May Griffith

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. ncbi request reprint Artificial human corneas: scaffolds for transplantation and host regeneration
    May Griffith
    University of Ottawa Eye Institute, University of Ottawa, Ontario, Canada
    Cornea 21:S54-61. 2002
  2. ncbi request reprint A simple, cross-linked collagen tissue substitute for corneal implantation
    Yuwen Liu
    National Research Council Canada, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 47:1869-75. 2006
  3. ncbi request reprint Immunological responses in mice to full-thickness corneal grafts engineered from porcine collagen
    Lei Liu
    Department of Ophthalmology, Institute of Medical Science, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Biomaterials 28:3807-14. 2007
  4. ncbi request reprint Recombinant human collagen for tissue engineered corneal substitutes
    Wenguang Liu
    Deptartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 29:1147-58. 2008
  5. doi request reprint Innervation of tissue-engineered recombinant human collagen-based corneal substitutes: a comparative in vivo confocal microscopy study
    Neil Lagali
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:3895-902. 2008
  6. ncbi request reprint Artificial corneas: a regenerative medicine approach
    M Griffith
    University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Eye (Lond) 23:1985-9. 2009
  7. doi request reprint Regeneration of corneal cells and nerves in an implanted collagen corneal substitute
    Christopher R McLaughlin
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Cornea 27:580-9. 2008
  8. doi request reprint Tissue-engineered recombinant human collagen-based corneal substitutes for implantation: performance of type I versus type III collagen
    Kimberley Merrett
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:3887-94. 2008
  9. doi request reprint Collagen-phosphorylcholine interpenetrating network hydrogels as corneal substitutes
    Wenguang Liu
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 30:1551-9. 2009
  10. doi request reprint PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering
    Mehrdad Rafat
    Department of Chemical Engineering, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 29:3960-72. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Artificial human corneas: scaffolds for transplantation and host regeneration
    May Griffith
    University of Ottawa Eye Institute, University of Ottawa, Ontario, Canada
    Cornea 21:S54-61. 2002
    ..To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas...
  2. ncbi request reprint A simple, cross-linked collagen tissue substitute for corneal implantation
    Yuwen Liu
    National Research Council Canada, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 47:1869-75. 2006
    ..To develop a simple corneal substitute from cross-linked collagen...
  3. ncbi request reprint Immunological responses in mice to full-thickness corneal grafts engineered from porcine collagen
    Lei Liu
    Department of Ophthalmology, Institute of Medical Science, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Biomaterials 28:3807-14. 2007
    ..Retro-TE corneal membrane formation was the main complication and barrier to clarity...
  4. ncbi request reprint Recombinant human collagen for tissue engineered corneal substitutes
    Wenguang Liu
    Deptartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 29:1147-58. 2008
    ..For clinical use, implants based on fully characterized, recombinant human collagen eliminate the risk of pathogen transfer or xenogeneic immuno-responses posed by animal collagens...
  5. doi request reprint Innervation of tissue-engineered recombinant human collagen-based corneal substitutes: a comparative in vivo confocal microscopy study
    Neil Lagali
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:3895-902. 2008
    ..A retrospective comparison to innervation in porcine collagen-based biosynthetic grafts was also performed...
  6. ncbi request reprint Artificial corneas: a regenerative medicine approach
    M Griffith
    University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Eye (Lond) 23:1985-9. 2009
    ..The tissue-engineered matrices can either be produced as sterile acellular matrices, or complete with functional cells, ready for implantation...
  7. doi request reprint Regeneration of corneal cells and nerves in an implanted collagen corneal substitute
    Christopher R McLaughlin
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Cornea 27:580-9. 2008
    ..Our objective was to evaluate promotion of tissue regeneration by extracellular matrix (ECM) mimics, by using corneal implantation as a model system...
  8. doi request reprint Tissue-engineered recombinant human collagen-based corneal substitutes for implantation: performance of type I versus type III collagen
    Kimberley Merrett
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:3887-94. 2008
    ..To compare the efficacies of recombinant human collagens types I and III as corneal substitutes for implantation...
  9. doi request reprint Collagen-phosphorylcholine interpenetrating network hydrogels as corneal substitutes
    Wenguang Liu
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 30:1551-9. 2009
    ..We also show that porcine collagen can be substituted with recombinant human collagen, resulting in a fully-synthetic implant that is free from the potential risks of disease transmission (e.g. prions) present in animal source materials...
  10. doi request reprint PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering
    Mehrdad Rafat
    Department of Chemical Engineering, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 29:3960-72. 2008
    ..It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves...
  11. doi request reprint Collagen and glycopolymer based hydrogel for potential corneal application
    Chao Deng
    University of Ottawa Eye Institute, Ottawa, Ont, Canada K1H 8L6
    Acta Biomater 6:187-94. 2010
    ..Taken together, the IPN hydrogel might be a promising material for use in corneal lamellar keratoplasty...
  12. doi request reprint Crosslinked collagen hydrogels as corneal implants: effects of sterically bulky vs. non-bulky carbodiimides as crosslinkers
    Jae Il Ahn
    Ottawa Hospital Research Institute and University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Acta Biomater 9:7796-805. 2013
    ..In conclusion, CMC is a viable alternative to EDC as a crosslinker for collagen-based biomaterials for use as corneal implants, and potentially for use in other tissue engineering applications. ..
  13. doi request reprint Genipin cross-linked fibrin hydrogels for in vitro human articular cartilage tissue-engineered regeneration
    Emma V Dare
    Department of Cellular and Molecular Medicine, University of Ottawa, Ont, Canada
    Cells Tissues Organs 190:313-25. 2009
    ....
  14. doi request reprint Biosynthetic corneal implants for replacement of pathologic corneal tissue: performance in a controlled rabbit alkali burn model
    Joanne M Hackett
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Invest Ophthalmol Vis Sci 52:651-7. 2011
    ..To evaluate the performance of structurally reinforced, stabilized recombinant human collagen-phosphorylcholine (RHCIII-MPC) hydrogels as corneal substitutes in a rabbit model of severe corneal damage...
  15. ncbi request reprint Innervation of tissue-engineered corneal implants in a porcine model: a 1-year in vivo confocal microscopy study
    Neil S Lagali
    University of Ottawa Eye Institute, Ottawa, ON, Canada
    Invest Ophthalmol Vis Sci 48:3537-44. 2007
    ..To examine the pattern of nerve regeneration within tissue-engineered corneal substitutes grafted into host porcine corneas over a 1-year postoperative period...
  16. doi request reprint Synthetic neoglycopolymer-recombinant human collagen hybrids as biomimetic crosslinking agents in corneal tissue engineering
    Kimberley Merrett
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1S 8M5, Canada
    Biomaterials 30:5403-8. 2009
    ..Tensile strength is adequate for transplantation, but lower than that of the optimized control materials...
  17. doi request reprint A collagen–chitosan hydrogel for endothelial differentiation and angiogenesis
    Chao Deng
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Tissue Eng Part A 16:3099-109. 2010
    ....
  18. pmc Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation
    Fengfu Li
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada K1H 8L6
    Proc Natl Acad Sci U S A 100:15346-51. 2003
    ..These biosynthetic ECM replacements should have applicability to many areas of tissue engineering and regenerative medicine, especially where nerve function is required...
  19. ncbi request reprint Functional innervation in tissue engineered models for in vitro study and testing purposes
    Erik J Suuronen
    University of Ottawa Eye Institute, Ottawa Health Research Institute Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8L6, Canada
    Toxicol Sci 82:525-33. 2004
    ..These results are important to consider for the development of any optimized TE models for in vitro study and testing purposes...
  20. doi request reprint Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
    Wenguang Liu
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, K1H8M5
    J Mater Sci Mater Med 19:3365-71. 2008
    ....
  21. doi request reprint Surface modification of collagen-based artificial cornea for reduced endothelialization
    Mehrdad Rafat
    Department of Chemical Engineering, University of Ottawa, Ottawa, Ontario, Canada
    J Biomed Mater Res A 88:755-68. 2009
    ..Both of the untreated and alginate grafted corneal materials were found to be superior to human cornea in optical and swelling properties...
  22. doi request reprint Fibrin glues in combination with mesenchymal stem cells to develop a tissue-engineered cartilage substitute
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng Part A 17:323-35. 2011
    ..In addition, BM-hMSCs are valid and potentially superior alternatives to chondrocytes for tissue engineering of articular cartilage...
  23. ncbi request reprint Bioengineered corneas for transplantation and in vitro toxicology
    Christopher R McLaughlin
    University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Front Biosci (Landmark Ed) 14:3326-37. 2009
    ..More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested...
  24. ncbi request reprint Building in vitro models of organs
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Int Rev Cytol 244:137-73. 2005
    ..Many of the models, with further development and refinement, have the potential to be useful as functional substitute tissues and organs for transplantation or for in vitro toxicology testing...
  25. ncbi request reprint Innervated human corneal equivalents as in vitro models for nerve-target cell interactions
    Erik J Suuronen
    University of Ottawa Eye Institute, Ottawa Health Research Institute Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    FASEB J 18:170-2. 2004
    ..This model could also be used as an in vitro alternative to animals for safety and efficacy testing of chemicals and drugs...
  26. ncbi request reprint Bioengineered corneas: how close are we?
    David J Carlsson
    National Research Council ICPET Canada, Ottawa, Ontario, Canada
    Curr Opin Ophthalmol 14:192-7. 2003
    ..For correction of refractive errors, a synthetic corneal onlay that allows stable overgrowth of epithelium appears to be promising...
  27. ncbi request reprint Fibrin sealants from fresh or fresh/frozen plasma as scaffolds for in vitro articular cartilage regeneration
    Emma V Dare
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng Part A 15:2285-97. 2009
    ..Our results indicate that CryoSeal fibrin glue derived from fresh plasma is suitable as a tissue engineering scaffold for human articular chondrocytes, and therefore should be evaluated for autologous articular cartilage regeneration...
  28. ncbi request reprint Tissue-engineered injectable collagen-based matrices for improved cell delivery and vascularization of ischemic tissue using CD133+ progenitors expanded from the peripheral blood
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin St, Laboratory H553, Ottawa, Ontario, Canada, K1Y 4W7
    Circulation 114:I138-44. 2006
    ..This study investigated the expansion of CD133+ cells and the use of an injectable collagen-based tissue engineered matrix to support cell delivery and implantation within target ischemic tissue...
  29. ncbi request reprint LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control
    Mariana Vignoni
    Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Nanoscale 6:5725-8. 2014
    ..In addition, LL37 capped silver nanoparticles have anti-biofilm formation activity. ..
  30. pmc Enterovirus 70 binds to different glycoconjugates containing alpha2,3-linked sialic acid on different cell lines
    M Reza Nokhbeh
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada K1H 8M5
    J Virol 79:7087-94. 2005
    ....
  31. ncbi request reprint Characterization and inhibition of fibrin hydrogel-degrading enzymes during development of tissue engineering scaffolds
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng 13:1469-77. 2007
    ..These findings suggest that plasmin and MMPs contribute independently to fibrin hydrogel breakdown, but that either enzyme can achieve extracellular matrix breakdown...
  32. doi request reprint A biomimetic scaffold for culturing limbal stem cells: a promising alternative for clinical transplantation
    Subhadra Dravida
    University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    J Tissue Eng Regen Med 2:263-71. 2008
    ..RHC-III scaffold supports and retains the growth and stemness of limbal stem cells, in addition to resembling human cornea; thus, it could be a good replacement scaffold for growing cells for clinical transplantation...
  33. doi request reprint Impact of dye-protein interaction and silver nanoparticles on rose bengal photophysical behavior and protein photocrosslinking
    Madeline J Simpson
    Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, Canada
    Photochem Photobiol 89:1433-41. 2013
    ..Both crosslinked rHC and AgNP@collagen were able to support fibroblasts proliferation, but only the material containing silver was resistant to S. epidermidis infection. ..
  34. doi request reprint Design of xanthone propionate photolabile protecting group releasing acyclovir for the treatment of ocular herpes simplex virus
    Jessie A Blake
    Department of Chemistry, University of Ottawa, Ottawa, Canada
    Photochem Photobiol Sci 11:539-47. 2012
    ..Furthermore, complete release of the drug is theoretically possible given a sufficient dose of light . Surprisingly the acyclovir photocage, also showed some antiviral activity towards HSV-1...
  35. doi request reprint The biocompatibility and antibacterial properties of collagen-stabilized, photochemically prepared silver nanoparticles
    Emilio I Alarcon
    Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada
    Biomaterials 33:4947-56. 2012
    ....
  36. pmc Controlled release of bevacizumab through nanospheres for extended treatment of age-related macular degeneration
    Fengfu Li
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada
    Open Ophthalmol J 6:54-8. 2012
    ..The drug release rate could be adjusted by alteration of the drug/polymer ratio. The use of such nano- and microspheres as bevacizumab delivery vehicles may improve the treatment of wet AMD...
  37. ncbi request reprint Localization of candidate stem and progenitor cell markers within the human cornea, limbus, and bulbar conjunctiva in vivo and in cell culture
    Sandy Gian Vascotto
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Anat Rec A Discov Mol Cell Evol Biol 288:921-31. 2006
    ....
  38. ncbi request reprint Collagen-poly(N-isopropylacrylamide)-based membranes for corneal stroma scaffolds
    Shigeto Shimmura
    Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital Cornea Center, Ichikawa, Chiba, Japan
    Cornea 22:S81-8. 2003
    ..To investigate the feasibility of using the biocompatibility of collagen-based blended biomaterials as cell-delivery systems in ocular surface reconstruction in vivo...
  39. ncbi request reprint Biofunctionalization of collagen for improved biological response: scaffolds for corneal tissue engineering
    Xiaodong Duan
    Department of Chemical Engineering, McMaster University, 1280 Main St W, Hamilton, Ont, Canada L8S 4L7
    Biomaterials 28:78-88. 2007
    ..It was found that YIGSR incorporation into the bulk and YIGSR modification of surface promoted the adhesion and proliferation of human corneal epithelial cells as well as neurite extension from dorsal root ganglia...
  40. pmc Interleukin-1alpha released from epithelial cells after adenovirus type 37 infection activates intercellular adhesion molecule 1 expression on human vascular endothelial cells
    Cheng Hsien Chang
    Department of Microbiology and Immunology, Dalhousie University, Halifax B3H 4H7, Nova Scotia, Canada
    J Virol 76:427-31. 2002
    ..The results thus identify epithelial cell-derived IL-1alpha as a potentially important activator of endothelial cells in Ad37-induced inflammation...