David Moher

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. pmc Developing a reporting guideline for social and psychological intervention trials
    Evan Mayo-Wilson
    Centre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Trials 14:242. 2013
  2. pmc Developing a guideline for clinical trial protocol content: Delphi consensus survey
    Jennifer Marie Tetzlaff
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    Trials 13:176. 2012
  3. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013
  4. pmc Bibliometric and content analysis of the Cochrane Complementary Medicine Field specialized register of controlled trials
    L Susan Wieland
    University of Maryland School of Medicine, Baltimore, MD, USA
    Syst Rev 2:51. 2013
  5. pmc Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:46. 2013
  6. pmc Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 2:45. 2013
  7. pmc PROSPERO at one year: an evaluation of its utility
    Alison Booth
    Centre for Reviews and Dissemination, University of York, Alcuin B Block, Heslington, York, YO10 5DD, UK
    Syst Rev 2:4. 2013
  8. pmc Chronic Care Model Decision Support and Clinical Information Systems interventions for people living with HIV: a systematic review
    Anjori Pasricha
    Faculty of Medicine, University of Ottawa, Ottawa, Canada
    J Gen Intern Med 28:127-35. 2013
  9. pmc Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement
    Don Husereau
    Institute of Health Economics, Edmonton, Canada
    Cost Eff Resour Alloc 11:6. 2013
  10. pmc Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature
    Joel J Gagnier
    Departments of Orthopaedic Surgery and Epidemiology, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI, USA
    BMC Med Res Methodol 12:111. 2012

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. pmc Developing a reporting guideline for social and psychological intervention trials
    Evan Mayo-Wilson
    Centre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Trials 14:242. 2013
    ..We invite readers to participate in the project by visiting our website, in order to help us reach the best-informed consensus on these guidelines (http://tinyurl.com/CONSORT-study). ..
  2. pmc Developing a guideline for clinical trial protocol content: Delphi consensus survey
    Jennifer Marie Tetzlaff
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    Trials 13:176. 2012
    ....
  3. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013
    ..As such, our objective is to evaluate the comparative effectiveness, safety and cost-effectiveness of DPP-4 inhibitors versus intermediate acting insulin for T2DM patients who have failed both first- and second-line diabetes treatments...
  4. pmc Bibliometric and content analysis of the Cochrane Complementary Medicine Field specialized register of controlled trials
    L Susan Wieland
    University of Maryland School of Medicine, Baltimore, MD, USA
    Syst Rev 2:51. 2013
    ..The objective of this study is to describe the sources and characteristics of citations included in the CAM Field specialized register...
  5. pmc Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:46. 2013
    ..To examine this further, we are proposing to conduct a systematic review and network meta-analysis on the comparative safety of 5-HT3 receptor antagonists among patients undergoing chemotherapy or surgery...
  6. pmc Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 2:45. 2013
    ....
  7. pmc PROSPERO at one year: an evaluation of its utility
    Alison Booth
    Centre for Reviews and Dissemination, University of York, Alcuin B Block, Heslington, York, YO10 5DD, UK
    Syst Rev 2:4. 2013
    ..After one year of operation we describe access and use, explore user experience and identify areas for future improvement...
  8. pmc Chronic Care Model Decision Support and Clinical Information Systems interventions for people living with HIV: a systematic review
    Anjori Pasricha
    Faculty of Medicine, University of Ottawa, Ottawa, Canada
    J Gen Intern Med 28:127-35. 2013
    ..Decision Support (DS) and Clinical Information Systems (CIS) are two components of this model that aim to improve care by changing health care provider behavior...
  9. pmc Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement
    Don Husereau
    Institute of Health Economics, Edmonton, Canada
    Cost Eff Resour Alloc 11:6. 2013
    ..We encourage other journals and groups, to endorse CHEERS. The author team plans to review the checklist for an update in five years...
  10. pmc Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature
    Joel J Gagnier
    Departments of Orthopaedic Surgery and Epidemiology, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI, USA
    BMC Med Res Methodol 12:111. 2012
    ..The objective of this study is to summarize and collate suggested methods for investigating clinical heterogeneity in systematic reviews...
  11. pmc Do health care institutions value research? A mixed methods study of barriers and facilitators to methodological rigor in pediatric randomized trials
    Michele P Hamm
    Alberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Med Res Methodol 12:158. 2012
    ..Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials...
  12. pmc Protocol for development of the guideline for reporting evidence based practice educational interventions and teaching (GREET) statement
    Anna C Phillips
    School of Health Sciences, University of South Australia, GPO Box 2471, Adelaide 5001, Australia
    BMC Med Educ 13:9. 2013
    ..The aim of this program of research is to develop the Guideline for Reporting EBP Educational interventions and Teaching (GREET) statement and an accompanying explanation and elaboration (E&E) paper...
  13. pmc Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement
    Don Husereau
    Institute of Health Economics, Edmonton, Canada
    BMC Med 11:80. 2013
    ..We encourage other journals and groups, to endorse CHEERS. The author team plans to review the checklist for an update in five years...
  14. pmc Does journal endorsement of reporting guidelines influence the completeness of reporting of health research? A systematic review protocol
    Larissa Shamseer
    Centre for Practice Changing Research, Ottawa Hospital Research Institute, The Ottawa Hospital General Campus, 501 Smyth Road, Box 201B, Ottawa, ON, K1H 8L6, Canada
    Syst Rev 1:24. 2012
    ..The objective of this study was to assess whether endorsement of reporting guidelines by journals influences the completeness of reporting of health studies...
  15. pmc Why prospective registration of systematic reviews makes sense
    Lesley Stewart
    Centre for Reviews and Dissemination CRD, University of York, Heslington, York, UK, YO10 5DD
    Syst Rev 1:7. 2012
    ..Registration offers advantages to many stakeholders in return for modest additional effort from the researchers registering their reviews...
  16. pmc An empirical study using permutation-based resampling in meta-regression
    Joel J Gagnier
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA
    Syst Rev 1:18. 2012
    ....
  17. pmc The nuts and bolts of PROSPERO: an international prospective register of systematic reviews
    Alison Booth
    Centre for Reviews and Dissemination, University of York, Alcuin B Block, Heslington, York, UK, YO10 5DD
    Syst Rev 1:2. 2012
    ..The objectives were to reduce unplanned duplication of reviews and provide transparency in the review process, with the aim of minimizing reporting bias...
  18. pmc Establishing a new journal for systematic review products
    David Moher
    Clincal Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital General Campus, 501 Smyth Road, Box 201B, Ottawa, ON K1H 8L6, Canada
    Syst Rev 1:1. 2012
    ..We look forward to participating in the voyage with all of our readers...
  19. doi request reprint CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada
    Int J Surg 10:28-55. 2012
    ..The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials...
  20. pmc Investigator experiences with financial conflicts of interest in clinical trials
    Paula A Rochon
    Women s College Research Institute at Women s College Hospital, Toronto, Canada
    Trials 12:9. 2011
    ..We obtained information from investigators about adherence to practices that minimize the introduction of such bias in their clinical trials experience...
  21. pmc CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, NC 27709, USA
    Trials 11:32. 2010
    ..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
  22. pmc A descriptive analysis of child-relevant systematic reviews in the Cochrane Database of Systematic Reviews
    Simon Bow
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 10:34. 2010
    ..The objective of this study was to describe child-relevant SRs from the Cochrane Database of Systematic Reviews (CDSR, Issue 2, 2009)...
  23. pmc How can we improve the interpretation of systematic reviews?
    Andrea C Tricco
    Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    BMC Med 9:31. 2011
    ..Please see Research article: http://www.biomedcentral.com/1741-7015/9/30/...
  24. pmc CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, NC 27709, USA
    BMC Med 8:18. 2010
    ..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
  25. pmc Practitioners' validation of framework of team-oriented practice models in integrative health care: a mixed methods study
    Isabelle Gaboury
    Department of Community Health Sciences, University of Calgary, Calgary, Canada
    BMC Health Serv Res 10:289. 2010
    ..Models differ theoretically, based on a series of hypotheses. To date, this framework has not been empirically validated. This paper aims to test nine hypotheses in an attempt to validate the MTHP framework...
  26. doi request reprint Describing reporting guidelines for health research: a systematic review
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 64:718-42. 2011
    ..To describe the process of development, content, and methods of implementation of reporting guidelines for health research...
  27. pmc Guidance for developers of health research reporting guidelines
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Med 7:e1000217. 2010
    b>David Moher and colleagues from the EQUATOR network offer guidance and recommended steps for developing health research reporting guidelines.
  28. doi request reprint CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials
    David Moher
    Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 63:e1-37. 2010
    ..The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials...
  29. pmc Resources for authors of reports of randomized trials: harnessing the wisdom of authors, editors, and readers
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, USA
    Trials 12:98. 2011
    ..We invite authors, editors, and readers worldwide to nominate examples of well reported items for the database...
  30. ncbi request reprint [CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials (Chinese version)]
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada, K1H 8L6
    Zhong Xi Yi Jie He Xue Bao 8:701-41. 2010
    ..The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials...
  31. doi request reprint STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Genet Epidemiol 33:581-98. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  32. pmc Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Toronto, ON, Canada
    Eur J Epidemiol 24:37-55. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  33. doi request reprint Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:597-608.e4. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  34. ncbi request reprint STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement
    Julian Little
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 150:206-15. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  35. pmc STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 6:e22. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  36. doi request reprint Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Ottawa, Canada
    Hum Genet 125:131-51. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  37. pmc How effective is tetracaine 4% gel, before a venipuncture, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial
    Brigitte Lemyre
    Department of Pediatrics, University of Ottawa, Ottawa, Canada
    BMC Pediatr 7:7. 2007
    ..Evidence of its efficacy and safety in neonates is limited. The objective of this study was to assess the efficacy and safety of topical tetracaine on the pain response of neonates during a venipuncture...
  38. pmc Can electronic search engines optimize screening of search results in systematic reviews: an empirical study
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 6:7. 2006
    ..Our objective is to test the ability of an Ultraseek search engine to rank MEDLINE records of the included studies of Cochrane reviews within the top half of all the records retrieved by the Boolean MEDLINE search used by the reviewers...
  39. ncbi request reprint The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review
    Catherine Dube
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Ontario, Canada
    Gastroenterology 128:S57-67. 2005
    ..The prevalence is higher still in high-risk groups. Clinicians in a variety of specialties should have a high index of suspicion for the diagnosis of CD and in particular need to pay close attention to the identified high-risk groups...
  40. doi request reprint An international survey indicated that unpublished systematic reviews exist
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:617-623.e5. 2009
    ..To determine the frequency of unpublished systematic reviews (SRs) and explore factors contributing to their occurrence...
  41. ncbi request reprint Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Toronto, Ontario, Canada
    J Clin Epidemiol 58:769-76. 2005
    ....
  42. ncbi request reprint Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review
    Amy C Plint
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Med J Aust 185:263-7. 2006
    ..To determine whether the adoption of the CONSORT checklist is associated with improvement in the quality of reporting of randomised controlled trials (RCTs)...
  43. pmc Epidemiology and reporting characteristics of systematic reviews
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    PLoS Med 4:e78. 2007
    ..We set out to capture a representative cross-sectional sample of published SRs and examine them in terms of a broad range of epidemiological, descriptive, and reporting characteristics, including emerging aspects not previously examined...
  44. doi request reprint Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis
    Alexander Tsertsvadze
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 151:650-61. 2009
    ..Erectile dysfunction (ED) is a common male sexual disorder. The relative benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal testing in men with ED, are uncertain...
  45. ncbi request reprint Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews
    Margaret L Lawson
    Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Epidemiol 58:777-84. 2005
    ....
  46. pmc An evaluation of epidemiological and reporting characteristics of complementary and alternative medicine (CAM) systematic reviews (SRs)
    Lucy Turner
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    PLoS ONE 8:e53536. 2013
    ..Here, methodological and reporting characteristics of a sample of CAM-related SRs and a sample of control SRs are evaluated and compared...
  47. pmc National evaluation of policies on individual financial conflicts of interest in Canadian academic health science centers
    Joel Lexchin
    School of Health Policy and Management, York University, Toronto, ON, Canada
    J Gen Intern Med 23:1896-903. 2008
    ..Conflicts of interest (COI) in research are an important emerging topic of investigation and are frequently cited as a serious threat to the integrity of human participant research...
  48. doi request reprint Non-Cochrane vs. Cochrane reviews were twice as likely to have positive conclusion statements: cross-sectional study
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:380-386.e1. 2009
    ..To determine which factors predict favorable results and positive conclusions in systematic reviews (SRs) and to assess the level of agreement between SR results and conclusions...
  49. ncbi request reprint The diagnostic accuracy of serologic tests for celiac disease: a systematic review
    Alaa Rostom
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
    Gastroenterology 128:S38-46. 2005
    ..If true, the nearly perfect negative predictive value of these tests would drop. The positive predictive value of these tests is likely lower than reported when the tests are applied in low-prevalence populations...
  50. doi request reprint Developing integrative primary healthcare delivery: adding a chiropractor to the team
    Michael J Garner
    Carlington Community and Health Services, Ottawa, Ontario, Canada
    Explore (NY) 4:18-24. 2008
    ..Physicians and other healthcare practitioners are now being placed in multidisciplinary teams, yet little research on integration exists...
  51. doi request reprint Systematic reviews can be produced and published faster
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    J Clin Epidemiol 61:531-6. 2008
    ....
  52. pmc Systematic review of the effectiveness of training programs in writing for scholarly publication, journal editing, and manuscript peer review (protocol)
    James Galipeau
    Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, K1H 8L6, Canada
    Syst Rev 2:41. 2013
    ..However, little research has taken stock of journalology training opportunities or evaluations of their effectiveness...
  53. doi request reprint Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals
    Lucy Turner
    Ottawa Hospital Research Institute, Ottawa, Canada
    Cochrane Database Syst Rev 11:MR000030. 2012
    ..In 2006, a systematic review of eight studies evaluating the "effectiveness of CONSORT in improving reporting quality in journals" was published...
  54. pmc Effect of point of care information on inpatient management of bronchiolitis
    W James King
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    BMC Pediatr 7:4. 2007
    ..We studied the effects of access to point-of-care medical evidence in a computerised physician order entry system (CPOE) on management and clinical outcome of children with bronchiolitis...
  55. doi request reprint Surveillance search techniques identified the need to update systematic reviews
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    J Clin Epidemiol 61:755-62. 2008
    ..This article reports on literature surveillance methods to identify new evidence eligible for updating systematic reviews...
  56. doi request reprint Few systematic reviews exist documenting the extent of bias: a systematic review
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1N 6N5, Canada
    J Clin Epidemiol 61:422-34. 2008
    ..To summarize the evidence concerning bias and confounding in conducting systematic reviews (SRs)...
  57. ncbi request reprint The influence of display and statistical factors on the interpretation of metaanalysis results by physicians
    Parminder S Raina
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Med Care 43:1242-9. 2005
    ..The objective of this study was to determine the extent to which various factors affect the interpretation of metaanalytic results by physicians...
  58. pmc Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals? A Cochrane review
    Lucy Turner
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Syst Rev 1:60. 2012
    ..A systematic review recently published in the Cochrane Library assesses whether journal endorsement of CONSORT impacts the completeness of reporting of RCTs; those findings are summarised here...
  59. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  60. pmc Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    CMAJ 171:349-50. 2004
  61. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
    ..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
  62. ncbi request reprint Should meta-analysts search Embase in addition to Medline?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    J Clin Epidemiol 56:943-55. 2003
    ..88-0.99). Searching Medline but not Embase risks biasing a meta-analysis by finding studies that show larger estimates, but their prevalence seems low enough that the risk may be slight, provided the rest of the search is comprehensive...
  63. ncbi request reprint The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, University of Ottawa, Ottawa, Ontario, Canada
    Clin Oral Investig 7:2-7. 2003
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  64. ncbi request reprint A systematic review identified few methods and strategies describing when and how to update systematic reviews
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    J Clin Epidemiol 60:1095-1104. 2007
    ..SRs are most helpful if they are current; however, most of them are not being updated. This SR summarizes strategies and methods describing when and how to update SRs...
  65. doi request reprint Developing a reporting guideline for social and psychological intervention trials
    Evan Mayo-Wilson
    Evan Mayo Wilson, DPhhil, MSc, Centre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, London, UK Paul Montgomery, DPhil, Centre for Evidence Based Intervention, University of Oxford, Oxford, UK Sally Hopewell, DPhil, Centre for Statistics in Medicine, University of Oxford, Oxford, UK Geraldine Macdonald, MSc, Institute of Child Care Research, Queen s University Belfast, Belfast UK David Moher, PhD, MSc, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Centre for Practice Changing Research CPCR, The Ottawa Hospital, Ottawa, Canada Sean Grant, MSc, Centre for Evidence Based Intervention, University of Oxford, Oxford, UK
    Br J Psychiatry 203:250-4. 2013
    ..We invite readers to participate in the project by visiting our website, in order to help us reach the best-informed consensus on these guidelines (http://tinyurl.com/CONSORT-study). ..
  66. pmc Effectiveness of brief interventions as part of the screening, brief intervention and referral to treatment (SBIRT) model for reducing the non-medical use of psychoactive substances: a systematic review protocol
    Matthew M Young
    Canadian Centre on Substance Abuse CCSA, 75 Albert Street, Ottawa, ON, K1P 5E7, Canada
    Syst Rev 1:22. 2012
    ....
  67. pmc Evidence summaries: the evolution of a rapid review approach
    Sara Khangura
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, 501 Smyth Road, Box 208, Ottawa, Ontario, K1H 8L6, Canada
    Syst Rev 1:10. 2012
    ..This paper outlines our experience with rapidly producing, publishing and disseminating evidence summaries in the context of our Knowledge to Action (KTA) research program...
  68. pmc Following 411 Cochrane protocols to completion: a retrospective cohort study
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 3:e3684. 2008
    ..g., funding) are being published, this may lead to inaccurate decisions. We examined the frequency of published and unpublished Cochrane reviews and protocol factors that predict the publication of Cochrane reviews...
  69. ncbi request reprint Blinded versus unblinded assessments of risk of bias in studies included in a systematic review
    Kate Morissette
    Health Canada, Ottawa, Ontario, Canada
    Cochrane Database Syst Rev 9:MR000025. 2011
    ..e. the assessor is unaware of the study author's name, institution, sponsorship, journal, etc.) versus unblinded assessments of risk of bias yield systematically different assessments in a systematic review...
  70. doi request reprint The art and science of knowledge synthesis
    Andrea C Tricco
    Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 64:11-20. 2011
    ..To review methods for completing knowledge synthesis...
  71. pmc Updating systematic reviews: an international survey
    Chantelle Garritty
    The Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
    PLoS ONE 5:e9914. 2010
    ..However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear...
  72. pmc Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females: a randomized, double-blind, placebo-controlled trial
    Wendy Spettigue
    Mental Health Department, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada
    BMC Pediatr 8:4. 2008
    ..This randomized, double-blind placebo-controlled trial seeks to examine the effectiveness and safety of olanzapine in female youth with AN...
  73. doi request reprint Systematic review: comparative effectiveness and harms of combination therapy and monotherapy for dyslipidemia
    Mukul Sharma
    University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Institute, Ottawa, Ontario, Canada
    Ann Intern Med 151:622-30. 2009
    ..Statin therapy effectively prevents vascular disease, but treatment targets are often not achieved...
  74. doi request reprint A review of five cardiology journals found that observer variability of measured variables was infrequently reported
    Robert M Gow
    Children s Hospital of Eastern Ontario Research Institute, 410 Smyth Road, Ottawa, Ontario, Canada K1H 8L1
    J Clin Epidemiol 61:394-401. 2008
    ..To investigate the reporting of the analysis of interobserver and intra-observer variability within clinical research studies from five high-impact cardiology journals published in 2005...
  75. pmc Guidelines for randomized clinical trial protocol content: a systematic review
    Jennifer M Tetzlaff
    Ottawa Methods Centre, Ottawa Hospital Research Institute, Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
    Syst Rev 1:43. 2012
    ..The objective of this study was to systematically identify and review RCT protocol guidelines, to assess their characteristics and methods of development, and to compare recommendations...
  76. pmc Reporting guidelines for survey research: an analysis of published guidance and reporting practices
    Carol Bennett
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    PLoS Med 8:e1001069. 2010
    ..Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is a need to develop a reporting guideline for survey research...
  77. doi request reprint Assessment of systematic effects of methodological characteristics on candidate genetic associations
    Badr Aljasir
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada
    Hum Genet 132:167-78. 2013
    ..2 % of the between-study variance in the magnitude of the reported genetic associations. Our findings are consistent with the view that better conducted and better reported genetic association research may lead to less inflated results...
  78. pmc Measurement properties of questionnaires assessing complementary and alternative medicine use in pediatrics: a systematic review
    Karine Toupin April
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 7:e39611. 2012
    ..However, no studies have attempted to appraise measurement properties of these questionnaires. The aim of this systematic review was to critically appraise and summarize measurement properties of questionnaires of CAM use in pediatrics...
  79. doi request reprint Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Lancet 379:2252-61. 2012
    ..We aimed to assess the effects of QI strategies on glycated haemoglobin (HbA(1c)), vascular risk management, microvascular complication monitoring, and smoking cessation in patients with diabetes...
  80. pmc Searching for controlled trials of complementary and alternative medicine: a comparison of 15 databases
    Elise Cogo
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Evid Based Complement Alternat Med 2011:858246. 2011
    ..Low overlap between databases indicates comprehensive CAM literature searches will require multiple databases...
  81. doi request reprint Oral sildenafil citrate (viagra) for erectile dysfunction: a systematic review and meta-analysis of harms
    Alexander Tsertsvadze
    Clinical Epidemiology Program, Ottawa Health Research Institute, Box 208, 501 Smyth Rd, Ottawa K1H 8L6, Ontario, Canada
    Urology 74:831-836.e8. 2009
    ..To summarize and compare evidence on harms in sildenafil- and placebo-treated men with erectile dysfunction (ED) in a systematic review and meta-analysis...
  82. pmc Funding source, trial outcome and reporting quality: are they related? Results of a pilot study
    Tammy J Clifford
    Chalmers Research Group, Ottawa, Canada
    BMC Health Serv Res 2:18. 2002
    ..There has been increasing concern regarding the potential effects of the commercialization of research...
  83. ncbi request reprint How quickly do systematic reviews go out of date? A survival analysis
    Kaveh G Shojania
    Ottawa Health Research Institute, University of Ottawa, Chalmers Research Group, and Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Ann Intern Med 147:224-33. 2007
    ..Systematic reviews are often advocated as the best source of evidence to guide clinical decisions and health care policy, yet we know little about the extent to which they require updating...
  84. pmc An evaluation of the completeness of safety reporting in reports of complementary and alternative medicine trials
    Lucy Ann Turner
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa Hospital, Ontario, Canada
    BMC Complement Altern Med 11:67. 2011
    ..The objectives of this study are to assess the quality of safety reporting in CAM RCTs; to explore the influence of different trial characteristics on the quality of safety reporting...
  85. ncbi request reprint Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration
    Joel J Gagnier
    Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 59:1134-49. 2006
    ..These recommendations for the reporting of herbal medicinal products presented here are open to revision as more evidence accumulates and critical comments are collected...
  86. ncbi request reprint Consequences of testing for celiac disease
    Ann Cranney
    Ottawa Health Research Institute, Ottawa, Canada
    Gastroenterology 128:S109-20. 2005
    ..The literature suggests that compliance is less than ideal in these individuals, especially if diagnosed when adults. Long-term outcomes have not been extensively studied in those with silent CD...
  87. ncbi request reprint Issues related to the conduct of systematic reviews: a focus on the nutrition field
    David Moher
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Am J Clin Nutr 88:1191-9. 2008
    ..Recommendations are then provided, such as developing a capacity-building program, searching the primary literature for research gaps, and extending reporting tools such as the QUOROM Statement to the field of nutrition...
  88. doi request reprint Systematic review of the benefits and harms of calcitriol and alfacalcidol for fractures and falls
    Siobhan O'Donnell
    Clinical Epidemiology Program, Ottawa Health Research Institute, 1053 Carling Avenue, ASB 1 006, Ottawa, Ontario, Canada, K1Y 4E9
    J Bone Miner Metab 26:531-42. 2008
    ..Hypercalcemia and hypercalciuria are potential side effects...
  89. pmc Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program
    Jacqueline Halton
    University of Ottawa, Ontario, Canada
    J Bone Miner Res 24:1326-34. 2009
    ..5-14.5). These results show that vertebral compression is an under-recognized complication of newly diagnosed ALL. Whether the fractures will resolve through bone growth during or after leukemia chemotherapy remains to be determined...
  90. pmc STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Ottawa, ON, Canada
    Eur J Clin Invest 39:247-66. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct or analysis...
  91. pmc A review of interventions triggered by hepatitis A infected food-handlers in Canada
    Andrea C Tricco
    Epidemiology and Biostatistics, GlaxoSmithKline Canada, Mississauga, Ontario, Canada
    BMC Health Serv Res 6:157. 2006
    ..We undertook a systematic review of such incidents to evaluate the extent of viral transmission through food contamination and the scope of post-exposure prophylaxis (PEP) interventions...
  92. ncbi request reprint Critical appraisal of clinical studies in Chinese herbal medicine
    Simon Dagenais
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Zhong Xi Yi Jie He Xue Bao 4:455-66. 2006
    ....
  93. doi request reprint Updating comparative effectiveness reviews: current efforts in AHRQ's Effective Health Care Program
    Alexander Tsertsvadze
    University of Ottawa Evidence Based Practice Center, Clinical Epidemiology Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6
    J Clin Epidemiol 64:1208-15. 2011
    ..To review the current knowledge and efforts on updating systematic reviews (SRs) as applied to comparative effectiveness reviews (CERs)...
  94. pmc Poor reporting of scientific leadership information in clinical trial registers
    Melanie Sekeres
    Kunin Lunenfeld Applied Research Unit, Baycrest, Toronto, Ontario, Canada
    PLoS ONE 3:e1610. 2008
    ..Identifying those scientifically responsible for trial conduct increases accountability. The objective is to examine the proportion of registered clinical trials providing valid scientific leadership information...
  95. pmc Identifying null meta-analyses that are ripe for updating
    Nicholas J Barrowman
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 3:13. 2003
    ..As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date...
  96. doi request reprint The long-term gastrointestinal functional outcomes following curative anterior resection in adults with rectal cancer: a systematic review and meta-analysis
    Adena S Scheer
    Department of General Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada
    Dis Colon Rectum 54:1589-97. 2011
    ..Significant variability and a lack of transparency exist in the reporting of anterior resection outcomes...
  97. doi request reprint Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials
    Ping Wu
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Stroke 41:e171-9. 2010
    ..To comprehensively assess the efficacy of acupuncture in poststroke rehabilitation, we conducted a systematic review and meta-analysis of all randomized clinical trials of acupuncture for poststroke rehabilitation...
  98. ncbi request reprint Chiropractic care of musculoskeletal disorders in a unique population within Canadian community health centers
    Michael J Garner
    Carlington Community and Health Services, Ottawa, Ontario, Canada
    J Manipulative Physiol Ther 30:165-70. 2007
    ....
  99. doi request reprint Intravesical oxybutynin for children with poorly compliant neurogenic bladder: a systematic review
    Luis Antonio Guerra
    Division of Pediatric Urology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    J Urol 180:1091-7. 2008
    ..They may become nonresponders to the drug or present with severe side effects. We evaluated the effectiveness and tolerability of intravesical oxybutynin in children with poorly compliant neurogenic bladder...
  100. ncbi request reprint Benefits and harms associated with the practice of bed sharing: a systematic review
    Tanya Horsley
    Department of Pediatrics, University of Ottawa, and Department of Pediatrics, The Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    Arch Pediatr Adolesc Med 161:237-45. 2007
    ..To examine evidence of benefits and harms to children associated with bed sharing, factors (eg, smoking) altering bed sharing risk, and effective strategies for reducing harms associated with bed sharing...
  101. pmc How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221]
    Brigitte Lemyre
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    BMC Med 4:11. 2006
    ..The objective of this trial was to assess the safety and efficacy of tetracaine gel on the pain response of very low birth weight (VLBW) infants during insertion of a PICC...