Nongnuj Tanphaichitr

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. ncbi request reprint New insights into sperm-zona pellucida interaction: involvement of sperm lipid rafts
    Nongnuj Tanphaichitr
    Hormones Growth Development, Ottawa Health Research Institute and Department of Biochemistry Microbiology Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Front Biosci 12:1748-66. 2007
  2. doi request reprint Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner
    Hongbin Xu
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Reproduction 144:209-19. 2012
  3. ncbi request reprint Role of sperm surface arylsulfatase A in mouse sperm-zona pellucida binding
    Julierut Tantibhedhyangkul
    Hormones Growth Development Group, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Biol Reprod 67:212-9. 2002
  4. ncbi request reprint Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice
    Hongbin Xu
    Ottawa Health Research Institute, Hormones, Growth, Development, and Department of Biochemistry Microbiology Immunology, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Toxicol Sci 82:590-7. 2004
  5. doi request reprint Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization
    Sitthichai Iamsaard
    Chronic Disease, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    J Cell Physiol 226:2817-26. 2011
  6. pmc Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells
    Hongbin Xu
    Chronic Diseases Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    J Lipid Res 52:2187-97. 2011
  7. ncbi request reprint Acquisition of arylsulfatase A onto the mouse sperm surface during epididymal transit
    Wattana Weerachatyanukul
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
    Biol Reprod 69:1183-92. 2003
  8. ncbi request reprint Towards a more precise assay of sperm function in egg binding
    Nongnuj Tanphaichitr
    Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada
    J Obstet Gynaecol Can 25:461-70. 2003
  9. ncbi request reprint Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability
    Charles Gyamera-Acheampong
    Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Biol Reprod 74:666-73. 2006
  10. ncbi request reprint Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid-containing phosphatidylcholine compared to washed capacitated mouse sperm
    Anna Furimsky
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
    Biol Reprod 72:574-83. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint New insights into sperm-zona pellucida interaction: involvement of sperm lipid rafts
    Nongnuj Tanphaichitr
    Hormones Growth Development, Ottawa Health Research Institute and Department of Biochemistry Microbiology Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Front Biosci 12:1748-66. 2007
    ..A number of ZP binding molecules are also present in sperm lipid rafts. In this review, we have provided an argument that sperm lipid rafts may be the platforms on the sperm surface for ZP interaction...
  2. doi request reprint Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner
    Hongbin Xu
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Reproduction 144:209-19. 2012
    ..The availability of the active site pocket of ASA bound to the ZP suggested that ASA would still retain enzymatic activity, which might be important for subsequent sperm penetration through the ZP...
  3. ncbi request reprint Role of sperm surface arylsulfatase A in mouse sperm-zona pellucida binding
    Julierut Tantibhedhyangkul
    Hormones Growth Development Group, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Biol Reprod 67:212-9. 2002
    ..Moreover, in vivo fertilization was markedly decreased when mouse sperm pretreated with anti-AS-A IgG were artificially inseminated into females. All of these results designated a new function for AS-A in mouse gamete interaction...
  4. ncbi request reprint Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice
    Hongbin Xu
    Ottawa Health Research Institute, Hormones, Growth, Development, and Department of Biochemistry Microbiology Immunology, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Toxicol Sci 82:590-7. 2004
    ..1-10 microg/mL), although the decreases were not as pronounced as those for CH. These results showed that TCE exposure leads to impairment of sperm fertilizing ability, which may be attributed to TCE metabolites, CH, and TCOH...
  5. doi request reprint Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization
    Sitthichai Iamsaard
    Chronic Disease, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    J Cell Physiol 226:2817-26. 2011
    ..This result suggested that ADAM2 may be a natural substrate of sperm PCSK4 and its cleavage by the enzyme during acrosome reaction may be relevant to the fertilization process...
  6. pmc Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells
    Hongbin Xu
    Chronic Diseases Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    J Lipid Res 52:2187-97. 2011
    ....
  7. ncbi request reprint Acquisition of arylsulfatase A onto the mouse sperm surface during epididymal transit
    Wattana Weerachatyanukul
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
    Biol Reprod 69:1183-92. 2003
    ..This finding suggests that AS-A in the epididymal fluid may deposit onto sperm via its affinity to sulfogalactosylglycerolipid...
  8. ncbi request reprint Towards a more precise assay of sperm function in egg binding
    Nongnuj Tanphaichitr
    Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada
    J Obstet Gynaecol Can 25:461-70. 2003
    ..Infertile men with sperm having ability to bind to rec hZP3 can be advised to select standard IVF or intrauterine insemination, which have fewer genetic and medical risks...
  9. ncbi request reprint Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability
    Charles Gyamera-Acheampong
    Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Biol Reprod 74:666-73. 2006
    ..These sperm physiologic anomalies likely contribute to the severe subfertility of PCSK4-deficient male mice...
  10. ncbi request reprint Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid-containing phosphatidylcholine compared to washed capacitated mouse sperm
    Anna Furimsky
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
    Biol Reprod 72:574-83. 2005
    ..These results suggested that PGC mouse sperm should be used in fertilization experiments and that SGG and DHA should be considered to be important biomarkers for sperm fertilizing ability...
  11. ncbi request reprint Sperm surface arylsulfatase A can disperse the cumulus matrix of cumulus oocyte complexes
    Alexander Wu
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    J Cell Physiol 213:201-11. 2007
    ....
  12. pmc Quantification of seminolipid by LC-ESI-MS/MS-multiple reaction monitoring: compensatory levels in Cgt(+/⁻) mice
    Kessiri Kongmanas
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    J Lipid Res 51:3548-58. 2010
    ..The results also indicated that 78% of SGG levels in Cgt(+/⁻) mice were sufficient for normal spermatogenesis...
  13. doi request reprint Interaction of arylsulfatase-A (ASA) with its natural sulfoglycolipid substrates: a computational and site-directed mutagenesis study
    Matthias Schenk
    Chronic Disease, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    Glycoconj J 26:1029-45. 2009
    ..However, our dockings suggested additional intermolecular hydrogen bonding and hydrophobic interactions between ASA and SGC/SGG, thus contributing to the specificity of SGC/SGG as natural substrates...
  14. ncbi request reprint Binding of arylsulfatase A to mouse sperm inhibits gamete interaction and induces the acrosome reaction
    Euridice Carmona
    Hormones Growth Development Group, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1Y 4E9
    Biol Reprod 66:1820-7. 2002
    ..Our results demonstrate a promising potential for AS-A as a nonhormonal, vaginal contraceptive...
  15. ncbi request reprint Use of atomic force microscopy for morphological and morphometric analyses of acrosome intact and acrosome-reacted human sperm
    Andrew Mai
    Hormones Growth Development Group, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Mol Reprod Dev 63:471-9. 2002
    ..This would allow future studies on subcellular changes, related to the acrosome reaction, at the submicron resolution level under more physiological conditions, since AFM does not require fixing or staining of the samples...
  16. doi request reprint Human exposure to endocrine disrupters and semen quality
    Karen P Phillips
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:188-220. 2008
    ..An overview of the human semen quality literature is presented that examines the role of endocrine disrupters including organochlorines (OC), dioxins, phthalates, phytoestrogens, and chemical mixtures (pesticides and tobacco smoke)...
  17. ncbi request reprint Sperm capacitation induces an increase in lipid rafts having zona pellucida binding ability and containing sulfogalactosylglycerolipid
    Maroun Bou Khalil
    Hormones Growth Development Group, Ottawa Health Research Institute, Ottawa, ON, Canada K1Y 4E9
    Dev Biol 290:220-35. 2006
    ....
  18. ncbi request reprint Arylsulfatase a is present on the pig sperm surface and is involved in sperm-zona pellucida binding
    Euridice Carmona
    Hormones Growth Development Research Group, Ottawa Health Research Institute, Ontario, Canada K1Y 4E9
    Dev Biol 247:182-96. 2002
    ..Similarly, purified ZP3alpha, a major sperm receptor component of ZP3, exhibited great inhibitory effect on AS-A-ZP binding. All of these results designated a new function of AS-A in gamete interaction...
  19. doi request reprint An efficient and convenient synthesis of deuterium-labelled seminolipid isotopomers and their ESI-MS characterization
    Laura Franchini
    Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Universita di Milano, Via Saldini 50, 20133 Milano, Italy
    Chem Phys Lipids 152:78-85. 2008
    ..Extension of the procedure could provide a route for the preparation of isotopomers of other compounds of the same general class...
  20. ncbi request reprint Visualizing the localization of sulfoglycolipids in lipid raft domains in model membranes and sperm membrane extracts
    Wattana Weerachatyanukul
    Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, ON Canada K1A 0R6
    Biochim Biophys Acta 1768:299-310. 2007
    ..The possible implications of these results for the involvement of SGG-rich lipid rafts in modulating sperm-egg interactions in vivo and the utility of model membranes for studying the behavior of lipid rafts are discussed...