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Genomes and GenesSpecies | Nova ScotiaSummaryOrganization: Nova Scotia Country: Canada Top Publications
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The Halifax explosion and the birth of a surgical specialty-myth or realityD Alex Gillis
The IWK Health Centre, Halifax, Nova Scotia, Canada B3K 6R8
J Pediatr Surg 45:855-8. 2010..He has been recognized as the "father of pediatric surgery" in North America. The authors present a written refutation of this causal association by Dr Ladd...
Plasma esterases and inflammation in ageing and frailtyRuth E Hubbard
Department of Geriatric Medicine, School of Medicine, Cardiff University, 3rd Floor, Academic Centre, Llandough Hospital, Penarth, UK
Eur J Clin Pharmacol 64:895-900. 2008..Esterases are enzymes of drug metabolism known to be reduced in frail older people and during acute illness. The mechanism for this is unknown. The aim of this study was to examine esterase activity and inflammation in ageing and frailty...
Alternative scoring of the Cutaneous Assessment Tool in juvenile dermatomyositis: results using abbreviated formatsAdam M Huber
Izaak Walton Killam Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Arthritis Rheum 59:352-6. 2008..The goal of this study was to determine whether alternative scoring methods would shorten the CAT without compromising its measurement characteristics...
Preliminary validation and clinical meaning of the Cutaneous Assessment Tool in juvenile dermatomyositisAdam M Huber
Division of Pediatric Rheumatology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Arthritis Rheum 59:214-21. 2008..To provide preliminary validation of the Cutaneous Assessment Tool (CAT), a new tool to assess cutaneous manifestations of juvenile dermatomyositis (DM), and to explore the clinical meaning of CAT scores...
The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathyA M Huber
IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Rheumatology (Oxford) 46:1606-11. 2007..We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients...
The prevention and management of infections in children with asplenia or hypospleniaVictoria E Price
Division of Hematology Oncology, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850 5980 University Ave, P O Box 9700, Halifax, Canada, B3K 6R8 Halifax, Canada
Infect Dis Clin North Am 21:697-710, viii-ix. 2007..This article reviews the current literature on the prevention and management of severe infections in children with underlying asplenia or hyposplenia...
Acinar pattern of mammary Paget's disease: a case reportPenny J Barnes
Division of Anatomical Pathology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Breast J 13:520-6. 2007..A predominant acinar pattern of MPD is extremely uncommon and, to our knowledge, has not been formally reported. The histological features and differential diagnosis are discussed...
Complementary and alternative therapies: survey of knowledge and attitudes of health professionals at a tertiary pediatric/women's care facilityJanis Brown
Department of Interdisciplinary Research, IWK Health Centre, Halifax, NS, Canada
Complement Ther Clin Pract 13:194-200. 2007....
NaviStar ThermoCool catheter for ventricular tachycardiaAmir Abdelwahab
QEII Health Sciences Centre, Department of Medicine, Cardiology Division, 1796 Summer Street, Room 2501, Halifax, Nova Scotia, B3H 3A7, Canada
Expert Rev Med Devices 4:307-14. 2007..The design of this catheter, its clinical profile, its potential advantages and possible complications associated with its use in ventricular tachycardia ablation are discussed herein...
The impact of warfarin use on clinical outcomes in atrial fibrillation: a population-based studyRatika Parkash
Department of Medicine, Dalhousie University and Capital Health, Halifax, Canada
Can J Cardiol 23:457-61. 2007..Atrial fibrillation (AF) is the most common adult arrhythmia, and significantly increases the risk of ischemic stroke. Oral anticoagulation may be underused and may be less effective in community settings than clinical trial settings...
Awareness and symbol use improves future-oriented decision making in preschoolersNancy Garon
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
Dev Neuropsychol 31:39-59. 2007..These results suggest an interaction between conscious awareness, symbol use, and making advantageous future-oriented decisions during the preschool period...
Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adultsShelly A McNeil
Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
Vaccine 25:3464-74. 2007....
A therapeutic alliance can exist without face-to-face contactPatricia Lingely-Pottie
IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
J Telemed Telecare 12:396-9. 2006..The present study provides evidence that a strong, positive therapeutic alliance can exist in the absence of face-to-face contact using non-professional telephone coaches...
Mental retardation in children ages 6 to 16Sarah E Shea
Department of Pediatrics, Dalhousie University, Division of Developmental Pediatrics, Halifax, Nova Scotia, Canada
Semin Pediatr Neurol 13:262-70. 2006..This review discusses the definition of MR, an approach to investigation, common comorbidities, and a general approach to management...
Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factorsB A Nassar
Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
Scand J Clin Lab Invest 68:286-91. 2008..Two CX3CR1 mutations, V249I and T280M, reportedly decrease coronary artery disease (CAD) risk independent of established risk factors. An I249 protective effect is attributed to reducing CX3CR1 binding to fractalkine, its ligand...
Do available questionnaires measure the communication factors that patients and families consider important at end of life?Eva Grunfeld
Cancer Outcomes ResearchProgram, Cancer Care Nova Scotia, Canada
J Clin Oncol 26:3874-8. 2008..There is a need to further develop questionnaires that have the capacity to specifically measure those communication domains that are important to patients with cancer and their families at EOL...
Assessment protocol for serial casting after botulinum toxin a injections to treat equinus gaitBarbara Kelly
School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada
Pediatr Phys Ther 20:233-41. 2008..The purpose of this study was to investigate feasibility of an assessment protocol for a trial of post-Botox casting to treat equinus gait in cerebral palsy...
Examining the impact of health research facilitated by small peer-reviewed research operating grants in a women's and children's health centreAndrew J Caddell
Research Services, IWK Health Centre, 5850 5980 University Avenue, PO Box 9700, Halifax, NS, B3K 6R8, Canada
BMC Res Notes 3:107. 2010..These grants are rigorously peer-reviewed. To evaluate the impact of these grants, an assessment was completed of several different areas of impact...
The value of multiple surveillance cultures for methicillin-resistant Staphylococcus aureusKevin R Forward
Department of Pathology, Medicine, and Microbiology, Dalhousie University, Halifax, NS, Canada
Am J Infect Control 38:596-9. 2010..We evaluated our experience in a low prevalence setting to determine the extent to which multiple swabs increased detection rates and the incremental costs of doing so...
Sex or survival: short-term versus long-term androgen deprivation in patients with locally advanced prostate cancer treated with radiotherapyDerek R Wilke
Department of Radiation Oncology, Nova Scotia Cancer Center, Queen Elizabeth II Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
Cancer 116:1909-17. 2010..The seminal question is whether or not the gains are worth the adverse effects of LTAD with respect to patient preferences...
Assessment of cognitive function in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis by computerized neuropsychological testsJohn G Hanly
Dalhousie University, Halifax, Nova Scotia, Canada
Arthritis Rheum 62:1478-86. 2010..This study was undertaken to compare patients with SLE, patients with rheumatoid arthritis (RA), and patients with multiple sclerosis (MS) with healthy controls using the Automated Neuropsychological Assessment Metrics (ANAM)...
Healthcare provider and parent behavior and children's coping and distress at anesthesia inductionJill MacLaren Chorney
Department of Anesthesiology, University of California, Irvine, Orange, CA, USA
Anesthesiology 111:1290-6. 2009..To date, no study has evaluated the impact of specific healthcare provider and parent behaviors on children's distress and coping during anesthesia induction...
Demystifying neuropsychiatric lupus--is it possible?John G Hanly
Division of Rheumatology, Department of Medicine and Department of Pathology, Capital Health and Dalhousie University, Halifax, Nova Scotia, Canada
Bull NYU Hosp Jt Dis 67:276-80. 2009..Although much work remains to be done on this complex and fascinating aspect of lupus, there is an emerging consensus on the pathogenesis and treatment of NP-SLE...
Multicentric outcome analysis of sirolimus-based immunosuppression in 252 liver transplant recipientsMichele Molinari
Department of Surgery, Dalhousie University Medical Center, Halifax, NS, Canada
Transpl Int 23:155-68. 2010..Bone marrow and renal functions were similar in both the groups. Our findings would suggest that SRL is safe and effective for very selected OLT recipients. Randomized controlled trials are necessary to confirm our results...
Bridging the gap: knowledge seeking and sharing in a virtual community of emergency practiceJanet A Curran
IWK Health Centre, Nova Scotia, Canada
Eval Health Prof 32:312-25. 2009..The results provide direction for design of a virtual community of practice, which may reduce current knowledge resource disparities...
Hepatic resection versus radiofrequency ablation for hepatocellular carcinoma in cirrhotic individuals not candidates for liver transplantation: a Markov model decision analysisMichele Molinari
Department of Surgery, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Rm 6 254 Victoria Building, Victoria General Hospital, Halifax, NS, Canada
Am J Surg 198:396-406. 2009..A small randomized controlled trial confirmed these findings, although underpowered to detect a significant difference at 5-year interval...
Becoming a nurse: a meta-study of early professional socialization and career choice in nursingSheri L Price
Women s Health, IWK Health Centre, Halifax, Nova Scotia, Canada
J Adv Nurs 65:11-9. 2009..This paper is a report of a meta-study of early professional socialization and career choice in nursing...
Healthcare managers' decision making: findings of a small scale exploratory studyJackie MacDonald
Department of Information Studies, University of Sheffield, Sheffield, UK
Health Informatics J 14:247-58. 2008..Most considered organizational knowledge in the first two decision phases and external knowledge, including research, in the third phase. All participants engaged in satisficing to some degree...
Subjective quality of life in psychiatric patients: diagnosis and illness-specific profilesEva Goppoldova
Maritime Psychiatry, IWK Health Centre, Halifax, Nova Scotia
Can J Psychiatry 53:587-93. 2008..This is the first study of psychiatric diagnosis and illness stage specific profiles of subjective quality of life (SQOL) impairment...
Chronic kidney disease in the context of cardiovascular disease: a brief overviewNatalie Nichols
Queen Elizabeth II Health Sciences Centre, Halifax, Canada
Can J Cardiovasc Nurs 18:6-11. 2008
Can epidemiological studies assist in the evaluation of community treatment orders? - The experience of Western Australia and Nova ScotiaStephen Kisely
Departments of Community Health and Epidemiology and Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
Int J Law Psychiatry 29:507-15. 2006..Western Australia with controls drawn from both within the jurisdiction and from another without this measure (Nova Scotia)...
Body-surface potential mapping to aid ablation of scar-related ventricular tachycardiaJohn L Sapp
Faculty of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada B3H 3A7
J Electrocardiol 39:S87-95. 2006....
Massive intracavitary clot formation during cardiopulmonary bypassJean Francois Legare
Dalhousie University, Department of Surgery, Halifax, Nova Scotia
Can J Cardiol 20:825-6. 2004..The clinical scenario is described in detail and potential explanations and relevance are discussed...
Maximizing the clinical outcome with mTOR inhibitors in the renal transplant recipient: defining the role of calcineurin inhibitorsBjorn Nashan
Multi Organ Transplant Program, QEII Health Sciences Centre, Dalhousie University, VG Site, 1278 Tower Road 6S 202 Victoria Building, B3H 2Y9, Halifax, Nova Scotia, Canada
Transpl Int 17:279-85. 2004....
Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregiversEva Grunfeld
Ottawa Regional Cancer Centre and Division of Medical Oncology, University of Ottawa, and Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa Hospital, ON
CMAJ 170:1795-801. 2004..We prospectively examined the psychosocial, occupational and economic impact of caring for a person with a terminal illness...
Impact of compulsory community treatment on admission rates: survival analysis using linked mental health and offender databasesStephen R Kisely
University Department of Psychiatry at Fremantle Hospital, University of Western Australia, Australia
Br J Psychiatry 184:432-8. 2004..There is controversy as to whether compulsory community treatment for psychiatric patients reduces hospital admission rates...
Considerations and costs of disclosing study findings to research participantsConrad V Fernandez
Division of Pediatric Hematology and Oncology, Department of Pediatrics, IWK Health Centre Halifax, Nova Scotia
CMAJ 170:1417-9. 2004
Elapsed time from breast cancer detection to first adjuvant therapy in a Canadian province, 1999-2000Daniel Rayson
Division of Medical Oncology, Queen Elizabeth II Health Sciences Centre, Halifax, NS
CMAJ 170:957-61. 2004..or mammographic detection of breast abnormality to initiation of first adjuvant therapy in women with invasive breast cancer in Nova Scotia and to examine the effect of age, disease stage and place of residence on these intervals.
Evolution of interprofessional learning: Dalhousie University's "From Family Violence to Health" moduleGrace M Johnston
School of Health Services, Administration, Dalhousie University, Halifax, Nova Scotia, Canada
J Can Dent Assoc 69:658. 2003..Feedback from practitioners on the development of IP education is welcomed, particularly with regard to the IP module addressing family violence...
Case of acute lymphoblastic leukemia presenting with t(14;18)/BCL2, t(8;14)/cMYC, and t(1;2)/FCGR2BWenda L Greer
Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Am J Hematol 74:112-8. 2003..This report reiterates the poor prognosis associated with activation of cMYC together with elevated Bcl-2 expression. These data also support recent evidence that dysregulation of FCGR2B may play a role in tumor progression...
Metabolite changes resulting from treatment in children with ADHD: a 1H-MRS studyNormand Carrey
Maritime Psychiatry, IWK Health Centre, 5850 University Avenue, Halifax, Nova Scotia, Canada B3J 3G9
Clin Neuropharmacol 26:218-21. 2003..No other metabolites demonstrated any change in response to medication. These findings suggest that glutamate may be involved in treatment response in attention deficit hyperactivity disorder, especially in the striatum...
Knowledge and attitudes of pregnant women with regard to collection, testing and banking of cord blood stem cellsConrad V Fernandez
Department of Pediatrics, Dalhousie University, Halifax, NS
CMAJ 168:695-8. 2003..We sought to examine pregnant women's knowledge and attitudes regarding cord blood banking, as their support is crucial to the success of cord blood transplant programs...
The effect of recalling paracetamol on hospital admissions for poisoning in Western AustraliaStephen R Kisely
University Department of Psychiatry at Fremantle Hospital, University of Western Australia, Fremantle, WA
Med J Aust 178:72-4. 2003..To assess the effect of two recalls of paracetamol products on rates of intentional and unintentional overdoses of paracetamol in all age groups, as well as any effect on poisoning by other agents...
Neuromotor dysfunction in early psychosisDavid Whitehorn
Nova Scotia Early Psychosis Program, Dartmouth, Canada
Ann Clin Psychiatry 14:113-21. 2002..Atypical antipsychotic agents can alleviate psychosis without inducing EPSS. Preexisting EPSS may be corrected...
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-upAdam M Huber
IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
J Pediatr 141:198-203. 2002..To determine the clinical outcomes of children with chronic recurrent multifocal osteomyelitis (CRMO)...
Clinical practice guidelines for the management of dyslipidemiaNatalie Nichols
Can J Cardiovasc Nurs 14:7-10. 2004..Dietary and lifestyle interventions will be discussed in addition to pharmacotherapy as management strategies for achieving therapeutic lipid targets...
The use of clinical practice guidelines for community-acquired pneumonia in hospitals in Atlantic CanadaSamuel G Campbell
Department of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia
Can Respir J 11:301-3. 2004..The extent of adoption of CPGs in Canada is unclear...
Better knowledge translation for effective cancer control: a priority for actionEva Grunfeld
Cancer Care Nova Scotia, Dalhousie University, 1278 Tower Road, Halifax, Nova Scotia, Canada B3H 2Y9
Cancer Causes Control 15:503-10. 2004..Adding a knowledge translation component to national cancer control programs can help ensure that even small efforts directed at cancer control can have maximum impact...
Determinants of perinatal mortality and serious neonatal morbidity in the second twinB Anthony Armson
Department of Obstetrics and Gynaecology and the Perinatal Epidemiology Research Unit, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Obstet Gynecol 108:556-64. 2006..To identify potential determinants of perinatal mortality and neonatal morbidity among second twins relative to first twins...
Two successive outbreaks of mumps in Nova Scotia among vaccinated adolescents and young adultsGaynor Watson-Creed
The Nova Scotia Department of Health Promotion and Protection, Halifax, NS
CMAJ 175:483-8. 2006..Although rare in Canada, outbreaks have recently occurred throughout the world, including a large outbreak in the United Kingdom, where more than 56,000 cases were reported in 2004-2005...
Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosusJohn G Hanly
Division of Rheumatology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
J Rheumatol 33:1553-8. 2006..To determine the prevalence of circulating anti-NR2 antibodies and their association with neuropsychiatric systemic lupus erythematosus (NP-SLE), particularly cognitive function, in women with SLE...
A female advantage in the serial production of non-representational learned gesturesKaren Chipman
Department of Psychology, University of Western Ontario, Ont, Canada
Neuropsychologia 44:2315-29. 2006..They are consistent with emerging evidence of a sex difference in the anatomical organization of the praxis system...
Pediatric kidney stones: long-term outcomesRobert D Schwarz
IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Urology 67:812-6. 2006..To determine the specific risks for recurrent stone disease and which initial evaluations resulted in an effective reduction of risk, we undertook a long-term follow-up study of children who had experienced upper tract urinary stones...
Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factorsA E Warren
Division of Pediatric Cardiology, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Heart 92:1496-500. 2006..To describe the incidence and rate of dilatation of the ascending aorta in children with bicuspid aortic valve (BAV) and to determine factors that predict rapid aortic dilatation...
Randomized trial of long-term follow-up for early-stage breast cancer: a comparison of family physician versus specialist careEva Grunfeld
Cancer Outcomes Research Program, Cancer Care Nova Scotia and Dalhousie University, Halifax, Nova Scotia
J Clin Oncol 24:848-55. 2006..It is usual practice for routine follow-up to take place in specialist clinics. This study tested the hypothesis that follow-up by the patient's family physician is a safe and acceptable alternative to specialist follow-up...
Celiac disease: evaluation of the diagnosis and dietary compliance in Canadian childrenMohsin Rashid
Division of Gastroenterology and Nutrition, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
Pediatrics 116:e754-9. 2005..We sought to characterize the clinical features at presentation as well as the associated disorders, family history, and evaluation of compliance with a gluten-free diet in children with celiac disease from across Canada...
Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic modelBassam A Nassar
Department of Pathology, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada B3H 4H7
Clin Biochem 39:109-14. 2006....
Transmission of hepatitis C virus to several organ and tissue recipients from an antibody-negative donorBarna D Tugwell
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Ann Intern Med 143:648-54. 2005..A patient developed acute hepatitis C shortly after tissue transplantation. Ninety-one tissues or organs had been recovered from the donor...
Agreement between emergency physician diagnosis and radiologist reports in patients discharged from an emergency department with community-acquired pneumoniaSamuel G Campbell
Department of Emergency Medicine, Queen Elizabeth II Health Sciences Centre, Dalhousie University, 1796 Summer Street, Halifax, Nova Scotia, Canada
Emerg Radiol 11:242-6. 2005..1%) were read as normal. EPs and radiologists frequently disagree on whether a patient has pneumonia or not. Perhaps it is time to revisit the gold standard status of plain chest X-ray...
An international study of the effect of physical ill health on psychiatric recovery in primary careStephen Kisely
Department of Psychiatry, Community Health and Epidemiology, Dalhousie University, Centre for Clinical Research, Halifax, Canada
Psychosom Med 67:116-22. 2005..The aim of this study was to determine the association between physical morbidity and recovery from psychiatric illness in primary care...
Residential mobility during pregnancyDeshayne B Fell
Perinatal Epidemiology Research Unit, Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia B3K 6R8, Canada
Paediatr Perinat Epidemiol 18:408-14. 2004..The potential for differential exposure misclassification should be considered should any of the risk factors for moving identified by this study also be risk factors for the outcome under study...
Histologic examination of "fascia" used in colporrhaphyS A Farrell
Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Nova Scotia, Canada
Obstet Gynecol 98:794-8. 2001..To perform a histologic examination of tissue identified as fascia and used during colporrhaphy...
