Dean Fergusson

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. pmc Joint contracture following prolonged stay in the intensive care unit
    Heidi Clavet
    Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
    CMAJ 178:691-7. 2008
  2. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
  3. pmc Clinical review: Canadian National Advisory Committee on Blood and Blood Products--Massive transfusion consensus conference 2011: report of the panel
    Walter H Dzik
    Blood Transfusion Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Crit Care 15:242. 2011
  4. ncbi request reprint Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial
    Dean A Fergusson
    Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    JAMA 308:1443-51. 2012
  5. pmc The quality of research synthesis in surgery: the case of laparoscopic surgery for colorectal cancer
    Guillaume Martel
    Department of Surgery, Department of Epidemiology and Community Medicine, and Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    Syst Rev 1:14. 2012
  6. ncbi request reprint Transfusion of leukoreduced red blood cells may decrease postoperative infections: two meta-analyses of randomized controlled trials
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 51:417-24. 2004
  7. pmc Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, 501 Smyth Road, Box 201, Ottawa, Ontario, Canada K1H 8L6
    BMJ 330:396. 2005
  8. ncbi request reprint The epidemiology of major joint contractures: a systematic review of the literature
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada
    Clin Orthop Relat Res 456:22-9. 2007
  9. ncbi request reprint Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    Clin Trials 2:218-29; discussion 229-32. 2005
  10. ncbi request reprint Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 45:1640-57. 2005

Detail Information

Publications102 found, 100 shown here

  1. pmc Joint contracture following prolonged stay in the intensive care unit
    Heidi Clavet
    Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
    CMAJ 178:691-7. 2008
    ..We sought to document the incidence of, the risk factors for and the reversibility of joint contractures among patients who stayed in a tertiary intensive care unit (ICU) for 2 weeks or longer...
  2. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
    ..Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in neurocritically ill patients...
  3. pmc Clinical review: Canadian National Advisory Committee on Blood and Blood Products--Massive transfusion consensus conference 2011: report of the panel
    Walter H Dzik
    Blood Transfusion Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Crit Care 15:242. 2011
    ..The present report is intended to provide guidance to practitioners, hospitals, and policy-makers...
  4. ncbi request reprint Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial
    Dean A Fergusson
    Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    JAMA 308:1443-51. 2012
    ..Even though red blood cells (RBCs) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of organ dysfunction, nosocomial infection, and length of hospital stay...
  5. pmc The quality of research synthesis in surgery: the case of laparoscopic surgery for colorectal cancer
    Guillaume Martel
    Department of Surgery, Department of Epidemiology and Community Medicine, and Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    Syst Rev 1:14. 2012
    ..The objective of this study was to synthesize all such systematic reviews in terms of clinical effectiveness, to appraise their quality, and to determine whether areas of duplication exist across reviews...
  6. ncbi request reprint Transfusion of leukoreduced red blood cells may decrease postoperative infections: two meta-analyses of randomized controlled trials
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 51:417-24. 2004
    ..To evaluate the efficacy and effectiveness of red blood cell leukoreduction in reducing postoperative infection, mortality and cancer recurrence, two meta-analyses of randomized controlled trials (RCTs) were conducted...
  7. pmc Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, 501 Smyth Road, Box 201, Ottawa, Ontario, Canada K1H 8L6
    BMJ 330:396. 2005
    ..To establish whether an association exists between use of selective serotonin reuptake inhibitors (SSRIs) and suicide attempts...
  8. ncbi request reprint The epidemiology of major joint contractures: a systematic review of the literature
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada
    Clin Orthop Relat Res 456:22-9. 2007
    ..The lack of epidemiologic data is a major impediment to providing appropriate treatment...
  9. ncbi request reprint Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    Clin Trials 2:218-29; discussion 229-32. 2005
    ..Randomized controlled trials of aprotinin evaluating its effect on the outcome of perioperative transfusion have been published since 1987, and systematic reviews were conducted in 1992 and 1997...
  10. ncbi request reprint Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 45:1640-57. 2005
    ....
  11. doi request reprint The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design
    Dean Fergusson
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfus Med Rev 23:55-61. 2009
    ..The Age of Red Blood Cells in Premature Infants (ARIPI) trial is registered at the US National Institutes of Health (ClinicalTrials.gov) no. NCT00326924 and current controlled trials ISRCTN65939658...
  12. pmc Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis
    Dean Fergusson
    Ottawa Health Research Institute, 501 Smyth Road, Box 201, Ottawa, ON, Canada K1H 8L6
    BMJ 325:652-4. 2002
  13. ncbi request reprint Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants
    Dean Fergusson
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
    JAMA 289:1950-6. 2003
    ..Premature infants, given their immature immune state, may be uniquely predisposed to the effects of transfused leukocytes...
  14. pmc Turning a blind eye: the success of blinding reported in a random sample of randomised, placebo controlled trials
    Dean Fergusson
    Ottawa Health Research Institute, Clinical Epidemiology Program, 501 Smyth Road, Box 201, Ottawa, ON, Canada K1H 8L6
    BMJ 328:432. 2004
    ..To examine the reporting and success of double blinding in a sample of randomised, placebo controlled trials from leading general medicine and psychiatry journals...
  15. pmc Overdiagnosis of asthma in obese and nonobese adults
    Shawn D Aaron
    Ottawa Health Research Institute, Ottawa, Ont, USA
    CMAJ 179:1121-31. 2008
    ..It is unclear whether asthma is overdiagnosed in developed countries, particularly among obese individuals, who may be more likely than nonobese people to experience dyspnea...
  16. ncbi request reprint Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
    Shawn D Aaron
    The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 146:545-55. 2007
    ..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...
  17. doi request reprint Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis
    Kaïssa de Boer
    The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Thorax 66:680-5. 2011
    ..The aim of this study was to determine if frequent pulmonary exacerbations are associated with greater declines in lung function, or an accelerated time to death or lung transplantation in adults with CF...
  18. doi request reprint Effect of clinical variables and immunosuppression on serum cystatin C and beta-trace protein in kidney transplant recipients
    Christine A White
    Department of Medicine, Division of Nephrology, Queen s University, Kingston, Canada
    Am J Kidney Dis 54:922-30. 2009
    ..The aim of this study is to examine the independent effect of various clinical parameters on serum concentrations of creatinine, cystatin C, and BTP in kidney transplant recipients...
  19. doi request reprint Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids
    Sheldon Magder
    McGill University, Montreal Quebec, Canada
    Crit Care Med 38:2117-24. 2010
    ....
  20. ncbi request reprint Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
    Can J Anaesth 55:819-26. 2008
    ..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
  21. ncbi request reprint Exploring quality of life for patients undergoing major surgery: the perspectives of surgeons, other healthcare professionals, and patients
    Darcy J Ammerman
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Canada
    Surgery 141:100-9. 2007
    ..Surgeons, other healthcare professionals, and patients may identify different health-related concerns related to the quality of life of patients undergoing major surgery...
  22. ncbi request reprint Transfusion rates vary significantly amongst Canadian medical centres
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 52:581-90. 2005
    ..To document variation of transfusion practice following repair of hip fracture or cardiac surgery, as well as those requiring intensive care following a surgical intervention or multiple trauma (high risk patients)...
  23. ncbi request reprint Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions
    Paul C Hebert
    University of Ottawa Centre for Transfusion Research, and Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada
    JAMA 289:1941-9. 2003
    ..A number of countries have implemented a policy of universal leukoreduction of their blood supply, but the potential role of leukoreduction in decreasing postoperative mortality and infection is unclear...
  24. ncbi request reprint Resuscitating patients with early severe sepsis: a Canadian multicentre observational study
    Lauralyn A McIntyre
    Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Can J Anaesth 54:790-8. 2007
    ..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
  25. pmc Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    BMJ 345:e5798. 2012
    ....
  26. pmc Selenium and lung cancer: a systematic review and meta analysis
    Heidi Fritz
    Department of Research and Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 6:e26259. 2011
    ..We conducted a systematic review of selenium for lung cancers, and assessed potential interactions with conventional therapies...
  27. doi request reprint The Age of Blood Evaluation (ABLE) randomized controlled trial: study design
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Transfus Med Rev 25:197-205. 2011
    ....
  28. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  29. doi request reprint Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populations
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Kidney Int 76:784-91. 2009
    ..These results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well...
  30. ncbi request reprint Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review of the evidence
    Atul V Mulay
    Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transplantation 82:1153-62. 2006
    ..Conversion from a calcineurin inhibitor to sirolimus has been used as a strategy to improve deteriorating renal allograft function but the efficacy and safety of this intervention is unknown...
  31. ncbi request reprint Black cohosh and breast cancer: a systematic review
    Heidi Fritz
    The Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Integr Cancer Ther 13:12-29. 2014
    ..However, controversy exists around safety in breast cancer, because of its purported estrogenic activity. We conducted a systematic review of black cohosh use in women with or at risk of breast cancer...
  32. pmc Radiotherapy after radical prostatectomy: treatment recommendations differ between urologists and radiation oncologists
    Luke T Lavallee
    Division of Urology, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 8:e79773. 2013
    ..The purpose of this study was to describe opinions of urologists and radiation oncologists regarding adjuvant and salvage radiotherapy following radical prostatectomy...
  33. pmc Selective serotonin reuptake inhibitors for unipolar depression: a systematic review of classic long-term randomized controlled trials
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ont
    CMAJ 178:1293-301. 2008
    ..We conducted a systematic review to examine the efficacy and acceptability of long-term therapy with selective serotonin reuptake inhibitors relative to placebo in the treatment of unipolar depression...
  34. ncbi request reprint Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  35. ncbi request reprint The before/after study design in transfusion medicine: methodologic considerations
    Dean Fergusson
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Transfus Med Rev 16:296-303. 2002
    ..We have outlined the major methodologic issues one must consider when undertaking a before/after study design. When properly conceived, conducted, and analyzed, such a before/after study design can yield informative associations...
  36. ncbi request reprint The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment
    Shawn D Aaron
    The Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Can Respir J 11:581-5. 2004
    ....
  37. ncbi request reprint The societal unit cost of allogenic red blood cells and red blood cell transfusion in Canada
    Mo Amin
    Centre for Transfusion Research, University of Ottawa, Ottawa, Canada
    Transfusion 44:1479-86. 2004
    ..The unit cost of allogenic RBCs and RBC transfusion in Canada in 1994 was estimated at 152.17 US dollars. The objective of this study was to determine the unit cost of allogenic RBC transfusion in Canada from a societal perspective...
  38. pmc A survey of Canadian intensivists' resuscitation practices in early septic shock
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
    Crit Care 11:R74. 2007
    ..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock...
  39. doi request reprint Impaired gastrointestinal transit and its associated morbidity in the intensive care unit
    Tiffany Nguyen
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Crit Care 28:537.e11-7. 2013
    ..To determine the proportion of critically ill adults developing impaired gastrointestinal transit (IGT) using a clinically pragmatic definition, its associated morbidity and risk factors...
  40. pmc Soy, red clover, and isoflavones and breast cancer: a systematic review
    Heidi Fritz
    Department of Research and Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 8:e81968. 2013
    ..We conducted a systematic review of soy and red clover for efficacy in improving menopausal symptoms in women with breast cancer, and for potential impact on risk of breast cancer incidence or recurrence...
  41. pmc Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes
    Fengxia Xiao
    Division of Nephrology, Department of Medicine, Ottawa Hospital Research Institute, Kidney Research Centre, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 7:e37649. 2012
    ..Urinary ACE2 could be a marker of renal renin-angiotensin system activation in these patients...
  42. ncbi request reprint Changes in body weight and serum lipid profile in obese patients treated with orlistat in addition to a hypocaloric diet: a systematic review of randomized clinical trials
    Brian Hutton
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Canada
    Am J Clin Nutr 80:1461-8. 2004
    ..Obesity is a growing health concern in Canada and the United States, and pharmacologic therapies such as orlistat are being more commonly prescribed to assist with weight loss...
  43. doi request reprint Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis
    Shawn D Aaron
    Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada, K1H 8L6
    JAMA 304:2145-53. 2010
    ..Studies from Australia and the United Kingdom have shown that some patients with cystic fibrosis are infected with common transmissible strains of Pseudomonas aeruginosa...
  44. pmc Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis
    Natalie Oake
    Department of Medicine, University of Ottawa, and the Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ont
    CMAJ 179:235-44. 2008
    ..We sought to determine the association between anticoagulation intensity and the risk of hemorrhagic and thromboembolic events. We also sought to determine how under-or overanticoagulation would influence patient outcomes...
  45. ncbi request reprint Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians' transfusion practices
    Alan Tinmouth
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Arch Intern Med 165:845-52. 2005
    ..Therefore, we performed a systematic review of the literature to examine the effectiveness of behavioral interventions to reduce blood product utilization...
  46. ncbi request reprint The effectiveness of interventions to reduce physician's levels of inappropriate transfusion: what can be learned from a systematic review of the literature
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    Transfusion 42:1224-9. 2002
  47. doi request reprint Estimating glomerular filtration rate in kidney transplantation: is the new chronic kidney disease epidemiology collaboration equation any better?
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Chem 56:474-7. 2010
    ..The performance of the new equation for kidney transplant recipients (KTRs) is unknown...
  48. doi request reprint The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis
    Brendan B McCormick
    Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Am J Kidney Dis 52:454-63. 2008
    ..Pentoxifylline is a potential therapeutic agent for diabetic kidney disease because it has anti-inflammatory, antifibrotic, and hemorheological properties...
  49. pmc Antiplatelet medications in hemodialysis patients: a systematic review of bleeding rates
    Swapnil Hiremath
    Division of Nephrology, University of Ottawa, Kidney Research Centre, Ottawa, Ontario, Canada
    Clin J Am Soc Nephrol 4:1347-55. 2009
    ..However, these patients are also at increased risk of bleeding compared with the general population, and an aim was made to quantify this risk with antiplatelet agents...
  50. pmc Does analysis using "last observation carried forward" introduce bias in dementia research?
    Frank J Molnar
    The Division of Geriatric Medicine, Department of Internal Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:751-3. 2008
  51. ncbi request reprint A novel equation to estimate glomerular filtration rate using beta-trace protein
    Christine A White
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Canada
    Clin Chem 53:1965-8. 2007
    ..The utility of BTP has been limited by the lack of an equation to translate BTP into an estimate of GFR. The objectives of this study were to develop a BTP-based GFR estimation equation...
  52. doi request reprint Green tea and lung cancer: a systematic review
    Heidi Fritz
    Canadian College of Naturopathic Medicine, Toronto, ON, Canada
    Integr Cancer Ther 12:7-24. 2013
    ..Green tea is a beverage widely used by lung cancer patients and the public for its purported anticancer properties. The authors conducted a systematic review of green tea for the treatment and prevention of lung cancer...
  53. ncbi request reprint Effectiveness of WBC reduction in neonates: what is the evidence of benefit?
    Dean Fergusson
    Center for Transfusion Research and the Department of Medicine, Ottawa Hospital, University of Ottawa, Ontario, Canada
    Transfusion 42:159-65. 2002
    ..In addition, nosocomial infection, mortality, and duration of stay were identified and analyzed...
  54. ncbi request reprint A pilot trial evaluating the clinical effects of prolonged storage of red cells
    Paul C Hebert
    University of Ottawa Centre forTransfusion Research, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ontario, Canada
    Anesth Analg 100:1433-8, table of contents. 2005
    ..05). A large clinical trial comparing red cell storage times is feasible and warranted given the limited available evidence...
  55. ncbi request reprint Checking whether there is an increased risk of post-transplant lymphoproliferative disorder and other cancers with specific modern immunosuppression regimens in renal transplantation: protocol for a network meta-analysis of randomized and observational st
    Brian Hutton
    Ottawa Hospital Research Institute, Center for Practice Changing Research, 501 Smyth Road, K1H 8 L6 Ottawa, ON, Canada
    Syst Rev 3:16. 2014
    ....
  56. ncbi request reprint Spot urine protein measurements in kidney transplantation: a systematic review of diagnostic accuracy
    Ayub Akbari
    Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Nephrol Dial Transplant 29:919-26. 2014
    ..Recent guidelines have recommended quantification of proteinuria by spot protein-to-creatinine ratio (PCR) or spot albumin-to-creatinine ratio (ACR). Validity of spot measurements remains unclear in renal transplant recipients...
  57. ncbi request reprint Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol
    Manoj M Lalu
    Department of Medicine Division of Critical Care, University of Ottawa, Ottawa, ON, Canada
    Syst Rev 3:48. 2014
    ..Prior to a human clinical trial, our aim is to conduct a systematic review to compare the efficacy and safety of MSC therapy versus controls in preclinical models of acute lung injury that mimic some aspects of the human ARDS...
  58. ncbi request reprint Short Daily versus Conventional Hemodialysis for Hypertensive Patients: A Randomized Cross-Over Study
    Deborah L Zimmerman
    Associate Professor of Medicine, Division of Nephrology, Ottawa Hospital, Kidney Research Centre of the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 9:e97135. 2014
    ..It is unclear from these studies if anti-hypertensive management had been optimized prior to starting short daily hemodialysis. Also, the potential mechanism(s) of blood pressure improvement remain to be fully elucidated...
  59. doi request reprint Micronutrient deficiency and treatment adherence in a randomized controlled trial of micronutrient supplementation in ART-naïve persons with HIV
    Louise Balfour
    CIHR Canadian HIV Trials Network CTN, Vancouver, British Columbia, Canada Division of Infectious Diseases, Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, Ontario, Canada
    PLoS ONE 9:e85607. 2014
    ..The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance (RDA) vitamins in slowing HIV immune deficiency progression in ART-naïve people with HIV infection...
  60. pmc Blood transfusion and hemostatic agents used during radical cystectomy
    Nahid Punjani
    University of Ottawa Medical School, University of Ottawa, Ottawa, ON
    Can Urol Assoc J 7:E275-80. 2013
    ..The purpose of this study was to determine what intra-operative techniques and hemostatic agents are currently used by uro-oncologists to prevent and control blood loss during radical cystectomy...
  61. pmc Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials
    Manoj M Lalu
    Department of Anesthesiology, University of Ottawa, Ottawa, Canada
    PLoS ONE 7:e47559. 2012
    ..There is interest in using these cells in critical illness, however, the safety profile of these cells is not well known. We thus conducted a systematic review of clinical trials that examined the use MSCs to evaluate their safety...
  62. doi request reprint A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery
    Nadine Shehata
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Transfusion 52:91-9. 2012
    ..Because a definitive trial will require thousands of patients, and because there is variability in transfusion practices, a pilot study was undertaken to determine adherence to proposed strategies...
  63. ncbi request reprint Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial
    Shawn D Aaron
    The Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
    Lancet 366:463-71. 2005
    ....
  64. ncbi request reprint The Canadian ACE-inhibitor trial to improve renal outcomes and patient survival in kidney transplantation--study design
    Greg A Knoll
    Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Nephrol Dial Transplant 23:354-8. 2008
    ..Observational studies in the kidney transplant population have produced conflicting results with some studies showing benefit and others no benefit of renin-angiotensin system blockade...
  65. pmc Diagnostic accuracy of surface coil magnetic resonance imaging at 1.5 T for local staging of elevated risk prostate cancer
    Brian Kim
    Division of Urology, Department of Surgery, University of Ottawa, Ottawa, ON
    Can Urol Assoc J 4:257-62. 2010
    ..The purpose of this study was to estimate the sensitivity and specificity of surface coil magnetic resonance imaging (MRI) for prostate cancer stage using surgical pathologic data as the reference standard...
  66. ncbi request reprint A 15-year analysis of early and late autologous hematopoietic stem cell transplant in relapsed, aggressive, transformed, and nontransformed follicular lymphoma
    Mitchell Sabloff
    The Ottawa Hospital Blood and Marrow Transplant Program, University of Ottawa, Ottawa, Ontario, Canada
    Biol Blood Marrow Transplant 13:956-64. 2007
    ....
  67. pmc Continuous multi-parameter heart rate variability analysis heralds onset of sepsis in adults
    Saif Ahmad
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 4:e6642. 2009
    ..We hypothesized that by continuously tracking individual patient HRV over time in patients as they develop sepsis, we would demonstrate reduced HRV in association with the onset of sepsis...
  68. doi request reprint Association of diagnostic radiation exposure and second abdominal-pelvic malignancies after testicular cancer
    Carl van Walraven
    University of Ottawa, Ottawa, Ontario, Canada
    J Clin Oncol 29:2883-8. 2011
    ..Men recovering from low-grade testicular cancer frequently undergo serial abdominal-pelvic computerized tomography (CT) scanning to monitor for recurrent disease...
  69. ncbi request reprint Does this patient have deep vein thrombosis?
    Philip S Wells
    Department of Medicine, University of Ottawa, Ontario
    JAMA 295:199-207. 2006
    ..Missed DVT diagnosis may result in fatal pulmonary embolism. Since many patients may have DVT, a selective and efficient diagnostic process is needed...
  70. pmc Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trial study
    Shi Wu Wen
    OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6 Clinical Epidemiology Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6 Department of Epidemiology, Biostatistics and Occupational Health and Department of Pediatrics, McGill University Faculty of Medicine, 3175 Cote Ste Catherine, Montreal, QC, Canada H3T 1C5 Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada
    J Pregnancy 2013:294312. 2013
    ..Recruitment in Argentina, UK, Netherlands, Brazil, West Indies, and United States is expected to begin by the second or third quarter of 2013. This trial is registered with NCT01355159...
  71. pmc Diagnostic randomized controlled trials: the final frontier
    Marc Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, ON, Canada
    Trials 13:137. 2012
    ..Doing so will better ensure that patients are offered diagnostic procedures that will make a clinical difference...
  72. ncbi request reprint Reliability of point-of-care testing for glucose measurement in critically ill adults
    Salmaan Kanji
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
    Crit Care Med 33:2778-85. 2005
    ..Therefore, it is imperative that bedside glucose testing methods be safe and accurate...
  73. ncbi request reprint Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism?
    Marc Carrier
    University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Ann Intern Med 149:323-33. 2008
    ..Screening for malignant conditions can potentially diagnose more cases of cancer and at earlier stages, thereby preventing cancer-associated morbidity and perhaps mortality...
  74. pmc Quinolone prophylaxis for the prevention of BK virus infection in kidney transplantation: study protocol for a randomized controlled trial
    Atul Humar
    Department of Medicine, Faculty of Medicine and Dentistry, 2J2 00 WC Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2R7, Canada
    Trials 14:185. 2013
    ..We hypothesize that administration of a quinolone antibiotic, when given early post-transplantation, will prevent the establishment of BK viral replication in the urine and thus prevent systemic BK virus infection...
  75. doi request reprint Diagnostic tests in urology: urine cytology
    Luke T Lavallee
    Division of Urology, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    BJU Int 110:E789-91. 2012
    ..This evidence-based medicine article explores how positive or negative urine cytology will impact the probability that a patient has urothelial carcinoma of the bladder before cystoscopy...
  76. doi request reprint Informed consent documents do not encourage good-quality decision making
    Jamie C Brehaut
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, General Campus, 501 Smyth Road, Centre for Practice Changing Research, Box 201B, Ottawa, Ontario, Canada K1H 8L6
    J Clin Epidemiol 65:708-24. 2012
    ..We assessed the extent to which existing informed consent documents (ICDs) conform to the International Patient Decision Aid Standards for supporting decision making...
  77. doi request reprint Design and methods of the MAINTAIN study: a randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection
    Neera Singhal
    Department of Medicine, University of Ottawa at Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Contemp Clin Trials 31:604-11. 2010
    ..We discuss here the study design and methods, often used for evaluation of complementary and adjunctive treatments for health maintenance in HIV infection, which are common interventions...
  78. ncbi request reprint Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
    Lauralyn McIntyre
    Centre for Transfusion and Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario
    J Trauma 57:563-8; discussion 568. 2004
    ..An analysis from the prospective multicenter randomized controlled trial (Transfusion Requirements in Critical Care Trial) compared the use of restrictive and liberal transfusion strategies with resuscitated critically ill trauma patients...
  79. doi request reprint Complications and catheter survival with prolonged embedding of peritoneal dialysis catheters
    Pierre Antoine Brown
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Nephrol Dial Transplant 23:2299-303. 2008
    ..We undertook this study to test the hypothesis that catheter survival on PD is a function of the time a catheter is left embedded prior to use...
  80. doi request reprint Decisions about lumping vs. splitting of the scope of systematic reviews of complex interventions are not well justified: a case study in systematic reviews of health care professional reminders
    Michelle C Weir
    University of Toronto, Faculty of Medicine, Toronto, ON, Canada
    J Clin Epidemiol 65:756-63. 2012
    ....
  81. doi request reprint The role of randomized controlled trials in evidence-based urology
    Luke T Lavallee
    Department of Surgery, Division of Urology, Ottawa University Hospital, General Campus, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada
    World J Urol 29:257-63. 2011
    ..To review the current and future role of randomized controlled trials (RCTs) in urology...
  82. ncbi request reprint Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation
    Jason Tay
    Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa, Ontario, Canada
    Biol Blood Marrow Transplant 13:206-17. 2007
    ..77; 95% CI, 0.46-1.31), or overall survival (RR, 1.22; 95 % CI, 0.96-1.54). UA appears effective for HVOD prophylaxis in patients undergoing HSCT and should be considered as a prevention strategy by HSCT centers to reduce HVOD...
  83. ncbi request reprint The prevalence of antibodies to the platelet factor 4 -heparin complex and association with access thrombosis in patients on chronic hemodialysis
    Marc Carrier
    Thrombosis Program, Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada
    Thromb Res 120:215-20. 2007
    ....
  84. ncbi request reprint Identification of domains relevant to health-related quality of life in patients undergoing major surgery
    Daniel B Morris
    Clinical Epidemiology Program, Ottawa Health Research Institute, 501 Smyth Road, 201, Ottawa, ON, K1H 8L6, Canada
    Qual Life Res 15:841-54. 2006
    ..A new evaluative instrument tailored to patients undergoing major surgery may therefore be warranted...
  85. doi request reprint Preservation of renal function following partial or radical nephrectomy using 24-hour creatinine clearance
    Aaron T D Clark
    Division of Urology, Department of Surgery, University of Ottawa, Ontario, Canada
    Eur Urol 54:143-49. 2008
    ..To compare the effect on renal function of partial and radical nephrectomy using creatinine clearance measurements from 24-hr urine collection...
  86. ncbi request reprint Canaries in the mineshaft: the dermatology workforce shortage in Eastern Ontario
    Caroline Heughan
    Division of Dermatology, University of Ottawa and the Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, ON
    J Cutan Med Surg 12:217-22. 2008
    ..Until 2005, all dermatology residents at the University of Ottawa were committed to return to their funding area at the completion of their training. This has left Eastern Ontario with a critical shortage of dermatologists...
  87. doi request reprint Systematic review of measures of clinical significance employed in randomized controlled trials of drugs for dementia
    Frank J Molnar
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    J Am Geriatr Soc 57:536-46. 2009
    ..A preliminary organizational framework of measures of clinical significance is presented in this article to facilitate the work of such a consensus forum...
  88. doi request reprint Status of psychological trials in breast cancer patients: a report of three meta-analyses
    Sandra C Naaman
    Faculty of Medicine, University of Ottawa, Ontario, Canada
    Psychiatry 72:50-69. 2009
    ..Patients with advanced breast disease appear to benefit more from longer term interventions which emphasize support. Recommendations are also made for future clinical trials...
  89. pmc A review of influenza vaccine immunogenicity and efficacy in HIV-infected adults
    Curtis Cooper
    University of Ottawa, Division of Infectious Diseases The Ottawa Hospital, Ottawa Health Research Institute Methods Centre, Ottawa, Ontario
    Can J Infect Dis Med Microbiol 19:419-23. 2008
    ..HIV-seropositive adults are at an increased risk for influenza infection. They also develop more severe influenza disease and are hyporesponsive to current influenza vaccinations...
  90. ncbi request reprint Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: a systematic review of randomized trials
    Atul V Mulay
    Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Am J Transplant 5:1748-56. 2005
    ..Longer follow-up is needed to determine if these changes will result in a significant improvement in patient and graft survival...
  91. ncbi request reprint Do beta-blockers reduce short-term mortality following acute myocardial infarction? A systematic review and meta-analysis
    Abdullah Al-Reesi
    Deparment of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    CJEM 10:215-23. 2008
    ..We sought to determine whether patients receiving beta-blockers acutely (within 72 h) following AMI had a lower mortality rate at 6 weeks than patients receiving placebo...
  92. ncbi request reprint Effect of study setting on anticoagulation control: a systematic review and metaregression
    Carl van Walraven
    Clinical Epidemiology Program, Ottawa Health Research Institute, C405, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, ON, K1Y 4E9 Canada
    Chest 129:1155-66. 2006
    ..The effect of study-level factors, especially study setting, on anticoagulation control is unknown...
  93. ncbi request reprint Effect of weight reduction on respiratory function and airway reactivity in obese women
    Shawn D Aaron
    Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    Chest 125:2046-52. 2004
    ..Population-based studies have documented an association between obesity and an increased prevalence of asthma in women...
  94. doi request reprint Few systematic reviews exist documenting the extent of bias: a systematic review
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1N 6N5, Canada
    J Clin Epidemiol 61:422-34. 2008
    ..To summarize the evidence concerning bias and confounding in conducting systematic reviews (SRs)...
  95. ncbi request reprint Topical nonsteroidal anti-inflammatory drugs for corneal abrasions: meta-analysis of randomized trials
    Lisa Anne Calder
    BScH, Department of Emergency Medicine, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Acad Emerg Med 12:467-73. 2005
    ..To determine the effectiveness of topical nonsteroidal anti-inflammatory drugs (NSAIDs) in traumatic corneal abrasions...
  96. ncbi request reprint Consensus conference on vCJD screening of blood donors: report of the panel
    Jeffrey McCullough
    University of Minnesota, Minneapolis, Minnesota 55455, USA
    Transfusion 44:675-83. 2004
  97. pmc Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials
    Lisa Rambout
    Department of Pharmacy, The Ottawa Hospital, Ottawa, Ont
    CMAJ 177:469-79. 2007
    ..To gauge the potential impact on disease burden, we performed a systematic review of the evidence from randomized controlled trials...
  98. doi request reprint Impact of study design on the results of continuation studies of antidepressants
    Dorian Deshauer
    J Clin Psychopharmacol 28:467-8. 2008
  99. ncbi request reprint Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials
    J Robert Swenson
    Department of Psychiatry, University of Ottawa, Ontario
    Can J Psychiatry 51:923-9. 2006
    ..To examine whether selective serotonin reuptake inhibitor (SSRI) antidepressants were associated with an increased or decreased risk of cardiovascular adverse events (AEs)...
  100. ncbi request reprint Absorbable versus nonabsorbable sutures in the management of traumatic lacerations and surgical wounds: a meta-analysis
    Tawfik Al-Abdullah
    Emergency Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Pediatr Emerg Care 23:339-44. 2007
    ..To complete a systematic review of randomized controlled trials (RCTs) that compare the cosmetic outcomes and complications of traumatic lacerations and surgical incisions closed with absorbable sutures versus nonabsorbable sutures...
  101. doi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    ..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...