Alexandra Papaioannou

Summary

Country: Canada

Publications

  1. ncbi request reprint Assessing compliance, acceptance, and tolerability of teriparatide in patients with osteoporosis who fractured while on antiresorptive treatment or were intolerant to previous antiresorptive treatment: an 18-month, multicenter, open-label, prospective stu
    Jonathan D Adachi
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Ther 29:2055-67. 2007
  2. pmc Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
    Guowei Li
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Syst Rev 2:64. 2013
  3. pmc Measurement equivalence of the SF-36 in the Canadian Multicentre Osteoporosis Study
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    Health Qual Life Outcomes 10:29. 2012
  4. pmc Surgical preferences of patients at risk of hip fractures: hemiarthroplasty versus total hip arthroplasty
    Noor Alolabi
    Division of Orthopaedic Surgery, McMaster University, Hamilton, Canada
    BMC Musculoskelet Disord 12:289. 2011
  5. pmc The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women
    Robert B Hopkins
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 12:209. 2011
  6. pmc Osteoporosis in Canadian adult cystic fibrosis patients: a descriptive study
    Christine Brenckmann
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, B3H 4H7, Canada
    BMC Musculoskelet Disord 4:13. 2003
  7. pmc Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: a cross-sectional study
    Karen A Beattie
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 9:119. 2008
  8. pmc The osteoporosis care gap in Canada
    A Papaioannou
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Musculoskelet Disord 5:11. 2004
  9. pmc Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled Phase 3 study of postmenopausal women with osteoporosis
    Claus Christiansen
    Center for Clinical and Basic Research, Ballerup, Denmark
    BMC Musculoskelet Disord 11:130. 2010
  10. pmc Prediction of falls using a risk assessment tool in the acute care setting
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Med 2:1. 2004

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Assessing compliance, acceptance, and tolerability of teriparatide in patients with osteoporosis who fractured while on antiresorptive treatment or were intolerant to previous antiresorptive treatment: an 18-month, multicenter, open-label, prospective stu
    Jonathan D Adachi
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Ther 29:2055-67. 2007
    ..It has been found to significantly reduce vertebral fractures by 65%, and nonvertebral fragility fractures by 53% in treatment-naive postmenopausal women who have previously suffered a vertebral fracture...
  2. pmc Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
    Guowei Li
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Syst Rev 2:64. 2013
    ....
  3. pmc Measurement equivalence of the SF-36 in the Canadian Multicentre Osteoporosis Study
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    Health Qual Life Outcomes 10:29. 2012
    ..This study examined the measurement equivalence (ME) of the 36-item Medical Outcomes Study Short Form Survey (SF-36), a widely-used measure of HRQOL, by sex and race in a population-based Canadian sample...
  4. pmc Surgical preferences of patients at risk of hip fractures: hemiarthroplasty versus total hip arthroplasty
    Noor Alolabi
    Division of Orthopaedic Surgery, McMaster University, Hamilton, Canada
    BMC Musculoskelet Disord 12:289. 2011
    ..The purpose of this study was to elicit surgical preferences of patients at risk of sustaining hip fracture using a novel decision board...
  5. pmc The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women
    Robert B Hopkins
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 12:209. 2011
    ..The purpose was to estimate the relative efficacy of reduction of fractures in post-menopausal women, and to assess robustness of the results...
  6. pmc Osteoporosis in Canadian adult cystic fibrosis patients: a descriptive study
    Christine Brenckmann
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, B3H 4H7, Canada
    BMC Musculoskelet Disord 4:13. 2003
    ..Cystic fibrosis is the most common fatal autosomal recessive genetic disease in the Caucasian population. Osteoporosis is increasingly being recognised as an important complication in people with cystic fibrosis...
  7. pmc Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: a cross-sectional study
    Karen A Beattie
    Dept of Medicine, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 9:119. 2008
    ..Thus, the purpose of this pilot study is to estimate reference values of medial joint space width and cartilage morphometry in healthy individuals of all ages using standard radiography and peripheral magnetic resonance imaging...
  8. pmc The osteoporosis care gap in Canada
    A Papaioannou
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Musculoskelet Disord 5:11. 2004
    ..However, the extent to which patients who fracture are assessed and treated for osteoporosis is not clear...
  9. pmc Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled Phase 3 study of postmenopausal women with osteoporosis
    Claus Christiansen
    Center for Clinical and Basic Research, Ballerup, Denmark
    BMC Musculoskelet Disord 11:130. 2010
    ..We report the safety findings from a 3-year phase 3 study (NCT00205777) of bazedoxifene, a novel selective estrogen receptor modulator under development for the prevention and treatment of postmenopausal osteoporosis...
  10. pmc Prediction of falls using a risk assessment tool in the acute care setting
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Med 2:1. 2004
    ..Although the tool has several strengths, certain limitations exist which may not allow generalizability to a Canadian setting. Thus, we tested the STRATIFY tool with some modification and re-weighting of items in Canadian hospitals...
  11. pmc The association between compliance and persistence with bisphosphonate therapy and fracture risk: a review
    Jonathan Adachi
    McMaster University, Hamilton, Canada
    BMC Musculoskelet Disord 8:97. 2007
    ..Sub optimal levels of compliance and persistence with bisphosphonates are potentially compromising the reduction of post menopausal osteoporotic (PMO) fracture risk...
  12. doi request reprint Zoledronic acid results in better health-related quality of life following hip fracture: the HORIZON-Recurrent Fracture Trial
    J D Adachi
    St Joseph s Healthcare, McMaster University, 501 25 Charlton Ave E, Hamilton, ON, L8N 1Y2, Canada
    Osteoporos Int 22:2539-49. 2011
    ..At month 24 and end of the study visit, ZOL significantly improved patients' overall health state compared to placebo as assessed by the EQ-5D VAS...
  13. doi request reprint Upper gastrointestinal tolerability of alendronate sodium monohydrate 10 mg once daily in postmenopausal women: a 12-week, randomized, double-blind, placebo-controlled, exploratory study
    Jonathan D Adachi
    McMaster University, Hamilton, Ontario, Canada
    Clin Ther 31:1747-53. 2009
    ....
  14. ncbi request reprint Similar proportions of women lose bone mineral density with raloxifene or alendronate treatment
    Jonathan D Adachi
    St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada
    J Clin Densitom 8:273-7. 2005
    ..In conclusion, similar proportions of women did not respond to raloxifene or alendronate therapy, as measured by changes in lumbar spine or femoral neck BMD, when precision error was taken into account...
  15. ncbi request reprint In whom and how to prevent glucocorticoid-induced osteoporosis
    Jonathan D Adachi
    St Joseph s Healthcare, McMaster University, Hamilton, Ont, Canada
    Best Pract Res Clin Rheumatol 19:1039-64. 2005
    ..Today we have therapies with proven efficacy for the prevention of vertebral fractures and bone loss. Consequently recognition of glucocorticoid-induced osteoporosis is extremely important given the availability of effective therapy...
  16. ncbi request reprint Corticosteroid-Induced osteoporosis: detection and management
    J D Adachi
    Department of Medicine, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada
    Drug Saf 24:607-24. 2001
    ..Given our current knowledge and the evidence that is outlined in this review, it is hoped that patients who require therapy with corticosteroids for more than 3 months will be offered appropriate preventative treatment...
  17. ncbi request reprint Vertebral fracture risk reduction with risedronate in post-menopausal women with osteoporosis: a meta-analysis of individual patient data
    Jonathan D Adachi
    McMaster University, Hamilton, Ontario, Canada
    Aging Clin Exp Res 17:150-6. 2005
    ..These trials included two large vertebral fracture studies that used time-to-event methods to evaluate the effects of treatment on fracture risk, thereby allowing both the occurrence and the timing of fractures to be considered...
  18. doi request reprint Treating osteoporosis in Canada: what clinical efficacy data should be considered by policy decision makers?
    J D Adachi
    Department of Medicine, St Joseph s, Healthcare McMaster University, 25 Charlton Avenue East, Suite 501, Hamilton, Ontario, L8N 1Y2, Canada
    Osteoporos Int 20:1785-93. 2009
    ..The choice of clinical efficacy data is an important consideration in health economic models evaluating osteoporosis therapies...
  19. pmc Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women
    Jonathan D Adachi
    St Joseph s Hospital, McMaster University, 501 25 Charlton Ave E, Hamilton, Ontario, L8N 1Y2, Canada
    Mayo Clin Proc 85:806-13. 2010
    ....
  20. pmc Subtrochanteric fractures in bisphosphonate-naive patients: results from the HORIZON-recurrent fracture trial
    Jonathan D Adachi
    McMaster University, Hamilton, ON, Canada
    Calcif Tissue Int 89:427-33. 2011
    ..In patients with recent hip fracture who received zoledronic acid therapy, the incidence of new subtrochanteric fractures was too small to draw any meaningful conclusions...
  21. ncbi request reprint The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos)
    J D Adachi
    Department of Medicine, St Joseph s Hospital, McMaster University, Charlton Avenue East, Suite 501, L8 N 1Y2 Hamilton, Ontario, Canada
    Osteoporos Int 14:895-904. 2003
    ..06; 95% CI: -0.11, -0.00) for women, and rib fractures (-0.06; 95% CI: -0.12, -0.00) for men. In conclusion, this study demonstrates a negative association between osteoporotic fractures and quality of life in both women and men...
  22. ncbi request reprint Quality of life in osteoporosis
    G Ioannidis
    Department of Medicine, Charlton Medical Centre, Hamilton, Ontario, Canada
    Nurs Clin North Am 36:481-9, ix. 2001
    ..Educational efforts are needed for health care professionals to increase the credibility of assessing health status in clinical practice...
  23. ncbi request reprint Determinants of health-related quality of life in women with vertebral fractures
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 17:355-63. 2006
    ..We demonstrated that several modifiable factors influence HRQL in patients with vertebral fractures, and physicians should be aware of these and other markers of reduced HRQL to enhance patient care...
  24. pmc Longitudinal analysis of vertebral fracture and BMD in a Canadian cohort of adult cystic fibrosis patients
    Alexandra Papaioannou
    Department of Medicine, McMaster University, 1200 Main St W, Hamilton ON, L8N 3Z5, Canada
    BMC Musculoskelet Disord 9:125. 2008
    ..In this study, we examined longitudinal change in bone mineral density (BMD) and the prevalence of vertebral fractures in adult CF patients, without lung-transplant, attending a Canadian specialty clinic...
  25. ncbi request reprint What is the number of older Canadians needed to screen by measurement of bone density to detect an undiagnosed case of osteoporosis? a population-based study from CaMos
    Anna M Sawka
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    J Clin Densitom 9:413-8. 2006
    ..9%, 97.0%; 68 of 73) were not aware of it. Thus, the minimum NNS by BMD testing to detect one previously undiagnosed case of osteoporosis in Canada is: 6 women aged >or=65 yr, 13 men aged >or=65 yr, and 10 men aged >or=70 yr...
  26. pmc The utilization of appropriate osteoporosis medications improves following a multifaceted educational intervention: the Canadian quality circle project (CQC)
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Canada
    BMC Med Educ 9:54. 2009
    ..However, appropriate therapy utilization of the disease remains suboptimal. Thus, the objective of the study was to change physicians' therapy administration behavior in accordance with the Osteoporosis Canada 2002 guidelines...
  27. ncbi request reprint Hip protectors decrease hip fracture risk in elderly nursing home residents: a Bayesian meta-analysis
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 60:336-44. 2007
    ....
  28. pmc Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 181:265-71. 2009
    ..Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality...
  29. pmc Changes in trabecular bone microarchitecture in postmenopausal women with and without type 2 diabetes: a two year longitudinal study
    Janet M Pritchard
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 14:114. 2013
    ..The aim of this study was to compare two year changes in trabecular bone microarchitecture in women with and without type 2 diabetes...
  30. ncbi request reprint Changes to osteoporosis prevalence according to method of risk assessment
    J Brent Richards
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 22:228-34. 2007
    ....
  31. pmc A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: no advantage of loading doses over daily supplementation
    Alexandra Papaioannou
    McMaster University, HHSC, St Peter s Hospital Juravinski Research Centre, 88 Maplewood Avenue Hamilton, ON L8M 1W9, Canada
    BMC Musculoskelet Disord 12:135. 2011
    ..The primary aim of our study was to examine whether large loading doses in addition to daily vitamin D offered any advantage over a simple daily low-dose vitamin D regimen for increasing vitamin D levels...
  32. ncbi request reprint Bone strength: the whole is greater than the sum of its parts
    K Shawn Davison
    Clinical Research Scientist, Department of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Semin Arthritis Rheum 36:22-31. 2006
    ..To summarize the current knowledge regarding the various determinants of bone strength...
  33. ncbi request reprint Do hip protectors decrease the risk of hip fracture in institutional and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 16:1461-74. 2005
    ..Thus, there is little evidence to support the use of hip protectors outside the nursing home setting. The potential benefit of hip protectors in reducing hip fractures in nursing home residents requires further confirmation...
  34. pmc An interdisciplinary knowledge translation intervention in long-term care: study protocol for the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial
    Courtney C Kennedy
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Implement Sci 7:48. 2012
    ..This protocol describes the evaluation of a multifaceted, interdisciplinary KT intervention aimed at integrating evidence-based osteoporosis and fracture prevention strategies into LTC care processes...
  35. doi request reprint Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts
    W D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Osteoporos Int 22:1873-83. 2011
    ..A procedure for creating a simplified version of fracture risk assessment tool (FRAX®) is described. Calibration, fracture prediction, and concordance were compared with the full FRAX tool using two large, complementary Canadian datasets...
  36. pmc Dietary patterns in Canadian men and women ages 25 and older: relationship to demographics, body mass index, and bone mineral density
    Lisa Langsetmo
    Dalla Lana School of Public Health, University of Toronto, 155 College St, Toronto, ON, Canada
    BMC Musculoskelet Disord 11:20. 2010
    ....
  37. pmc A team-based approach to warfarin management in long term care: a feasibility study of the MEDeINR electronic decision support system
    Alexandra Papaioannou
    Department of Medicine, McMaster University, 1280 Main Street West, Hamilton L8N 3Z5, Canada
    BMC Geriatr 10:38. 2010
    ..We evaluated the MEDeINR system in a pre-post implementation design by examining the impact on INR control, testing frequency, and experiences of staff in using the system...
  38. doi request reprint Alendronate once weekly for the prevention and treatment of bone loss in Canadian adult cystic fibrosis patients (CFOS trial)
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton Health Sciences, Chedoke Site, Building 74, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5
    Chest 134:794-800. 2008
    ..A multicenter, randomized, controlled trial was conducted to assess the efficacy, tolerability, and safety of therapy with oral alendronate (FOSAMAX; Merck; Whitehouse Station, NJ) in adults with CF and low bone mass...
  39. doi request reprint The evaluation of an interdisciplinary pain protocol in long term care
    Sharon Kaasalainen
    School of Nursing, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    J Am Med Dir Assoc 13:664.e1-8. 2012
    ....
  40. pmc Adverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate: a retrospective cohort study
    Daniel T Grima
    Center for Osteoporosis and Arthritis Research and Education COARE, 1185 Rushbrooke Dr, Oakville, ON, L6 M 1H8, Canada
    BMC Musculoskelet Disord 11:68. 2010
    ..The objective of our study was to quantify changes in AE rates and BMD scores, as well as associated alendronate discontinuation among patients before and after switch from brand to generic alendronate...
  41. pmc Parathyroid hormone for the treatment of osteoporosis: a systematic review
    Ann Cranney
    Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 175:52-9. 2006
    ....
  42. doi request reprint Association of larger holes in the trabecular bone at the distal radius in postmenopausal women with type 2 diabetes mellitus compared to controls
    Janet M Pritchard
    McMaster University, Hamilton, Ontario, Canada
    Arthritis Care Res (Hoboken) 64:83-91. 2012
    ..The study objective was to compare trabecular bone microarchitecture of postmenopausal women with type 2 DM and women without type 2 DM...
  43. pmc Optimizing care in osteoporosis: the Canadian quality circle project
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 9:130. 2008
    ....
  44. pmc Do patients perceive a link between a fragility fracture and osteoporosis?
    Lora Giangregorio
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada
    BMC Musculoskelet Disord 9:38. 2008
    ..To evaluate factors associated with whether patients associate their fracture with future fracture risk...
  45. pmc A scoping review of strategies for the prevention of hip fracture in elderly nursing home residents
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 5:e9515. 2010
    ..Elderly nursing home residents are at increased risk of hip fracture; however, the efficacy of fracture prevention strategies in this population is unclear...
  46. pmc Evaluation of easily measured risk factors in the prediction of osteoporotic fractures
    Robert Bensen
    Medical Science, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 6:47. 2005
    ..As few premonitory symptoms for fracture exist, it is of critical importance that physicians effectively and efficiently identify individuals at increased fracture risk...
  47. ncbi request reprint Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos)
    Alexandra Papaioannou
    Department of Medicine, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 16:568-78. 2005
    ..Furthermore, various anthropometric measures, disease conditions, and medications are associated with a new fracture. Identifying postmenopausal women at risk is important given that fracture prevention therapies are now available...
  48. ncbi request reprint Adherence to bisphosphonates and hormone replacement therapy in a tertiary care setting of patients in the CANDOO database
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 14:808-13. 2003
    ..In conclusion, alendronate users were more likely to discontinue therapy than etidronate users over the follow-up period. Potential barriers to long-term patient adherence to osteoporosis therapies need to be evaluated...
  49. ncbi request reprint Are there differences between men and women prescribed bisphosphonate therapy in canadian subspecialty osteoporosis practices?
    Anna M Sawka
    McMaster University, St Joseph s Healthcare, Centre for Evaluation of Medicines, Hamilton, Ontario, Canada
    J Rheumatol 31:1993-5. 2004
    ..To determine if there are differences between men and women referred for treatment of osteoporosis in Canada...
  50. pmc Does alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women
    Anna M Sawka
    Department of Medicine, St, Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 6:39. 2005
    ..Our objective was to systematically review the anti-fracture efficacy of alendronate in men with low bone mass or with a history of prevalent fracture(s) and incorporate prior knowledge of alendronate efficacy in women in the analysis...
  51. doi request reprint Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos
    L A Fraser
    Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 22:829-37. 2011
    ..The Canadian FRAX tool showed good calibration and discrimination for both hip and major osteoporotic fractures...
  52. pmc Improvement in health-related quality of life in osteoporosis patients treated with teriparatide
    Arthur N Lau
    Division of Rheumatology and Department of Medicine, St, Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 9:151. 2008
    ..To determine whether patients with osteoporosis treated with teriparatide experienced improvement in HRQL and pain symptoms after several months of therapy...
  53. pmc What are the beliefs, attitudes and practices of front-line staff in long-term care (LTC) facilities related to osteoporosis awareness, management and fracture prevention?
    Arthur N Lau
    Division of Rheumatology and Department of Medicine, St, Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 10:73. 2010
    ..A secondary question assessed was the nurse's and PSW's attitudes and beliefs regarding the role and benefits of vitamin D for LTC patients...
  54. doi request reprint Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(®): a population-based report from CAMOS
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Densitom 14:286-93. 2011
    ..In summary, the T-score difference between the lumbar spine and femoral neck is an independent risk factor for major osteoporotic fractures that is independent of the FRAX probability calculated with femoral neck BMD...
  55. doi request reprint 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates
    L S Greene-Finestone
    Public Health Agency of Canada, Ottawa, Ontario, Canada
    Osteoporos Int 22:1389-99. 2011
    ..Results showed that serum 25-hydroxyvitamin D levels <75 nmol/L were common. Given Canada's high latitude, attention should be given to strategies for enhancing vitamin D status in the population...
  56. doi request reprint Prevalence of osteoporosis in osteoarthritic patients undergoing total hip or total knee arthroplasty
    Anna Labuda
    Department of Physical Medicine and Rehabilitation, Henderson General Hospital, Hamilton, ON, Canada
    Arch Phys Med Rehabil 89:2373-4. 2008
    ..To determine the prevalence of osteoporosis in osteoarthritic patients undergoing total hip or total knee arthroplasty...
  57. ncbi request reprint Patient adherence to osteoporosis medications: problems, consequences and management strategies
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs Aging 24:37-55. 2007
    ..Future studies are needed regarding strategies to increase adherence to osteoporosis medications...
  58. doi request reprint Fragility fractures and the osteoporosis care gap in women: the Canadian Multicentre Osteoporosis Study
    L A Fraser
    Departments of Epidemiology and Medicine, Hamilton Health Sciences Chedoke Site, McMaster University, 1200 Main Street West, Hamilton, ON L8N3Z5, Canada
    Osteoporos Int 22:789-96. 2011
    ..We found that approximately half of these women were not being treated, indicating a significant care gap in osteoporosis treatment...
  59. ncbi request reprint Rational use of oral bisphosphonates for the treatment of osteoporosis
    Julian M R Mathoo
    McMaster University, 201 25 Charlton Ave E, Hamiton, Ontario, L8N 1Y2 Canada
    Curr Osteoporos Rep 2:17-23. 2004
    ..Once-weekly dosing options with alendronate and risedronate are effective and reduce serious adverse drug effects, and therefore, are welcome additions to our therapeutic armamentarium...
  60. doi request reprint Family physicians' personal and practice characteristics that are associated with improved utilization of bone mineral density testing and osteoporosis medication prescribing
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Popul Health Manag 12:131-8. 2009
    ..The education of both clinicians and policy makers regarding these new insights may translate to enhanced individual practices and an improved overall health care system to optimize the environment for managing osteoporosis...
  61. doi request reprint Trends in hip fracture rates in Canada
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    JAMA 302:883-9. 2009
    ..Hip fractures are a public health concern because they are associated with significant morbidity, excess mortality, and the majority of the costs directly attributable to osteoporosis...
  62. ncbi request reprint What predicts early fracture or bone loss on bisphosphonate therapy?
    Anna M Sawka
    McMaster University, Hamilton, ON, CA
    J Clin Densitom 6:315-22. 2003
    ..13, 0.62, p = 0.002). In conclusion, early fracture on bisphosphonate therapy is most strongly predicted by a previous history of fracture and early bone loss is most strongly predicted by the potency of the prescribed bisphosphonate...
  63. ncbi request reprint Estimating the prevalence of renal insufficiency in seniors requiring long-term care
    Amit X Garg
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Kidney Int 65:649-53. 2004
    ..The objective of this study was to estimate the prevalence of low glomerular filtration rate (GFR) in a large sample of elderly adults living in long-term care facilities, and to compare two commonly used methods for estimating GFR...
  64. ncbi request reprint The effects of antifracture therapies on the components of bone strength: assessment of fracture risk today and in the future
    K Shawn Davison
    Clinical Research Scientist, Department of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Semin Arthritis Rheum 36:10-21. 2006
    ..To summarize the current knowledge regarding the impact of the most common antifracture medications on the various determinants of bone strength...
  65. doi request reprint The burden of illness of osteoporosis in Canadian men
    Jean Eric Tarride
    Programs for Assessment of Technology in Health PATH Research Institute, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1830-8. 2012
    ..Male osteoporosis has a substantial economic burden on the Canadian society...
  66. ncbi request reprint Effect of selective serotonin reuptake inhibitors on the risk of fracture
    J Brent Richards
    Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Arch Intern Med 167:188-94. 2007
    ..Our objective was to examine the effect of daily SSRI use on the risk of incident clinical fragility fracture...
  67. pmc Management of osteoporosis in men: an update and case example
    Aliya A Khan
    Division of Endocrinology and Geriatrics, Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 176:345-8. 2007
    ..The current paper supplements that guideline and provides a review and synthesis of the current literature on the diagnosis and management of osteoporosis in men...
  68. ncbi request reprint The use of hip protectors in long-term care facilities: a survey of nursing home staff
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network and University of Toronto, Ontario, Canada
    J Am Med Dir Assoc 8:229-32. 2007
    ..To determine the level of exposure to hip protectors and barriers to their use in nursing homes...
  69. pmc Validation of the GALS musculoskeletal screening exam for use in primary care: a pilot study
    Karen A Beattie
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 9:115. 2008
    ..The secondary goal was to examine the incidence of MSK disorders and assess the frequency with which new diagnoses not previously documented in patients' charts were identified...
  70. ncbi request reprint A systematic review of the effect of alendronate on bone mineral density in men
    Anna M Sawka
    McMaster University, Hamilton, Ontario, Canada L8N 1Y2
    J Clin Densitom 8:7-13. 2005
    ..We conclude that 10 mg of oral daily alendronate is significantly associated with increase in BMD at the lumbar spine and hip in men over 2-3 yr and that these changes are similar to those previously observed in postmenopausal women...
  71. pmc Closing the osteoporosis care gap: increased osteoporosis awareness among geriatrics and rehabilitation teams
    Derek A Haaland
    McMaster University, Department of Medicine, Main Street West, Hamilton, Ontario, Canada
    BMC Geriatr 9:28. 2009
    ....
  72. doi request reprint Injury measurement properties of serum interleukin-6 following lumbar decompression surgery
    Dinesh Kumbhare
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Surg Res 157:161-7. 2009
    ....
  73. ncbi request reprint Influence of fracture history and bone mineral density testing on the treatment of osteoporosis in two non-academic community centers
    Meagan E Hamel
    Department of Clinical Epidemiology and Biostatistics, Centre for Evaluation of Medicines, Father Sean O Sullivan Research Centre, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 16:208-15. 2005
    ....
  74. ncbi request reprint Treating osteoporosis: economic aspects of bisphosphonate therapy
    Courtney C Kennedy
    Department of Medicine, McMaster University, Ontario, Canada
    Expert Opin Pharmacother 7:1457-67. 2006
    ..This paper reviews a number of these studies regarding the economic benefits of treating osteoporosis with bisphosphonates and considers for whom prevention and/or treatment is most warranted...
  75. doi request reprint Nurses' perceived barriers to optimal pain management in older adults on acute medical units
    Esther Coker
    School of Nursing, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Appl Nurs Res 23:139-46. 2010
    ....
  76. pmc Quality of anticoagulation and use of warfarin-interacting medications in long-term care: a chart review
    Madeleine Verhovsek
    McMaster University, Hamilton, Ontario, Canada
    BMC Geriatr 8:13. 2008
    ....
  77. ncbi request reprint Osteoporosis in men: epidemiology, diagnosis, prevention, and treatment
    Wojciech P Olszynski
    Department of Medicine, University of Saskatchewan, Saskatoon Osteoporosis Centre, Saskatoon, Saskatchewan, Canada
    Clin Ther 26:15-28. 2004
    ..Osteoporosis and fragility fractures in men account for substantial health care expenditures and decreased quality of life...
  78. ncbi request reprint Pain management decision making among long-term care physicians and nurses
    Sharon Kaasalainen
    McMaster University, Canada
    West J Nurs Res 29:561-80; discussion 581-8. 2007
    ..These findings may facilitate the development of innovative approaches to pain management in LTC settings...
  79. doi request reprint Combined vertebral fracture assessment and bone mineral density measurement: a patient-friendly new tool with an important impact on the Canadian Risk Fracture Classification
    Pieter L Jager
    Department of Nuclear Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Can Assoc Radiol J 61:194-200. 2010
    ..Our purpose was to determine the added value of VFA and its impact on the Canadian fracture risk classification using data from a Dutch academic cohort...
  80. ncbi request reprint Cost-effectiveness of alternative treatments for women with osteoporosis in Canada
    Ron Goeree
    Program for Assessment of Technology in Health PATH, McMaster University, Ontario, Canada
    Curr Med Res Opin 22:1425-36. 2006
    ..During the years following menopause, estrogen levels decline leading to accelerated bone loss and an increased risk of osteoporosis and osteoporosis-related fractures...
  81. ncbi request reprint Diagnosis and management of vertebral fractures in elderly adults
    Alexandra Papaioannou
    Department of Medicine, Division of Geriatric Medicine AP McMaster University, Hamilton, Ontario, Canada
    Am J Med 113:220-8. 2002
    ..There is evidence from randomized controlled trials that pharmacologic therapy can reduce the risk of future fractures by 40% to 50%. Vertebroplasty may be effective in the control of pain and in obtaining stability of the spine...
  82. pmc Canadian Quality Circle pilot project in osteoporosis: rationale, methods, and feasibility
    George Ioannidis
    McMaster University in Hamilton, Ont
    Can Fam Physician 53:1694-700. 2007
    ..PROBLEM ADDRESSED Family physicians are not adequately following the 2002 Osteoporosis Canada guidelines for providing optimal care to patients with osteoporosis...
  83. ncbi request reprint Tolerability of different dosing regimens of bisphosphonates for the treatment of osteoporosis and malignant bone disease
    Raja S Bobba
    Division of Rheumatology, McMaster University, Hamilton, Ontario, Canada
    Drug Saf 29:1133-52. 2006
    ..However, a decrease in renal function, albeit rare, remains a significant complication of zoledronic acid; therefore, regular renal monitoring is recommended...
  84. ncbi request reprint Benefit-risk assessment of raloxifene in postmenopausal osteoporosis
    Ann Cranney
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Drug Saf 28:721-30. 2005
    ..Raloxifene can be recommended for the prevention of vertebral fractures in women with osteopenia/osteoporosis who are not at high risk of non-vertebral fractures and who do not have a past history of venous thromboembolism...
  85. ncbi request reprint Long-term tolerability of the bisphosphonates in postmenopausal osteoporosis: a comparative review
    Raheem B Kherani
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drug Saf 25:781-90. 2002
    ..Each of these bisphosphonates have been shown to have comparable safety with placebo up to 3 to 4 years, with the most rigourous trials carried out for alendronate and risedronate. Long-term comparative studies are awaited...
  86. ncbi request reprint Diagnosis and treatment of Paget's disease of bone
    Robert G Josse
    Division of Endocrinology and Metabolism, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario
    Clin Invest Med 30:E210-23. 2007
    ..The Panel recommends treating PDB with bisphosphonates that have demonstrated superior efficacy and remission rates...
  87. ncbi request reprint The impact of fragility fracture on health-related quality of life : the importance of antifracture therapy
    Ted Xenodemetropoulos
    St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Drugs Aging 21:711-30. 2004
    ..Information collected by HR-QOL instruments may provide new insight as to how to improve quality of life for patients with fractures and how to properly allocate healthcare spending...
  88. pmc Review of the safety and efficacy of risedronate for the treatment of male osteoporosis
    Raja Bobba
    Department of Medicine, St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    Clin Interv Aging 2:275-82. 2007
    ..In men, risedronate either maintains or increases bone mineral density. In placebo controlled trials it has been shown to be safe and effective in preventing fractures...
  89. ncbi request reprint Hormone replacement therapy improves distal radius bone structure by endocortical mineral deposition
    Monique E Muller
    McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 81:952-8. 2003
    ..This study suggests that the improvements in fracture risk resulting from HRT are explained by a reversal of net endocortical resorption of bone...
  90. ncbi request reprint Corticosteroid-induced osteoporosis: a guide to optimum management
    Ann Cranney
    Queen s University, Kingston, Ontario, Canada
    Treat Endocrinol 1:271-9. 2002
    ..Teriparatide (recombinant human parathyroid hormone 1-34) shows promise as a future anabolic agent for the prevention and treatment of patients with corticosteroid-induced osteoporosis...
  91. ncbi request reprint Biochemical measurement of muscle injury created by lumbar surgery
    Dinesh Kumbhare
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Clin Invest Med 30:12-20. 2007
    ..To use the model to examine the consistency of the time course of CK concentration changes...
  92. ncbi request reprint In vivo measurement of apparent trabecular bone structure of the radius in women with low bone density discriminates patients with recent wrist fracture from those without fracture
    Norma J MacIntyre
    Human Mobility Research Centre, Queen s University, Kingston General Hospital, Ontario, Canada
    J Clin Densitom 6:35-43. 2003
    ..2-24.3). Thus, estimation of in vivo trabecular bone porosity by measuring the average diameter of the pQCT-imaged marrow spaces in the ultradistal radius identifies individuals with low bone mass most at risk for osteoporotic fracture...
  93. ncbi request reprint Development and pilot testing of a decision aid for postmenopausal women with osteoporosis
    Ann Cranney
    Department of Medicine, Ottawa Hospital, C4 CEU, 1053 Carling Avenue, Ontario, Canada K1Y4 E9
    Patient Educ Couns 47:245-55. 2002
    ..Our decision aid shows promise in preparing women for counseling about osteoporosis therapies. Long-term adherence to chosen therapy and quality of life will be evaluated in a randomized controlled trial...
  94. ncbi request reprint A 6-mo home-based exercise program may slow vertebral height loss
    Colin E Webber
    Hamilton Health Sciences, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Densitom 6:391-400. 2003
    ..1 mm anteriorly, -0.3 mm at the mid-location, and +0.2 mm posteriorly. The benefit of exercise in preserving vertebral morphometry in patients with osteoporosis deserves further investigation...
  95. ncbi request reprint The natural progression of health-related quality of life: results of a five-year prospective study of SF-36 scores in a normative population
    Wilma M Hopman
    Clinical Research Centre, Kingston General Hospital and Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, K7L 2V7, Canada
    Qual Life Res 15:527-36. 2006
    ..Such norms are important to establish, because the effect of any intervention may be confounded by changes due to the natural progression of HRQOL over time...
  96. ncbi request reprint North American male reference population for speed of sound in bone at multiple skeletal sites
    Stephen R Hayman
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Clin Densitom 5:63-71. 2002
    ..Longitudinal monitoring of healthy men should be performed to confirm these cross-sectional results...
  97. doi request reprint The Safe Functional Motion test is reliable for assessment of functional movements in individuals at risk for osteoporotic fracture
    Norma J MacIntyre
    School of Rehabilitation Science, McMaster University, IAHS Room 403, 1400 Main Street West, Hamilton, ON, L8S 1C7, Canada
    Clin Rheumatol 29:143-50. 2010
    ..69, 0.76, and 0.83 for TUG, BERG, and CBMS, respectively). SFM-SF provides reliable measures of functional movements in community-dwelling individuals at risk for osteoporotic fracture...
  98. ncbi request reprint Prevalence of knee abnormalities in patients with osteoarthritis and anterior cruciate ligament injury identified with peripheral magnetic resonance imaging: a pilot study
    Hao Wu
    Department of Medical Sciences, McMaster University, Hamilton, ON
    Can Assoc Radiol J 58:167-75. 2007
    ....
  99. ncbi request reprint Measurement of cervical flexor endurance following whiplash
    Dinesh A Kumbhare
    Department of Medicine, McMaster University and Center for Acute Injury Rehabilitation, St Joseph s Hospital, Hamilton, Ontario, Canada
    Disabil Rehabil 27:801-7. 2005
    ....
  100. ncbi request reprint Relationship between changes in bone mineral density and vertebral fracture risk associated with risedronate: greater increases in bone mineral density do not relate to greater decreases in fracture risk
    Nelson B Watts
    University of Cincinnati Osteoporosis Center, Cincinnati, OH, USA
    J Clin Densitom 7:255-61. 2004
    ..Although patients showing an increase in BMD had a lower fracture risk than patients showing a decrease in BMD, greater increases in BMD did not necessarily predict greater decreases in fracture risk...
  101. ncbi request reprint Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial
    Pierre D Delmas
    University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
    J Clin Endocrinol Metab 87:3609-17. 2002
    ..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr...