Brian Hutton

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. doi request reprint Identifying an optimal antiemetic regimen for patients receiving anthracycline and cyclophosphamide-based chemotherapy for breast cancer - An inspection of the evidence base informing clinical decision-making
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Canada University of Ottawa, School of Epidemiology, Public Health and Preventive Medicine, Canada Electronic address
    Cancer Treat Rev 41:951-9. 2015
  2. doi request reprint Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Canada
    Syst Rev 4:114. 2015
  3. pmc Do sugar-sweetened beverages cause adverse health outcomes in adults? A systematic review protocol
    Candyce Hamel
    Clinical Epidemiology Program, Centre for Practice Changing Research, Ottawa Hospital Research Institute, 501 Smyth Road, Box 201B, Ottawa, ON K1H 8L6, Canada
    Syst Rev 3:108. 2014
  4. pmc Do sugar-sweetened beverages cause adverse health outcomes in children? A systematic review protocol
    Adrienne Stevens
    Healthy Active Living and Obesity Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    Syst Rev 3:96. 2014
  5. pmc Comparative safety of anti-epileptic drugs among infants and children exposed in utero or during breastfeeding: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1 T8, Canada
    Syst Rev 3:68. 2014
  6. pmc Safety and effectiveness of antiretroviral therapies for HIV-infected women and their infants and children: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 3:51. 2014
  7. pmc Safety, effectiveness, and cost of long-acting versus intermediate-acting insulin for type 1 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, ON M5B 1T8, Canada
    Syst Rev 2:73. 2013
  8. pmc Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis
    Ferrán Catalá-López
    Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines and Healthcare Products Agency AEMPS, Madrid, Spain
    BMC Med 12:15. 2014
  9. pmc Checking whether there is an increased risk of post-transplant lymphoproliferative disorder and other cancers with specific modern immunosuppression regimens in renal transplantation: protocol for a network meta-analysis of randomized and observational st
    Brian Hutton
    Ottawa Hospital Research Institute, Center for Practice Changing Research, 501 Smyth Road, K1H 8 L6 Ottawa, ON, Canada
    Syst Rev 3:16. 2014
  10. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013

Collaborators

Detail Information

Publications43

  1. doi request reprint Identifying an optimal antiemetic regimen for patients receiving anthracycline and cyclophosphamide-based chemotherapy for breast cancer - An inspection of the evidence base informing clinical decision-making
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Canada University of Ottawa, School of Epidemiology, Public Health and Preventive Medicine, Canada Electronic address
    Cancer Treat Rev 41:951-9. 2015
    ..Despite consensus recommendations for antiemetics in breast cancer patients receiving anthracycline and cyclophosphamide-based chemotherapy, control of chemotherapy-induced nausea and vomiting (CINV) remains sub-optimal...
  2. doi request reprint Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Canada
    Syst Rev 4:114. 2015
    ..This systematic review and network meta-analysis of randomized studies will synthesize available evidence addressing this knowledge gap...
  3. pmc Do sugar-sweetened beverages cause adverse health outcomes in adults? A systematic review protocol
    Candyce Hamel
    Clinical Epidemiology Program, Centre for Practice Changing Research, Ottawa Hospital Research Institute, 501 Smyth Road, Box 201B, Ottawa, ON K1H 8L6, Canada
    Syst Rev 3:108. 2014
    ..We will assess whether the consumption of sugar-sweetened beverages in adults is associated with adverse health outcomes and what the potential moderating factors are...
  4. pmc Do sugar-sweetened beverages cause adverse health outcomes in children? A systematic review protocol
    Adrienne Stevens
    Healthy Active Living and Obesity Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    Syst Rev 3:96. 2014
    ..We will assess whether the consumption of sugar-sweetened beverages in children is associated with adverse health outcomes and what the potential moderating factors are...
  5. pmc Comparative safety of anti-epileptic drugs among infants and children exposed in utero or during breastfeeding: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1 T8, Canada
    Syst Rev 3:68. 2014
    ....
  6. pmc Safety and effectiveness of antiretroviral therapies for HIV-infected women and their infants and children: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 3:51. 2014
    ..We aim to evaluate the comparative safety and effectiveness of the use of antiretroviral drugs among HIV-infected women and the effects on their infants and children through a systematic review and network meta-analysis...
  7. pmc Safety, effectiveness, and cost of long-acting versus intermediate-acting insulin for type 1 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, ON M5B 1T8, Canada
    Syst Rev 2:73. 2013
    ..Our objective is to evaluate the comparative effectiveness, safety, and cost of long-acting insulin versus intermediate-acting insulin through a systematic review and network meta-analysis...
  8. pmc Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis
    Ferrán Catalá-López
    Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines and Healthcare Products Agency AEMPS, Madrid, Spain
    BMC Med 12:15. 2014
    ..The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades...
  9. pmc Checking whether there is an increased risk of post-transplant lymphoproliferative disorder and other cancers with specific modern immunosuppression regimens in renal transplantation: protocol for a network meta-analysis of randomized and observational st
    Brian Hutton
    Ottawa Hospital Research Institute, Center for Practice Changing Research, 501 Smyth Road, K1H 8 L6 Ottawa, ON, Canada
    Syst Rev 3:16. 2014
    ....
  10. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013
    ..As such, our objective is to evaluate the comparative effectiveness, safety and cost-effectiveness of DPP-4 inhibitors versus intermediate acting insulin for T2DM patients who have failed both first- and second-line diabetes treatments...
  11. pmc Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:46. 2013
    ..To examine this further, we are proposing to conduct a systematic review and network meta-analysis on the comparative safety of 5-HT3 receptor antagonists among patients undergoing chemotherapy or surgery...
  12. pmc Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 2:45. 2013
    ....
  13. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  14. pmc Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    BMJ 345:e5798. 2012
    ....
  15. ncbi request reprint Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    Clin Trials 2:218-29; discussion 229-32. 2005
    ..Randomized controlled trials of aprotinin evaluating its effect on the outcome of perioperative transfusion have been published since 1987, and systematic reviews were conducted in 1992 and 1997...
  16. doi request reprint Treatment choices for patients with invasive lobular breast cancer: a doctor survey
    Carmel Jacobs
    The Ottawa Hospital Cancer Center, University of Ottawa, Ottawa, Ontario, Canada
    J Eval Clin Pract 21:740-8. 2015
    ..Invasive lobular breast cancer (ILC) has distinct features that present challenges for management. We surveyed doctors regarding management approaches, opinions on quality of evidence supporting their practice, and future research needs...
  17. ncbi request reprint Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial
    Dean A Fergusson
    Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    JAMA 308:1443-51. 2012
    ..Even though red blood cells (RBCs) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of organ dysfunction, nosocomial infection, and length of hospital stay...
  18. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  19. ncbi request reprint Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis
    Alexis F Turgeon
    Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, the University of Ottawa and the Canadian Blood Service, Ottawa, Ontario, Cananda
    Ann Intern Med 146:193-203. 2007
    ..Intravenous immunoglobulin therapy has been proposed as an adjuvant treatment for sepsis. Yet, its benefit remains unclear, and its use is not currently recommended...
  20. doi request reprint Defining optimal control of chemotherapy-induced nausea and vomiting-based on patients' experience
    Catalina Hernandez Torres
    Division of Medical Oncology and Department of Medicine, University of Ottawa, Ottawa, Canada
    Support Care Cancer 23:3341-59. 2015
    ..The objective of this study is to determine the optimal definition of CINV control from the patients' perspective...
  21. doi request reprint Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials
    Sasha Mazzarello
    Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Breast Cancer Res Treat 152:1-8. 2015
    ..Treatment of urogenital atrophy remains a challenging issue and there is a paucity of RCT evidence addressing this knowledge gap. It is evident that more prospective trials are needed...
  22. doi request reprint Choice of study endpoint significantly impacts the results of breast cancer trials evaluating chemotherapy-induced nausea and vomiting
    Terry Ng
    Department of Medicine and Division of Medical Oncology, The Ottawa Hospital and University of Ottawa, 501 Smyth Road, Box 912, Ottawa, ON, K1H8L6, Canada
    Breast Cancer Res Treat 155:337-44. 2016
    ..Primary endpoints of studies, including those mandated by regulatory bodies, should account for nausea to reflect patient experience. Reporting of endpoints should be more comprehensive to allow for cross-trial comparisons. ..
  23. ncbi request reprint Reliability of point-of-care testing for glucose measurement in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
    Crit Care Med 33:2778-85. 2005
    ..Therefore, it is imperative that bedside glucose testing methods be safe and accurate...
  24. doi request reprint Optimisation of steroid prophylaxis schedules in breast cancer patients receiving docetaxel chemotherapy-a survey of health care providers and patients
    Carmel Jacobs
    The Ottawa Hospital Cancer Center and University of Ottawa, Ottawa, ON, Canada
    Support Care Cancer 23:3269-75. 2015
    ..We surveyed health care providers and patients about their experiences with steroid prophylaxis...
  25. doi request reprint Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities
    Chris Cameron
    School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, 451 Smyth Road, Suite RGN 3105, Ottawa, ON, K1H 8 M5, Canada
    Syst Rev 4:147. 2015
    ..However, thoughtful integration of randomized and non-randomized studies may offer opportunities to provide more timely, comprehensive, and generalizable evidence about the comparative safety and effectiveness of medical treatments...
  26. ncbi request reprint Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 45:1640-57. 2005
    ....
  27. pmc Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review
    Carmel Jacobs
    Division of Medical Oncology, Ottawa Hospital Cancer Centre, and Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Oncologist 20:210-23. 2015
    ..Many cancer patients receive supplemental ascorbate (vitamin C) in the belief that it synergizes the anticancer effects of chemotherapy and reduces its toxicity...
  28. pmc Does analysis using "last observation carried forward" introduce bias in dementia research?
    Frank J Molnar
    The Division of Geriatric Medicine, Department of Internal Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:751-3. 2008
  29. ncbi request reprint Transfusion rates vary significantly amongst Canadian medical centres
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 52:581-90. 2005
    ..To document variation of transfusion practice following repair of hip fracture or cardiac surgery, as well as those requiring intensive care following a surgical intervention or multiple trauma (high risk patients)...
  30. doi request reprint The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design
    Dean Fergusson
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfus Med Rev 23:55-61. 2009
    ..The Age of Red Blood Cells in Premature Infants (ARIPI) trial is registered at the US National Institutes of Health (ClinicalTrials.gov) no. NCT00326924 and current controlled trials ISRCTN65939658...
  31. doi request reprint Clinical outcomes of immunoglobulin use in solid organ transplant recipients: protocol for a systematic review and meta-analysis
    Juthaporn Cowan
    Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Canada
    Syst Rev 4:167. 2015
    ..Clinical outcomes of prophylaxis or treatment of hypogammaglobulinemia in solid organ transplant recipients are not well established and are in need of further study...
  32. pmc Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality
    Carmel Jacobs
    Division of Medical Oncology, The Ottawa Hospital Cancer Centre and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 9:e110469. 2014
    ..For assessment of transparency of document development, 7 additional items were taken from the Institute of Medicine's standards for practice guidelines and the Journal of Clinical Oncology guidelines for authors of guidance documents...
  33. doi request reprint The incidence and clinical impact of bone metastases in non-small cell lung cancer
    Michael Kuchuk
    Division of Medical Oncology, The Ottawa Hospital Cancer Centre, Ottawa, and Department of Medicine, University of Ottawa, Ottawa, Canada
    Lung Cancer 89:197-202. 2015
    ..While bone metastases (BM) commonly cause morbidity, bone-targeted agent (BTA) use is variable. We investigated the incidence and impact of BM among unselected NSCLC patients...
  34. doi request reprint Imaging for metastatic disease in patients with newly diagnosed breast cancer: are doctor's perceptions in keeping with the guidelines?
    Demetrios Simos
    Department of Medicine, Division of Medical Oncology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada
    J Eval Clin Pract 21:67-73. 2015
    ..The objective of this study was to assess doctor's views on imaging guidelines, and an attempt to establish why personal and local clinical practice patterns regarding imaging may differ from current guidelines...
  35. pmc The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions for improvement
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 9:e92508. 2014
    ..Some have suggested the quality of reporting of network meta-analyses (a technique used to synthesize information to compare multiple interventions) is sub-optimal. We sought to review information addressing this claim...
  36. pmc A review of influenza vaccine immunogenicity and efficacy in HIV-infected adults
    Curtis Cooper
    University of Ottawa, Division of Infectious Diseases The Ottawa Hospital, Ottawa Health Research Institute Methods Centre, Ottawa, Ontario
    Can J Infect Dis Med Microbiol 19:419-23. 2008
    ..HIV-seropositive adults are at an increased risk for influenza infection. They also develop more severe influenza disease and are hyporesponsive to current influenza vaccinations...
  37. pmc Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, 501 Smyth Road, Box 201, Ottawa, Ontario, Canada K1H 8L6
    BMJ 330:396. 2005
    ..To establish whether an association exists between use of selective serotonin reuptake inhibitors (SSRIs) and suicide attempts...
  38. pmc Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioral therapy for the treatment and management of chronic pain disorders: protocol for a systematic review and meta-analysis with indirect comparisons
    Taylor Hatchard
    School of Psychology, University of Ottawa, Ottawa, Canada
    Syst Rev 3:134. 2014
    ....
  39. pmc A Microsoft-Excel-based tool for running and critically appraising network meta-analyses--an overview and application of NetMetaXL
    Stephen Brown
    Ottawa Hospital Research Institute, Center for Practice Changing Research Building, Ottawa Hospital General Campus, PO Box 201B, Ottawa, ON K1H 8L6, Canada
    Syst Rev 3:110. 2014
    ....
  40. doi request reprint A protocol for a systematic review of the diagnostic accuracy of blood markers, synovial fluid, and tissue testing in periprosthetic joint infections (PJI)
    Paul E Beaule
    Division of Orthopaedic Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada
    Syst Rev 4:148. 2015
    ..Therefore, we will conduct a systematic review on diagnostic performance of blood markers, synovial fluids, and tissue tests for diagnosing PJI...
  41. doi request reprint A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
    ..This article uses a problem-based format to address the biological mechanism, validity, and results of a scenario in which therapeutic substitutions may be considered...
  42. ncbi request reprint The epidemiology of major joint contractures: a systematic review of the literature
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada
    Clin Orthop Relat Res 456:22-9. 2007
    ..The lack of epidemiologic data is a major impediment to providing appropriate treatment...
  43. ncbi request reprint A 15-year analysis of early and late autologous hematopoietic stem cell transplant in relapsed, aggressive, transformed, and nontransformed follicular lymphoma
    Mitchell Sabloff
    The Ottawa Hospital Blood and Marrow Transplant Program, University of Ottawa, Ottawa, Ontario, Canada
    Biol Blood Marrow Transplant 13:956-64. 2007
    ....