Paul C Hebert

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. pmc The reporting of theoretical health risks by the media: Canadian newspaper reporting of potential blood transmission of Creutzfeldt-Jakob disease
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Public Health 4:1. 2004
  2. ncbi request reprint Controversies in RBC transfusion in the critically ill
    Paul C Hebert
    Centre for Transfusion Research, University of Ottawa, and Clinical Epidemiology Program of the Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
    Chest 131:1583-90. 2007
  3. ncbi request reprint A pilot trial evaluating the clinical effects of prolonged storage of red cells
    Paul C Hebert
    University of Ottawa Centre forTransfusion Research, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ontario, Canada
    Anesth Analg 100:1433-8, table of contents. 2005
  4. ncbi request reprint Overview of transfusion practices in perioperative and critical care
    P C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute
    Vox Sang 87:209-17. 2004
  5. ncbi request reprint Clinical consequences of anemia and red cell transfusion in the critically ill
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Department of Medicine, The Ottawa Hospital General Campus, Ottawa, Ontario K1H 8L6, Canada
    Crit Care Clin 20:225-35. 2004
  6. ncbi request reprint Physiologic aspects of anemia
    Paul C Hebert
    Centre for Transfusion Research, Clinical Epidemiology Program, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada
    Crit Care Clin 20:187-212. 2004
  7. ncbi request reprint Anemia and red cell transfusion in critically ill patients
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiological Program, Ottawa Health Research Institute, Ontario, Canada
    Crit Care Med 31:S672-7. 2003
  8. ncbi request reprint Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research, and Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
    JAMA 289:1941-9. 2003
  9. ncbi request reprint Overview of transfusion practices in perioperative and critical care
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 50:S65-75. 2003
  10. ncbi request reprint Transfusion rates vary significantly amongst Canadian medical centres
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 52:581-90. 2005

Detail Information

Publications43

  1. pmc The reporting of theoretical health risks by the media: Canadian newspaper reporting of potential blood transmission of Creutzfeldt-Jakob disease
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Public Health 4:1. 2004
    ..In this article we describe how the Canadian print media reported the theoretical risk of blood transmission of Creutzfeldt-Jakob disease (CJD)...
  2. ncbi request reprint Controversies in RBC transfusion in the critically ill
    Paul C Hebert
    Centre for Transfusion Research, University of Ottawa, and Clinical Epidemiology Program of the Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
    Chest 131:1583-90. 2007
    ..This review will examine some of the important controversies still surrounding the use of RBC transfusion in the critically ill patient...
  3. ncbi request reprint A pilot trial evaluating the clinical effects of prolonged storage of red cells
    Paul C Hebert
    University of Ottawa Centre forTransfusion Research, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ontario, Canada
    Anesth Analg 100:1433-8, table of contents. 2005
    ..There were no differences in prolonged respiratory, cardiovascular, or renal support after randomization (P > 0.05). A large clinical trial comparing red cell storage times is feasible and warranted given the limited available evidence...
  4. ncbi request reprint Overview of transfusion practices in perioperative and critical care
    P C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute
    Vox Sang 87:209-17. 2004
  5. ncbi request reprint Clinical consequences of anemia and red cell transfusion in the critically ill
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Department of Medicine, The Ottawa Hospital General Campus, Ottawa, Ontario K1H 8L6, Canada
    Crit Care Clin 20:225-35. 2004
    ..At this juncture, high-quality clinical evidence is not yet available for many decisions related to red cell transfusions. We anticipate that risks and benefits of red cells and alternatives will be elucidated in the coming years...
  6. ncbi request reprint Physiologic aspects of anemia
    Paul C Hebert
    Centre for Transfusion Research, Clinical Epidemiology Program, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada
    Crit Care Clin 20:187-212. 2004
    ..In the meantime, prudent and conservative management, based on awareness of risks and sound understanding of the normal and pathological physiology, must remain the guiding principle...
  7. ncbi request reprint Anemia and red cell transfusion in critically ill patients
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiological Program, Ottawa Health Research Institute, Ontario, Canada
    Crit Care Med 31:S672-7. 2003
  8. ncbi request reprint Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research, and Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
    JAMA 289:1941-9. 2003
    ..A number of countries have implemented a policy of universal leukoreduction of their blood supply, but the potential role of leukoreduction in decreasing postoperative mortality and infection is unclear...
  9. ncbi request reprint Overview of transfusion practices in perioperative and critical care
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 50:S65-75. 2003
  10. ncbi request reprint Transfusion rates vary significantly amongst Canadian medical centres
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 52:581-90. 2005
    ..To document variation of transfusion practice following repair of hip fracture or cardiac surgery, as well as those requiring intensive care following a surgical intervention or multiple trauma (high risk patients)...
  11. ncbi request reprint Revisiting transfusion practices in critically ill patients
    Paul C Hebert
    Centre for Transfusion and Clinical Epidemiology Program, University of Ottawa, 501 Smyth Road, Box 201, Ottawa, Ontario, K1H 8L6, Canada
    Crit Care Med 33:7-12; discussion 232-2. 2005
    ..The objective of this study was to characterize contemporary red cell transfusion practice in the critically ill and to examine changes in practice over time...
  12. ncbi request reprint Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis
    Alexis F Turgeon
    Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, the University of Ottawa and the Canadian Blood Service, Ottawa, Ontario, Cananda
    Ann Intern Med 146:193-203. 2007
    ..Intravenous immunoglobulin therapy has been proposed as an adjuvant treatment for sepsis. Yet, its benefit remains unclear, and its use is not currently recommended...
  13. ncbi request reprint Red blood cell transfusion practices amongst Canadian anesthesiologists: a survey
    Alexis F Turgeon
    Critical Care Medicine Program, University of Ottawa, Ottawa, Ontario, Canada
    Can J Anaesth 53:344-52. 2006
    ..To assess red blood cell transfusion practices among Canadian anesthesiologists...
  14. doi request reprint Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
    Can J Anaesth 55:819-26. 2008
    ..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
  15. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  16. ncbi request reprint Identification of domains relevant to health-related quality of life in patients undergoing major surgery
    Daniel B Morris
    Clinical Epidemiology Program, Ottawa Health Research Institute, 501 Smyth Road, 201, Ottawa, ON, K1H 8L6, Canada
    Qual Life Res 15:841-54. 2006
    ..A new evaluative instrument tailored to patients undergoing major surgery may therefore be warranted...
  17. ncbi request reprint Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury
    Lauralyn A McIntyre
    Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
    Neurocrit Care 5:4-9. 2006
    ..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)...
  18. pmc Joint contracture following prolonged stay in the intensive care unit
    Heidi Clavet
    Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
    CMAJ 178:691-7. 2008
    ..We sought to document the incidence of, the risk factors for and the reversibility of joint contractures among patients who stayed in a tertiary intensive care unit (ICU) for 2 weeks or longer...
  19. ncbi request reprint Reliability of point-of-care testing for glucose measurement in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
    Crit Care Med 33:2778-85. 2005
    ..Therefore, it is imperative that bedside glucose testing methods be safe and accurate...
  20. ncbi request reprint Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  21. ncbi request reprint Evaluation of a universal leukoreduction program in Canada
    Paul C Hebert
    Department of Medicine, Ottawa Hospital, General Campus, Ottawa, Ontario, Canada
    Vox Sang 83:207-9. 2002
  22. pmc A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
    ..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock...
  23. ncbi request reprint Can we safely restrict transfusion in trauma patients?
    Lauralyn A McIntyre
    Department of Medicine, Division of Critical Care, Centre for Transfusion and Critical Care Research, Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    Curr Opin Crit Care 12:575-83. 2006
    ..The question is how much and when? It is important to weigh the risks and benefits of red blood cell transfusions, as well alternatives to transfusion as these products are not benign...
  24. doi request reprint Joint contractures in the intensive care unit: association with resource utilization and ambulatory status at discharge
    Heidi Clavet
    The Bone and Joint Laboratory, University of Ottawa, Ottawa, Ontario, Canada
    Disabil Rehabil 33:105-12. 2011
    ....
  25. ncbi request reprint The effectiveness of interventions to reduce physician's levels of inappropriate transfusion: what can be learned from a systematic review of the literature
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    Transfusion 42:1224-9. 2002
  26. ncbi request reprint Review of the clinical practice literature on patient characteristics associated with perioperative allogeneic red blood cell transfusion
    Madhu Priya Khanna
    Centre for Transfusion Research Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfus Med Rev 17:110-9. 2003
    ..Ongoing research in designing large prospective cohort studies evaluating transfusion patterns are needed to further elucidate how patient characteristics impact the transfusion threshold...
  27. doi request reprint A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
    Dean A Fergusson
    Ottawa Health Research Institute, Ottawa, Canada
    N Engl J Med 358:2319-31. 2008
    ..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences...
  28. ncbi request reprint The design of randomized clinical trials in critically ill patients
    Paul C Hebert
    Critical Care Program, University of Ottawa, Ottawa, Canada
    Chest 121:1290-300. 2002
    ..In conclusion, we describe some of the major challenges and possible solutions to help a potential investigator through the myriad of difficulties in initiating an RCT in a complex environment...
  29. ncbi request reprint Transfusion of leukoreduced red blood cells may decrease postoperative infections: two meta-analyses of randomized controlled trials
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 51:417-24. 2004
    ..To evaluate the efficacy and effectiveness of red blood cell leukoreduction in reducing postoperative infection, mortality and cancer recurrence, two meta-analyses of randomized controlled trials (RCTs) were conducted...
  30. ncbi request reprint Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
    Lauralyn McIntyre
    Centre for Transfusion and Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario
    J Trauma 57:563-8; discussion 568. 2004
    ..An analysis from the prospective multicenter randomized controlled trial (Transfusion Requirements in Critical Care Trial) compared the use of restrictive and liberal transfusion strategies with resuscitated critically ill trauma patients...
  31. ncbi request reprint The application of the precautionary principle to the blood system: the Canadian blood system's vCJD donor deferral policy
    Kumanan Wilson
    University of Ottawa Centre for Transfusion Research, Ottawa, Canada
    Transfus Med Rev 17:89-94. 2003
    ..This dilemma is somewhat unique to the public health sector and will likely recur in future applications of the principle to transfusion policy...
  32. doi request reprint Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Crit Care Med 36:2100-5. 2008
    ..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing...
  33. ncbi request reprint Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 45:1640-57. 2005
    ....
  34. ncbi request reprint Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants
    Dean Fergusson
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
    JAMA 289:1950-6. 2003
    ..Premature infants, given their immature immune state, may be uniquely predisposed to the effects of transfused leukocytes...
  35. ncbi request reprint Cell salvage does not minimize perioperative allogeneic blood transfusion in abdominal vascular surgery: a systematic review
    Gonzalo G Alvarez
    University of Ottawa, Centre for Transfusion Research, Ottawa, Ontario, Canada
    Can J Anaesth 51:425-31. 2004
    ..To determine whether the use of cell salvage reduces the proportion of patients receiving at least one unit of allogeneic packed red blood cells during the perioperative period of an elective vascular surgery...
  36. ncbi request reprint Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians' transfusion practices
    Alan Tinmouth
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Arch Intern Med 165:845-52. 2005
    ..Therefore, we performed a systematic review of the literature to examine the effectiveness of behavioral interventions to reduce blood product utilization...
  37. ncbi request reprint Effectiveness of WBC reduction in neonates: what is the evidence of benefit?
    Dean Fergusson
    Center for Transfusion Research and the Department of Medicine, Ottawa Hospital, University of Ottawa, Ontario, Canada
    Transfusion 42:159-65. 2002
    ..In addition, nosocomial infection, mortality, and duration of stay were identified and analyzed...
  38. ncbi request reprint The TRICC trial: a focus on the sub-group analysis
    Paul C Hebert
    Department of Medicine, Ottawa Hospital, General Campus, Ottawa, Ontario, Canada
    Vox Sang 83:387-96. 2002
  39. pmc Systematic review of the effectiveness of training programs in writing for scholarly publication, journal editing, and manuscript peer review (protocol)
    James Galipeau
    Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, K1H 8L6, Canada
    Syst Rev 2:41. 2013
    ..However, little research has taken stock of journalology training opportunities or evaluations of their effectiveness...
  40. ncbi request reprint Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, Ottawa Hospital, General Campus, 501 Smyth, Ottawa, Ontario K1H 8L6, Canada
    Intensive Care Med 30:804-10. 2004
    ..This study evaluates the efficiency and safety of a nurse-managed insulin protocol in critically ill adults...
  41. pmc Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour
    Ryan Zarychanski
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 177:593-7. 2007
    ..We examined the frequency of colorectal cancer screening in 4 Canadian provinces and the influence of patient contact with a family physician on the uptake of cancer screening...
  42. ncbi request reprint Exploring quality of life for patients undergoing major surgery: the perspectives of surgeons, other healthcare professionals, and patients
    Darcy J Ammerman
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Canada
    Surgery 141:100-9. 2007
    ..Surgeons, other healthcare professionals, and patients may identify different health-related concerns related to the quality of life of patients undergoing major surgery...
  43. ncbi request reprint Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review
    Lauralyn A McIntyre
    Division of Intensive Care, Department of Medicine, The Ottawa Hospital, General Campus, University of Ottawa, Ottawa, Ontario, Canada
    JAMA 289:2992-9. 2003
    ..The benefits of therapeutic hypothermia as a treatment for traumatic brain injury (TBI) remain unclear...