Jean Pierre Pelletier

Summary

Affiliation: Osteoarthritis Research Unit
Country: Canada

Publications

  1. ncbi request reprint In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes
    Jean Pierre Pelletier
    Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:1582-93. 2003
  2. doi request reprint What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
    J P Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec, Canada
    Ann Rheum Dis 72:1594-604. 2013
  3. pmc Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis
    Pascale Rialland
    Department of Biomedical Sciences, GREPAQ Research Group in Animal Pharmacology of Quebec, St Hyacinthe Qc J2S 7C6, Canada
    BMC Vet Res 8:162. 2012
  4. doi request reprint Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 72:250-7. 2013
  5. pmc Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model
    Maxim Moreau
    Research Group in Animal Pharmacology of Quebec Department of Veterinary Biomedicine, Faculty of Veterinary Medicine Université de Montréal, 1500 des vétérinaires St, St Hyacinthe, QC J2S 7C6, Canada
    Arthritis Res Ther 13:R98. 2011
  6. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
  7. pmc High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
    Isabel García-Arnandis
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Arthritis Res Ther 12:R165. 2010
  8. pmc Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional study
    Miranda L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, 89 Commercial Road, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Arthritis Res Ther 10:R58. 2008
  9. pmc Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage
    Nadia Zayed
    Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center, Notre Dame Hospital, Montreal, QC, Canada
    Arthritis Res Ther 10:R146. 2008
  10. pmc The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study
    Stephanie K Tanamas
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Commercial Rd, Melbourne 3004, Victoria, Australia
    Arthritis Res Ther 12:R58. 2010

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes
    Jean Pierre Pelletier
    Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:1582-93. 2003
    ..Additional aims were to assess the effects of the inhibitor on levels of phosphorylated extracellular signal-regulated kinase 1/2 (phospho-ERK-1/2) and matrix metalloproteinase 1 (MMP-1; collagenase 1) in OA chondrocytes...
  2. doi request reprint What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
    J P Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec, Canada
    Ann Rheum Dis 72:1594-604. 2013
    ..Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement. ..
  3. pmc Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis
    Pascale Rialland
    Department of Biomedical Sciences, GREPAQ Research Group in Animal Pharmacology of Quebec, St Hyacinthe Qc J2S 7C6, Canada
    BMC Vet Res 8:162. 2012
    ..We hypothesized that these methods would produce convergent results related to diet changes. A Type I error of 0.05 was adjusted to correct for the multiplicity of the primary clinical endpoints...
  4. doi request reprint Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 72:250-7. 2013
    ..To explore the disease-modifying effect, under therapeutic conditions, of strontium ranelate (SrRan) on the progression of joint structural changes and on the major pathophysiological pathways in an experimental osteoarthritis dog model...
  5. pmc Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model
    Maxim Moreau
    Research Group in Animal Pharmacology of Quebec Department of Veterinary Biomedicine, Faculty of Veterinary Medicine Université de Montréal, 1500 des vétérinaires St, St Hyacinthe, QC J2S 7C6, Canada
    Arthritis Res Ther 13:R98. 2011
    ....
  6. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
    ....
  7. pmc High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
    Isabel García-Arnandis
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Arthritis Res Ther 12:R165. 2010
    ..We have recently reported that HMGB1 is released by osteoarthritic synoviocytes after activation with interleukin-1beta (IL-1β) The present study investigated the role of HMGB1 in synovial inflammation in osteoarthritis (OA)...
  8. pmc Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional study
    Miranda L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, 89 Commercial Road, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Arthritis Res Ther 10:R58. 2008
    ..Joint loading mediated via gait parameters may be associated with meniscal tears, and determining whether such an association exists was the aim of this study...
  9. pmc Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage
    Nadia Zayed
    Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center, Notre Dame Hospital, Montreal, QC, Canada
    Arthritis Res Ther 10:R146. 2008
    ....
  10. pmc The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study
    Stephanie K Tanamas
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Commercial Rd, Melbourne 3004, Victoria, Australia
    Arthritis Res Ther 12:R58. 2010
    ....
  11. pmc Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume
    Changhai Ding
    Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
    Arthritis Res Ther 9:R21. 2007
    ....
  12. doi request reprint Treatment with tiludronic acid helps reduce the development of experimental osteoarthritis lesions in dogs with anterior cruciate ligament transection followed by reconstructive surgery: a 1-year study with quantitative magnetic resonance imaging
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    J Rheumatol 38:118-28. 2011
    ....
  13. doi request reprint Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis
    J P Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    Ann Rheum Dis 69:2095-101. 2010
    ..To explore the impact of disease-modifying osteoarthritis drug (DMOAD) treatment on biomarker levels and their correlation with cartilage volume loss and disease symptoms in a 2-year phase III clinical trial in patients with knee OA...
  14. ncbi request reprint The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 34:527-38. 2004
    ....
  15. pmc The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre hospitalier de l Université de Montréal CHUM Hôpital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res 4:13-9. 2002
    ..Moreover, our laboratory has long sought to develop protective agents for osteoarthritic structural joint tissues. The most significant concepts that have originated from our lab are briefly outlined in this commentary...
  16. pmc Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 8:206. 2006
    ....
  17. doi request reprint A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI
    J P Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 16:S8-13. 2008
    ..This study aimed at developing a magnetic resonance imaging (MRI) scoring system allowing reliable and sensitive assessment of synovitis severity in knee OA patients without the use of a contrast agent...
  18. pmc The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R1091-102. 2005
    ..Moreover, our findings also indicate the possible auto-regulation of 5-LOX gene expression by licofelone in OA cartilage...
  19. ncbi request reprint Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis
    Jean Pierre Pelletier
    Head, Arthritis Division and Director, Osteoarthritis Research Unit, Centre hospitalier de l Université de Montréal CHUM Hôpital Notre Dame, Montreal, Québec H2L 4M1 Canada
    Osteoarthritis Cartilage 12:S63-8. 2004
    ..Based on the discovery of major pathophysiological pathways leading to the structural changes observed in OA, novel ways to treat the progression of OA lesions are emerging...
  20. ncbi request reprint New trends in the treatment of osteoarthritis
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Semin Arthritis Rheum 34:13-4. 2005
  21. pmc Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Center, 1560 Sherbrooke Street East, Montreal, QC, Canada H2L 4M1
    Arthritis Res Ther 9:R74. 2007
    ..This study also further confirms the correlation between cartilage volume loss and JSN and symptomatic changes at 24 months...
  22. ncbi request reprint Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase
    J P Pelletier
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Clin Exp Rheumatol 21:171-7. 2003
    ..The study also aimed to explore the effect of the drug on the level of important factors involved in this phenomenon, i.e., caspase-3 and inducible nitric oxide synthase (iNOS)...
  23. ncbi request reprint DMOAD developments: present and future
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    Bull NYU Hosp Jt Dis 65:242-8. 2007
    ..These studies are ushering the field into a new era in the development of DMOADs and, hence, the prospect of a cure for this disease...
  24. ncbi request reprint Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1
    Saranette Cheng
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Canada
    J Biol Chem 279:22057-65. 2004
    ..These data define mPGES-1 and Egr-1 as novel targets of PPARgamma and suggest that inhibition of mPGES-1 gene transcription may be one of the mechanisms by which PPARgamma regulates inflammatory responses...
  25. ncbi request reprint Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:3925-33. 2004
    ....
  26. ncbi request reprint Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts
    Ginette Tardif
    Osteoarthritis Research Unit, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:2521-30. 2004
    ....
  27. ncbi request reprint Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes
    Christelle Boileau
    Notre Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada
    Arthritis Rheum 52:488-500. 2005
    ..The effects of PD-0200347 on the major pathways involved in OA cartilage degradation, including matrix metalloproteinases (MMPs) and the inducible form of nitric oxide synthase (iNOS), were also studied...
  28. ncbi request reprint Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors
    Christelle Boileau
    Osteoarthritis Research Unit, Hĵpital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:1446-53. 2002
    ..e., caspase-3, COX-2, and inducible nitric oxide synthase (iNOS)...
  29. ncbi request reprint Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
    Maxim Moreau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    J Rheumatol 33:1176-83. 2006
    ..The effect of drug treatment on the expression and activity of metalloproteases in the OA cartilage was also studied...
  30. ncbi request reprint Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition
    Yosabeth Paredes
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 46:1804-12. 2002
    ....
  31. ncbi request reprint Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
    Xinfang Li
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    J Rheumatol 32:887-95. 2005
    ..We analyzed expression of mPGES-1 in human normal and osteoarthritic (OA) cartilage and determined the effect of different inflammatory agonists on the expression of mPGES-1 in OA chondrocytes...
  32. ncbi request reprint Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 38:333-41. 2006
    ..These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA...
  33. pmc Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes
    Hassan Afif
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Montreal, 1560 Sherbrooke East, Pavillon J, A DeSève, Y 2628, Montreal, QC, H2L 4M1, Canada
    Arthritis Res Ther 9:R31. 2007
    ..The IL-1-induced downregulation of PPARgamma expression might be a new and additional important process by which IL-1 promotes articular inflammation and cartilage degradation...
  34. ncbi request reprint Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism
    Tanja Kalajdzic
    Unité de recherche en arthrose, University of Montreal, Montreal, Quebec H2L 4M1, Canada
    Arthritis Rheum 46:494-506. 2002
    ....
  35. ncbi request reprint Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta
    Mohamed Benderdour
    Osteoarthritis Research Unit, Hĵpital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:1262-72. 2002
    ..In a comparative manner we identified IL-17 and IL-1beta induced transcription factors mediating upregulation of this enzyme's production...
  36. pmc The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein
    Kelitha Maxis
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada, H2L 4M1
    Arthritis Res Ther 8:R181. 2006
    ..The expression of FLAP in OA osteoblasts is also modulated differently by 1,25(OH)2D3 and TGF-beta depending on their endogenous low and high PGE2 levels...
  37. pmc Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R119. 2009
    ..Hence, we further investigated the possible implication of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes...
  38. ncbi request reprint Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis
    Patrick Marcouiller
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec
    J Rheumatol 32:704-12. 2005
    ....
  39. ncbi request reprint Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening
    Qin Shi
    Orthopedics Department, Hĵpital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:1437-45. 2002
    ..This study explored whether osteoblast metabolism in trabecular bone of failed total hip replacement (fTHR) in primary osteoarthritis (OA) plays a role in differential failure...
  40. ncbi request reprint Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation
    Dragan V Jovanovic
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal CHUM, Montreal, Quebec, Canada
    J Rheumatol 29:2165-75. 2002
    ..To investigate the regulation of osteoarthritis (OA) synovial fibroblast nitric oxide (NO) induced cell death...
  41. pmc Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes
    Jean Pierre Raynauld
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R21. 2006
    ..These data confirm the significant advantage of qMRI for reliably measuring knee structural changes at as early as 12 months, and for identifying risk factors associated with OA progression...
  42. pmc Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production
    Christina Alexandra Manacu
    Research Center, Sainte Justine Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R324-32. 2005
    ..ET-1 also induces NO release via iNOS induction. ET-1 and NO should thus become important target molecules for future therapies aimed at stopping cartilage destruction...
  43. ncbi request reprint Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage
    Mélanie Guévremont
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de Université de Montréal, Montreal, Quebec, Canada
    J Bone Miner Res 18:1073-81. 2003
    ..In summary, this study raises the hypothesis that the HGF found in articular cartilage is produced by osteoblasts, diffuses into the cartilage, and may be implicated in the OA process...
  44. pmc Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R177. 2006
    ..The altered response of OA Obs to IGF-1 may be due to abnormal IGF-1 signaling in these cells. This is mostly linked with abnormal IRS-1/Syp and IRS-1/Grb2 interaction in these cells...
  45. pmc Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2
    Nadia Zayed
    Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, and University of Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 58:3530-40. 2008
    ..To investigate the effects of prostaglandin D2 (PGD2) on interleukin-1beta (IL-1beta)-induced matrix metalloproteinase 1 (MMP-1) and MMP-13 expression in human chondrocytes and the signaling pathways involved in these effects...
  46. ncbi request reprint The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide
    Christelle Boileau
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, 1560 Rue Sherbrooke East, Montreal, Quebec H2L 4M1, Canada
    Arthritis Rheum 46:2637-47. 2002
    ..Interleukin-18 (IL-18) was also studied and served as reference for the effects of ICE...
  47. ncbi request reprint Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction
    Marjolaine Roy-Beaudry
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:2855-64. 2003
    ..Recently, it was suggested that endothelin 1 (ET-1), a potent vasoconstrictor, may be involved in MMP regulation. This study investigated the role of ET-1 in OA cartilage degradation...
  48. ncbi request reprint Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter
    Zhiyong Fan
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 54:2471-80. 2006
    ..In this study, we sought to determine the importance of individual AGRE bases in promoter activity and to identify AGRE binding proteins from L-OA and H-OA chondrocyte complexes...
  49. pmc Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
    Ginette Tardif
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    BMC Musculoskelet Disord 10:148. 2009
    ..MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes...
  50. pmc Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI
    Lukas Martin Wildi
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Canada
    Ann Rheum Dis 70:982-9. 2011
    ..To determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with knee osteoarthritis (OA)...
  51. doi request reprint Expression of peroxisome proliferator-activated receptors α, β, γ, and H- and L-prostaglandin D synthase during osteoarthritis in the spontaneous hartley guinea pig and experimental dog models
    Sarah Salwa Nebbaki
    Osteoarthritis Research Unit, University of Montreal Hospital Research Center CRCHUM, Notre Dame Hospital, Montreal, Quebec, Canada
    J Rheumatol 40:877-90. 2013
    ....
  52. pmc Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 9:R121. 2007
    ..These results suggest PAR-2 as a potential new therapeutic target for the treatment of OA...
  53. pmc Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
    Arthritis Res Ther 9:R117. 2007
    ..This was confirmed by the decreased resorptive activity for the combination of CS and GS. These data are of major significance and may help to explain how these two drugs exert a positive effect on OA pathophysiology...
  54. ncbi request reprint Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes
    Jean Pierre Raynauld
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, and Université de Montréal, Montreal, Quebec, Canada
    Arthritis Rheum 50:476-87. 2004
    ..To evaluate the change in osteoarthritic (OA) knee cartilage volume over a two-year period with the use of magnetic resonance imaging (MRI) and to correlate the MRI changes with radiologic changes...
  55. pmc Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes
    Sarah Salwa Nebbaki
    Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center CR CHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, J, A, DeSève Pavillion, Y 2628, and Department of Medicine, University of Montreal, Montreal, QC H2L 4M1, Canada
    Arthritis Res Ther 14:R69. 2012
    ..The PPARγ promoter harbors an overlapping Egr-1/specificity protein 1 (Sp1) binding site. In this study, our objective was to define the roles of Egr-1 and Sp1 in IL-1-mediated down-regulation of PPARγ expression...
  56. doi request reprint Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Bone 44:1143-50. 2009
    ..In this study, we investigated the expression, production, modulation, and role of PAR-2 in human OA subchondral bone osteoblasts...
  57. doi request reprint Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes
    Fatima Ezzahra El Mansouri
    Research Centre of the University of Montreal Hospital Centre, Notre Dame Hospital, and University of Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 63:168-79. 2011
    ..To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1β (IL-1β)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes...
  58. doi request reprint Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Rheumatology (Oxford) 48:1482-90. 2009
    ..Furthermore, the role of OPG and RANKL on the production of catabolic/anabolic factors was assessed...
  59. doi request reprint Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1
    Nadia Zayed
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    J Rheumatol 38:492-502. 2011
    ..We examined the effects of valproic acid (VA), a histone deacetylase inhibitor, on interleukin 1ß (IL-1ß)-induced mPGES-1 expression in human chondrocytes, and evaluated the roles of Egr-1 and NAB1 in these effects...
  60. doi request reprint Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Bone 43:284-91. 2008
    ..The impact of the modulation of RANKL1 and 3 on the membranous RANKL level was also studied...
  61. ncbi request reprint New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Curr Rheumatol Rep 8:30-6. 2006
    ..This paper should help the reader better understand the most recent advances regarding the roles of these factors in this disease process, and how new therapeutic targets may be identified...
  62. doi request reprint Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue thickening in canine experimental stifle osteoarthritis: comparison between 1.5 T magnetic resonance imaging and computed radiography
    Marc André D'Anjou
    Companion Animal Research Group, Departement de Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Vet Surg 37:166-77. 2008
    ....
  63. ncbi request reprint Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines
    Wendy He
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:546-53. 2002
    ....
  64. doi request reprint Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada
    Bone 49:559-67. 2011
    ..In this study, we investigated in human OA subchondral bone osteoblasts the modulatory effect of strontium ranelate on the above key factors...
  65. doi request reprint In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis
    Gladys Valverde-Franco
    University of Montreal Hospital Research Centre, Quebec, Canada
    Arthritis Rheum 64:3614-25. 2012
    ..However, the specific in vivo role of this ephrin receptor in OA remains unknown. We investigated in mice the in vivo effect of bone-specific EphB4 overexpression on OA pathophysiology...
  66. pmc Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis
    Jean Pierre Raynauld
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 10:R129. 2008
    ..We aimed to compare these two different approaches looking at the global knee and subregions, using data from an osteoarthritis (OA) multicentre randomised clinical trial...
  67. pmc Extracellular localization of galectin-3 has a deleterious role in joint tissues
    Audrée Janelle-Montcalm
    Unité de recherche en arthrose, Centre de Recherche de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
    Arthritis Res Ther 9:R20. 2007
    ..These findings indicate that high levels of extracellular gal-3, which could be encountered locally during the inflammatory process, have deleterious effects in both cartilage and subchondral bone tissues...
  68. doi request reprint Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    J Rheumatol 37:656-64. 2010
    ..Because of differences in CS in terms of purity and the production/purification process, we compared the effects of 3 different types of CS on human OA cartilage...
  69. doi request reprint Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, CR CHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, JA de Sève Pavilion, 2nd Floor, Montreal, Quebec H2L 4M1, Canada
    Ann Rheum Dis 69:1179-84. 2010
    ....
  70. doi request reprint Peroxisome proliferator-activated receptor gamma in osteoarthritis
    Hassan Fahmi
    Osteoarthritis Research Unit, Notre Dame Hospital, University of Montreal Hospital Research Centre CRCHUM, 1560 Sherbrooke East, Pavillon J A DeSève, Y 2628, Montreal, QC, H2L 4M1, Canada
    Mod Rheumatol 21:1-9. 2011
    ..Finally, the role of PPARγ polymorphism in the pathogenesis of OA and related musculoskeletal diseases will also be discussed...
  71. doi request reprint Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation
    Jean Pierre Raynauld
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Ann Rheum Dis 70:1382-8. 2011
    ..To identify predictive factors for total knee replacement (TKR) using data from MRI of knee osteoarthritis patients in a phase III multicentre disease-modifying osteoarthritis drug (DMOAD) study...
  72. ncbi request reprint The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboli
    Christelle Boileau
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 56:2288-98. 2007
    ....
  73. pmc Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 10:R71. 2008
    ..In osteoclasts, we studied MMP-13 and cathepsin K production as well as cell differentiation, proliferation, and survival...
  74. ncbi request reprint The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Future directions in the research and treatment of osteoarthritis (OA) will be based on the emerging picture of pathophysiological events that modulate the initiation and progression of OA...
  75. doi request reprint Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1
    Mohit Kapoor
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    J Rheumatol 39:635-44. 2012
    ..We investigated its effect on prostaglandin E(2) (PGE(2)) in human OA chondrocytes, and the level in the PGE(2) pathway at which its effect takes place...
  76. pmc Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model
    Roxana Monemdjou
    University of Montreal Hospital Research Centre and University of Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 64:1551-61. 2012
    ..Therefore, this study sought to determine the in vivo role of PPARγ in endochondral ossification and cartilage development, using cartilage-specific PPARγ-knockout (KO) mice...
  77. pmc Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis
    Nadir Chabane
    Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R44. 2009
    ....
  78. pmc Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
    Jordi Monfort
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada
    Arthritis Res Ther 8:R26. 2006
    ..Awareness of SLRP degradation products, especially those of biglycan and fibromodulin, may assist in early detection of OA cartilage degradation...
  79. doi request reprint An open-label pilot study evaluating by magnetic resonance imaging the potential for a disease-modifying effect of celecoxib compared to a modelized historical control cohort in the treatment of knee osteoarthritis
    Jean Pierre Raynauld
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Semin Arthritis Rheum 40:185-92. 2010
    ..The aim of the study was to evaluate by quantitative magnetic resonance imaging the effect of celecoxib 200 mg daily on cartilage volume loss over 12 months in knee osteoarthritis...
  80. doi request reprint Assessment of cartilage changes over time in knee osteoarthritis disease-modifying osteoarthritis drug trials using semiquantitative and quantitative methods: pros and cons
    Lukas Martin Wildi
    University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Care Res (Hoboken) 65:686-94. 2013
    ....
  81. doi request reprint Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 58:3820-30. 2008
    ..The purpose of this study was to investigate the importance of the ephrin system in OA subchondral bone osteoblasts...
  82. doi request reprint Targeting subchondral bone for treating osteoarthritis: what is the evidence?
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada
    Best Pract Res Clin Rheumatol 24:51-70. 2010
    ....
  83. doi request reprint Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI
    Lukas Martin Wildi
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    Ann Rheum Dis 69:2118-24. 2010
    ....
  84. ncbi request reprint A novel negative regulatory element in the human collagenase-3 proximal promoter region
    Mohamed Benderdour
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal CHUM, Hopital Notre Dame, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada, H2L 4M1
    Biochem Biophys Res Commun 291:1151-9. 2002
    ..UV cross-linking revealed the presence of 48 and 97 kDa proteins in complex 1 and 27, 35, and 73 kDa proteins in complex 2. These findings suggest that the AGRE site plays a rate-limiting role in human collagenase-3 production...
  85. doi request reprint Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype
    Faezeh Vasheghani
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre
    Am J Pathol 182:1099-106. 2013
    ..In conclusion, PPARγ is a critical regulator of cartilage health, the lack of which leads to an accelerated spontaneous OA phenotype...
  86. doi request reprint Future therapeutics for osteoarthritis
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Montreal, Quebec, Canada
    Bone 51:297-311. 2012
    ..This article is part of a Special Issue entitled "Osteoarthritis"...
  87. pmc Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R41. 2009
    ....
  88. pmc Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging
    Wei Li
    ArthroVision Inc, 1871 Sherbrooke Street East, Montreal, Quebec H2K 1B6, Canada
    Arthritis Res Ther 12:R173. 2010
    ..This study aimed at developing and validating a fully automated system based on magnetic resonance imaging (MRI) for the quantification of joint effusion volume in knee OA patients...
  89. ncbi request reprint Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial
    Jean Pierre Raynauld
    Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:370-7. 2003
    ..To evaluate the safety and efficacy of long-term intraarticular (IA) steroid injections for knee pain related to osteoarthritis (OA)...
  90. doi request reprint Cartilage in normal and osteoarthritis conditions
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Montreal, Canada
    Best Pract Res Clin Rheumatol 22:351-84. 2008
    ..The alterations in osteoarthritic cartilage are numerous and involve morphologic and metabolic changes in chondrocytes, as well as biochemical and structural alterations in the extracellular matrix macromolecules...
  91. doi request reprint Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production
    Denis Couchourel
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 60:1438-50. 2009
    ..Bone tissue in osteoarthritis (OA) is composed of abundant undermineralized osteoid matrix. The aim of this study was to investigate the mechanisms responsible for this abnormal matrix, using in vitro OA subchondral osteoblasts...
  92. doi request reprint R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts
    Elie Abed
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 63:3865-75. 2011
    ..The purpose of this study was to investigate the potential role of Rspo-1 and Rspo-2 in OA osteoblasts...
  93. doi request reprint Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    J Rheumatol 38:911-20. 2011
    ..Evidence indicates that proteinase-activated receptor (PAR)-2 participates in the degradative processes of human osteoarthritis (OA). We evaluated the in vivo effect of PAR-2 on articular lesions in a PAR-2-knockout (KO) mouse model of OA...
  94. ncbi request reprint Is osteoarthritis a disease involving only cartilage or other articular tissues?
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Eklem Hastalik Cerrahisi 21:2-14. 2010
    ..We will summarize the current pathological mechanisms that occur in the abovementioned articular tissues, and briefly discuss their interconnections during OA...
  95. doi request reprint A fully automated human knee 3D MRI bone segmentation using the ray casting technique
    Pierre Dodin
    ArthroVision, 1871 Sherbrooke Street East, Montreal, QC H2K 1B6, Canada
    Med Biol Eng Comput 49:1413-24. 2011
    ..94 ± 0.05; 0.92 ± 0.07). This newly developed fully automated bone segmentation method will enable large scale studies to be conducted within shorter time durations, as well as increase stability in the reading of pathological bone...
  96. ncbi request reprint Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts
    Daniel Lajeunesse
    Unité de recherche en arthrose, Centre de recherche du Centre hospitalier de I Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    Bone 33:703-10. 2003
    ..Taken together, these results could suggest that HA of increasing MW has positive effects on OA Ob by modifying their biological synthetic capacities...
  97. doi request reprint Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
    Mohit Kapoor
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    Nat Rev Rheumatol 7:33-42. 2011
    ..This Review discusses the current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA and addresses the potential of anticytokine therapy in the treatment of this disease...
  98. doi request reprint Human hip joint cartilage: MRI quantitative thickness and volume measurements discriminating acetabulum and femoral head
    Wei Li
    ArthroVision, Montreal, QC H2K 1B6, Canada
    IEEE Trans Biomed Eng 55:2731-40. 2008
    ....
  99. ncbi request reprint New insights into the major pathophysiological processes responsible for the development of osteoarthritis
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Semin Arthritis Rheum 34:6-8. 2005
  100. ncbi request reprint Cyclooxygenase-2 and prostaglandins in articular tissues
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Quebec, Canada
    Semin Arthritis Rheum 33:155-67. 2003
    ....
  101. ncbi request reprint Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model
    Claude Kauffmann
    ArthroVision, Montreal, QC, Canada
    IEEE Trans Biomed Eng 50:978-88. 2003
    ..11% to 0.32%. This method improves noninvasive 3-D analysis of cartilage thickness and volume and is well suited for in vivo follow-up clinical studies of OA knees...