Research Topics
| Paul C HebertSummaryAffiliation: Ottawa Health Research Institute Country: Canada Publications
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Detail Information
Publications
The reporting of theoretical health risks by the media: Canadian newspaper reporting of potential blood transmission of Creutzfeldt-Jakob diseaseKumanan Wilson
Department of Medicine, University of Toronto, Toronto, Canada
BMC Public Health 4:1. 2004..In this article we describe how the Canadian print media reported the theoretical risk of blood transmission of Creutzfeldt-Jakob disease (CJD)...
A pilot trial evaluating the clinical effects of prolonged storage of red cellsPaul C Hebert
University of Ottawa Centre forTransfusion Research, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ontario, Canada
Anesth Analg 100:1433-8, table of contents. 2005..There were no differences in prolonged respiratory, cardiovascular, or renal support after randomization (P > 0.05). A large clinical trial comparing red cell storage times is feasible and warranted given the limited available evidence...- Overview of transfusion practices in perioperative and critical careP C Hebert
University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute
Vox Sang 87:209-17. 2004 - Clinical consequences of anemia and red cell transfusion in the critically illPaul C Hebert
University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Department of Medicine, The Ottawa Hospital General Campus, Ottawa, Ontario K1H 8L6, Canada
Crit Care Clin 20:225-35. 2004..At this juncture, high-quality clinical evidence is not yet available for many decisions related to red cell transfusions. We anticipate that risks and benefits of red cells and alternatives will be elucidated in the coming years... - Physiologic aspects of anemiaPaul C Hebert
Centre for Transfusion Research, Clinical Epidemiology Program, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada
Crit Care Clin 20:187-212. 2004..In the meantime, prudent and conservative management, based on awareness of risks and sound understanding of the normal and pathological physiology, must remain the guiding principle... - Controversies in RBC transfusion in the critically illPaul C Hebert
Centre for Transfusion Research, University of Ottawa, and Clinical Epidemiology Program of the Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
Chest 131:1583-90. 2007..This review will examine some of the important controversies still surrounding the use of RBC transfusion in the critically ill patient... - Anemia and red cell transfusion in critically ill patientsPaul C Hebert
University of Ottawa Centre for Transfusion Research and the Clinical Epidemiological Program, Ottawa Health Research Institute, Ontario, Canada
Crit Care Med 31:S672-7. 2003 - Overview of transfusion practices in perioperative and critical carePaul C Hebert
University of Ottawa Centre for Transfusion Research and the Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
Can J Anaesth 50:S65-75. 2003 - Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusionsPaul C Hebert
University of Ottawa Centre for Transfusion Research, and Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
JAMA 289:1941-9. 2003..A number of countries have implemented a policy of universal leukoreduction of their blood supply, but the potential role of leukoreduction in decreasing postoperative mortality and infection is unclear... - Revisiting transfusion practices in critically ill patientsPaul C Hebert
Centre for Transfusion and Clinical Epidemiology Program, University of Ottawa, 501 Smyth Road, Box 201, Ottawa, Ontario, K1H 8L6, Canada
Crit Care Med 33:7-12; discussion 232-2. 2005..The objective of this study was to characterize contemporary red cell transfusion practice in the critically ill and to examine changes in practice over time... - Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsisAlexis F Turgeon
Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, the University of Ottawa and the Canadian Blood Service, Ottawa, Ontario, Cananda
Ann Intern Med 146:193-203. 2007..Intravenous immunoglobulin therapy has been proposed as an adjuvant treatment for sepsis. Yet, its benefit remains unclear, and its use is not currently recommended... - Resuscitating patients with early severe sepsis: a Canadian multicentre observational studyLauralyn A McIntyre
Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Can J Anaesth 54:790-8. 2007..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure... 
Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trialLauralyn A McIntyre
University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
Can J Anaesth 55:819-26. 2008..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...- Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injuryLauralyn A McIntyre
Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
Neurocrit Care 5:4-9. 2006..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)... - Reliability of point-of-care testing for glucose measurement in critically ill adultsSalmaan Kanji
Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
Crit Care Med 33:2778-85. 2005.... 
Joint contracture following prolonged stay in the intensive care unitHeidi Clavet
Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
CMAJ 178:691-7. 2008..We sought to document the incidence of, the risk factors for and the reversibility of joint contractures among patients who stayed in a tertiary intensive care unit (ICU) for 2 weeks or longer...- Evaluation of a universal leukoreduction program in CanadaPaul C Hebert
Department of Medicine, Ottawa Hospital, General Campus, Ottawa, Ontario, Canada
Vox Sang 83:207-9. 2002 - A survey of Canadian intensivists' resuscitation practices in early septic shockLauralyn A McIntyre
University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
Crit Care 11:R74. 2007..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock... - Can we safely restrict transfusion in trauma patients?Lauralyn A McIntyre
Department of Medicine, Division of Critical Care, Centre for Transfusion and Critical Care Research, Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
Curr Opin Crit Care 12:575-83. 2006..The question is how much and when? It is important to weigh the risks and benefits of red blood cell transfusions, as well alternatives to transfusion as these products are not benign... - Joint contractures in the intensive care unit: association with resource utilization and ambulatory status at dischargeHeidi Clavet
The Bone and Joint Laboratory, University of Ottawa, Ottawa, Ontario, Canada
Disabil Rehabil 33:105-12. 2011.... - The design of randomized clinical trials in critically ill patientsPaul C Hebert
Critical Care Program, University of Ottawa, Ottawa, Canada
Chest 121:1290-300. 2002..In conclusion, we describe some of the major challenges and possible solutions to help a potential investigator through the myriad of difficulties in initiating an RCT in a complex environment... - Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?Lauralyn McIntyre
Centre for Transfusion and Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario
J Trauma 57:563-8; discussion 568. 2004..An analysis from the prospective multicenter randomized controlled trial (Transfusion Requirements in Critical Care Trial) compared the use of restrictive and liberal transfusion strategies with resuscitated critically ill trauma patients... - Transfusion of leukoreduced red blood cells may decrease postoperative infections: two meta-analyses of randomized controlled trialsDean Fergusson
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Can J Anaesth 51:417-24. 2004..To evaluate the efficacy and effectiveness of red blood cell leukoreduction in reducing postoperative infection, mortality and cancer recurrence, two meta-analyses of randomized controlled trials (RCTs) were conducted... - Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practicesDeborah J Cook
Department of Medicine, McMaster University, Hamilton, ON, Canada
Crit Care Med 36:2100-5. 2008..As critical care practice increases in scope, size, and complexity, enrollment of critically ill patients into clinical studies is increasing... - Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic reviewDean Fergusson
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Transfusion 45:1640-57. 2005.... - A comparison of aprotinin and lysine analogues in high-risk cardiac surgeryDean A Fergusson
Ottawa Health Research Institute, Ottawa, Canada
N Engl J Med 358:2319-31. 2008..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences... - Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infantsDean Fergusson
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
JAMA 289:1950-6. 2003..Premature infants, given their immature immune state, may be uniquely predisposed to the effects of transfused leukocytes... - The TRICC trial: a focus on the sub-group analysisPaul C Hebert
Department of Medicine, Ottawa Hospital, General Campus, Ottawa, Ontario, Canada
Vox Sang 83:387-96. 2002 - Effectiveness of WBC reduction in neonates: what is the evidence of benefit?Dean Fergusson
Center for Transfusion Research and the Department of Medicine, Ottawa Hospital, University of Ottawa, Ontario, Canada
Transfusion 42:159-65. 2002..In addition, nosocomial infection, mortality, and duration of stay were identified and analyzed... - Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians' transfusion practicesAlan Tinmouth
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Arch Intern Med 165:845-52. 2005..Appropriately designed clinical trials are still needed to determine the relative effectiveness of different interventions to change practices... - Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adultsSalmaan Kanji
Department of Pharmacy, Ottawa Hospital, General Campus, 501 Smyth, Ottawa, Ontario K1H 8L6, Canada
Intensive Care Med 30:804-10. 2004..This study evaluates the efficiency and safety of a nurse-managed insulin protocol in critically ill adults... - Frequency of colorectal cancer screening and the impact of family physicians on screening behaviourRyan Zarychanski
Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
CMAJ 177:593-7. 2007..We examined the frequency of colorectal cancer screening in 4 Canadian provinces and the influence of patient contact with a family physician on the uptake of cancer screening... - Exploring quality of life for patients undergoing major surgery: the perspectives of surgeons, other healthcare professionals, and patientsDarcy J Ammerman
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Canada
Surgery 141:100-9. 2007..Surgeons, other healthcare professionals, and patients may identify different health-related concerns related to the quality of life of patients undergoing major surgery... - Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic reviewLauralyn A McIntyre
Division of Intensive Care, Department of Medicine, The Ottawa Hospital, General Campus, University of Ottawa, Ottawa, Ontario, Canada
JAMA 289:2992-9. 2003..The benefits of therapeutic hypothermia as a treatment for traumatic brain injury (TBI) remain unclear...