E Leberer

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. ncbi Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Curr Biol 7:539-46. 1997
  2. ncbi Activation of myosin-I by members of the Ste20p protein kinase family
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    J Biol Chem 271:31787-90. 1996
  3. pmc Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Canada
    Proc Natl Acad Sci U S A 93:13217-22. 1996
  4. ncbi Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases
    T Leeuw
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Nature 391:191-5. 1998
  5. ncbi Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Mol Gen Genet 241:241-54. 1993
  6. ncbi Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Mol Gen Genet 252:608-21. 1996
  7. pmc Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Mol Biol Cell 10:2425-40. 1999
  8. pmc Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
    E Leberer
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    EMBO J 16:83-97. 1997
  9. pmc Genetic identification of residues involved in association of alpha and beta G-protein subunits
    M Whiteway
    National Research Council, Biotechnology Research Institute, Montreal, Quebec, Canada
    Mol Cell Biol 14:3223-9. 1994
  10. pmc Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction
    E Leberer
    Biotechnology Research Institute, National Research of Canada, Montreal, Quebec
    EMBO J 13:3050-64. 1994

Collaborators

Detail Information

Publications25

  1. ncbi Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Curr Biol 7:539-46. 1997
    ..A molecular and genetic understanding of the potential role of morphological switching in the pathogenicity of C. albicans would be of significant benefit in view of the increasing incidence of candidiasis...
  2. ncbi Activation of myosin-I by members of the Ste20p protein kinase family
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    J Biol Chem 271:31787-90. 1996
    ....
  3. pmc Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Canada
    Proc Natl Acad Sci U S A 93:13217-22. 1996
    ..albicans, one of which has a protein kinase cascade that is analogous to the mating response pathway in S. cerevisiae and might have become adapted to the control of mycelial formation in asexual C. albicans...
  4. ncbi Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases
    T Leeuw
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Nature 391:191-5. 1998
    ....
  5. ncbi Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Mol Gen Genet 241:241-54. 1993
    ....
  6. ncbi Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Mol Gen Genet 252:608-21. 1996
    ....
  7. pmc Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Mol Biol Cell 10:2425-40. 1999
    ..In addition, Ste50p appears to modulate Ste11p autophosphorylation and is itself a substrate of the Ste11p kinase. Therefore, both in vivo and in vitro data support a role for Ste50p in the regulation of Ste11p activity...
  8. pmc Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
    E Leberer
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    EMBO J 16:83-97. 1997
    ..These results suggest that Ste20p is regulated in different developmental pathways by different mechanisms which involve heterotrimeric and small GTP binding proteins...
  9. pmc Genetic identification of residues involved in association of alpha and beta G-protein subunits
    M Whiteway
    National Research Council, Biotechnology Research Institute, Montreal, Quebec, Canada
    Mol Cell Biol 14:3223-9. 1994
    ..Because the ability of the modified G alpha subunit to suppress the Ste4 mutations is allele specific, it is likely that the residues defined by this analysis play a direct role in G-protein subunit association...
  10. pmc Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction
    E Leberer
    Biotechnology Research Institute, National Research of Canada, Montreal, Quebec
    EMBO J 13:3050-64. 1994
    ..We propose that Sig1p represents a novel negative regulator of G beta gamma-mediated signal transduction...
  11. ncbi Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p
    M S Whiteway
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Science 269:1572-5. 1995
    ..Thus, association of the G protein and the MAP kinase cassette via the scaffolding protein Ste5p may transmit the G protein signal...
  12. ncbi Cell cycle- and Cln2p-Cdc28p-dependent phosphorylation of the yeast Ste20p protein kinase
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2
    J Biol Chem 273:28107-15. 1998
    ..In cells that express only the Cln2p G1 cyclin, minor overexpression of Ste20p causes aberrant morphology, suggesting a proper coordination of Ste20p and Cln-Cdc28p activity may be required for the control of cell shape...
  13. ncbi Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    J Biol Chem 270:15984-92. 1995
    ....
  14. ncbi Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans
    E Leberer
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada
    Mol Microbiol 42:673-87. 2001
    ..albicans cells through the induction of polarized morphogenesis. These findings elucidate a new medically relevant role for Ras in cellular morphogenesis and virulence in an important human infectious disease...
  15. ncbi The phosphorylation site for Ste20p-like protein kinases is essential for the function of myosin-I in yeast
    C Wu
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    J Biol Chem 272:30623-6. 1997
    ..Our results suggest that phosphorylation of the head domain by Ste20p-like protein kinases plays an essential role in the function of myosin-I in yeast cells...
  16. ncbi Molecular cloning of the CRM1 gene from Candida albicans
    M Raymond
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Yeast 16:531-8. 2000
    ..Southern blot analysis suggests that CaCRM1 is present at a single locus within the C. albicans genome. The nucleotide sequence of the CaCRM1 gene has been deposited at GenBank under Accession No. AF178855...
  17. ncbi Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin
    T Leeuw
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Science 270:1210-3. 1995
    ..Thus, the association of Bem1p with Ste20p and Ste5p may contribute to the conveyance of spatial information that regulates polarized rearrangement of the actin cytoskeleton during yeast mating...
  18. pmc The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components
    E Leberer
    Biotechnology Research Institute, National Research Council of Canada
    EMBO J 11:4815-24. 1992
    ..This points to a potentially new mechanism of G-protein mediated signal transduction, the activation of a protein kinase through G beta gamma...
  19. pmc Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling
    E Leberer
    Eukaryotic Genetics Group, National Research Council of Canada, Montreal, Quebec
    EMBO J 11:4805-13. 1992
    ..These results underline the positive signalling role of yeast G beta and assign for the first time the positive signalling function of a G-protein beta subunit to specific structural features...
  20. pmc Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans
    C R Rocha
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Mol Biol Cell 12:3631-43. 2001
    ..These findings suggest that fungal adenylyl cyclases and other regulators of the cAMP signaling pathway may be useful targets for antifungal drugs...
  21. pmc Myosin I is required for hypha formation in Candida albicans
    U Oberholzer
    Genetics Division, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Eukaryot Cell 1:213-28. 2002
    ....
  22. ncbi Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy
    J Song
    , Biotechnology Research Institute, National Research Council of Canada, , , Canada
    J Biol Chem 276:41205-12. 2001
    ....
  23. pmc A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex
    M Evangelista
    Department of Biology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    J Cell Biol 148:353-62. 2000
    ..These findings suggest that myosin-I proteins may participate in a diverse set of motility functions through a role in actin assembly...
  24. pmc Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p
    J Kim
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 20:8826-35. 2000
    ..These results demonstrate that Asg7p mediates a regulatory process that blocks signaling from a G protein beta subunit and causes its relocalization within the cell...
  25. ncbi A comprehensive analysis of gene expression profiles in a yeast N-glycosylation mutant
    B Klebl
    Aventis Pharma GmbH Deutschland, Aventis Center for Functional Genomics, Fraunhoferstrasse 13, D-82152 Martinsried, Germany
    Biochem Biophys Res Commun 286:714-20. 2001
    ....