Reinhold Vieth

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. doi Implications for 25-hydroxyvitamin D testing of public health policies about the benefits and risks of vitamin D fortification and supplementation
    Reinhold Vieth
    Department of Nutritional Sciences and Department of Laboratory Medicine and Pathobiology, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    Scand J Clin Lab Invest Suppl 243:144-53. 2012
  2. pmc Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area: associations with vitamin D intake and skin pigmentation
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    BMC Public Health 8:336. 2008
  3. ncbi There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D concentrations increase
    R Vieth
    Department of Nutritional Sciences, University of Toronto, and Mount Sinai Hospital, Toronto, Canada
    J Endocrinol Invest 28:183-6. 2005
  4. ncbi Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is slower during spring-summer
    R Vieth
    Mount Sinai Hospital, Toronto Sunnybrook Regional Cancer Center, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Am J Ther 13:394-9. 2006
  5. ncbi Why "Vitamin D" is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont, Canada M5G 1X5
    J Steroid Biochem Mol Biol 89:571-3. 2004
  6. ncbi Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    J Steroid Biochem Mol Biol 89:575-9. 2004
  7. pmc Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients
    Reinhold Vieth
    Department of Laboratory Medicine and Pathology, University of Toronto, Canada
    Nutr J 3:8. 2004
  8. ncbi Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, M5G 1L5, Canada
    J Nutr 136:1117-22. 2006
  9. ncbi The role of vitamin D in the prevention of osteoporosis
    Reinhold Vieth
    Department of Nutritional Sciences, Laboratory Medicine and Pathology, University of Toronto, Ontario, Canada
    Ann Med 37:278-85. 2005
  10. ncbi What is the optimal vitamin D status for health?
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, Canada
    Prog Biophys Mol Biol 92:26-32. 2006

Detail Information

Publications82

  1. doi Implications for 25-hydroxyvitamin D testing of public health policies about the benefits and risks of vitamin D fortification and supplementation
    Reinhold Vieth
    Department of Nutritional Sciences and Department of Laboratory Medicine and Pathobiology, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    Scand J Clin Lab Invest Suppl 243:144-53. 2012
    ..The implication of all these things for the clinical laboratory is that there will continue to be a demand for 25(OH)D measurements for many years to come...
  2. pmc Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area: associations with vitamin D intake and skin pigmentation
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    BMC Public Health 8:336. 2008
    ..The main goal of this study was to examine the vitamin D status and vitamin D intake of young Canadian adults of diverse ancestry during the winter months...
  3. ncbi There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D concentrations increase
    R Vieth
    Department of Nutritional Sciences, University of Toronto, and Mount Sinai Hospital, Toronto, Canada
    J Endocrinol Invest 28:183-6. 2005
  4. ncbi Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is slower during spring-summer
    R Vieth
    Mount Sinai Hospital, Toronto Sunnybrook Regional Cancer Center, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Am J Ther 13:394-9. 2006
    ..The therapeutic implication is that vitamin D supplementation in the range of 2000 IU/d, a dose comparable to the effect of summer, can benefit men monitored for rising PSA...
  5. ncbi Why "Vitamin D" is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont, Canada M5G 1X5
    J Steroid Biochem Mol Biol 89:571-3. 2004
    ..e. a glandular secretory product, having little or no inherent biologic potency, that is converted peripherally to an active hormone...
  6. ncbi Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada M5G 1X5
    J Steroid Biochem Mol Biol 89:575-9. 2004
    ..If 70 nmol/L is regarded as a minimum desirable target 25(OH)D concentration, then current recommendations of 15 mcg per day do not meet the criterion of an RDA...
  7. pmc Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients
    Reinhold Vieth
    Department of Laboratory Medicine and Pathology, University of Toronto, Canada
    Nutr J 3:8. 2004
    ..For adults, vitamin D intake of 100 mcg (4000 IU)/day is physiologic and safe. The adequate intake (AI) for older adults is 15 mcg (600 IU)/day, but there has been no report focusing on use of this dose...
  8. ncbi Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, M5G 1L5, Canada
    J Nutr 136:1117-22. 2006
    ....
  9. ncbi The role of vitamin D in the prevention of osteoporosis
    Reinhold Vieth
    Department of Nutritional Sciences, Laboratory Medicine and Pathology, University of Toronto, Ontario, Canada
    Ann Med 37:278-85. 2005
    ..This amount of vitamin D results in the optimal function of many aspects of health, including balance and muscle strength that lessen the risk of fracture beyond what is possible via the quality and quantity of bone itself...
  10. ncbi What is the optimal vitamin D status for health?
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, Canada
    Prog Biophys Mol Biol 92:26-32. 2006
    ..Therefore, advice to avoid UVB light should be accompanied by encouragement to supplement with vitamin D in an amount that will correct for the nutrient deficit that sun-avoidance will cause...
  11. ncbi Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D
    Reinhold Vieth
    Department of Laboratory Medicine and Pathology, University of Toronto and Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Clin Endocrinol Metab 88:185-91. 2003
    ..Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function...
  12. ncbi Vitamin D poisoning by table sugar
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada MG5 1X5
    Lancet 359:672. 2002
  13. ncbi How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, M5G 1X5, ON, Canada
    Anticancer Res 29:3675-84. 2009
    ..It also explains why higher 25(OH)D concentrations are not good if they fluctuate, and that desirable 25(OH)D concentrations are ones that are both high and stable...
  14. pmc Vitamin D insufficiency: no recommended dietary allowance exists for this nutrient
    Reinhold Vieth
    Department of Laboratory Medicine and Pathology, University of Toronto, ON
    CMAJ 166:1541-2. 2002
  15. ncbi Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
    R Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Ontario, Canada
    Am J Clin Nutr 69:842-56. 1999
    ....
  16. doi Vitamin D and cancer mini-symposium: the risk of additional vitamin D
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Ann Epidemiol 19:441-5. 2009
    ....
  17. ncbi Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level
    R Vieth
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 73:288-94. 2001
    ..The Food and Nutrition Board of the National Academy of Sciences states that 95 microg vitamin D/d is the lowest observed adverse effect level (LOAEL)...
  18. ncbi Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it
    R Vieth
    Mount Sinai Hospital, Toronto, Canada
    Eur J Clin Nutr 55:1091-7. 2001
    ..We asked whether women self-reporting the recommended consumption of vitamin D from milk and multivitamins would be less likely to have low wintertime 25-hydroxyvitamin D (25(OH)D) levels...
  19. pmc Prospective associations of vitamin D with β-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:2947-53. 2011
    ..To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), β-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes...
  20. doi Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:168-75. 2011
    ..However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components...
  21. doi Association of vitamin D related information from a telephone interview with 25-hydroxyvitamin D
    Harleen Sahota
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:232-8. 2008
    ..82 versus "none"; P = 0.0006). The R(2) was 0.29 for the summer model and was 0.21 for the winter model. Overall, there was evidence to suggest that questions designed to assess vitamin D exposure were in fact related to serum 25(OH)D...
  22. ncbi Safety of vitamin D3 in adults with multiple sclerosis
    Samantha M Kimball
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:645-51. 2007
    ....
  23. doi Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer
    Kristina M Blackmore
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada M5T3L9
    Am J Epidemiol 168:915-24. 2008
    ..51, 1.22) tumors. This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required...
  24. doi The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, Canada
    J Steroid Biochem Mol Biol 126:72-7. 2011
    ..The 24,25:25VD(3) ratio may therefore have clinical utility as a marker for VD(3) catabolism and a predictor of serum 25VD(3) response to VD(3) supplementation...
  25. pmc Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis
    Samantha Kimball
    Departments of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:2826-34. 2011
    ..The active metabolite of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], is a potent modulator of immune cells in vitro...
  26. doi Prospective association of 25(OH)D with metabolic syndrome
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 80:502-7. 2014
    ..Vitamin D may play a role in the aetiology of the metabolic syndrome (MetS), yet the majority of previous studies have been cross-sectional, and the limited number of prospective studies has yielded inconsistent results...
  27. doi Vitamin D association with estradiol and progesterone in young women
    Julia A Knight
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Cancer Causes Control 21:479-83. 2010
    ..We conducted a study to determine whether there is an association between circulating 25-hydroxyvitamin D (25(OH)D) and estradiol and progesterone in young women...
  28. doi Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women
    Laura N Anderson
    Cancer Care Ontario, Toronto, Canada
    Am J Clin Nutr 91:1699-707. 2010
    ..Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk...
  29. doi Urinary calcium response to high dose vitamin D3 with calcium supplementation in patients with multiple sclerosis
    Samantha M Kimball
    University of Toronto, Department of Nutritional Sciences and Mount Sinai Hospital, Department of Pathology and Laboratory Medicine, Toronto, ON, Canada M5G 1X5
    Clin Biochem 44:930-2. 2011
    ..To characterize the effect of vitamin D(3) intake on urinary calcium:creatinine ratios across predefined ranges of serum 25(OH)D...
  30. doi Vitamin D3 fortification, quantification, and long-term stability in Cheddar and low-fat cheeses
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, 150 College Street, Toronto, Ontario M5S 3E2, Canada
    J Agric Food Chem 56:7964-9. 2008
    ..The fortification process did not alter the yield, chemical composition, or flavor of the Cheddar cheese. We conclude that industrially manufactured Cheddar and low-fat cheeses are suitable for vitamin D3 fortification...
  31. doi Relationship between vitamin D during perinatal development and health
    Jovana Kaludjerovic
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Midwifery Womens Health 55:550-60. 2010
    ..This review summarizes the risks of vitamin D deficiency for human health and provides the current vitamin D recommendations for mothers and their newborns...
  32. pmc Solar ultraviolet-B radiation and vitamin D: a cross-sectional population-based study using data from the 2007 to 2009 Canadian Health Measures Survey
    Jamie A Greenfield
    Office of Biotechnology, Genomics and Population Health, Public Health Agency of Canada, 180 Queen Street West, Toronto, Canada
    BMC Public Health 12:660. 2012
    ..The purpose of this study was to measure the association between ground-level solar UV-B and serum concentrations of 25-hydroxyvitamin D (25(OH)D) using a secondary analysis of the 2007 to 2009 Canadian Health Measures Survey (CHMS)...
  33. doi Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice
    Edwin C Y Chow
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 304:E977-89. 2013
    ..The data revealed that 1,25(OH)2D3 equilibrates with tissues rapidly, and VDR target genes respond quickly to exogenously administered 1,25(OH)2D3...
  34. ncbi Vitamin D and reduced risk of breast cancer: a population-based case-control study
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada M5T 3L9
    Cancer Epidemiol Biomarkers Prev 16:422-9. 2007
    ..We conducted a population-based case-control study to assess the evidence for a relationship between sources of vitamin D and breast cancer risk...
  35. doi Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    J Nutr 140:2213-20. 2010
    ..001), and with study year (r(2) = 0.02; P = 0.009). Our study confirms that serum 25(OH)D concentrations undergo strong seasonal variation at high latitudes and are influenced by vitamin D intake, skin pigmentation, and sun exposure...
  36. ncbi No association between 25-hydroxyvitamin D and mammographic density
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 5th Floor, 60 Murray Street, Toronto, Ontario, Canada M5G 1X5
    Cancer Epidemiol Biomarkers Prev 15:1988-92. 2006
    ..Unlike some previous reports, vitamin D does not seem to be related to mammographic density in this cohort...
  37. ncbi The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, M563E2 Toronto, Canada
    J Nutr 138:1365-71. 2008
    ..003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification...
  38. doi Randomized clinical trial of vitamin D3 doses on prostatic vitamin D metabolite levels and ki67 labeling in prostate cancer patients
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 98:1498-507. 2013
    ..Vitamin D3 might benefit prostate cancer (PCa) patients because prostate cells can locally synthesize the active hormone calcitriol...
  39. ncbi Determination of 1,25-dihydroxyvitamin D concentrations in human colon tissues and matched serum samples
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Anticancer Res 32:259-63. 2012
    ..The objectives of this study were to determine whether 1,25(OH)(2)D is present in human colon tissue and to characterize the relationship between human colon tissue and serum 1,25(OH)(2)D concentrations...
  40. doi Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study
    Brenda Banwell
    Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Lancet Neurol 10:436-45. 2011
    ....
  41. doi Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 nmol/L (30 ng/ml)
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Best Pract Res Clin Endocrinol Metab 25:681-91. 2011
    ....
  42. doi A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases
    Eitan Amir
    Department of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 116:284-91. 2010
    ..This study therefore aimed to assess the effect of this dose of vitamin D(3) in patients with bone metastases from breast cancer...
  43. pmc Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
    Angela M Cheung
    Department of Medicine, Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 5:e196. 2008
    ..This study was conducted to determine whether daily high-dose vitamin K1 supplementation safely reduces bone loss, bone turnover, and fractures...
  44. doi An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D
    Dennis Wagner
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Clin Biochem 42:1549-56. 2009
    ..To compare two new automated assays with the well-established reference method, DiaSorin radioimmunoassay (RIA), for quantitation of serum total 25-hydroxyvitamin D [25(OH)D]...
  45. ncbi Vitamin D: a growing perspective
    Samantha Kimball
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Crit Rev Clin Lab Sci 45:339-414. 2008
    ..Here we review the available data concerning vitamin D status and health effects of vitamin D in pregnancy through to and including adolescence...
  46. doi Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation
    Lei Fu
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
    Clin Biochem 42:1174-7. 2009
    ..To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year...
  47. pmc Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1379-81. 2010
    ..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
  48. ncbi A comparison of automated methods for the quantitation of serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D
    Samantha M Kimball
    Department of Nutritional Sciences, University of Toronto, Department of Laboratory Medicine and Pathology, Mt Sinai Hospital, Ontario, Canada
    Clin Biochem 40:1305-10. 2007
    ..To compare automated platforms with the routinely used methods in our clinical laboratory for the quantitation of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D]...
  49. ncbi Vitamin D toxicity, policy, and science
    Reinhold Vieth
    Departments of Nutritional Sciences, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    J Bone Miner Res 22:V64-8. 2007
    ....
  50. ncbi Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy
    Tony Choon Seng Woo
    Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
    Nutr Cancer 51:32-6. 2005
    ..There were no side effects reported by any patient. Further study is needed to confirm this finding and to explore the potential therapeutic benefit of nutrient vitamin D in prostate cancer...
  51. ncbi Comparison of self-reported lifetime sun exposure with two methods of cutaneous microtopography
    Lynn Weiler
    Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Epidemiol 165:222-30. 2007
    ..10). While the Beagley-Gibson method was associated with more variables than the skin line count method, both methods require further refinement before graded skin replicas can be recommended as a substitute for self-report measures...
  52. doi Self-prescribed high-dose vitamin D3: effects on biochemical parameters in two men
    Samantha Kimball
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Ann Clin Biochem 45:106-10. 2008
    ..Close monitoring of biochemical responses confirmed that an increase in urinary calcium:creatinine ratio precedes hypercalcaemia as serum 25(OH)D concentrations rise...
  53. doi Unusually prolonged vitamin D intoxication after discontinuation of vitamin D: possible role of primary hyperparathyroidism
    Hulya Taskapan
    Division of Nephrology, Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Int Urol Nephrol 40:801-5. 2008
    ..In this unusual case, primary hyperparathyroidism probably prevented an appropriate increase in the vitamin D-catabolizing enzyme, 25(OH)D-24-hydroxylase, thereby slowing metabolic clearance of 25(OH) vitamin D...
  54. doi Sun exposure questionnaire predicts circulating 25-hydroxyvitamin D concentrations in Caucasian hospital workers in southern Italy
    H E C Hanwell
    Department of Nutritional Sciences, University of Toronto, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    J Steroid Biochem Mol Biol 121:334-7. 2010
    ..Recent sun exposure should correlate with circulating 25-hydroxyvitamin D [25(OH)D] due to ultraviolet B (UVB)-catalyzed cutaneous synthesis of vitamin D...
  55. ncbi Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene
    D E Cole
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Mol Genet Metab 72:168-74. 2001
    ..These data are the first to show significant association between a common polymorphism and concentrations of a serum electrolyte. The A986S polymorphism is also a potential predisposing factor in disorders of bone and mineral metabolism...
  56. pmc A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis
    J M Burton
    Division of Neurology, St Michael s Hospital, Toronto, Canada
    Neurology 74:1852-9. 2010
    ..Our aim was to assess the tolerability of high-dose oral vitamin D and its impact on biochemical, immunologic, and clinical outcomes in patients with MS prospectively...
  57. ncbi Evaluation of a 1,25-dihydroxyvitamin D enzyme immunoassay
    Isolde Seiden-Long
    Department of Laboratory Medicine and Pathobiology, University of Toronto Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Clin Chem 53:1104-8. 2007
    ..We evaluated a 1,25(OH)(2)D enzyme immunoassay (EIA) from IDS Ltd. that uses solid-phase immunoextraction and colorimetric detection and compared results to those of the thymus radioreceptor assay (RRA) for 1,25(OH)(2)D...
  58. ncbi Novel fluorescent compound (DDP) in calf, rabbit, and human articular cartilage and synovial fluid
    Harpal K Gahunia
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Rheumatol 29:154-60. 2002
    ....
  59. doi Change in urinary markers of osteoclast activity following palliative radiotherapy for bone metastases
    E Chow
    Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 21:336-42. 2009
    ..To examine the effect of radiotherapy for bone metastases on urinary markers of osteoclast activity...
  60. ncbi Effect of high vegetable protein diets on urinary calcium loss in middle-aged men and women
    D J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Eur J Clin Nutr 57:376-82. 2003
    ..To determine the effect of high-protein diets, which have recently been promoted for their health benefits, on urinary calcium losses and bone turnover in older subjects...
  61. ncbi Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer-1 (AIB1), are associated with quantitative calcaneal ultrasound
    M S Patel
    Department of Pediatrics Genetics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Bone Miner Res 15:2231-9. 2000
    ..This is the first demonstration of specific genetic effects on calcaneal QUS encoded by alleles of genes directly involved in mediating estrogen effects on bone...
  62. ncbi A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations
    D E Cole
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Lancet 353:112-5. 1999
    ..The CASR missense polymorphism, A986S, is common in the general population and is, therefore, a prime candidate as a genetic determinant of extracellular calcium concentration...
  63. ncbi Was it inappropriate to give patients with osteoporosis calcitriol instead of vitamin D?
    Reinhold Vieth
    J Am Geriatr Soc 56:575-6; author reply 576-7. 2008
  64. pmc Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford Oxford, United Kingdom
    Am J Clin Nutr 88:441-7. 2008
    ..Recent epidemiologic, experimental, and clinical evidence support an effect for low environmental supplies of vitamin D in mediating an increased susceptibility to MS...
  65. ncbi Estimates of optimal vitamin D status
    Bess Dawson-Hughes
    Osteoporos Int 16:713-6. 2005
    ..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture...
  66. ncbi Teriparatide, osteoporosis, calcium, and vitamin D
    Reinhold Vieth
    N Engl J Med 353:634-5; author reply 634-5. 2005
  67. ncbi The case against ergocalciferol (vitamin D2) as a vitamin supplement
    Lisa A Houghton
    School of Nutrition and Dietetics, Acadia University, Wolfville, Canada
    Am J Clin Nutr 84:694-7. 2006
    ..Vitamin D2, or ergocalciferol, should not be regarded as a nutrient suitable for supplementation or fortification...
  68. pmc Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children
    Joyce Maalouf
    Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Bliss Street, Beirut, Lebanon
    J Clin Endocrinol Metab 93:2693-701. 2008
    ..Hypovitaminosis D is prevalent in youth worldwide, but the safety of vitamin D at doses exceeding 200 IU/d is unknown in this age group. We assessed the safety of high doses of vitamin D(3) administered to apparently healthy schoolchildren...
  69. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
    ..Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL...
  70. ncbi The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  71. ncbi A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health Human Services, Rockville, Maryland 20852, USA
    Cancer Res 66:10213-9. 2006
    ..Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer...
  72. ncbi Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study
    Reinhold Vieth
    Am J Clin Nutr 76:490-1; author reply 491. 2002
  73. ncbi Inaccuracies in relating 25-hydroxyvitamin D to ischemic heart disease
    Reinhold Vieth
    Eur J Epidemiol 18:461-2. 2003
  74. ncbi Lack of generalizable evidence of the superiority of alfacalcidol over plain vitamin D in the treatment of glucocorticoid-induced osteoporosis: comment on the article by Ringe et al
    H Richard Barthel
    Rheumatol Int 24:250-1. 2004
  75. ncbi Misuse of terminology to imply that 1,25-dihydroxy-vitamin D is a nutrient: there is no evidence for an association between vitamin D and allergy
    Reinhold Vieth
    J Allergy Clin Immunol 113:790-1; author reply 791-2. 2004
  76. ncbi Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in nordic countries
    Reinhold Vieth
    Int J Cancer 111:468; author reply 469. 2004
  77. ncbi Vitamin D ingestion and changes to rat aorta
    Reinhold Vieth
    Cardiovasc Res 56:323-4; author reply 325. 2002
  78. pmc 13th Workshop consensus for vitamin D nutritional guidelines
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, 5456 Boyce Hall, University of California Riverside, Riverside, CA 92521, USA
    J Steroid Biochem Mol Biol 103:204-5. 2007
  79. doi Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients
    Sophia Ish-Shalom
    Metabolic Bone Diseases Unit, Rambam Health Care Campus, Haifa, Israel
    J Clin Endocrinol Metab 93:3430-5. 2008
    ..Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them...
  80. ncbi Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial
    Ghada El-Hajj Fuleihan
    Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Bliss Street, 113 6044 Beirut, Lebanon
    J Clin Endocrinol Metab 91:405-12. 2006
    ..Despite the high prevalence of hypovitaminosis D in children and adolescents worldwide, the impact of vitamin D deficiency on skeletal health is unclear...
  81. ncbi Vitamin D in congestive heart failure
    Reinhold Vieth
    Am J Clin Nutr 83:731-2. 2006
  82. ncbi Vitamin D nutrition does not cause peripheral artery disease
    Reinhold Vieth
    Arterioscler Thromb Vasc Biol 25:e41; author reply e41-2. 2005