Research Topics
Species | M A RodgerSummaryAffiliation: Ottawa Health Research Institute Country: Canada Publications
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Publications
The outpatient treatment of deep vein thrombosis delivers cost savings to patients and their families, compared to inpatient therapyMarc A Rodger
University of Ottawa, Ottawa, ON, Canada
Thromb Res 112:13-8. 2003..The aim of this study is to determine if some or all of these cost savings to third party payers are shifted to patients and their families...
An update on thrombophilia and placenta mediated pregnancy complications: what should we tell our patients?Marc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 131:S25-7. 2013..Do thrombophilias cause placenta mediated pregnancy complications? Does low molecular weight heparin prevent recurrent placenta mediated pregnancy complications?..- Tinzaparin versus dalteparin for periprocedure prophylaxis of thromboembolic events in hemodialysis patients: a randomized trialMarc A Rodger
The Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Am J Kidney Dis 60:427-34. 2012..Our primary objective was to compare whether tinzaparin and dalteparin differentially accumulate in HD patients... 
Comparing multiple competing interventions in the absence of randomized trials using clinical risk-benefit analysisAlejandro Lazo-Langner
Department of Medicine, University of Western Ontario, London ON, Canada
BMC Med Res Methodol 12:3. 2012....- Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trialSusan R Kahn
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
BMC Cardiovasc Disord 7:21. 2007..Elastic compression stockings (ECS) could be helpful in preventing PTS; however, data on their effectiveness are scarce and conflicting... - Do thrombophilias cause placenta-mediated pregnancy complications?Marc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Semin Thromb Hemost 33:597-603. 2007.... - The interobserver reliability of pretest probability assessment in patients with suspected pulmonary embolismMarc A Rodger
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 116:101-7. 2005..We sought to determine (for patients with suspected PE) the interobserver reliability of pretest probability assessment (by overall impression (gestalt) versus an explicit clinical model)... - The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studiesMarc A Rodger
Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
PLoS Med 7:e1000292. 2010..We undertook a systematic review and a meta-analysis of prospective cohort studies to estimate the association of maternal FVL or PGM carrier status and placenta-mediated pregnancy complications... - Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapyMarc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
CMAJ 179:417-26. 2008..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants... - Inherited thrombophilia and pregnancy complications revisitedMarc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Obstet Gynecol 112:320-4. 2008.... - Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trialM A Rodger
Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 5:1600-6. 2007..The risk of decreased bone mineral density (BMD) with prophylactic dose long-term low-molecular-weight heparin (LMWH) is unknown... - Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTEM A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
Thromb Res 126:222-6. 2010..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study... - Unprovoked venous thromboembolism: Short term or indefinite anticoagulation? Balancing long-term risk and benefitM Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa Hospital, General Campus, Ottawa, Ont, Canada
Blood Rev 24:171-8. 2010.... - Anticoagulant prophylaxis for placenta mediated pregnancy complicationsMarc A Rodger
Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 127:S76-80. 2011.... - Diagnosis and treatment of venous thromboembolism in pregnancyMarc A Rodger
Department of Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Best Pract Res Clin Haematol 16:279-96. 2003..It highlights the poverty of research upon which to base clinical recommendations for this common problem yet offers practical but conservative approaches to patients with suspected and confirmed pregnancy-associated VTE... - Evidence base for the management of venous thromboembolism in pregnancyMarc Rodger
Ottawa Hospital, Ottawa Hospital Research Institute, and University of Ottawa, Ottawa, Ontario, Canada
Hematology Am Soc Hematol Educ Program 2010:173-80. 2010..Prevention requires an optimal balancing of absolute increased bleeding risk from pharmacologic thromboprophylaxis and the absolute benefit of reduced DVT and PE, which, while serious, are relatively uncommon... - Normal functional protein S activity does not exclude protein S deficiencyMarc A Rodger
Department of Medicine, University of Ottawa, Ottawa, ON, Canada
Pathophysiol Haemost Thromb 33:202-5. 2003..Functional PS activity testing should not be used as a screening test to eliminate free antigenic PS testing for the laboratory diagnosis of PS deficiency... - Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolismM J Kovacs
Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
J Thromb Haemost 8:1926-32. 2010.... - Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysisM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
J Thromb Haemost 9:1119-25. 2011.... - Diagnostic value of arterial blood gas measurement in suspected pulmonary embolismM A Rodger
Department of Medicine, University of Ottawa, Ontario, Canada
Am J Respir Crit Care Med 162:2105-8. 2000..We conclude that ABG data alone or in combination with other clinical data are not useful in the assessment of suspected PE... - Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrenceA Hamadah
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Thromb Haemost 9:2406-10. 2011..Whether baseline imaging, conducted after completion of anticoagulation, helps in interpreting diagnostic testing in patients who subsequently have suspected recurrent VTE is unknown... - Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studiesM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Thromb Haemost 8:1716-22. 2010..We sought to summarize the proportion of subsegmental PE diagnosed with single- and multiple-detectors CTPA and assess the safety of diagnostic strategies based on single- or multiple-detectors CTPA to exclude PE... - Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, ON, Canada
Clin Lab Haematol 28:9-13. 2006..8% of initial protein C and protein S results were accurate. If protein C and protein S are measured at the time of diagnosis of acute venous thromboembolism, the majority of the results will be normal and false positives are uncommon... - The management of thrombophilia during pregnancy: a Canadian surveyMarc A Rodger
Department of Medicine, University of Ottawa, Ottawa, ON
J Obstet Gynaecol Can 24:946-52. 2002.... - Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complexM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Kidney Int 73:213-9. 2008..Our study suggests that IgG-specific PF4-H antibody formation is associated with increased mortality in hemodialysis patients... - Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trialMark A Crowther
McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 150:293-300. 2009..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain... - Risk stratification for recurrent venous thromboembolism in unprovoked venous thromboembolism patientsM T Betancourt
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ontario, Canada
Acta Chir Belg 107:636-40. 2007..Research is also underway to determine the predictive ability of these known VTE recurrence risk factors, combinations of these risk factors and their interrelationships as well as to actively search for additional potential predictors... - Steady-state end-tidal alveolar dead space fraction and D-dimer: bedside tests to exclude pulmonary embolismM A Rodger
Department of Medicine, University of Ottawa, Ontario, Canada
Chest 120:115-9. 2001..15, (2) a negative D-dimer result, and (3) the combination of a steady-state end-tidal AVDSf of < 0.15 and a negative D-dimer result. Study design: Prospective cohort study... - The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trialsA Lazo-Langner
Division of Hematology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 5:729-37. 2007..Low-molecular-weight heparins (LMWH) have an antitumor effect in vitro and in experimental animal models of malignancy. Retrospective data suggest that it might improve survival in cancer patients... - A randomized trial comparing 2 low-molecular-weight heparins for the outpatient treatment of deep vein thrombosis and pulmonary embolismPhilip S Wells
Departments of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario
Arch Intern Med 165:733-8. 2005..No published trials have compared LMWHs, and few studies have examined outpatient therapy for PE. Only tinzaparin sodium has demonstrated superiority to unfractionated heparin in a clinical trial... - The outpatient bleeding risk index: validation of a tool for predicting bleeding rates in patients treated for deep venous thrombosis and pulmonary embolismPhilip S Wells
Department of Medicine, University of Ottawa, Ottawa Health Research Institute, Ontario, Canada
Arch Intern Med 163:917-20. 2003..We sought to determine the accuracy of the index in our population of patients... - Risk of subsequent thromboembolism for patients with pre-eclampsiaCarl van Walraven
Ottawa Health Research Institute, Ottawa, Canada K1Y 4E9
BMJ 326:791-2. 2003 - Lessons from ximelagatran: issues for future studies evaluating new oral direct thrombin inhibitors for venous thromboembolism prophylaxis in orthopedic surgeryAlejandro Lazo-Langner
Department of Medicine, The University of Western Ontario, London, Ontario, Canada
Clin Appl Thromb Hemost 15:316-26. 2009..These issues should be explicitly explored in future trials evaluating new direct thrombin inhibitors... - The factor XIII Val34Leu polymorphism: is it protective against idiopathic venous thromboembolism?Philip S Wells
Department of Medicine, University of Ottawa and the Ottawa Health Research Institute, Ottawa, Ontario, Canada
Blood Coagul Fibrinolysis 17:533-8. 2006..69 (95% confidence interval, 0.46-1.02) for the dominant model. Our results do not support an independent association of the FXIII Val34Leu polymorphism with idiopathic venous thromboembolism in our Caucasian Canadian study population... - The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolismPhilip S Wells
Department of Medicine, University of Ottawa, Canada
Thromb Haemost 90:829-34. 2003..33). The ACE D/D genotype was present in 25.3% of cases and 32.4% of controls for an adjusted odds ratio of 0.66 (95% CI = 0.433 to 0.997). We can conclude that the ACE D/D genotype is protective against idiopathic venous thromboembolism... - The bedside investigation of pulmonary embolism diagnosis study: a double-blind randomized controlled trial comparing combinations of 3 bedside tests vs ventilation-perfusion scan for the initial investigation of suspected pulmonary embolismMarc A Rodger
University of Ottawa, Ottawa Health Research Institute, and Department of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
Arch Intern Med 166:181-7. 2006..CONCLUSION: Excluding PE with at least 2 negative results on 3 bedside tests safely eliminates the need for diagnostic imaging in 34% of patients with suspected PE... - A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restrictionHeather E A Howley
University of Ottawa, Ottawa, Ontario, Canada
Am J Obstet Gynecol 192:694-708. 2005..The purpose of this study was to conduct a systematic review of the literature of studies that examined the association between factor V Leiden and/or prothrombin gene variant and intrauterine growth restriction... - Effect of an interactive voice response system on oral anticoagulant managementNatalie Oake
Clinical Epidemiology Program, Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, ON K1Y 4E9
CMAJ 180:927-33. 2009..Monitoring oral anticoagulants is logistically challenging for both patients and medical staff. We evaluated the effect of adding an interactive voice response system to computerized decision support for oral anticoagulant management... - Systematic review: case-fatality rates of recurrent venous thromboembolism and major bleeding events among patients treated for venous thromboembolismMarc Carrier
University of Ottawa, Ottawa Hospital Research Institute, Ontario, Canada
Ann Intern Med 152:578-89. 2010..Case-fatality rates are important for assessing the risks and benefits of anticoagulation in patients with venous thromboembolism (VTE)... - Thrombophilia and the risk for hemodialysis vascular access thrombosisGreg A Knoll
Division of Nephrology, Department of Medicine, University of Ottawa, Ontario, Canada K1H 7W9
J Am Soc Nephrol 16:1108-14. 2005..34 to 2.61). This study suggests that thrombophilia is associated with access thrombosis in dialysis patients. Large, multicenter, prospective cohort studies are needed to confirm the observations from this case-control study... - The prevalence of antibodies to the platelet factor 4 -heparin complex and association with access thrombosis in patients on chronic hemodialysisMarc Carrier
Thrombosis Program, Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 120:215-20. 2007.... - Heparin-induced osteoporosis and pregnancyGenevieve Le Templier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Canada
Curr Opin Pulm Med 14:403-7. 2008..With increasing long-term low-molecular-weight heparin use, for a variety of indications, this was an important knowledge gap... - The risk of dialysis access thrombosis is related to the transforming growth factor-beta1 production haplotype and is modified by polymorphisms in the plasminogen activator inhibitor-type 1 geneAlejandro Lazo-Langner
Division of Hematology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario Canada
Blood 108:4052-8. 2006..We concluded that low TGF-beta1 production haplotype is a risk factor for hemodialysis access thrombosis and that in the presence of the 4G/4G PAI-1 genotype there is an additional increase in risk... - Overview of current venous thromboembolism protocols in hip reconstructionAlejandro Lazo-Langner
Department of Medicine, University of Western Ontario, 800 Commissioners Road, E PO Box 5010 Room A2 401, London, ON N6A 5W9, Canada
Orthop Clin North Am 40:427-36. 2009..This article reviews the current evidence-based recommendations for anticoagulant prophylaxis after total-hip arthroplasty and provides insight into the current areas of active research and controversy... - A pilot study to assess the feasibility of a multicenter cluster randomized trial for the management of asymptomatic persons with a thrombophiliaPhilip S Wells
University of Ottawa, ON, Canada
J Genet Couns 18:475-82. 2009..The question of the best educational approach in these patients remains unanswered. The value of testing and following asymptomatic carriers of probands with VTE and thrombophilia remains unknown... - Excluding pulmonary embolism at the bedside with low pre-test probability and D-dimer: safety and clinical utility of 4 methods to assign pre-test probabilityMarc Carrier
Department of Medicine, University of Ottawa, ON, Canada
Thromb Res 117:469-74. 2006..Non-Elisa D-dimer in combination with pre-test probability of suspected PE can safely exclude PE at the bedside. Pre-test probability can be assigned by gestalt or by using clinical models (Wells, Wicki, Rodger)... - Pelvic magnetic resonance venography reveals high rate of pelvic vein thrombosis after cesarean sectionMarc A Rodger
The Ottawa Hospital, Ottawa, Ontario, Canada
Am J Obstet Gynecol 194:436-7. 2006..Pelvic magnetic resonance venography may be a useful surrogate outcome in obstetric thromboprophylaxis studies but the clinical significance is not known... - Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trialDavid R Anderson
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
JAMA 298:2743-53. 2007..Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli)... - Inter-observer reliability of measures to assess the post-thrombotic syndromeMarc A Rodger
Thromb Haemost 100:164-6. 2008