Cai Song

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. ncbi Changes in the immune system in rodent models of depression
    Brian E Leonard
    Department of Pharmacology, National University of Ireland, Galway, Ireland
    Int J Neuropsychopharmacol 5:345-56. 2002
  2. ncbi Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration
    Cai Song
    Neuroscience Division, Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, BC Canada V6T 2A1
    J Lipid Res 45:1112-21. 2004
  3. ncbi Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons
    Aaron Y Lai
    Department of Psychiatry, Neurochemical Research Unit, University of Alberta, Canada
    J Neuroimmunol 175:97-106. 2006
  4. ncbi Omega-3 fatty acid eicosapentaenoic acid. A new treatment for psychiatric and neurodegenerative diseases: a review of clinical investigations
    Cai Song
    University of Prince Edward Island, Department of Biomedical Sciences, AVC, 550 University Avenue, Charlottetown, PE, Canada
    Expert Opin Investig Drugs 16:1627-38. 2007
  5. doi Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment
    C Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Pharmacopsychiatry 42:182-8. 2009
  6. doi Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
    Cai Song
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, and Canada National Research Institute for Nutriscience and Health, Charlottetown, PE, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:760-8. 2011
  7. doi Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment
    Cai Song
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3
    J Neurosci 29:14-22. 2009
  8. ncbi Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats
    Cai Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada C1A 4P3
    J Nutr 138:954-63. 2008
  9. ncbi The olfactory bulbectomised rat as a model of depression
    Cai Song
    Department of Biomedical Science, AVC, University of Prince Edward Island and National Institute of Nutrisciences and Health, Charlottetown, Canada
    Neurosci Biobehav Rev 29:627-47. 2005
  10. ncbi Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion
    Cai Song
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, Charlottetown, PE, Canada
    Neuropsychopharmacology 32:736-44. 2007

Collaborators

Detail Information

Publications20

  1. ncbi Changes in the immune system in rodent models of depression
    Brian E Leonard
    Department of Pharmacology, National University of Ireland, Galway, Ireland
    Int J Neuropsychopharmacol 5:345-56. 2002
    ..The review concludes with a brief account of the various rodent models of depression in which evidence of immune activation as been demonstrated...
  2. ncbi Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration
    Cai Song
    Neuroscience Division, Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, BC Canada V6T 2A1
    J Lipid Res 45:1112-21. 2004
    ..These effects of IL-1 were attenuated by the chronic administration of E-EPA. By contrast, rats fed with the soybean oil diet showed no effect on the changes induced by the IL-1 administration...
  3. ncbi Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons
    Aaron Y Lai
    Department of Psychiatry, Neurochemical Research Unit, University of Alberta, Canada
    J Neuroimmunol 175:97-106. 2006
    ..These findings suggest that IL-1beta selectively regulates AMPA receptor phosphorylation and surface expression through extracellular calcium and an unknown mechanism involving NMDA receptor activity...
  4. ncbi Omega-3 fatty acid eicosapentaenoic acid. A new treatment for psychiatric and neurodegenerative diseases: a review of clinical investigations
    Cai Song
    University of Prince Edward Island, Department of Biomedical Sciences, AVC, 550 University Avenue, Charlottetown, PE, Canada
    Expert Opin Investig Drugs 16:1627-38. 2007
    ..Further clinical studies are required to fully explore the effects of EPA on other neurodegenerative diseases. The limitations of previous studies and further research directions have also been discussed...
  5. doi Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment
    C Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Pharmacopsychiatry 42:182-8. 2009
    ....
  6. doi Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
    Cai Song
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, and Canada National Research Institute for Nutriscience and Health, Charlottetown, PE, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:760-8. 2011
    ....
  7. doi Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment
    Cai Song
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3
    J Neurosci 29:14-22. 2009
    ..These results suggest that an interaction exists between inflammation and NGF in the depression model. EPA may improve depression via its anti-inflammation properties and the upregulation of NGF...
  8. ncbi Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats
    Cai Song
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada C1A 4P3
    J Nutr 138:954-63. 2008
    ..01). AA did not counteract any of the changes induced by IL-1. These results suggest that EPA, GLA, and AA play different roles in the neuroendocrine-immune network...
  9. ncbi The olfactory bulbectomised rat as a model of depression
    Cai Song
    Department of Biomedical Science, AVC, University of Prince Edward Island and National Institute of Nutrisciences and Health, Charlottetown, Canada
    Neurosci Biobehav Rev 29:627-47. 2005
    ..Thus the olfactory bulbectomized rat is not only a model for detecting antidepressant activity but also one for exploring the inter-relationships between these systems that are also dysfunctional in patients with major depression...
  10. ncbi Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion
    Cai Song
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, Charlottetown, PE, Canada
    Neuropsychopharmacology 32:736-44. 2007
    ....
  11. doi Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment
    Pornnarin Taepavarapruk
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, Charlottetown PEC1A4P3, Canada
    J Neurochem 112:1054-64. 2010
    ..This study revealed important mechanisms by which IL-1beta impairs, while E-EPA improves memory through IL-1-glucocorticoid-ACh release and IL-1-NGF-ACh release pathways...
  12. doi ω-3 fatty acid eicosapentaenoic acid attenuates MPP+-induced neurodegeneration in fully differentiated human SH-SY5Y and primary mesencephalic cells
    Dirk W Luchtman
    National Research Institute for Nutrisciences and Health and Department of Biomedical Science, University of Prince Edward Island, Charlottetown, Canada
    J Neurochem 124:855-68. 2013
    ..However, EPA did not prevent mitochondrial enlargement or a decrease in mitochondrial membrane potential. This study demonstrated cellular mechanisms by which EPA provided neuroprotective effects in experimental PD...
  13. doi Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease
    Dirk W Luchtman
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, and NRC Institute for Nutriscience and Health, Charlottetown, PE, Canada C1A 5T1
    Physiol Behav 98:130-8. 2009
    ..The study also provided additional evidence for the validity of the relatively new chronic MPTP/probenecid model. In all, the results suggested that dosing regimens should be carefully pre-considered...
  14. doi Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices
    QingJia Meng
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, and Institute for Nutrisciences and Health, National Research Council of Canada, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3
    Eur J Pharmacol 649:127-34. 2010
    ..EPA may provide modest beneficial effects in Parkinson's disease, but further investigation is warranted...
  15. doi Eicosapentaenoic acid (EPA) increases cell viability and expression of neurotrophin receptors in retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cells
    Wei Kou
    Dept of Biomedical Sciences, AVC, University of Prince Edward Island, Charlottetown PE, Canada
    Eur J Nutr 47:104-13. 2008
    ..However, the exact cellular mechanisms are not well understood. Brain-derived neurotrophic factor (BDNF) is one of neurotrophins, which is involved in neuron differentiation, survival, and synaptogenesis...
  16. ncbi Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats
    Cai Song
    Department of Psychiatry, University of British Columbia, Canada
    J Lipid Res 44:1984-91. 2003
    ..Ethyl-GLA only antagonised IL-1-induced inflammatory changes, whereas AA caused an increase in the secretion of corticosterone and PGE2, and induced anxiety-like behavior without enhancing the effects of IL-1...
  17. ncbi Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids
    Cai Song
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, Canada, V6T 2A1
    Eur J Neurosci 18:1739-43. 2003
    ..This facilitation of defensive behaviour could reflect adaptive responses which may enhance survival during sickness...
  18. ncbi The effect of thymectomy and IL-1 on memory: implications for the relationship between immunity and depression
    Cai Song
    Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, BC, Canada V6T 2A1
    Brain Behav Immun 16:557-68. 2002
    ....
  19. ncbi Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
    ..EPA may, furthermore, enhance the action of antidepressants, like many SSRIs that are p-gp substrates, which are actively transported out of the intracerebral space at the level of the blood-brain barrier...
  20. ncbi Dietary ethyl-eicosapentaenoic acid but not soybean oil reverses central interleukin-1-induced changes in behavior, corticosterone and immune response in rats
    Cai Song
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Stress 7:43-54. 2004
    ..Food enriched with ethyl-EPA but not soybean oil, significantly attenuated most of these changes. These results demonstrate that ethyl-EPA has anti-inflammatory, anti-stress and anti-anxiety effects in rats...