Brian Hutton

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. doi request reprint Checking whether there is an increased risk of post-transplant lymphoproliferative disorder and other cancers with specific modern immunosuppression regimens in renal transplantation: protocol for a network meta-analysis of randomized and observational st
    Brian Hutton
    Ottawa Hospital Research Institute, Center for Practice Changing Research, 501 Smyth Road, K1H 8 L6 Ottawa, ON, Canada
    Syst Rev 3:16. 2014
  2. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013
  3. pmc Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:46. 2013
  4. pmc Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 2:45. 2013
  5. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
  6. pmc Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    BMJ 345:e5798. 2012
  7. ncbi request reprint Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    Clin Trials 2:218-29; discussion 229-32. 2005
  8. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
  9. ncbi request reprint Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial
    Dean A Fergusson
    Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    JAMA 308:1443-51. 2012
  10. ncbi request reprint Reliability of point-of-care testing for glucose measurement in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
    Crit Care Med 33:2778-85. 2005

Detail Information

Publications18

  1. doi request reprint Checking whether there is an increased risk of post-transplant lymphoproliferative disorder and other cancers with specific modern immunosuppression regimens in renal transplantation: protocol for a network meta-analysis of randomized and observational st
    Brian Hutton
    Ottawa Hospital Research Institute, Center for Practice Changing Research, 501 Smyth Road, K1H 8 L6 Ottawa, ON, Canada
    Syst Rev 3:16. 2014
    ....
  2. pmc Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:47. 2013
    ..As such, our objective is to evaluate the comparative effectiveness, safety and cost-effectiveness of DPP-4 inhibitors versus intermediate acting insulin for T2DM patients who have failed both first- and second-line diabetes treatments...
  3. pmc Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St, Michael s Hospital, 209 Victoria Street, East Building, Room 716, Toronto, Ontario M5B 1T8, Canada
    Syst Rev 2:46. 2013
    ..To examine this further, we are proposing to conduct a systematic review and network meta-analysis on the comparative safety of 5-HT3 receptor antagonists among patients undergoing chemotherapy or surgery...
  4. pmc Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis
    Andrea C Tricco
    Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, East Building, Toronto, ON M5B 1 T8, Canada
    Syst Rev 2:45. 2013
    ....
  5. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  6. pmc Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    BMJ 345:e5798. 2012
    ....
  7. ncbi request reprint Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    Clin Trials 2:218-29; discussion 229-32. 2005
    ..Randomized controlled trials of aprotinin evaluating its effect on the outcome of perioperative transfusion have been published since 1987, and systematic reviews were conducted in 1992 and 1997...
  8. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  9. ncbi request reprint Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial
    Dean A Fergusson
    Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    JAMA 308:1443-51. 2012
    ..Even though red blood cells (RBCs) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of organ dysfunction, nosocomial infection, and length of hospital stay...
  10. ncbi request reprint Reliability of point-of-care testing for glucose measurement in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
    Crit Care Med 33:2778-85. 2005
    ..Therefore, it is imperative that bedside glucose testing methods be safe and accurate...
  11. ncbi request reprint Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 45:1640-57. 2005
    ....
  12. ncbi request reprint Transfusion rates vary significantly amongst Canadian medical centres
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 52:581-90. 2005
    ..To document variation of transfusion practice following repair of hip fracture or cardiac surgery, as well as those requiring intensive care following a surgical intervention or multiple trauma (high risk patients)...
  13. doi request reprint The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design
    Dean Fergusson
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfus Med Rev 23:55-61. 2009
    ..The Age of Red Blood Cells in Premature Infants (ARIPI) trial is registered at the US National Institutes of Health (ClinicalTrials.gov) no. NCT00326924 and current controlled trials ISRCTN65939658...
  14. doi request reprint The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions for improvement
    Brian Hutton
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 9:e92508. 2014
    ..Some have suggested the quality of reporting of network meta-analyses (a technique used to synthesize information to compare multiple interventions) is sub-optimal. We sought to review information addressing this claim...
  15. pmc Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, 501 Smyth Road, Box 201, Ottawa, Ontario, Canada K1H 8L6
    BMJ 330:396. 2005
    ..To establish whether an association exists between use of selective serotonin reuptake inhibitors (SSRIs) and suicide attempts...
  16. doi request reprint A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
    ..This article uses a problem-based format to address the biological mechanism, validity, and results of a scenario in which therapeutic substitutions may be considered...
  17. ncbi request reprint A 15-year analysis of early and late autologous hematopoietic stem cell transplant in relapsed, aggressive, transformed, and nontransformed follicular lymphoma
    Mitchell Sabloff
    The Ottawa Hospital Blood and Marrow Transplant Program, University of Ottawa, Ottawa, Ontario, Canada
    Biol Blood Marrow Transplant 13:956-64. 2007
    ....
  18. ncbi request reprint The epidemiology of major joint contractures: a systematic review of the literature
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada
    Clin Orthop Relat Res 456:22-9. 2007
    ..The lack of epidemiologic data is a major impediment to providing appropriate treatment...