Briot J, Mailhot O, Bourdin B, Tétreault M, Najmanovich R, Parent L. A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit. J Biol Chem. 2018;293:7176-7188 pubmed publisher
..This three-way network appears to account for the CaVα2δ1-induced modulation of CaV1.2 currents. ..
Bourdin B, Shakeri B, TÃ©treault M, SauvÃ© R, Lesage S, Parent L. Functional characterization of CaVÎ±2Î´ mutations associated with sudden cardiac death. J Biol Chem. 2015;290:2854-69 pubmed publisher
..Altogether, our results provide novel insight in the molecular mechanism underlying the modulation of CaV1.2 currents by CaVÎ±2Î´. ..
TÃ©treault M, Bourdin B, Briot J, Segura E, Lesage S, Fiset C, et al
. Identification of Glycosylation Sites Essential for Surface Expression of the CaVÎ±2Î´1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity. J Biol Chem. 2016;291:4826-43 pubmed publisher
Bourdin B, Segura E, Tétreault M, Lesage S, Parent L. Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry. J Vis Exp. 2016;: pubmed publisher
..This specific approach offers objective relative quantification of the total and cell surface expression of ion channels that can be extended to study ion pumps and plasma membrane transporters. ..
Parent L. A helical segment makes potassium channels go-go. J Biol Chem. 2017;292:7706-7707 pubmed publisher
..Matthew D. Perry and colleagues now combine NMR spectroscopy and electrophysiological experiments to explore the functional properties of mutations within an overlooked hERG helix, finding important contributions to channel function. ..
Bourdin B, Briot J, Tétreault M, Sauve R, Parent L. Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaV?2?1 auxiliary subunit. J Biol Chem. 2017;292:17236-17249 pubmed publisher
..2 currents. By stabilizing the first extracellular loop of CaV1.2, CaV?2?1 may up-regulate currents by promoting conformations of the voltage sensor that are associated with the channel's open state. ..
Briot J, Tétreault M, Bourdin B, Parent L. Inherited Ventricular Arrhythmias: The Role of the Multi-Subunit Structure of the L-Type Calcium Channel Complex. Adv Exp Med Biol. 2017;966:55-64 pubmed publisher
Segura E, Bourdin B, Tétreault M, Briot J, Allen B, Mayer G, et al
. Proteolytic cleavage of the hydrophobic domain in the CaV?2?1 subunit improves assembly and activity of cardiac CaV1.2 channels. J Biol Chem. 2017;292:11109-11124 pubmed publisher
..2 currents. ..