Research Topics
| Brian M RossSummaryAffiliation: Northern Ontario School of Medicine Country: Canada Publications
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Detail Information
Publications
Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humansBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
BMC Psychiatry 8:S2. 2008..Schizophrenia patients were chosen because of evidence of increased free radical-mediated damage and cerebral lipid peroxidation in this disorder...- A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidationBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
BMC Psychiatry 8:S4. 2008..The aim was to carry out the first study of the relationship of smoking in humans to the level of n-3 lipid peroxidation indexed by the level of ethane in exhaled breath... - Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?Brian M Ross
Northern Ontario School of Medicine, Public Health Program, and Department of Chemistry, Lakehead University, Thunder Bay, Ontario, Canada
Lipids Health Dis 6:21. 2007..We have critically reviewed the double blind placebo controlled clinical trials published prior to April 2007 to determine whether omega-3 PUFA are likely to be efficacious in these disorders... 
Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolismBrian M Ross
Division of Medical Sciences, Northern Ontario School of Medicine and Department of Chemistry and Public Health Program, Lakehead University, Room MS 3002, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
Med Hypotheses 68:515-24. 2007....- Serum calcium-independent phospholipase A2 activity in bipolar affective disorderBrian M Ross
Northern Ontario School of Medicine, Lakehead University, Thunder Bay, ON, Canada
Bipolar Disord 8:265-70. 2006..In this study we determined whether a similar change takes place in patients with bipolar disorder with and without a history of psychosis... - Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometryBrian M Ross
Northern Ontario School of Medicine, Departments of Biology and Chemistry, and the Public Health Program, Lakehead University, Thunder Bay, Ontario, Canada
BMC Res Notes 1:41. 2008..Recent developments in the design of SIFT-MS instruments have increased the ion precursor count rates. It is, however, unclear as to how these advances will affect instrument sensitivity for breath analysis... - Stability of methylnicotinate in aqueous solution as utilized in the 'niacin patch test'Brian M Ross
Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada
BMC Res Notes 1:89. 2008..To aid in the determination of how long solutions of the drug should be stored before discarding we have used a collection of aged batches of methylnicotinate to determine the stability of the drug in aqueous solution... 
The analysis of oral air using selected ion flow tube mass spectrometry in persons with and without a history of oral malodourB M Ross
Northern Ontario School of Medicine, Thunder Bay, ON, Canada
Int J Dent Hyg 7:136-43. 2009....- Omega-3 polyunsaturated fatty acids and anxiety disordersBrian M Ross
Division of Medical Sciences, Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay, 955 Oliver Road, Ontario, Canada P7B5E1
Prostaglandins Leukot Essent Fatty Acids 81:309-12. 2009..Given the excellent side effect profile of omega-3 PUFA as well as their strong theoretical rationale, such future trials appear justified... - The use of selected ion flow tube mass spectrometry to detect and quantify polyamines in headspace gas and oral airBrian M Ross
Division of Medical Science, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada
Rapid Commun Mass Spectrom 23:3973-82. 2009..SIFT-MS therefore appears to be a practical means of measuring vapour-phase polyamine levels, having applications in biology, medicine and dentistry, and food science... - The combined use of thermal desorption and selected ion flow tube mass spectrometry for the quantification of xylene and toluene in airBrian M Ross
Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1
Rapid Commun Mass Spectrom 21:3608-12. 2007.... - Increased breath ethane levels in medicated patients with schizophrenia and bipolar disorder are unrelated to erythrocyte omega-3 fatty acid abundanceBrian M Ross
Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada
Prog Neuropsychopharmacol Biol Psychiatry 35:446-53. 2011..As such, breath hydrocarbon analysis may represent a simple, non-invasive means to monitor the metabolic processes occurring in these disorders... - Changes in oral trace gas concentrations following orthognathic surgery and intermaxillary fixation: a case study using selected ion flow tube mass spectrometryBrian M Ross
Division of Medical Sciences at the Northern Ontario School of Medicine in Thunder Bay, Ontario, MS 3002, Canada
Int J Oral Sci 3:160-4. 2011..This single case also suggests that the use of elastic ties and effective oral hygiene techniques, including the use of chlorhexidine mouthwash, may help ameliorate such post-surgical effects... - A preliminary investigation of exhaled breath from patients with celiac disease using selected ion flow tube mass spectrometryAlexa Hryniuk
Department of Biology, Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, ON P7B 5EI, Canada
J Gastrointestin Liver Dis 19:15-20. 2010..We aimed to determine whether breath analyses could be used to screen for the presence of CD... - Decreased activity of brain phospholipid metabolic enzymes in human users of cocaine and methamphetamineBrian M Ross
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont, Canada M5T 1R8
Drug Alcohol Depend 67:73-9. 2002..Decreased striatal Ca-PLA(2) and/or PCCT activity in cocaine users might also help to explain why CDP choline, which enhances phospholipid synthesis, reduces craving in some users of the drug cocaine... - Phospholipid and eicosanoid signaling disturbances in schizophreniaBrian M Ross
Ness Foundation, UNI Millennium Institute, Ness House, Dochgarroch, IV3 8GY, Inverness, Scotland, UK
Prostaglandins Leukot Essent Fatty Acids 69:407-12. 2003..It is suggested that intervention aimed at increasing the activity of PLA2-dependent signaling systems may be therapeutically useful in the treatment of the illness... - Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetryBrian M Ross
Ness Foundation, UHI Millennium Institute, Ness House, Dochfour Business Centre, Dochgarroch, Inverness, IV3 8GY, UK
Eur Neuropsychopharmacol 14:191-7. 2004..In conclusion, reduced methyl nicotinate response in schizophrenia has been demonstrated using an objective measure of vasodilation. Our data further support the potential utility of this measure as a diagnostic marker for schizophrenia... - The investigation of cytosolic phospholipase A2 using ELISADonald J Macdonald
Department of Biochemistry, Victoria Infirmary, Glasgow G42 9TY, Scotland, UK
Prostaglandins Leukot Essent Fatty Acids 70:377-81. 2004..When the cells are washed, the concentration of cPLA(2) in the red cell, as measured by ELISA, significantly increases. We advise against washing the red cell in any study that involves measuring cPLA(2) by ELISA... - Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorderBrian M Ross
Ness Foundation, UHI Millennium Institute, Ness House, Dochfour Business Centre, Inverness, Dochgarroch IV3 8GY, UK
J Affect Disord 82:285-90. 2004..To investigate whether abnormalities in this signalling system may occur in depressive illness, we undertook a study of methylnicotinate response in unipolar depression (UD)... - Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorderBrian M Ross
Ness Foundation, UHI Millennium Institute, Ness House, Dochfour Business Centre, Inverness IV3 8GY, Scotland, UK
Nutr Neurosci 6:277-81. 2003..Larger studies of ADHD using this non-invasive assessment of oxidative stress appear warranted... - On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosisRoderick Maclean
New Craigs Hospital, Highland Primary Care NHS Trust, Inverness, UK
Prog Neuropsychopharmacol Biol Psychiatry 27:927-33. 2003..The methylnicotinate insensitivity in schizophrenia, however, is likely to be due to a deficiency in the fatty acid precursors required for the vasodilatory reaction... - Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cellsOluwakemi Obajimi
Scottish Association for Marine Science, Dunstaffnage Marine Laboratory, Oban, Scotland
Pharmacol Res 52:183-91. 2005.... - Cyclooxygenase inhibitor modulation of dopamine-related behavioursBrian M Ross
Highland Psychiatric Research Foundation, UHI Millennium Institute, The Greenhouse, Beechwood Business Park North, Inverness, Scotland IV2 3ED, UK
Eur J Pharmacol 450:141-51. 2002..Their apparent ability to antagonise hypoactivity without generalised dopaminergic stimulation suggests that other, possibly multiple, neurotransmitter systems may be involved... - Antioxidant modulation of oxidant-stimulated uptake and release of arachidonic acid in eicosapentaenoic acid-supplemented human lymphoma U937 cellsOluwakemi Obajimi
Scottish Association for Marine Science, Dunstaffnage Marine Laboratory, Oban, Scotland
Prostaglandins Leukot Essent Fatty Acids 76:65-71. 2007..Our data suggest that antioxidants are not equally effective in combating the effects of oxidative stress upon membrane phospholipid turnover, and that optimal protection will require mixtures of antioxidants...