Wangxue Chen

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. ncbi request reprint Cryptosporidium parvum infection in gene-targeted B cell-deficient mice
    Wangxue Chen
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Canada K1A 0R6
    J Parasitol 89:391-3. 2003
  2. ncbi request reprint Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Dig Liver Dis 35:237-43. 2003
  3. ncbi request reprint Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    Wangxue Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington South, New Zealand
    J Gastroenterol Hepatol 17:987-93. 2002
  4. ncbi request reprint Structural characterization of archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) formulations prepared by different protocols and their efficacy upon intranasal immunization of mice
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Liposome Res 18:127-43. 2008
  5. ncbi request reprint Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- depende
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
    Vaccine 23:2477-85. 2005
  6. ncbi request reprint Toll-like receptor 4 (TLR4) does not confer a resistance advantage on mice against low-dose aerosol infection with virulent type A Francisella tularensis
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Room 3100, Ottawa, Ontario, Canada K1A 0R6
    Microb Pathog 37:185-91. 2004
  7. doi request reprint High susceptibility to respiratory Acinetobacter baumannii infection in A/J mice is associated with a delay in early pulmonary recruitment of neutrophils
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Microbes Infect 11:946-55. 2009
  8. pmc Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice
    Henk van Faassen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Infect Immun 75:5597-608. 2007
  9. pmc Molecular immunology of experimental primary tularemia in mice infected by respiratory or intradermal routes with type A Francisella tularensis
    J Wayne Conlan
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Mol Immunol 45:2962-9. 2008
  10. doi request reprint BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune
    Susan Twine
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario, K1A 0R6, Canada
    Vaccine 30:3634-45. 2012

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Cryptosporidium parvum infection in gene-targeted B cell-deficient mice
    Wangxue Chen
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Canada K1A 0R6
    J Parasitol 89:391-3. 2003
    ..These findings indicate clearly that B cells are not essential for host resistance to, and recovery from, C. parvum infection in mice...
  2. ncbi request reprint Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Dig Liver Dis 35:237-43. 2003
    ..Several species of Helicobacter colonise the biliary tract of animals and cause hepatobiliary diseases. Helicobacter species have also been identified in the gallbladder of a high proportion of Chilean patients with gallbladder cancer...
  3. ncbi request reprint Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    Wangxue Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington South, New Zealand
    J Gastroenterol Hepatol 17:987-93. 2002
    ..The objective of the present study was to investigate the frequency of the presence of C. pneumoniae DNA in intestinal biopsies from patients with IBD and from non-IBD controls...
  4. ncbi request reprint Structural characterization of archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) formulations prepared by different protocols and their efficacy upon intranasal immunization of mice
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Liposome Res 18:127-43. 2008
    ....
  5. ncbi request reprint Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- depende
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
    Vaccine 23:2477-85. 2005
    ..Further, understanding of how inhaled LVS elicits local cell-mediated protective immunity will be critical for devising improved vaccines against pulmonary tularemia...
  6. ncbi request reprint Toll-like receptor 4 (TLR4) does not confer a resistance advantage on mice against low-dose aerosol infection with virulent type A Francisella tularensis
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Room 3100, Ottawa, Ontario, Canada K1A 0R6
    Microb Pathog 37:185-91. 2004
    ..Combined, these data suggest that TLR4 does not contribute to resistance of mice to airborne type A F. tularensis infection...
  7. doi request reprint High susceptibility to respiratory Acinetobacter baumannii infection in A/J mice is associated with a delay in early pulmonary recruitment of neutrophils
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Microbes Infect 11:946-55. 2009
    ..Our results imply that the early recruitment of neutrophils into the lung is critical for initiating an efficient host defense against respiratory A. baumannii infection...
  8. pmc Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice
    Henk van Faassen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Infect Immun 75:5597-608. 2007
    ..baumannii from the lungs (P < 0.01). These results imply that neutrophils play a critical role in host resistance to respiratory A. baumannii infection...
  9. pmc Molecular immunology of experimental primary tularemia in mice infected by respiratory or intradermal routes with type A Francisella tularensis
    J Wayne Conlan
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Mol Immunol 45:2962-9. 2008
    ..For instance, IFN-gamma was highly upregulated in the skin of BALB/c, but not C57BL/6 mice after ID inoculation of the pathogen, whilst IL-10 mRNA upregulation was only consistently seen in the skin and lungs...
  10. doi request reprint BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune
    Susan Twine
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario, K1A 0R6, Canada
    Vaccine 30:3634-45. 2012
    ..tularensis after 30 days of vaccination, and elevated levels of pulmonary IL-17 on day 7 after respiratory challenge with SCHU S4 were all associated with protection...
  11. pmc Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario K1A 0R6, Canada
    Vaccine 28:1824-31. 2010
    ..A preliminary examination of immune responses to vaccination with LVS, SCHU S4DeltaclpB, or SCHU S4Delta0918DeltacapB provided no obvious correlate to their relative efficacies...
  12. pmc Lymphotoxin-alpha plays only a minor role in host resistance to respiratory infection with virulent type A Francisella tularensis in mice
    Deng Zhang
    National Research Council Canada, Institute for Biological Sciences, Ottawa, ON, Canada
    Mediators Inflamm 2008:239740. 2008
    ..tularensis infection, it does play a subtle role in the multiplication/dissemination of F. tularensis...
  13. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
    ..baumannii-induced suppression of airway eosinophilia. Our results suggest that A. baumannii inhibits allergic airway inflammation by direct suppression of local pulmonary Th2 cytokine responses to the allergen...
  14. ncbi request reprint Susceptibility of immunodeficient mice to aerosol and systemic infection with virulent strains of Francisella tularensis
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada K1A 0R6
    Microb Pathog 36:311-8. 2004
    ..Combined, our results indicate that, unlike LVS, normal type A and type B F. tularensis strains are so extremely virulent that even immunocompetent mice are virtually defenseless to low dose aerosol and intradermal challenges with them...
  15. ncbi request reprint Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic back
    Wangxue Chen
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
    Vaccine 21:3690-700. 2003
    ..tularensis. Neither mouse strain immunized with LVS was able to resist aerosol challenge with Type A F. tularensis, and only immunized BALB/c mice withstood exposure to aerosols of Type B F. tularensis...
  16. pmc Virulence comparison in mice of distinct isolates of type A Francisella tularensis
    Susan M Twine
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont K1A 0R6, Canada
    Microb Pathog 40:133-8. 2006
    ..Another isolate was highly virulent, but all examined cases appeared somewhat less virulent than FSC033. The implication of these findings for future infection and immunity studies is discussed...
  17. doi request reprint Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice
    Rhonda Kuolee
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A0R6, Canada
    Microbes Infect 13:447-56. 2011
    ..These results imply that although neutrophils are not a major effector cell in defense against subsp. tularensis infection, NADPH phagocyte oxidase does play a marginal role...
  18. pmc Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis
    Rhonda Kuolee
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada
    Vaccine 25:3781-91. 2007
    ..These results suggest that oral immunization should be explored further as an alternative vaccination strategy to combat tularemia...
  19. doi request reprint Safety evaluation of calcium administered intranasally to mice
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Int J Toxicol 28:510-8. 2009
    ..Doses of calcium up to 11 mg/kg appear to be safe in a mouse model...
  20. ncbi request reprint Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Vaccine 25:8622-36. 2007
    ..Thus, polar archaeal lipids appear to be promising for developing a non-replicating mucosal adjuvant and vaccine delivery system...
  21. pmc Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
    Hua Shen
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 5:e13349. 2010
    ..A live vaccine strain (LVS) derived from the less virulent holarctica subspecies confers incomplete protection against aerosol challenge with subsp. tularensis. Moreover, correlates of protection have not been established for LVS...
  22. pmc Intranasal immunization with an archaeal lipid mucosal vaccine adjuvant and delivery formulation protects against a respiratory pathogen challenge
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada
    PLoS ONE 5:e15574. 2010
    ..05). These results suggest that the AMVAD system is a promising mucosal adjuvant and vaccine delivery technology, and should be explored further for its applications in combating mucosal infectious diseases...
  23. pmc Low dose aerosol infection of mice with virulent type A Francisella tularensis induces severe thymus atrophy and CD4+CD8+ thymocyte depletion
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ont, Canada K1A 0R6
    Microb Pathog 39:189-96. 2005
    ..tularensis infection may represent a key pathogenic mechanism in tularemia and could hinder the development of an effective primary immune response against this highly virulent pathogen...
  24. pmc Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 7:e40019. 2012
    ..baumannii to limit initial pathogen replication and the secretion of proinflammatory cytokines and chemokines for the rapid recruitment of other innate immune cells such as neutrophils...
  25. ncbi request reprint c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment
    Lisa Zhao
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Int Immunopharmacol 11:1378-83. 2011
    ..baumannii infection in mice through a neutrophil-dependent mechanism and that c-di-GMP should be further explored as an immunomodulator for the treatment of A. baumannii infection...
  26. doi request reprint Pentabody-mediated antigen delivery induces antigen-specific mucosal immune response
    Shenghua Li
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Mol Immunol 46:1718-26. 2009
    ....
  27. doi request reprint Safety of intranasally administered archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) vaccine in mice
    Girishchandra B Patel
    National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada
    Int J Toxicol 27:329-39. 2008
    ..These results demonstrate that at 10-fold excess dose of that required for vaccine efficacy, intranasally administered AMVAD vaccine appears to be relatively safe...
  28. ncbi request reprint Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen
    Hua Shen
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ont, Canada K1A 0R6
    Vaccine 22:2116-21. 2004
    ..tularensis even after vaccination with LVS, though immunized C3H/HeN mice appeared to be slightly more resistant than the rest to such an assault...
  29. ncbi request reprint Toll-like receptor 4 (TLR4) plays a relatively minor role in murine defense against primary intradermal infection with Francisella tularensis LVS
    Wangxue Chen
    National Research Council Canada, Institute for Biological Sciences, 100 Sussex Drive, Room 3100, Ottawa, ON K1A 0R6, Canada
    Immunol Lett 97:151-4. 2005
  30. doi request reprint Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an α-1,6-glucan chain
    Eleonora Altman
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    Vaccine 30:7332-41. 2012
    ..pylori 26695 HP0826::Kan mutant induce broadly cross-reactive functional antibodies in immunized animals and should be considered for further vaccine development and testing...
  31. pmc Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    Infect Immun 77:1015-21. 2009
    ..Thus, NADPH phagocyte oxidase appears to play a crucial role in the neutrophil-mediated host defense against A. baumannii...
  32. ncbi request reprint Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis
    Hua Shen
    National Research Council Canada, Institute for Biological Sciences, 100 Sussex Drive, Room 3065 Ottawa, Ont, Canada K1A OR6
    Microb Pathog 37:107-10. 2004
    ..However, the results presented herein show that wild-type F. novicida elicits almost no protection in mice against challenge with virulent F. tularensis...
  33. doi request reprint Archaeal lipid mucosal vaccine adjuvant and delivery system
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, ON K1A 0R6, Canada
    Expert Rev Vaccines 9:431-40. 2010
    ..The responses are sustained over time and are subject to good memory-boost responses. The AMVAD formulations are stable during storage, have a good safety profile and show protective efficacy in a murine model of infection/challenge...
  34. pmc Modulation of toxin production by the flagellar regulon in Clostridium difficile
    Annie Aubry
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    Infect Immun 80:3521-32. 2012
    ..This is the first demonstration of differential flagellum-related transcriptional regulation of toxin production in C. difficile and provides evidence for elaborate regulatory networks for virulence genes in C. difficile...
  35. pmc Infection of mice with Francisella as an immunological model
    J Wayne Conlan
    National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada
    Curr Protoc Immunol . 2011
    ..Moreover, studies using Francisella, particularly the Live Vaccine Strain (LVS), serve as a convenient and tractable model system that appears to be representative of mammalian host responses to intracellular pathogens in general...
  36. ncbi request reprint Production of a D-glycero-D-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and functionality of antibodies to this LPS structure
    Susan M Logan
    Institute for Biological Sciences, National Research Council, Ottawa, Ont, Canada K1A 0R6
    Vet Microbiol 116:175-86. 2006
    ..This illustrates that it is possible to raise functional antibodies against the conserved inner core LPS structure...
  37. ncbi request reprint M cell-targeted delivery of vaccines and therapeutics
    Rhonda Kuolee
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada
    Expert Opin Drug Deliv 5:693-702. 2008
    ..Their high transcytotic ability make M cells an attractive target for mucosally delivered vaccines and therapeutics...
  38. doi request reprint The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    Vaccine 28:3080-5. 2010
    ....
  39. ncbi request reprint Activation of the mucosal immune system in irritable bowel syndrome
    Vinton S Chadwick
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Gastroenterology 122:1778-83. 2002
    ..A role for the mucosal immune system in the pathogenesis of irritable bowel syndrome is suggested by its association with intestinal infections...
  40. ncbi request reprint Archaeosome immunostimulatory vaccine delivery system
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Curr Drug Deliv 2:407-21. 2005
    ..Extensive murine model studies suggest that archaeosomes are safe...
  41. ncbi request reprint Serum resistance, gallium nitrate tolerance and extrapulmonary dissemination are linked to heme consumption in a bacteremic strain of Acinetobacter baumannii
    Louis de Léséleuc
    Human Health Therapeutics Portfolio, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Int J Med Microbiol 304:360-9. 2014
    ..Heme consumption systems in A. baumannii may constitute major virulence factors for lethal bacteremic isolates. ..
  42. doi request reprint Simultaneous analysis of cardiolipin and lipid A from Helicobacter pylori by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Ping Zhou
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    Mol Biosyst 8:720-5. 2012
    ..pylori cells recovered from the stomachs of infected Mongolian gerbils demonstrated only minor changes in acyl chain combination. This is the first report of simultaneous analysis of CL and lipid A from ex vivo cells of H. pylori...
  43. ncbi request reprint 6th Annual Vaccines: all things considered
    Wangxue Chen
    National Research Council Canada, Institute for Biological Sciences, 100 Sussex Drive, Room 3100, Ottawa, ON K1A 0R6, Canada
    Expert Rev Vaccines 8:281-4. 2009
    ..As part of the conference's tradition, two posters were selected for oral presentation. This meeting report will highlight the main issues discussed...
  44. ncbi request reprint Archaeosomes as adjuvants for combination vaccines
    Girishchandra B Patel
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Liposome Res 14:191-202. 2004
    ..These results show that archaeosomes could be used as adjuvants in developing combination vaccines...
  45. ncbi request reprint High prevalence of Mycoplasma pneumoniae in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Newtown, New Zealand
    Dig Dis Sci 46:2529-35. 2001
    ..Epidemiological studies in IBD suggest acquisition of some agents early in life probably during epidemics in temperate latitudes. M. pneumoniae could be one of the ubiquitous agents implicated in the pathogenesis of IBD...
  46. ncbi request reprint The structure of the polysaccharide isolated from Acinetobacter baumannii strain LAC-4
    Evgeny Vinogradov
    Human Health Therapeutics Portfolio, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada Electronic address
    Carbohydr Res 390:42-5. 2014
    ..The structure interpretation was based mostly on NMR data. Polysaccharide was obtained using a procedure of LPS O-chain preparation, although whether it is an LPS O-chain or capsular polysaccharide remained unclear. ..
  47. ncbi request reprint Experimental tularemia in mice challenged by aerosol or intradermally with virulent strains of Francisella tularensis: bacteriologic and histopathologic studies
    J Wayne Conlan
    National Research Council of Canada, Institute for Biological Sciences, 100 Sussex Drive, Room 3065, Ottawa, Ont, K1A OR6, Canada
    Microb Pathog 34:239-48. 2003
    ..Thus, it appears that regardless of the route of infection, systemic rather than pulmonary infection was the likely cause of death following low dose challenge with virulent F. tularensis...
  48. ncbi request reprint A novel pentamer versus pentamer approach to generating neutralizers of verotoxin 1
    Emily Stone
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr, Ottawa, Ont K1A 0R6, Canada
    Mol Immunol 44:2487-91. 2007
    ..This effort provides the basis of a novel type of VT neutralizer that can potentially be produced at a relatively low cost...
  49. ncbi request reprint Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1145-50. 2000
    ..The objective of the present study was to investigate the prevalence of L. monocytogenes DNA in intestinal biopsies from patients with IBD and from non-IBD controls by using nested polymerase chain reaction (PCR)...
  50. ncbi request reprint Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10
    W Chen
    The Wakefield Gastroenterology Research Laboratory, Wakefield Hospital, Newtown, Wellington, New Zealand
    J Gastroenterol Hepatol 16:377-83. 2001
    ..The objective of this study was to determine the role of endogenous IL-10 in the host defense against gastric colonization by Helicobacter pylori by using IL-10-deficient mice...
  51. doi request reprint Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine strain of Francisella tularensis
    R KuoLee
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    Clin Exp Allergy 38:1003-15. 2008
    ....
  52. ncbi request reprint Rapid elimination of Helicobacter pylori and reduction of histocompatibility leucocyte antigen-DR expression 12 h after a single dose of omeprazole, amoxycillin and metronidazole triple therapy
    W Chen
    Wakefield Gastroenterology Centre, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 14:322-7. 1999
    ..pylori, and the severity of gastric mucosal inflammation in the gastric biopsy specimens of patients before (0 h group, n = 14) and 12 h (12 h group, n = 14) after initiating anti-H. pylori treatment...
  53. ncbi request reprint Inhibition of mitogen-induced murine lymphocyte proliferation by Helicobacter pylori cell-free extract
    W Chen
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Wellington, New Zealand
    J Gastroenterol Hepatol 15:1000-6. 2000
    ..pylori cell-free extract (HPCE) has similar effects on murine lymphoid cells and could, therefore, be used to further delineate the mechanisms of alteration of lymphocyte function by H. pylori...
  54. pmc Fibrin-mediated protection against infection-stimulated immunopathology
    Lawrence L Johnson
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 197:801-6. 2003
    ....
  55. pmc Intestinal M cells: the fallible sentinels?
    Harvey Miller
    World J Gastroenterol 13:1477-86. 2007
    ..In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity...
  56. ncbi request reprint Role of Toll-like receptors in health and diseases of gastrointestinal tract
    Greg Harris
    World J Gastroenterol 12:2149-60. 2006
    ....
  57. ncbi request reprint Transcriptional profiling of host responses in mouse lungs following aerosol infection with type A Francisella tularensis
    Henrik Andersson
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    J Med Microbiol 55:263-71. 2006
    ..In keeping with this finding, tumour necrosis factor alpha and gamma interferon levels were found to be increased significantly in bronchoalveolar lavage on day 4...
  58. pmc Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis
    Isis K Mullarky
    Trudeau Institute, Saranac Lake, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    Infect Immun 73:3888-95. 2005
    ..While the pathological potential of excessive infection-stimulated fibrin deposition is well appreciated, our findings reveal that fibrin can function protectively, via multiple mechanisms, during bacterial infection...
  59. pmc Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice
    Stephen T Smiley
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Immunol 174:7904-11. 2005
    ..gondii infection observed in CD1d-deficient C57BL/6 mice, and establish T. gondii as a valuable tool for deciphering CD1d-dependent protective mechanisms...
  60. pmc Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis
    Helena Lindgren
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    Infect Immun 72:7172-82. 2004
    ....
  61. ncbi request reprint Vaccination protects B cell-deficient mice against an oral challenge with mildly virulent Toxoplasma gondii
    Lawrence L Johnson
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    Vaccine 22:4054-61. 2004
    ..Thus, a vaccine can protect against infection with a mildly virulent type II strain of T. gondii in the absence of a B cell-dependent immune response...