S Nattel

Summary

Country: Canada

Publications

  1. ncbi Ionic remodeling in the heart: pathophysiological significance and new therapeutic opportunities for atrial fibrillation
    S Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Circ Res 87:440-7. 2000
  2. ncbi Basic mechanisms of atrial fibrillation--very new insights into very old ideas
    S Nattel
    Research Center, Montreal Heart Institute, Quebec, Canada
    Annu Rev Physiol 62:51-77. 2000
  3. ncbi New ideas about atrial fibrillation 50 years on
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute Research Center, Quebec, Canada
    Nature 415:219-26. 2002
  4. ncbi Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling
    R J Ramirez
    Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8
    Am J Physiol Heart Circ Physiol 279:H1767-85. 2000
  5. ncbi Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street E, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 54:347-60. 2002
  6. ncbi Basic electrophysiology of the pulmonary veins and their role in atrial fibrillation: precipitators, perpetuators, and perplexers
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    J Cardiovasc Electrophysiol 14:1372-5. 2003
  7. ncbi New approaches to atrial fibrillation management: a critical review of a rapidly evolving field
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Drugs 62:2377-97. 2002
  8. ncbi Atrial electrophysiology and mechanisms of atrial fibrillation
    Stanley Nattel
    Research Center, Montreal Heart Institute, Montreal, Canada
    J Cardiovasc Pharmacol Ther 8:S5-11. 2003
  9. pmc Rhythm versus rate control for atrial fibrillation management: what recent randomized clinical trials allow us to affirm
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, Universite de Montreal, QC
    CMAJ 168:572-3. 2003
  10. ncbi Arrhythmogenic ionic remodeling: adaptive responses with maladaptive consequences
    S Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Trends Cardiovasc Med 11:295-301. 2001

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi Ionic remodeling in the heart: pathophysiological significance and new therapeutic opportunities for atrial fibrillation
    S Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Circ Res 87:440-7. 2000
    ....
  2. ncbi Basic mechanisms of atrial fibrillation--very new insights into very old ideas
    S Nattel
    Research Center, Montreal Heart Institute, Quebec, Canada
    Annu Rev Physiol 62:51-77. 2000
    ..Improvements in the clinical management of AF will inevitably follow the recent advances in our understanding of its detailed pathophysiology...
  3. ncbi New ideas about atrial fibrillation 50 years on
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute Research Center, Quebec, Canada
    Nature 415:219-26. 2002
    ..For over 50 years, the prevailing model of atrial fibrillation involved multiple simultaneous re-entrant waves, but in light of new discoveries this hypothesis is now undergoing re-evaluation...
  4. ncbi Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling
    R J Ramirez
    Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8
    Am J Physiol Heart Circ Physiol 279:H1767-85. 2000
    ..We conclude that this ionic model of the canine atrial AP agrees well with experimental measurements and gives potential insights into mechanisms underlying functionally important electrophysiological phenomena in canine atrium...
  5. ncbi Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street E, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 54:347-60. 2002
    ..The present paper reviews what is known about the mechanistic substrates that lead to AF and discusses the potential therapeutic consequences...
  6. ncbi Basic electrophysiology of the pulmonary veins and their role in atrial fibrillation: precipitators, perpetuators, and perplexers
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    J Cardiovasc Electrophysiol 14:1372-5. 2003
  7. ncbi New approaches to atrial fibrillation management: a critical review of a rapidly evolving field
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Drugs 62:2377-97. 2002
    ..In conclusion, significant advances are being made in the management of patients with AF but much more work remains to be done...
  8. ncbi Atrial electrophysiology and mechanisms of atrial fibrillation
    Stanley Nattel
    Research Center, Montreal Heart Institute, Montreal, Canada
    J Cardiovasc Pharmacol Ther 8:S5-11. 2003
    ..It is hoped that this improved mechanistic understanding will lead to the development of improved therapeutic options...
  9. pmc Rhythm versus rate control for atrial fibrillation management: what recent randomized clinical trials allow us to affirm
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, Universite de Montreal, QC
    CMAJ 168:572-3. 2003
  10. ncbi Arrhythmogenic ionic remodeling: adaptive responses with maladaptive consequences
    S Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Trends Cardiovasc Med 11:295-301. 2001
    ..An improved understanding of the mechanisms and consequences of arrhythmogenic ionic remodeling promises to lead to novel and improved therapeutic approaches...
  11. ncbi Dose-dependence of 4-aminopyridine plasma concentrations and electrophysiological effects in dogs : potential relevance to ionic mechanisms in vivo
    S Nattel
    Research Center and Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 101:1179-84. 2000
    ....
  12. ncbi Cardiac ultrarapid delayed rectifiers: a novel potassium current family o f functional similarity and molecular diversity
    S Nattel
    Montreal Heart Institute, Montreal, Quebec, Canada
    Cell Physiol Biochem 9:217-26. 1999
    ..The present article reviews the distribution, biophysical and pharmacological properties, molecular basis and functional role of I(Kur), as well as the potential value of I(Kur) as a target for new antiarrhythmic drug development...
  13. ncbi Cost evaluation of rhythm control methods for atrial fibrillation: evidence from CTAF
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Canada
    Card Electrophysiol Rev 7:211-4. 2003
    ....
  14. ncbi Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
    Tae Joon Cha
    5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
    Circulation 109:412-8. 2004
    ..The relative importance of ionic versus structural remodeling in CHF-related atrial fibrillation (AF) is controversial...
  15. ncbi The molecular and ionic specificity of antiarrhythmic drug actions
    S Nattel
    Research Center and Department of Medicine, Montreal Heart Institute, University of Montreal, Quebec, Canada
    J Cardiovasc Electrophysiol 10:272-82. 1999
    ....
  16. ncbi Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation
    S Nattel
    Research Center, Montreal Heart Institute, Quebec, Canada
    Cardiovasc Res 42:298-308. 1999
    ..The present paper reviews the state of knowledge regarding the mechanisms and clinical consequences for AF of atrial remodeling caused by rapid atrial activation...
  17. ncbi Electrophysiologic remodeling: are ion channels static players or dynamic movers?
    S Nattel
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Quebec, Canada
    J Cardiovasc Electrophysiol 10:1553-6. 1999
    ..We are only beginning to appreciate the nature and importance of these fundamental mechanisms, which undoubtedly will provide major clues to the understanding and treatment of cardiac disease and arrhythmias over the next 5 to 10 years...
  18. ncbi Mechanisms of termination of atrial fibrillation by Class I antiarrhythmic drugs: evidence from clinical, experimental, and mathematical modeling studies
    Stanley Nattel
    Department of Medicine and Research Center, University of Montreal, Montreal, Canada
    J Cardiovasc Electrophysiol 14:S133-9. 2003
    ..A better understanding of the ways in which Na+ channel blockers affect AF will be useful, not only for new antiarrhythmic drug development but also for gaining insight into the mechanisms of the arrhythmia...
  19. ncbi Potential ionic mechanism for repolarization differences between canine right and left atrium
    D Li
    Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circ Res 88:1168-75. 2001
    ..The larger LA I(Kr) may participate in the ability of the LA to act as a "driver region" for AF, with potentially important implications for understanding AF mechanisms and antiarrhythmic therapy...
  20. pmc Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes
    Y H Yeh
    Department of Medicine, Université de Montréal and Research Center, Montreal Heart Institute, Quebec, Canada
    Br J Pharmacol 152:1021-32. 2007
    ..This study investigated AT-induced remodelling of mAChR subtypes and K+-currents in left-atrial (LA) and PV cardiomyocytes...
  21. ncbi Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation
    R Gaspo
    Department of Medicine, Montreal Heart Institute, Quebec, Canada
    Cardiovasc Res 42:434-42. 1999
    ..The present study was designed to determine whether atrial tachycardia alters biochemical indices of the number of L-type Ca2+ channels and/or of the number and binding affinity of beta-adrenergic receptors...
  22. ncbi Ionic remodeling of cardiac Purkinje cells by congestive heart failure
    W Han
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 104:2095-100. 2001
    ..These results have important potential implications regarding ventricular arrhythmogenesis, particularly related to triggered activity in PCs, in patients with CHF...
  23. ncbi Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation
    L Yue
    Department of Pharmacology and Therapeutics, McGill University, Quebec, Canada
    Circ Res 84:776-84. 1999
    ..These observations provide a potential molecular basis for the self-perpetuating nature of AF...
  24. ncbi Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current
    H Wang
    Department of Medicine and Research Center, Montreal Heart Institute, University of Montreal, Quebec, Canada
    Circulation 102:1165-71. 2000
    ..Nicotine is a main constituent of cigarette smoke and smokeless tobacco, known to increase the risk of sudden cardiac death. This study aimed at establishing ionic mechanisms underlying potential electrophysiological effects of nicotine...
  25. pmc Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium
    L Yue
    Research Center and Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    J Physiol 527:467-78. 2000
    ..1 protein in canine ventricle. We conclude that the Shaw-type channel dKv3.1 is present in dog atrium, but not ventricle, and is the likely molecular basis of canine atrial IKur,d...
  26. ncbi Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs
    S Fareh
    Department of Medicine, University of Montreal, Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, H1T 1C8, Quebec, Canada
    Cardiovasc Res 49:762-70. 2001
    ..These findings are potentially important for understanding the mechanisms and prevention of clinically-relevant atrial-tachycardia-induced remodeling...
  27. ncbi Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model
    M Courtemanche
    Research Center, Montreal Heart Institute, QC, Canada
    Cardiovasc Res 42:477-89. 1999
    ..Direct evaluation of the results of ion channel depression is limited by the nonspecificity of the available pharmacological probes...
  28. ncbi Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators
    D Roy
    Montreal Heart Institute, QC, Canada
    N Engl J Med 342:913-20. 2000
    ..Uncontrolled studies have suggested that amiodarone in low doses may be more effective and safer than other agents in preventing recurrence, but this agent has not been tested in a large, randomized trial...
  29. ncbi The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF
    K Derakhchan
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 50:75-84. 2001
    ....
  30. ncbi Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells
    W Han
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Am J Physiol Heart Circ Physiol 280:H1075-80. 2001
    ..I(Ks) may therefore provide an important "braking" function to limit PC APD prolongation in the presence of beta-adrenergic stimulation...
  31. ncbi Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium
    Peter Melnyk
    Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 65:104-16. 2005
    ..Pulmonary veins have different ionic current properties compared to left atrium, with pulmonary vein inward-rectifier currents being smaller and delayed-rectifier currents larger than in left atrium...
  32. ncbi Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs
    A Benardeau
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 50:85-96. 2001
    ..There is also a clinical suggestion that acute L-type Ca(2) channel blockade can promote AF, consistent with an AF promoting effect of Ca(2+) channel inhibition...
  33. ncbi Phospholipid metabolite 1-palmitoyl-lysophosphatidylcholine enhances human ether-a-go-go-related gene (HERG) K(+) channel function
    J Wang
    Research Center, Montreal Heart Institute, Montreal, Canada
    Circulation 104:2645-8. 2001
    ..An increase in I(HERG) by Pal-LPC may contribute to K(+) loss, abnormal electrophysiology, and arrhythmia occurrence in the ischemic heart...
  34. ncbi Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 110:1520-6. 2004
    ..The in vivo effects of atrial tachycardia (AT) remodeling are altered by CHF. This study evaluated underlying mechanisms at the level of ionic remodeling...
  35. ncbi Method for simultaneous epicardial and endocardial mapping of in vivo canine heart: application to atrial conduction properties and arrhythmia mechanisms
    K Derakhchan
    Research Center, University of Montreal, Quebec, Canada
    J Cardiovasc Electrophysiol 12:548-55. 2001
    ..It has been suggested that the three-dimensional structure of the atria may be crucial in arrhythmogenesis; however, previous in vivo atrial activation mapping studies have been limited to either endocardial or epicardial approaches...
  36. ncbi Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation
    Y Shi
    Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Cardiovasc Res 52:217-25. 2001
    ..Whereas in ATR, electrophysiological remodeling is of prime importance in AF promotion, structural remodeling (as reflected in changes in atrial size and contraction) appears much more important in HF-induced AF...
  37. doi Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Arrhythm Electrophysiol 1:93-102. 2008
    ..Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate...
  38. pmc Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties
    Joachim R Ehrlich
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Physiol 551:801-13. 2003
    ....
  39. ncbi Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure
    D Li
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 104:2608-14. 2001
    ..ACE inhibition interferes with signal transduction leading to the AF substrate in CHF and may represent a useful new component to AF therapy...
  40. ncbi Rhythm control versus rate control for atrial fibrillation and heart failure
    Denis Roy
    Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
    N Engl J Med 358:2667-77. 2008
    ..However, the benefits and risks of this approach have not been adequately studied...
  41. ncbi Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone
    Kaori Shinagawa
    Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 107:1440-6. 2003
    ..The basis of the unique effectiveness of amiodarone for atrial fibrillation (AF) is poorly understood. The present study tested the hypothesis that amiodarone blocks electrical remodeling induced by atrial tachycardia...
  42. pmc Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium
    Joachim R Ehrlich
    Department of Medicine, University of Montral, Montreal, Quebec, Canada
    J Physiol 557:583-97. 2004
    ..8 +/- 0.3 to -4.5 +/- 0.5 pA pF(-1), P < 0.01). We conclude that I(KH) is a time-dependent, hyperpolarization-activated K(+) current that likely involves Kir3 subunits and appears to play a significant role in atrial physiology...
  43. ncbi Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle
    Z Wang
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 98:2422-8. 1998
    ..The present study was designed to define the relative levels of mRNA for various IRKs in human atrium and in failing and nonfailing ventricle...
  44. ncbi Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes
    H Sun
    Research Center and Department of Medicine, Montreal Heart Institute, Departments of Medicine and Physiology, University of Montreal, and Department of Pharmacology, McGill University, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Cardiovasc Res 49:751-61. 2001
    ..These findings are the first direct evidence for the frequently-postulated role of Ca(2+)-overload in tachycardia-induced abnormalities of atrial function...
  45. ncbi Amiodarone reduces procedures and costs related to atrial fibrillation in a controlled clinical trial
    G B Lumer
    Research Center, Montreal, Quebec, Canada
    Eur Heart J 23:1050-6. 2002
    ..The impact of various treatment options for atrial fibrillation on hospital costs has not been evaluated in a randomized trial...
  46. ncbi Sinus node dysfunction and sudden cardiac death following treatment with encainide
    R Lemery
    Department of Medicine, Montreal Heart Institute, Quebec, Canada
    Pacing Clin Electrophysiol 12:1607-12. 1989
    ..During a 6-month follow-up without antiarrhythmic drug treatment, this patient has had an uneventful course. We concluded that encainide can cause severe and life-threatening sinus node dysfunction...
  47. ncbi Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles
    Ling Xiao
    Department of Pharmacology and Therapeutics, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H570-80. 2006
    ..3 +/- 0.3 pA/pF; endocarium: -4.5 +/- 0.4 vs. -3.2 +/- 0.3 pA/pF; P < 0.05 for each). We conclude that there are sex-based transmural differences in ionic currents that may underlie sex differences in transmural cardiac repolarization...
  48. ncbi Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    Circulation 115:310-8. 2007
    ....
  49. ncbi Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes
    Pierre Coutu
    Research Center, Montreal Heart Institute, 5000 Belanger St East, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H2290-300. 2006
    ....
  50. doi Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
    Reza Wakili
    Department of Medicine and Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 3:530-41. 2010
    ..Action potential (AP)-prolonging drugs are reported to normalize atrial hypocontractility caused by atrial tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility...
  51. ncbi Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 111:728-35. 2005
    ..The relative importance of AT remodeling in PVs versus other atrial sites is unknown. The present study assessed AT-induced cellular changes in PVs versus left atrium (LA) and their relationship to arrhythmogenesis...
  52. ncbi Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentry
    P Comtois
    Department of Pharmacology and Therapeutics, McGill University, McIntyre Medical Sciences Building 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
    Europace 7:10-20. 2005
    ..The basis of this difference is explored in the context of the fundamental properties of the models...
  53. ncbi Modulation of flecainide's cardiac sodium channel blocking actions by extracellular sodium: a possible cellular mechanism for the action of sodium salts in flecainide cardiotoxicity
    S Ranger
    Department of Medicine, Montreal Heart Institute, Quebec, Canada
    J Pharmacol Exp Ther 264:1160-7. 1993
    ..Sodium's ability to displace blocking drug from the sodium channel may underlie the efficacy of sodium salts in treating flecainide toxicity, and could play a similar role in antagonizing cardiotoxicity of other class 1 compounds...
  54. ncbi Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure
    Hong Shi
    Research Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Cell Physiol Biochem 14:31-40. 2004
    ....
  55. doi Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
    Yung Hsin Yeh
    Department of Medicine, Montreal Heart Institute Research Center and Université de Montréal, Montreal, Quebec, Canada
    Circulation 119:1576-85. 2009
    ..This study examined the hypothesis that ATs impair SAN function by altering ion channel expression...
  56. doi Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current
    Xiao Yan Qi
    Montreal Heart Institute and Department of Medicine, Université de Montéal, Quebec, Canada
    Circ Res 103:845-54. 2008
    ..These studies elucidate for the first time the molecular feedback mechanisms underlying arrhythmogenic AT remodeling...
  57. ncbi Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada, and First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Cardiovasc Res 74:406-15. 2007
    ..Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood...
  58. ncbi Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium
    Renqiang Zou
    Research Center, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, Canada H1T 1C8
    Am J Physiol Heart Circ Physiol 289:H1002-12. 2005
    ....
  59. ncbi Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure
    Brett Burstein
    Department of Medicine and Physiology Institute of Biomedical Engineering, Research Center Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada
    Circ Res 105:1213-22. 2009
    ..Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention...
  60. ncbi Mechanisms of atrial fibrillation: lessons from animal models
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Prog Cardiovasc Dis 48:9-28. 2005
    ..The complementary nature of animal research and clinical investigation is emphasized and the clinical relevance of findings in experimental models is highlighted...
  61. ncbi Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 69:865-75. 2006
    ..This study evaluated the efficacy of anti-inflammatory and calcineurin-inhibitory drugs on promotion of atrial fibrillation by atrial tachycardia-induced remodeling in dogs...
  62. ncbi Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  63. ncbi Mechanisms of atrial remodeling and clinical relevance
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Curr Opin Cardiol 20:21-5. 2005
    ..This paper reviews recent progress in understanding atrial remodeling, as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment...
  64. ncbi Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties
    James Kneller
    Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Circ Res 90:E73-87. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  65. ncbi Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate
    Kaori Shinagawa
    Department of Medicine, Montreal Heart Institute and University of Montreal, Canada
    Circulation 105:251-7. 2002
    ..This study evaluated the effects of a pathological AF substrate on AT-induced remodeling...
  66. ncbi Identification of atrial tissue in pulmonary veins using intravascular ultrasound
    Peter G Guerra
    Department of Medicine, Montreal Heart Institute
    J Am Soc Echocardiogr 16:982-7. 2003
    ..Ectopic beats initiating AF always originated from these areas. PVs without thickening on IVUS did not have these potentials...
  67. ncbi Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart
    H Wang
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Mol Pharmacol 59:1029-36. 2001
    ....
  68. ncbi Oxidative preconditioning and apoptosis in L-cells. Roles of protein kinase B and mitogen-activated protein kinases
    H Han
    Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 276:26357-64. 2001
    ..We conclude that oxidative preconditioning protects cells against apoptosis and that this effect involves MAPK and PI3K/Akt pathways. This system may be important in regulating apoptotic cell death in development and disease states...
  69. ncbi The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    ..We addressed the importance of altered Ca(2+) handling, studying underlying mechanisms and consequences...
  70. doi Canadian Cardiovascular Society atrial fibrillation guidelines 2010: surgical therapy
    Pierre Page
    Research Center, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 27:67-73. 2011
    ..Thus, surgery should be used primarily as a concomitant procedure during cardiac surgery for other diseased states or as a stand-alone procedure after failure of prior attempts of catheter ablation and antiarrhythmic drugs...
  71. ncbi Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation
    James Kneller
    Department of Medicine, Research Center, Montreal Heart Institute, University of Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 54:416-26. 2002
    ..The present studies were designed to quantify Ca(2+)-handling changes and then to apply a mathematical AP model to assess the contributions of Ca(2+)-handling abnormalities and ICR to loss of APD rate-adaptation...
  72. ncbi Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs
    Kaori Shinagawa
    Department of Medicine, Montreal Heart Institute, and University of Montreal, Montreal, Canada
    Circulation 105:2672-8. 2002
    ..Clinical atrial fibrillation (AF) often results from pathologies that cause atrial structural remodeling. The reversibility of arrhythmogenic structural remodeling on removal of the underlying stimulus has not been studied systematically...
  73. doi Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins
    Tomas Datino
    5000 Belanger St East, Montreal, Quebec H1T 1C8, Canada
    Circulation 121:963-72. 2010
    ..Adenosine acutely reconnects pulmonary veins (PVs) after radiofrequency application, revealing "dormant conduction" and identifying PVs at risk of reconnection, but the underlying mechanisms are unknown...
  74. ncbi Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function
    Gernot Schram
    Department of Medicine, University of Montreal, Research Center, Montreal Heart Institute, Quebec, Canada
    Circ Res 90:939-50. 2002
    ....
  75. ncbi Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Physiol Rev 87:425-56. 2007
    ..We highlight areas of future investigation, as well as important opportunities for improved therapeutic approaches that are being opened by an improved understanding of the mechanisms of arrhythmogenic remodeling...
  76. doi Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia
    Masao Sakabe
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger St E, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 78:63-70. 2008
    ..This study addressed the effects of geranylgeranylacetone (GGA), an orally active HSP inducer, on the atrial fibrillation (AF) substrate associated with acute atrial ischaemia (AI)...
  77. doi Atrial structural remodeling as an antiarrhythmic target
    Brett Burstein
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    J Cardiovasc Pharmacol 52:4-10. 2008
    ..This review will highlight pharmacologic approaches that have shown promise for attenuating structural remodeling to achieve antiarrhythmic efficacy in AF...
  78. doi Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling
    Grigorios Katsouras
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Heart Rhythm 6:1465-72. 2009
    ....
  79. doi Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes
    Ling Xiao
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Res 103:733-42. 2008
    ..We conclude that tachycardia downregulates I to expression, with the Ca2+/calmodulin-dependent CaMKII and calcineurin/NFAT systems playing key Ca2+-sensing and signal-transducing roles in rate-dependent I to control...
  80. pmc Absence of protective effect of renin-angiotensin system inhibitors on atrial fibrillation development: insights from the Canadian Trial of Atrial Fibrillation (CTAF)
    Maryse Palardy
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 24:709-13. 2008
    ....
  81. doi Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats
    Alan Y Deng
    Research Centre, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    J Hypertens 26:1935-43. 2008
    ..Diastolic dysfunction often represents the onset of diastolic heart failure...
  82. doi Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates
    Philippe Comtois
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Am J Physiol Heart Circ Physiol 295:H1489-504. 2008
    ..These results provide new insights into the mechanisms by which rapidly unbinding class I antiarrhythmic agents, a class including several novel compounds of considerable promise, terminate AF...
  83. pmc New insights into the mechanisms and management of atrial fibrillation
    Paul Khairy
    Department of Medicine, Universite de Montreal, Montreal, Que
    CMAJ 167:1012-20. 2002
    ..Finally, we discuss recent insights into the basic mechanisms underlying AF that have potentially significant clinical implications...
  84. ncbi Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model
    Stephen Zicha
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Cardiovasc Res 66:472-81. 2005
    ....
  85. ncbi Time-dependent transients in an ionically based mathematical model of the canine atrial action potential
    James Kneller
    Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Am J Physiol Heart Circ Physiol 282:H1437-51. 2002
    ..The model agrees qualitatively with experimental observations, but quantitative discrepancies highlight limitations of long-term model simulations...
  86. ncbi Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle
    Peter Melnyk
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Am J Physiol Heart Circ Physiol 283:H1123-33. 2002
    ..1 and Kir2.3 subunits differ in the canine atrium versus ventricle. Overall protein density differences are insufficient to explain I(K1) discrepancies, which may be related to differences in subcellular distribution...
  87. ncbi Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure
    Yanfen Shi
    Montreal Heart Institute, Research Center and Department of Medicine, 5000 Belanger Street East, Montreal HlT 1C8 Quebec, Canada
    Cardiovasc Res 54:456-61. 2002
    ..There have been no studies performed to assess the effects of ACE inhibitors on atrial dimensions and emptying function in relationship to vulnerability to AF in the setting of experimental CHF...
  88. ncbi Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy
    Kaori Shinagawa
    Montreal Heart Institute, Research Center, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Pacing Clin Electrophysiol 26:752-64. 2003
    ..Despite great potential value, the development of pharmacological interventions to prevent atrial electrical remodeling is still in its infancy...
  89. ncbi Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP
    M Pourrier
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8
    J Membr Biol 194:141-52. 2003
    ..On the basis of the available information, we attempt to assess the potential involvement of these accessory K(+)-channel subunits in cardiac pathophysiology and in developing new therapeutic approaches...
  90. ncbi Predicting the entrainment of reentrant cardiac waves using phase resetting curves
    Leon Glass
    Centre for Nonlinear Dynamics and Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Phys Rev E Stat Nonlin Soft Matter Phys 65:021908. 2002
    ..The current work may lead to improved approaches to therapy through a better understanding of how typical clinical stimuli interact with abnormal reentrant cardiac rhythms...
  91. ncbi Effects of sustained beta-adrenergic stimulation on ionic currents of cultured adult guinea pig cardiomyocytes
    Li Ming Zhang
    Research Center and Department of Medicine, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Am J Physiol Heart Circ Physiol 282:H880-9. 2002
    ..The direct ionic current remodeling effects of sustained beta-adrenoceptor stimulation resemble changes reported with heart failure and may be important in arrhythmogenic ionic remodeling...
  92. ncbi Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers
    Marc Pourrier
    Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Circ Res 93:189-91. 2003
    ..Thus, the cardiac Purkinje system is a strong candidate to play a role in arrhythmic syndromes due to MiRP1 abnormalities...
  93. ncbi Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling
    Masao Sakabe
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circulation 116:2101-9. 2007
    ..There is epidemiological evidence that omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF), but clinical data are conflicting. The present study assessed the effects of PUFA on AF in experimental models...
  94. ncbi Can losartan prevent new-onset atrial fibrillation in hypertensive patients more effectively than atenolol?
    Stanley Nattel
    Cardiovascular Electrophysiology, University of Montreal and the Montreal Heart Institute, Montreal, Quebec, Canada
    Nat Clin Pract Cardiovasc Med 2:332-3. 2005
  95. ncbi Combined parasympathetic-sympathetic nerve discharge and pulmonary vein afterdepolarizations: a new unifying concept with basic and clinical relevance
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Heart Rhythm 2:632-3. 2005
  96. ncbi Contrasting gene expression profiles in two canine models of atrial fibrillation
    Sophie Cardin
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Res 100:425-33. 2007
    ....
  97. ncbi Atrial fibrillation: basic mechanisms, remodeling and triggers
    Akiko Shiroshita-Takeshita
    Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Interv Card Electrophysiol 13:181-93. 2005
  98. pmc Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts
    Stephen Zicha
    Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    J Physiol 561:735-48. 2004
    ..We conclude that both Kv4.3 and KChIP2 may contribute to epicardial-endocardial gradients in I(to), and that I(to) down-regulation in human and canine CHF appears due primarily to changes in Kv4.3...
  99. ncbi Coronary artery endothelial protection after local delivery of 17beta-estradiol during balloon angioplasty in a porcine model: a potential new pharmacologic approach to improve endothelial function
    B Chandrasekar
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Canada
    J Am Coll Cardiol 38:1570-6. 2001
    ..Since endothelial dysfunction can promote both restenosis and coronary spasm, local 17beta-E administration is a promising new approach to improve long-term results after PTCA...
  100. ncbi Is atrial remodeling a viable target for prevention of atrial fibrillation recurrence?
    Stanley Nattel
    J Cardiovasc Electrophysiol 15:885-6. 2004
  101. ncbi Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
    Nessrine Hanna
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 63:236-44. 2004
    ..Congestive heart failure (CHF) causes arrhythmogenic remodeling in both atria and ventricles, but differences between atrial and ventricular remodeling in CHF have not been well characterized...