Michael W McBurney

Summary

Affiliation: Ottawa Regional Cancer Centre
Country: Canada

Publications

  1. pmc SirT1 regulates energy metabolism and response to caloric restriction in mice
    Gino Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 3:e1759. 2008
  2. doi sirt1-null mice develop an autoimmune-like condition
    Jedon Sequeira
    Center for Cancer Therapeutics, Ottawa Health Research Institute, Box 926, 3rd Floor, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Exp Cell Res 314:3069-74. 2008
  3. ncbi The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells
    Michael W McBurney
    Ottawa Regional Cancer Centre and University of Ottawa, Ottawa, Canada
    Mol Cancer Res 1:402-9. 2003
  4. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
  5. ncbi Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes
    Michael W McBurney
    Department of Medicine, University of Ottawa, Ottawa Regional Cancer Centre, 503 Smyth Road, Ottawa, Ontario, K1H 1C4, Canada
    Exp Cell Res 274:1-8. 2002
  6. ncbi Reexpression of a cluster of silenced transgenes is associated with their rearrangement
    M W McBurney
    Ottawa Regional Cancer Center and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Genes Chromosomes Cancer 32:311-23. 2001
  7. ncbi Enhanced transgene expression in embryonal carcinoma stem cells: transcription through introns and exons increases gene copy numbers and forestalls silencing
    Michael W McBurney
    Ottawa Regional Cancer Centre, University of Ottawa, 503 Smyth Road, Ottawa K1H 1C4 Canada
    Exp Cell Res 288:313-23. 2003
  8. doi Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice
    Gino Boily
    Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6
    Exp Cell Res 316:2189-93. 2010
  9. doi SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
    Erin L Seifert
    Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Otttawa, Ontario, Canada
    FASEB J 26:555-66. 2012
  10. ncbi A role for RNA processing in regulating expression from transfected genes
    M W McBurney
    Ottawa Regional Cancer Center, University of Ottawa, Canada
    Somat Cell Mol Genet 24:203-15. 1998

Collaborators

  • Mary Ellen Harper
  • M A Christine Pratt
  • X Yang
  • Helen H Tai
  • Lin Feng Chen
  • Wei Gu
  • Peter Lansdorp
  • Wei Xu
  • ERIC M VERDIN
  • R Marmorstein
  • Leonard P Guarente
  • Paolo Sassone-Corsi
  • Y Lau
  • K Boekelheide
  • Po Zhao
  • Vittorio Sartorelli
  • J R Davie
  • J C Bell
  • Valter Longo
  • Karen Jardine
  • Gino Boily
  • Erin L Seifert
  • Xiao Hong He
  • G Boily
  • Ying Li
  • Marcella Fulco
  • Jedon Sequeira
  • Hye Sook Kwon
  • Sarah Saliba
  • Xiaohong He
  • Hiyaa S Ghosh
  • Melanie Ott
  • Ullas Kolthur-Seetharam
  • Christopher Kamel
  • Jing Wang
  • Sara Pagans
  • Frederic Picard
  • K Jardine
  • Annabelle Z Caron
  • P Liston
  • Katy Morin
  • Danielle Dewar-Darch
  • Josée Coulombe
  • B Pearce
  • X H He
  • Michael M Brent
  • Yana Cen
  • Sean Crawford
  • Carmen Estey
  • Eric P Hoffman
  • Christopher Kennedy
  • Cynthia Moffat
  • Anthony A Sauve
  • Warner C Greene
  • Martina Schnolzer
  • Jian Xuan
  • Meredith Evans
  • William Staines
  • Colin Rousseaux
  • Guillaume Sabourin
  • Prerana Jayakumar
  • Stephanie Bazinet
  • Lisa Bevilacqua
  • Rudi Mueller
  • Ruth Getachew
  • Paul D Robbins
  • James V Spencer
  • Bobby Ng
  • Francoise Dantzer
  • Gilbert de Murcia
  • Meena Abrol
  • Ying Chen
  • Brian J North
  • Qiwei Zhai
  • Manfred Jung
  • Katrin Kaehlcke
  • Estelle Lin
  • Angelika Pedal
  • Zhigang He
  • Roy Frye
  • Peter Henklein
  • Alexander Dorr
  • Claudia Hetzer-Egger
  • Brett L Marshall
  • Henning Hruby
  • Acharawan Topark-Ngarm
  • Rita Machado De Oliveira
  • Thanaset Senawong
  • Martin Kurtev
  • Namjin Chung

Detail Information

Publications31

  1. pmc SirT1 regulates energy metabolism and response to caloric restriction in mice
    Gino Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 3:e1759. 2008
    ..Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction...
  2. doi sirt1-null mice develop an autoimmune-like condition
    Jedon Sequeira
    Center for Cancer Therapeutics, Ottawa Health Research Institute, Box 926, 3rd Floor, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Exp Cell Res 314:3069-74. 2008
    ..We interpret these observations as consistent with a role for SIRT1 in sustaining normal immune function and in this way delaying the onset of autoimmune disease...
  3. ncbi The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells
    Michael W McBurney
    Ottawa Regional Cancer Centre and University of Ottawa, Ottawa, Canada
    Mol Cancer Res 1:402-9. 2003
    ..Our results failed to provide evidence that the mammalian SIR2alpha protein plays a role in gene silencing and suggest that the physiological substrate(s) for the SIR2alpha deacetylase may be nuclear proteins other than histones...
  4. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
    ..The phenotype of the sir2alpha null animals suggests that the SIR2alpha protein is essential for normal embryogenesis and for normal reproduction in both sexes...
  5. ncbi Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes
    Michael W McBurney
    Department of Medicine, University of Ottawa, Ottawa Regional Cancer Centre, 503 Smyth Road, Ottawa, Ontario, K1H 1C4, Canada
    Exp Cell Res 274:1-8. 2002
    ....
  6. ncbi Reexpression of a cluster of silenced transgenes is associated with their rearrangement
    M W McBurney
    Ottawa Regional Cancer Center and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Genes Chromosomes Cancer 32:311-23. 2001
    ....
  7. ncbi Enhanced transgene expression in embryonal carcinoma stem cells: transcription through introns and exons increases gene copy numbers and forestalls silencing
    Michael W McBurney
    Ottawa Regional Cancer Centre, University of Ottawa, 503 Smyth Road, Ottawa K1H 1C4 Canada
    Exp Cell Res 288:313-23. 2003
    ....
  8. doi Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice
    Gino Boily
    Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6
    Exp Cell Res 316:2189-93. 2010
    ..However, we show that mice lacking at least one allele of both Sirt1 and Igfbp1 genes have a much higher incidence of malocclusion...
  9. doi SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
    Erin L Seifert
    Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Otttawa, Ontario, Canada
    FASEB J 26:555-66. 2012
    ..Thus, the SirT1 protein has functions that can be attributed to the catalytic activity of the protein, as well as other functions that are conferred by the protein itself...
  10. ncbi A role for RNA processing in regulating expression from transfected genes
    M W McBurney
    Ottawa Regional Cancer Center, University of Ottawa, Canada
    Somat Cell Mol Genet 24:203-15. 1998
    ..Thus, the effect of the co-transfected Pgk-1 gene is to inhibit the process of gene inactivation possibly by functioning like an insulator or boundary element in the chromatin...
  11. ncbi SirT1 fails to affect p53-mediated biological functions
    Christopher Kamel
    Ottawa Health Research Institute and Departments of Medicine and Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada K1H 8L6
    Aging Cell 5:81-8. 2006
    ..These findings suggest that SirT1 does not affect many p53-mediated biological activities despite the fact that acetylated p53 has been shown to be a substrate for SirT1...
  12. ncbi Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor
    M A Pratt
    Department of Medicine, University of Ottawa, Ontario, Canada
    Differentiation 53:105-13. 1993
    ..Constitutive expression of Hox 1.6 from a heterologous promoter did not induce differentiation indicating that expression of this gene is insufficient to initiate the cascade of events that culminates in cell differentiation...
  13. ncbi Intragenic regions of the murine Pgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells
    M W McBurney
    University of Ottawa, Department of Medicine, Ottawa, Ontario, Canada
    Somat Cell Mol Genet 20:515-28. 1994
    ..The enhanced integration and expression of transfected plasmids required active transcription through an intragenic region of Pgk-1, perhaps resulting in more recombinogenic plasmid DNAs...
  14. ncbi Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
    P Liston
    Cancer Research Group, Ottawa Regional Cancer Center, 501 Smyth Road, Ottawa, K1H 8L6, Canada
    Nat Cell Biol 3:128-33. 2001
    ..Loss of control over apoptotic signalling is now recognized as a critical event in the development of cancer. Our results indicate that XAF1 may be important in mediating the apoptosis resistance of cancer cells...
  15. ncbi Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
    C N Adra
    Department of Medicine, University of Ottawa, Ont, Canada
    Gene 60:65-74. 1987
    ..The promoter of the mouse pgk-1 gene is homologous to the human pgk-1 promoter. A number of conserved motifs in the promoter may indicate a significant role for these sequences in expression of the pgk-1 gene...
  16. ncbi CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins
    Helen H Tai
    Ottawa Regional Cancer Centre, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ont, Canada
    Biochem Biophys Res Commun 308:170-6. 2003
    ..Splicing assays show that CHD1 overexpression can affect alternative splicing. These results suggest that CHD1 may function in both chromatin mediated transcriptional repression and RNA splicing...
  17. ncbi E2F inhibits transcriptional activation by the retinoic acid receptor
    S L Costa
    Ottawa Regional Cancer Centre, University of Ottawa, Canada
    Cell Growth Differ 7:1479-85. 1996
    ..Our evidence suggests that E2F-1 reduces expression from RA-inducible promoters by interacting with an unidentified coactivator(s) that is required by the RARs...
  18. pmc The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon
    P H Boer
    Department of Medicine, University of Ottawa, Canada
    Mol Cell Biol 7:3107-12. 1987
    ..The pgk-2 gene may, then, be a transcribed retroposon. Thus, gene duplication by retroposition may have been used as a mechanism for evolutionary diversification...
  19. doi SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    G Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, and Department of Medicine, University of Ottawa, Ontario, Canada
    Oncogene 28:2882-93. 2009
    ..Thus, our results suggest that SirT1 does not behave like a classical tumor-suppressor gene but the antitumor activity of resveratrol is mediated at least in part by SirT1...
  20. ncbi The family of mouse phosphoglycerate kinase genes and pseudogenes
    C N Adra
    Department of Medicine, University of Ottawa, Canada
    Somat Cell Mol Genet 14:69-81. 1988
    ..Our evidence suggests that pgk-1-derived retroposons arose initially more than 100 million years ago and have continued to arise until so recently that some are unique to different mouse strains...
  21. ncbi Murine PGK-1 promoter drives widespread but not uniform expression in transgenic mice
    M W McBurney
    Department of Medicine, University of Ottawa, Ontario, Canada
    Dev Dyn 200:278-93. 1994
    ..Thus, the Pgk-1 promoter drives transgene expression in all tissues but the levels of expression are not uniform in each cell...
  22. ncbi Polymorphisms in the coding and noncoding regions of murine Pgk-1 alleles
    P H Boer
    Department of Medicine, University of Ottawa, Canada
    Biochem Genet 28:299-308. 1990
    ..A number of other DNA sequence polymorphisms exist between Pgk-1b and Pgk-1a including part of an L1 repeated element unique to Pgk-1a...
  23. ncbi Expression of the Brachyury gene during mesoderm development in differentiating embryonal carcinoma cell cultures
    G Vidricaire
    Department of Medicine, University of Ottawa, Canada
    Development 120:115-22. 1994
    ..Aggregated D3 cells express Brachyury mRNA suggesting that the mutation(s) responsible for the phenotype of D3 cells is downstream of the chain of events initiated by Brachyury expression...
  24. pmc Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
    Hiyaa S Ghosh
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 408:105-11. 2007
    ..Taken together, these results suggest that the interaction between Sirt1 and TLE1 is important for mediating repression of NF-kappaB activity...
  25. ncbi Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
    Ullas Kolthur-Seetharam
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Strasbourg, France
    Cell Cycle 5:873-7. 2006
    ..Our findings establish a functional link between the two NAD+-dependent enzyme systems and provide a physiological interpretation for the mechanism of death in cells lacking SIRT1...
  26. pmc Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
    Marcella Fulco
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Dev Cell 14:661-73. 2008
    ..These experiments reveal that AMPK, Nampt, and SIRT1 are the molecular components of a functional signaling pathway that allows skeletal muscle cells to sense and react to nutrient availability...
  27. pmc SIRT1 regulates HIV transcription via Tat deacetylation
    Sara Pagans
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    PLoS Biol 3:e41. 2005
    ..These results support a model in which cycles of Tat acetylation and deacetylation regulate HIV transcription. SIRT1 recycles Tat to its unacetylated form and acts as a transcriptional coactivator during Tat transactivation...
  28. pmc SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
    Ying Li
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Cell Metab 8:38-48. 2008
    ..These results are consistent with findings in S. cerevisiae and other model systems, suggesting that mammalian sirtuins can play both protective and proaging roles...
  29. pmc A local mechanism mediates NAD-dependent protection of axon degeneration
    Jing Wang
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 170:349-55. 2005
    ..Furthermore, we provide evidence that such Nmnat1/NAD-mediated protection is primarily mediated by their effects on local bioenergetics. Together, our results suggest a novel molecular pathway for axon degeneration...
  30. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals...
  31. pmc Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
    Hye Sook Kwon
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 3:158-67. 2008
    ..These events likely contribute to the state of immune cell hyperactivation found in HIV-infected individuals...