Michael Rudnicki

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. Wang Y, Feige P, Brun C, Hekmatnejad B, Dumont N, Renaud J, et al. EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions. Cell Stem Cell. 2019;24:419-432.e6 pubmed publisher
    ..Therefore, activating an EGFR-dependent polarity pathway promotes functional rescue of dystrophin-deficient satellite cells and enhances muscle force generation. ..
  2. Feige P, Brun C, Ritso M, Rudnicki M. Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease. Cell Stem Cell. 2018;23:653-664 pubmed publisher
    ..We also highlight therapeutic opportunities for targeting satellite cell polarity and self-renewal to stimulate muscle regeneration. ..
  3. Feige P, Rudnicki M. Muscle stem cells. Curr Biol. 2018;28:R589-R590 pubmed publisher
    ..Feige and Rudnicki introduce muscle stem cells. ..
  4. Wang Y, Dumont N, Rudnicki M. Muscle stem cells at a glance. J Cell Sci. 2014;127:4543-8 pubmed publisher
    ..This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment. ..
  5. Rudnicki M, Williams B. Wnt signaling in bone and muscle. Bone. 2015;80:60-66 pubmed publisher
    ..This article is part of a Special Issue entitled "Muscle Bone Interactions". ..
  6. Dumont N, Wang Y, Rudnicki M. Intrinsic and extrinsic mechanisms regulating satellite cell function. Development. 2015;142:1572-81 pubmed publisher
    ..Here, we review recent discoveries of the intrinsic and extrinsic factors that regulate satellite cell behaviour in regenerating and degenerating muscles. ..
  7. Chang N, Sincennes M, Chevalier F, Brun C, Lacaria M, Segalés J, et al. The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment. Cell Stem Cell. 2018;22:755-768.e6 pubmed publisher
    ..Therefore, our experiments suggest that dysregulation of p38γ/Carm1 results in altered epigenetic gene regulation in Duchenne muscular dystrophy. ..
  8. Chang N, Chevalier F, Rudnicki M. Satellite Cells in Muscular Dystrophy - Lost in Polarity. Trends Mol Med. 2016;22:479-496 pubmed publisher
    ..In this review we highlight recent research advances in DMD and discuss the current state of treatment and, importantly, how we can incorporate satellite cell-targeted therapeutic strategies to correct satellite cell dysfunction in DMD. ..
  9. Sincennes M, Wang Y, Rudnicki M. Primary Mouse Myoblast Purification using Magnetic Cell Separation. Methods Mol Biol. 2017;1556:41-50 pubmed publisher
    ..Here, we describe an automated muscle dissociation protocol. We also propose an alternative to pre-plating using magnetic bead separation of primary myoblasts, which improve myoblast purity by minimizing fibroblast contamination. ..

More Information

Publications19

  1. Dumont N, Rudnicki M. Characterizing Satellite Cells and Myogenic Progenitors During Skeletal Muscle Regeneration. Methods Mol Biol. 2017;1560:179-188 pubmed publisher
    ..Here, we describe a method for immunodetection of satellite cells and their myogenic progeny in resting and regenerating skeletal muscles. ..
  2. Sincennes M, Brun C, Rudnicki M. Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease. Stem Cells Transl Med. 2016;5:282-90 pubmed publisher
    ..The potential of epigenetic drugs, such as HDAC inhibitors, as well as their molecular mechanism of action in muscle cells, will be addressed. ..
  3. Kuroda K, Kuang S, Taketo M, Rudnicki M. Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Skelet Muscle. 2013;3:5 pubmed publisher
    ..These results demonstrate a novel interaction between canonical Wnt and BMP signaling that induces myogenic differentiation towards slow muscle phenotype. ..
  4. Brun C, Rudnicki M. GDF11 and the Mythical Fountain of Youth. Cell Metab. 2015;22:54-6 pubmed publisher
    ..In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration. ..
  5. Chang N, Rudnicki M. Satellite cells: the architects of skeletal muscle. Curr Top Dev Biol. 2014;107:161-81 pubmed publisher
    ..Delineation of cellular hierarchy and understanding how lineage fate choices are determined within the satellite cell population will be invaluable for the advancement of muscle regenerative therapies. ..
  6. Hailesellasse Sene K, Porter C, Palidwor G, Perez Iratxeta C, Muro E, Campbell P, et al. Gene function in early mouse embryonic stem cell differentiation. BMC Genomics. 2007;8:85 pubmed
    ..The data generated constitute a valuable resource for further studies. All DNA microarray data used in this study are available in the StemBase database of stem cell gene expression data 1 and in the NCBI's GEO database. ..
  7. Pasut A, Chang N, Gurriaran Rodriguez U, Faulkes S, Yin H, Lacaria M, et al. Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation. Cell Rep. 2016;16:333-343 pubmed publisher
    ..Overall, these results show that Notch1 activation compensates for the loss of Pax7 in the quiescent state and acts as a molecular switch to promote brown adipogenesis in adult skeletal muscle. ..
  8. Huh M, Parker M, Scime A, Parks R, Rudnicki M. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol. 2004;166:865-76 pubmed
    ..Therefore, Rb plays a crucial role in the switch from proliferation to differentiation rather than maintenance of the terminally differentiated state. ..
  9. Brun C, Wang Y, Rudnicki M. Single EDL Myofiber Isolation for Analyses of Quiescent and Activated Muscle Stem Cells. Methods Mol Biol. 2018;1686:149-159 pubmed publisher
    ..Here, we describe a protocol to isolate single myofibers from the extensor digitorum longus muscle. Moreover, we detail experimental conditions for analyzing satellite cells in quiescence and progression through the myogenic lineage. ..
  10. Hernández Hernández J, García González E, Brun C, Rudnicki M. The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration. Semin Cell Dev Biol. 2017;72:10-18 pubmed publisher