P Morley

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. ncbi request reprint Parathyroid hormone: an anabolic treatment for osteoporosis
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Curr Pharm Des 7:671-87. 2001
  2. ncbi request reprint Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    Neurol Res 22:379-85. 2000
  3. ncbi request reprint Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart
    J S Tauskela
    National Research Council of Canada, Institute for Biological Sciences, Building M 54, Montreal Road Campus, Ottawa, Ontario, Canada
    Brain Res 827:143-51. 1999
  4. ncbi request reprint Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
    Neuropharmacology 35:1037-48. 1996
  5. ncbi request reprint The effect of muscarinic cholinergic agonists on intracellular calcium and progesterone production by chicken granulosa cells
    P Morley
    Department of Obstetrics and Gynecology, University of Ottawa, Ontario, Canada
    Endocrinology 130:663-70. 1992
  6. ncbi request reprint The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Montreal Road Campus, Building M-54, Ottawa, Ontario, Canada K1A 0R6
    Calcif Tissue Int 68:95-101. 2001
  7. ncbi request reprint Loss of cyclin D1 in necrotic and apoptotic models of cortical neuronal degeneration
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Building M 54, Montreal Road, Ottawa, Canada
    Brain Res 842:376-83. 1999
  8. ncbi request reprint A fluorescence confocal assay to assess neuronal viability in brain slices
    R Monette
    Institute for Biological Sciences, National Research Council of Canada, Ottawa
    Brain Res Brain Res Protoc 2:99-108. 1998
  9. ncbi request reprint Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Ottawa
    Brain Res 753:209-18. 1997
  10. ncbi request reprint Glutamate-treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine
    J P MacManus
    Apoptosis Research Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Exp Cell Res 233:310-20. 1997

Detail Information

Publications27

  1. ncbi request reprint Parathyroid hormone: an anabolic treatment for osteoporosis
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Curr Pharm Des 7:671-87. 2001
    ..In addition to treating osteoporosis, PTHs may be used to promote fracture healing, to restore bone loss in immobilized patients, or following excessive glucocorticoid or prolonged spaceflight, and to treat psoriasis...
  2. ncbi request reprint Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    Neurol Res 22:379-85. 2000
    ..The effects of glutamate and glutamate receptor antagonists on pancreatic cells needs to be better understood if these compounds are to be used as therapeutic agents to treat stroke...
  3. ncbi request reprint Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart
    J S Tauskela
    National Research Council of Canada, Institute for Biological Sciences, Building M 54, Montreal Road Campus, Ottawa, Ontario, Canada
    Brain Res 827:143-51. 1999
    ....
  4. ncbi request reprint Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
    Neuropharmacology 35:1037-48. 1996
    ..These results suggest that in vitro neuroprotection of CA1 neurons by 1S,3R-ACPD involves metabotropic glutamate receptors negatively linked to cAMP and possibly those which increase PKC activity...
  5. ncbi request reprint The effect of muscarinic cholinergic agonists on intracellular calcium and progesterone production by chicken granulosa cells
    P Morley
    Department of Obstetrics and Gynecology, University of Ottawa, Ontario, Canada
    Endocrinology 130:663-70. 1992
    ..These results also indicate that an increase in [Ca2+]i in chicken granulosa cells does not alone stimulate steroidogenesis, since the carbachol-induced increases in [Ca2+]i were not accompanied by increased progesterone production...
  6. ncbi request reprint The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats
    P Morley
    Institute for Biological Sciences, National Research Council of Canada, Montreal Road Campus, Building M-54, Ottawa, Ontario, Canada K1A 0R6
    Calcif Tissue Int 68:95-101. 2001
    ..8 nmol/100 g body weight. Thus, further constraint of the conformation of hPTH-(1-31)NH2 by introducing two lactam link-ages between Lys13-Glu17 and Glu22-Lys26 did not raise the osteogenicity above that of the monocyclic analog...
  7. ncbi request reprint Loss of cyclin D1 in necrotic and apoptotic models of cortical neuronal degeneration
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Building M 54, Montreal Road, Ottawa, Canada
    Brain Res 842:376-83. 1999
    ..These immunocytochemical observations were confirmed with immunoblot analysis. Therefore, cyclin D1 is not a reliable indicator of apoptosis in cortical neuronal cultures and should not be used as an indicator of apoptotic cell death...
  8. ncbi request reprint A fluorescence confocal assay to assess neuronal viability in brain slices
    R Monette
    Institute for Biological Sciences, National Research Council of Canada, Ottawa
    Brain Res Brain Res Protoc 2:99-108. 1998
    ....
  9. ncbi request reprint Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Ottawa
    Brain Res 753:209-18. 1997
    ....
  10. ncbi request reprint Glutamate-treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine
    J P MacManus
    Apoptosis Research Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Exp Cell Res 233:310-20. 1997
    ..It is concluded that excitotoxicity produced by glutamate did not induce cell death by an apoptotic mechanism in cultured cortical neurons...
  11. ncbi request reprint AMPA receptor-mediated regulation of a Gi-protein in cortical neurons
    Y Wang
    Cellular Neurobiology Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Nature 389:502-4. 1997
    ..These results suggest that, as well as acting as an ion channel, the AMPA receptor can exhibit metabotropic activity...
  12. ncbi request reprint Stimulation of membrane-associated protein kinase-C activity in spleen lymphocytes by hPTH-(1-31)NH2, its lactam derivative, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, and hPTH-(1-30)NH2
    J F Whitfield
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Cell Signal 11:159-64. 1999
    ....
  13. ncbi request reprint Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons
    S T Hou
    Institute for Biological Sciences, National Research Council Canada, Building M 54, 1500 Montreal Road, Ottawa, Ontario, K1A 0R6, Canada
    Neurosci Lett 306:153-6. 2001
    ..These findings suggest that increased expression of the transcription factor E2F1 may serve as a death signal during DA-evoked neuronal apoptosis...
  14. ncbi request reprint Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block
    G A Mealing
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Pharmacol Exp Ther 297:906-14. 2001
    ..However, there was a positive correlation between off-rate and degree of trapping. Models that can account for partial trapping are presented...
  15. ncbi request reprint Characterization of cyclin D1 expression in a rat global model of cerebral ischemia
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Building M 54, Montreal Road, K1A 0R6, Ottawa, Canada
    Brain Res 900:26-37. 2001
    ..This study suggests that cyclin D1 does not play a role in the death of vulnerable CA1 neurons in global ischemia...
  16. ncbi request reprint Brain derived neurotrophic factor induction of N-methyl-D-aspartate receptor subunit NR2A expression in cultured rat cortical neurons
    D L Small
    Cellular Neurobiology Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Neurosci Lett 252:211-4. 1998
    ..These results suggest that BDNF enhances NMDA receptor maturation, warranting further study of the mechanism of BDNF effects on NMDA receptor subunit expression and the role these effects play in development and neuronal injury...
  17. ncbi request reprint High-yield expression of fully bioactive N-terminal parathyroid hormone analog in Escherichia coli
    W L Sung
    Institute of Biological Sciences, National Research Council, Ottawa, ON, Canada
    IUBMB Life 49:131-5. 2000
    ..In the ovariectomized rat model of osteoporosis, [Asp35]hPTH-(1-35) was fully active as a bone anabolic agent...
  18. ncbi request reprint Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice
    T F Gendron
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    J Neurochem 78:316-24. 2001
    ..These findings are consistent with studies showing that overexpression of E2F1 in postmitotic neurons causes neuronal degeneration and the absence of E2F1 decreases infarct volume following cerebral ischemia...
  19. ncbi request reprint Evaluation of glutathione-sensitive fluorescent dyes in cortical culture
    J S Tauskela
    National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada
    Glia 30:329-41. 2000
    ..CMAC staining was employed to monitor astrocyte proliferation and to resolve astrocytes in living mixed cultures co-loaded with the Ca(2+)-sensitive dye, calcium green 5N-AM. GLIA 30:329-341, 2000. Published 2000 Wiley-Liss, Inc...
  20. ncbi request reprint Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C- and N-terminally truncated fragments of parathyroid hormone 1-34
    J F Whitfield
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    J Bone Miner Res 16:441-7. 2001
    ..The efficiency with which the N-terminally truncated PTH peptides stimulate PKC activity depends on the cellular context in which the PTHR1s are expressed...
  21. ncbi request reprint Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices
    D L Small
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Neurosci Lett 232:87-90. 1997
    ....
  22. ncbi request reprint The differentiation inducer, dimethyl sulfoxide, transiently increases the intracellular calcium ion concentration in various cell types
    P Morley
    Cell Signals Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    J Cell Physiol 156:219-25. 1993
    ..This large, DMSO-induced Ca2+ spike may play a role in the induction of cell differentiation by DMSO...
  23. ncbi request reprint The parathyroid hormone, its fragments and analogues--potent bone-builders for treating osteoporosis
    J Whitfield
    Institute for Biological Sciences, National Research Council of Canada, Bldg M 54, Montreal Road Campus, Ottawa, ON, Canada K1A 0R6
    Expert Opin Investig Drugs 9:1293-315. 2000
    ..These peptides should also accelerate the healing of fractures in persons of all ages and restore lost bone mass and mechanical strength to astronauts following their return to earth after long voyages in space...
  24. ncbi request reprint The bone-building action of the parathyroid hormone: implications for the treatment of osteoporosis
    J F Whitfield
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Drugs Aging 15:117-29. 1999
    ..In this article, we briefly summarise what has so far been learned about how these molecules stimulate the production of new biomechanically strong bone in animals and humans...
  25. ncbi request reprint Structural requirements for conserved arginine of parathyroid hormone
    J R Barbier
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada K1A 0R6
    Biochemistry 40:8955-61. 2001
    ..The data demonstrated that specific H-bonding, hydrophobicity of the side chain, stabilization of alpha-helix, and possibly specific cation positioning were all important in the interaction of Arg-20 with receptor groups...
  26. ncbi request reprint Biology of ischemic cerebral cell death
    D L Small
    Receptor and Ion Channels Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Prog Cardiovasc Dis 42:185-207. 1999
    ..The overall goal is to reduce disability and enhance quality of life for stroke survivors...
  27. ncbi request reprint Cross-tolerance to otherwise lethal N-methyl-D-aspartate and oxygen-glucose deprivation in preconditioned cortical cultures
    J S Tauskela
    National Research Council of Canada, Institute for Biological Sciences, Ottawa, ON, Canada
    Neuroscience 107:571-84. 2001
    ....