesis of neurosteroids in the frog brain
    Jean-Luc Do-Rego
    , , Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, 76821 Mont-Saint-Aignan, France
    J Neurosci 26:6749-60. 2006
    ..The present study provides the first evidence for a regulatory effect of VT and MT on neurosteroid biosynthesis. These data suggest that neurosteroids may mediate some of the behavioral actions of VT and MT...
  73. ncbi Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium
    Johanie Lepine
    Department of Molecular Endocrinology and Oncology, G1V 4G2 Quebec, Canada
    J Clin Endocrinol Metab 89:5222-32. 2004
    ..Data show that several UGT enzymes detected in the endometrium are involved in the glucuronidation of E(2) and its 2-OH, 4-OH, and 2-MeO metabolites that exert various biological effects in the tissue...
  74. ncbi Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary
    Jean Luc Do Rego
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP 23, University of Rouen, Mont Saint Aignan, France
    J Neurochem 100:251-68. 2007
    ..This is the first detailed immunohistochemical mapping of P450(C17) in the brain and pituitary of any vertebrate. Altogether, the present data provide evidence that CNS neurons and pituitary cells can synthesize androgens...
  75. ncbi Beta-amyloid peptides stimulate endozepine biosynthesis in cultured rat astrocytes
    Tursonjan Tokay
    INSERM U413, European Institute for Peptide Research (IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, UA CNRS, University of Rouen, Mont-Saint-Aignan, France
    J Neurochem 94:607-16. 2005
    ..Altogether, the present data suggest that Abeta-induced activation of endozepine biosynthesis and release may contribute to astrocyte proliferation associated with Alzheimer's disease...
  76. ncbi The Arabidopsis MEI1 gene encodes a protein with five BRCT domains that is involved in meiosis-specific DNA repair events independent of SPO11-induced DSBs
    Mathilde Grelon
    INRA, Station de Genetique et d Amelioration des plantes, Route de Saint Cyr 78026, Versailles Cedex, France
    Plant J 35:465-75. 2003
    ..Therefore, MEI1 is a BRCT-domain-containing protein that could be specific to the meiotic cell cycle and that plays a crucial role in some DNA repair events independent of SPO11 DSB recombination repair...
  77. ncbi Characterization of a radish introgression carrying the Ogura fertility restorer gene Rfo in rapeseed, using the Arabidopsis genome sequence and radish genetic mapping
    Sandra Giancola
    , INRA, Route de Saint-Cyr, 78026, Versailles Cedex, France
    Theor Appl Genet 107:1442-51. 2003
    ..Using markers closely linked to the Rfo gene in rapeseed and radish, we identified a contig spanning six bacterial artificial chromosome (BAC) clones on Arabidopsis chromosome 1, which is likely to carry the orthologous Rfo gene...
  78. ncbi Presence of neuropeptide Y and the Y1 receptor in the plasma membrane and nuclear envelope of human endocardial endothelial cells: modulation of intracellular calcium
    Danielle Jacques
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Can J Physiol Pharmacol 81:288-300. 2003
    ..Thus, NPY released by EECs may modulate excitation-secretion coupling of these cells...
  79. ncbi Ontogeny of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the frog brain
    Mauro Vallarino
    Department of Experimental Biology, University of Genova, Italy
    Ann N Y Acad Sci 1040:490-3. 2005
    ..These observations indicate that biosynthesis of biologically active steroids occurs in the brain of tadpoles, suggesting that neurosteroids may play a role in brain development...
  80. ncbi Cytoplasmic suppression of Ogura cytoplasmic male sterility in European natural populations of Raphanus raphanistrum
    Sandra Giancola
    Station de Genetique et d Amelioration des plantes, Institut Jean Pierre Bourgin, INRA UR254, Versailles, France
    Theor Appl Genet 114:1333-43. 2007
    ..Northern blots and circular RT-PCR analyses showed that orf138 gene expression was impaired in these plants because of a novel cytoplasm-dependent transcript-processing site...
  81. ncbi The putative Arabidopsis homolog of yeast vps52p is required for pollen tube elongation, localizes to Golgi, and might be involved in vesicle trafficking
    Eglantine Lobstein
    Institut National de la Recherche Agronomique, Station de Genetique et d Amelioration des plantes, Institut Jean Pierre Bourgin, Centre de Versailles Grignon, 78026 Versailles Cedex, France
    Plant Physiol 135:1480-90. 2004
    ..These results, together with the expression pattern of the POK::GUS fusion and the lack of plants homozygous for the pok mutation, suggest a more general role for POK in polar growth beyond the pollen tube elongation process...
  82. ncbi DOMINO1, a member of a small plant-specific gene family, encodes a protein essential for nuclear and nucleolar functions
    Sylvie Lahmy
    Laboratoire Génome et Développement des Plantes, CNRS UMR 5096, Universite de Perpignan, 52 Avenue de Villeneuve, 66860 Perpignan Cedex, France
    Plant J 39:809-20. 2004
    ..Using a GFP protein fusion, we show that DOMINO1 is targeted to the nucleus. We propose that inactivation of DOMINO1 has a negative effect on ribosome biogenesis and on the rate of cell division...
  83. ncbi QQT proteins colocalize with microtubules and are essential for early embryo development in Arabidopsis
    Sylvie Lahmy
    Laboratoire Génome et Développement des Plantes, UMRCNRS 5096, Universite de Perpignan, Avenue Paul Alduy, 66860 Perpignan Cedex, France
    Plant J 50:615-26. 2007
    ..We propose that QQT1 and QQT2 proteins participate in the organization of microtubules during cell division, and that this function is essential for the correct development of the early embryo...