N Martin Young

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. doi request reprint Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins
    N Martin Young
    Human Health Therapeutics, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6 Electronic address
    Mol Immunol 56:563-73. 2013
  2. ncbi request reprint Specificity analysis of the C-type lectin from rattlesnake venom, and its selectivity towards Gal- or GalNAc-terminated glycoproteins
    N Martin Young
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    Glycoconj J 28:427-35. 2011
  3. pmc Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii
    N Martin Young
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ont, Canada K1A 0R6
    Glycobiology 21:1266-76. 2011
  4. ncbi request reprint Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori
    Ian C Schoenhofen
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6
    J Biol Chem 281:8907-16. 2006
  5. ncbi request reprint A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni
    Stéphane Bernatchez
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 280:4792-802. 2005
  6. ncbi request reprint Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways
    Ian C Schoenhofen
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada
    J Biol Chem 281:723-32. 2006
  7. ncbi request reprint The cytoplasmic phosphoproteome of the Gram-negative bacterium Campylobacter jejuni: evidence for modification by unidentified protein kinases
    Sebastien Voisin
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
    Proteomics 7:4338-48. 2007
  8. pmc Three-dimensional structure and ligand interactions of the low molecular weight protein tyrosine phosphatase from Campylobacter jejuni
    Dmitri Tolkatchev
    Biomolecular NMR and Protein Research Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 15:2381-94. 2006
  9. doi request reprint Enzymatic synthesis and properties of glycoconjugates with legionaminic acid as a replacement for neuraminic acid
    David C Watson
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Glycobiology 21:99-108. 2011
  10. ncbi request reprint Probing genetic variation and glycoform distribution in lectins of the Erythrina genus by mass spectrometry
    Eric Bonneil
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Arch Biochem Biophys 426:241-9. 2004

Collaborators

Detail Information

Publications13

  1. doi request reprint Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins
    N Martin Young
    Human Health Therapeutics, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6 Electronic address
    Mol Immunol 56:563-73. 2013
    ..We describe the biosynthesis of the ChoP modification, the structures of the pathogen glycans known to carry ChoP groups and the host proteins that recognize ChoP. ..
  2. ncbi request reprint Specificity analysis of the C-type lectin from rattlesnake venom, and its selectivity towards Gal- or GalNAc-terminated glycoproteins
    N Martin Young
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    Glycoconj J 28:427-35. 2011
    ..Thus its ten closely-spaced sites each with a K(D) for GalNAc of ~2 mM appeared to make RSVL more selective than the four more widely-spaced sites of soybean agglutinin, with a ten-fold better K(D) for GalNAc...
  3. pmc Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii
    N Martin Young
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ont, Canada K1A 0R6
    Glycobiology 21:1266-76. 2011
    ..These data show that the structure of the M. morganii polysaccharide contains a unique zwitterionic repeating unit which allows for immune recognition by T-cells, making it the first identified T-cell-dependent O-chain antigen...
  4. ncbi request reprint Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori
    Ian C Schoenhofen
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6
    J Biol Chem 281:8907-16. 2006
    ....
  5. ncbi request reprint A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni
    Stéphane Bernatchez
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 280:4792-802. 2005
    ..These data indicate that Gne is the enzyme providing Gal and GalNAc residues with the synthesis of all three cell-surface carbohydrates in C. jejuni NCTC 11168...
  6. ncbi request reprint Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways
    Ian C Schoenhofen
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada
    J Biol Chem 281:723-32. 2006
    ....
  7. ncbi request reprint The cytoplasmic phosphoproteome of the Gram-negative bacterium Campylobacter jejuni: evidence for modification by unidentified protein kinases
    Sebastien Voisin
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
    Proteomics 7:4338-48. 2007
    ..jejuni phosphoproteins, though their overall phosphoproteome maps were distinctly different...
  8. pmc Three-dimensional structure and ligand interactions of the low molecular weight protein tyrosine phosphatase from Campylobacter jejuni
    Dmitri Tolkatchev
    Biomolecular NMR and Protein Research Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 15:2381-94. 2006
    ..The three-dimensional structure along with mapping of small-molecule binding will be discussed in the context of developing high-affinity inhibitors of this novel LMW-PTP...
  9. doi request reprint Enzymatic synthesis and properties of glycoconjugates with legionaminic acid as a replacement for neuraminic acid
    David C Watson
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Glycobiology 21:99-108. 2011
    ..These results show the feasibility of producing glycoconjugates with Leg5Ac7Ac residues as the terminal sugars, which should display novel biological properties...
  10. ncbi request reprint Probing genetic variation and glycoform distribution in lectins of the Erythrina genus by mass spectrometry
    Eric Bonneil
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Arch Biochem Biophys 426:241-9. 2004
    ..A minor glycan heterogeneity was observed for most lectins examined except for that of ECafL and ECorL where an extra hexose residue was observed on the reducing GlcNAc residue of the heptasaccharide...
  11. ncbi request reprint Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni
    N Martin Young
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 277:42530-9. 2002
    ..Comparison of the pgl locus with that of Neisseria meningitidis suggested that most of the homologous genes are probably involved in the biosynthesis of bacillosamine...
  12. pmc The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)
    Simon J Foote
    Pathogen Genomics Group, Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    J Bacteriol 190:1495-6. 2008
    ..Here we report the finished and annotated genome sequence of the reference serotype 5b strain L20. This strain has a rough appearance and readily forms biofilms, as is typical for most field isolates...
  13. ncbi request reprint Selective detection and identification of sugar nucleotides by CE-electrospray-MS and its application to bacterial metabolomics
    Evelyn C Soo
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada K1K 0H1
    Anal Chem 76:619-26. 2004
    ....