Jean Francois Legare

Summary

Affiliation: Nova Scotia
Country: Canada

Publications

  1. pmc Off-pump coronary artery bypass graft surgery is standard of care: where do you stand?
    Jean Francois Legare
    Dalhousie University, Halifax, Canada
    Can J Cardiol 22:1107-10. 2006
  2. ncbi Heat shock treatment results in increased recruitment of labeled PMN following myocardial infarction
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Physiol Heart Circ Physiol 293:H3210-5. 2007
  3. pmc The effect of total arterial grafting on medium-term outcomes following coronary artery bypass grafting
    Jean Francois Legare
    Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    J Cardiothorac Surg 2:44. 2007
  4. ncbi Off-pump coronary artery bypass graft surgery: where should we stand?
    Jean Francois Legare
    Division of Cardiovascular Surgery, New Halifax Infirmary, QEII HSC, Halifax, Nova Scotia, B3H 3A7, Canada
    Expert Rev Cardiovasc Ther 3:1027-33. 2005
  5. pmc Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary artery
    Jean Francois Legare
    Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, NS
    CMAJ 173:371-5. 2005
  6. ncbi Conversion to on pump from OPCAB is associated with increased mortality: results from a randomized controlled trial
    Jean Francois Legare
    Division of Cardiovascular Surgery, Dalhousie University, 1796 Summer Str Rm 2006, New Halifax Infirmary, Halifax, NS, Canada B3H 3A7
    Eur J Cardiothorac Surg 27:296-301. 2005
  7. ncbi Massive intracavitary clot formation during cardiopulmonary bypass
    Jean Francois Legare
    Dalhousie University, Department of Surgery, Halifax, Nova Scotia
    Can J Cardiol 20:825-6. 2004
  8. ncbi Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump
    Jean Francois Legare
    Division of Cardiovascular Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Circulation 109:887-92. 2004
  9. pmc How established wait time benchmarks significantly underestimate total wait times for cardiac surgery
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Cardiol 26:e17-21. 2010
  10. pmc Infiltration of polymorphonuclear cells into the post-ischaemic myocardium is dependent on beta2 and alpha4 integrins
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, NS, Canada
    Int J Exp Pathol 88:291-300. 2007

Collaborators

Detail Information

Publications42

  1. pmc Off-pump coronary artery bypass graft surgery is standard of care: where do you stand?
    Jean Francois Legare
    Dalhousie University, Halifax, Canada
    Can J Cardiol 22:1107-10. 2006
    ..The results of these randomized studies are likely responsible for the failure of off-pump CABG to become established as the standard of care...
  2. ncbi Heat shock treatment results in increased recruitment of labeled PMN following myocardial infarction
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Physiol Heart Circ Physiol 293:H3210-5. 2007
    ..These findings suggest that the proposed cardioprotective effect of HS may not be entirely due to a downregulation of myocardial inflammation as previously proposed...
  3. pmc The effect of total arterial grafting on medium-term outcomes following coronary artery bypass grafting
    Jean Francois Legare
    Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    J Cardiothorac Surg 2:44. 2007
    ..In this study, we assessed the impact of TAG on medium-term outcomes after CABG...
  4. ncbi Off-pump coronary artery bypass graft surgery: where should we stand?
    Jean Francois Legare
    Division of Cardiovascular Surgery, New Halifax Infirmary, QEII HSC, Halifax, Nova Scotia, B3H 3A7, Canada
    Expert Rev Cardiovasc Ther 3:1027-33. 2005
    ..Taken together, the evidence to date suggests that a large-scale, prospective, randomized trial may be required to resolve the dilemma...
  5. pmc Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary artery
    Jean Francois Legare
    Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, NS
    CMAJ 173:371-5. 2005
    ..Our main objective was to evaluate the safety of waiting for CABG among patients with left main coronary artery disease using a standardized triage system...
  6. ncbi Conversion to on pump from OPCAB is associated with increased mortality: results from a randomized controlled trial
    Jean Francois Legare
    Division of Cardiovascular Surgery, Dalhousie University, 1796 Summer Str Rm 2006, New Halifax Infirmary, Halifax, NS, Canada B3H 3A7
    Eur J Cardiothorac Surg 27:296-301. 2005
    ..The objective of the present study was to review all conversions in the setting of a randomized controlled trial comparing CABG with or without CPB...
  7. ncbi Massive intracavitary clot formation during cardiopulmonary bypass
    Jean Francois Legare
    Dalhousie University, Department of Surgery, Halifax, Nova Scotia
    Can J Cardiol 20:825-6. 2004
    ..The clinical scenario is described in detail and potential explanations and relevance are discussed...
  8. ncbi Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump
    Jean Francois Legare
    Division of Cardiovascular Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Circulation 109:887-92. 2004
    ..However, there is conflicting evidence to date from published trials comparing outcomes between CABG performed with and without CPB, with some trials indicating an advantage to the avoidance of CPB and others showing little benefit...
  9. pmc How established wait time benchmarks significantly underestimate total wait times for cardiac surgery
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Cardiol 26:e17-21. 2010
    ..Wait times for cardiac surgery are well established but may not reflect the total wait time patients experience...
  10. pmc Infiltration of polymorphonuclear cells into the post-ischaemic myocardium is dependent on beta2 and alpha4 integrins
    Jean Francois Legare
    Department of Surgery, Dalhousie University, Halifax, NS, Canada
    Int J Exp Pathol 88:291-300. 2007
    ..Our findings also suggest that PMN migration is dependent equally on beta2 and alpha4 integrins...
  11. pmc Fibroblast progenitor cells are recruited into the myocardium prior to the development of myocardial fibrosis
    Mryanda Sopel
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Int J Exp Pathol 93:115-24. 2012
    ..This suggests that fibrocytes rather than (as is often presumed) leucocytes may have effector functions in the initiation of myocardial fibrosis...
  12. ncbi Identifying patients at risk of intraoperative and postoperative transfusion in isolated CABG: toward selective conservation strategies
    Rakesh C Arora
    Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Ann Thorac Surg 78:1547-54. 2004
    ..We developed a predictive model, based on eight preoperative risk factors, of allogeneic blood product transfusion rates in patients undergoing a cardiac procedure...
  13. ncbi Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis
    Nicole L Rosin
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Pathol 182:714-26. 2013
    ..In addition, CTGF contributes to fibrocyte proliferation in the myocardium and enhances fibrocyte differentiation into a myofibroblast phenotype responsible for ECM deposition...
  14. doi Predicting in-hospital mortality after redo cardiac operations: development of a preoperative scorecard
    Sebastian Launcelott
    Department of Surgery, Division of Cardiac Surgery, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Ann Thorac Surg 94:778-84. 2012
    ..The present study generated a risk model and an easy-to-use scorecard for the preoperative prediction of in-hospital mortality for patients undergoing redo cardiac operations...
  15. doi Predicting prolonged intensive care unit length of stay in patients undergoing coronary artery bypass surgery--development of an entirely preoperative scorecard
    Christine Herman
    Division of Cardiac Surgery, Queen Elizabeth II Health Sciences Center, 1796 Summer Street, Rm 2629, Halifax, Nova Scotia, B3H 3A7, Canada
    Interact Cardiovasc Thorac Surg 9:654-8. 2009
    ..Based on preoperative clinical factors, a scorecard was developed allowing identification of these patients prior to surgery and allowing for strategies aimed at optimizing hospital resources...
  16. ncbi Are intraoperative precursor events associated with postoperative major adverse events?
    Christine R Herman
    Division of Cardiac Surgery, Dallhousie University, Halifax, Nova Scotia, Canada Department of Community Health and Epidemiology, Dallhousie University, Halifax, Nova Scotia, Canada Electronic address
    J Thorac Cardiovasc Surg 147:1499-504. 2014
    ..These events might be targets for strategies aimed at quality improvement...
  17. doi Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought
    Alec Falkenham
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Pathol 183:459-69. 2013
    ..Ablating CCR2 signaling did confer myocardial fibrosis reductions, but these benefits were not observed until much later and were likely the result of modulated proliferation through ablating the CCL12-CCR2 interaction. ..
  18. doi Myocardial migration by fibroblast progenitor cells is blood pressure dependent in a model of angII myocardial fibrosis
    Nicole L Rosin
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Hypertens Res 35:449-56. 2012
    ..Furthermore, the beneficial effects of hydralazine were observed while maintaining RAS activation, suggesting that the mechanism of fibrosis is blood pressure dependent...
  19. ncbi Integrins and monocyte migration to the ischemic myocardium
    Mryanda Sopel
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Invest Surg 23:79-86. 2010
    ..Characterize mononuclear cell migration after acute-myocardial infarction (MI)...
  20. doi Bilateral internal thoracic artery grafting is superior to other forms of multiple arterial grafting in providing survival benefit after coronary bypass surgery
    Ryan Kelly
    Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    J Thorac Cardiovasc Surg 144:1408-15. 2012
    ..The objective of this study was to examine the effect of arterial grafting on long-term coronary artery bypass grafting mortality...
  21. doi The changing face of cardiac surgery: practice patterns and outcomes 2001-2010
    Karen J Buth
    Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada Electronic address
    Can J Cardiol 30:224-30. 2014
    ..Our objective was to document changes in practice patterns and outcomes in a single tertiary cardiac surgery centre serving a large geographic area...
  22. ncbi Long-term outcomes in patients requiring stay of more than 48 hours in the intensive care unit following coronary bypass surgery
    Olivier P Heimrath
    Department of Surgery, Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Crit Care 22:153-8. 2007
    ..The primary objective of this study was to determine the long-term outcomes of all patients requiring prolonged intensive care unit (ICU) stay following coronary bypass surgery (CABG) surgery...
  23. pmc Treatment with activated protein C (aPC) is protective during the development of myocardial fibrosis: an angiotensin II infusion model in mice
    Mryanda J Sopel
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 7:e45663. 2012
    ..Using a model of myocardial fibrosis second to Angiotensin II (AngII) infusion, we investigated the novel therapeutic function aPC in the development of fibrosis...
  24. ncbi Is it safe to train residents to perform cardiac surgery?
    Roger J F Baskett
    The Maritime Heart Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Ann Thorac Surg 74:1043-8; discussion 1048-9. 2002
    ..The impact of surgical training on patient outcomes in cardiac surgery is unknown...
  25. pmc Development of a predictive model for major adverse cardiac events in a coronary artery bypass and valve population
    Christine R Herman
    Division of Cardiac Surgery, Queen Elizabeth II Health Science Center, Halifax, NS, Canada
    J Cardiothorac Surg 8:177. 2013
    ..Also, composite model end-points of morbidity and mortality, better reflect outcomes experienced by patients...
  26. doi Intraoperative graft flow measurements during coronary artery bypass surgery predict in-hospital outcomes
    Christine Herman
    Department of Surgery, Division of Cardiac Surgery, Dalhousie University, Halifax, NS, Canada
    Interact Cardiovasc Thorac Surg 7:582-5. 2008
    ..Our findings suggest that abnormal flows measured intraoperatively are independently associated with short-term in-hospital adverse outcome...
  27. ncbi The dome of the left atrium: an alternative approach for mitral valve repair
    Jean Francois Legare
    Dalhousie University, Halifax, Nova Scotia, Canada
    Eur J Cardiothorac Surg 23:272-6. 2003
    ..We report our experience with mitral valve repair carried out through the dome of the left atrium, in comparison with more standard approaches...
  28. doi New onset postoperative atrial fibrillation is associated with a long-term risk for stroke and death following cardiac surgery
    Peter Horwich
    Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Card Surg 28:8-13. 2013
    ..We sought to evaluate the long-term impact of post-cardiac surgery atrial fibrillation on the risk of stroke and survival...
  29. doi Heat shock treatment prior to myocardial infarction results in reduced ventricular remodeling
    Olivier Heimrath
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Invest Surg 22:9-15. 2009
    ..Heat shock (HS) treatment has been suggested to confer myocardial protection following ischemia. However, the effects of HS on left ventricular (LV) remodeling weeks after infarction have yet to be described...
  30. doi Highly purified human peripheral blood monocytes produce IL-6 but not TNFalpha in response to angiotensin II
    Laura Gelinas
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Renin Angiotensin Aldosterone Syst 12:295-303. 2011
    ..Monocytes produce pro-inflammatory cytokines in response to Angiotensin II (AngII)...
  31. ncbi Medium-term outcomes of coronary artery bypass graft surgery on pump versus off pump: results from a randomized controlled trial
    Wojtek Karolak
    Division of Cardiac Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Am Heart J 153:689-95. 2007
    ..The present study evaluates medium-term outcomes from patients that have been randomized to CABG surgery performed on pump versus off pump...
  32. doi Versatility of hemisternotomy for cardiac surgery
    David B S Macdonald
    Dalhousie University, Halifax, Nova Scotia, Canada
    J Card Surg 24:6-10. 2009
    ..This study reviews the experience of one center employing hemisternotomy and compares patient outcomes, both in-hospital and post-discharge, with a matched group of full sternotomy patients...
  33. doi Great mediastinal vein reconstruction using autologous superficial femoral vein superficial femoral vein graft
    Ehab Eshtaya
    Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Card Surg 23:736-8. 2008
    ..Although rarely used, the SFV provides an acceptable alternative for conduit in large vein reconstructions...
  34. pmc Unequal access to interventional cardiac care in Nova Scotia in patients with acute myocardial infarction complicated by cardiogenic shock
    J Mayich
    Department of Surgery, Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Cardiol 22:331-5. 2006
    ..The present study evaluated the outcomes of all patients having AMI complicated by CS in a single Canadian province...
  35. ncbi Implantable cardioverter-defibrillator implantation as a bridge to cardiac transplantation
    Michael R Da Rosa
    Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Heart Lung Transplant 26:1336-9. 2007
    ....
  36. pmc The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is not appropriate for withholding surgery in high-risk patients with aortic stenosis: a retrospective cohort study
    Dimitri Kalavrouziotis
    Department of Surgery, Division of Cardiac Surgery, Queen Elizabeth II Health Sciences Centre, Dalhousie University, 1796 Summer Street, Room 2269, Halifax, Nova Scotia, B3H 3A7, Canada
    J Cardiothorac Surg 4:32. 2009
    ..The objective of this study was to determine the accuracy of the EuroSCORE in predicting mortality following aortic valve replacement (AVR)...
  37. ncbi What has happened to multiple arterial grafting in coronary artery bypass grafting surgery?
    Tamer Elghobary
    Department of Surgery, Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Expert Rev Cardiovasc Ther 8:1099-105. 2010
    ....
  38. doi Revascularization for ischaemic cardiomyopathy
    Ganesh Shanmugam
    Department of Surgery, Division of Cardiac Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Curr Opin Cardiol 23:148-52. 2008
    ..This review evaluates the current state of knowledge on revascularization for the treatment of ischaemic cardiomyopathy...
  39. ncbi Con: atrial arrhythmia prophylaxis is not required for cardiac surgery
    Jean Francois Legare
    Departments of Cardiovascular Surgery, Anesthesiology, Pharmacology and Surgery, Dalhousie University and the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Cardiothorac Vasc Anesth 16:118-21. 2002
  40. doi Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells
    Mryanda J Sopel
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Lab Invest 91:565-78. 2011
    ..These data suggest that mesenchymal progenitor cells are recruited, and may have a primary role, in the initiation of myocardial fibrosis...
  41. pmc Predictors of implantable cardioverter-defibrillator use in patients with ischemic cardiomyopathy
    Ryan Kelly
    Departments of Surgery, Dalhousie University, Halifax, Nova Scotia
    Open Cardiovasc Med J 4:206-13. 2010
    ..The objective of this study was to identify and examine ICD utilization in a large group of eligible coronary artery bypass grafting (CABG) patients with impaired left ventricular function...
  42. ncbi Arterial filter bypass loop: what occurs in this area during cardiopulmonary bypass and are there potential patient implications
    Justin L Hawkins
    Cardiovascular Perfusion Services, Queen Elizabeth II QEII Health Science Center, Halifax, Nova Scotia, Canada
    J Extra Corpor Technol 42:71-4. 2010
    ....