Mark-S Silverberg

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. pmc Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis
    Andrea D Tyler
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital Inflammatory Bowel Disease Group, Toronto, Ontario, Canada
    PLoS ONE 8:e66934. 2013
  2. ncbi Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    Mark S Silverberg
    Department of Medicine, Mount Sinai Hospital IBD Centre, University of Tronto, Toronto, Ontario
    Can J Gastroenterol 19:5A-36A. 2005
  3. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
  4. doi Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease
    Matti Waterman
    Division of Gastroenterology, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada
    Gut 62:387-94. 2013
  5. ncbi The time has come for NOD2/CARD15 testing for families with Crohn's disease: pro
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Canada
    Inflamm Bowel Dis 11:504-6. 2005
  6. ncbi A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease
    Mark S Silverberg
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Inflamm Bowel Dis 9:1-9. 2003
  7. ncbi OCTNs: will the real IBD5 gene please stand up?
    Mark S Silverberg
    Mount Sinai Hospital IBD Centre, Department of Medicine, Toronto, Ontario, Canada
    World J Gastroenterol 12:3678-81. 2006
  8. ncbi CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease
    Bill Newman
    Department of Medicine, University of Toronto, Toronto, Canada
    Am J Gastroenterol 99:306-15. 2004
  9. ncbi Attitudes toward genetic testing in patients with inflammatory bowel disease
    Simon Lal
    Inflammatory Bowel Disease Centre, Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Eur J Gastroenterol Hepatol 19:321-7. 2007
  10. doi Genotype/phenotype correlations and implications for clinical practice
    Mark S Silverberg
    Mount Sinai Hospital, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 46:E4-5. 2008

Research Grants

  1. Identification of IBD Susceptibility Genes
    Mark Silverberg; Fiscal Year: 2007

Detail Information

Publications30

  1. pmc Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis
    Andrea D Tyler
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital Inflammatory Bowel Disease Group, Toronto, Ontario, Canada
    PLoS ONE 8:e66934. 2013
    ..The aim of this study was to determine whether specific organisms in the tissue-associated microbiota are associated with inflammatory pouch complications...
  2. ncbi Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    Mark S Silverberg
    Department of Medicine, Mount Sinai Hospital IBD Centre, University of Tronto, Toronto, Ontario
    Can J Gastroenterol 19:5A-36A. 2005
    ....
  3. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...
  4. doi Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease
    Matti Waterman
    Division of Gastroenterology, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada
    Gut 62:387-94. 2013
    ..The authors aimed to assess postoperative outcomes in patients who underwent abdominal surgery with recent exposure to anti-tumour necrosis factor therapy...
  5. ncbi The time has come for NOD2/CARD15 testing for families with Crohn's disease: pro
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Canada
    Inflamm Bowel Dis 11:504-6. 2005
  6. ncbi A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease
    Mark S Silverberg
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Inflamm Bowel Dis 9:1-9. 2003
    ....
  7. ncbi OCTNs: will the real IBD5 gene please stand up?
    Mark S Silverberg
    Mount Sinai Hospital IBD Centre, Department of Medicine, Toronto, Ontario, Canada
    World J Gastroenterol 12:3678-81. 2006
    ..Several other genes, including IRF1 and P4HA2 may be equally as likely to contain the IBD5 causal variant as the OCTN genes...
  8. ncbi CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease
    Bill Newman
    Department of Medicine, University of Toronto, Toronto, Canada
    Am J Gastroenterol 99:306-15. 2004
    ..Crohn's disease (CD) is a chronic inflammatory disease of the gut associated with allelic variants of CARD15 and HLA-DRB1 genes. We investigated the prevalence and effects of these variants in a Canadian CD cohort...
  9. ncbi Attitudes toward genetic testing in patients with inflammatory bowel disease
    Simon Lal
    Inflammatory Bowel Disease Centre, Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Eur J Gastroenterol Hepatol 19:321-7. 2007
    ..The aim of this study was to evaluate the attitudes of patients with inflammatory bowel disease toward genetic testing...
  10. doi Genotype/phenotype correlations and implications for clinical practice
    Mark S Silverberg
    Mount Sinai Hospital, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 46:E4-5. 2008
  11. doi Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype
    Cynthia H Seow
    Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1426-34. 2009
    ....
  12. ncbi Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease
    Mark S Silverberg
    Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada
    Eur J Hum Genet 15:328-35. 2007
    ....
  13. ncbi Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
    ..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
  14. pmc Genetics of inflammatory bowel disease: current status and future directions
    Thomas D Walters
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario
    Can J Gastroenterol 20:633-9. 2006
  15. ncbi The future of molecular approaches to inflammatory bowel disease
    Boyko Kabakchiev
    Mount Sinai Hospital Inflammatory Bowel Disease Group, Dr Zane Cohen Digestive Diseases Clinical Research Centre, University of Toronto, Toronto, Ontario, Canada
    Mol Diagn Ther 13:217-23. 2009
    ..This article summarizes the current state of molecular testing available for IBD, and the potential utility of such tests as research in the area widens...
  16. ncbi Risk factors for low bone density in Crohn's disease
    Aida Habtezion
    Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Inflamm Bowel Dis 8:87-92. 2002
    ..Disease activity, systemic inflammation, and hormonal and genetic factors may all be important determinants of bone loss in CD...
  17. ncbi Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease
    Elana A Maser
    Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 4:1248-54. 2006
    ..The effect of infliximab infused at scheduled intervals on antibody formation, preinfusion trough serum concentrations of infliximab, and their clinical significance was evaluated in patients with Crohn's disease...
  18. pmc Psychobiological subtypes of ulcerative colitis: pANCA status moderates the relationship between disease activity and psychological distress
    Robert G Maunder
    Department of Psychiatry, Mount Sinai Hospital, Toronto, Canada
    Am J Gastroenterol 101:2546-51. 2006
    ..This study sought to determine whether perinuclear antineutrophil cytoplasmic antibody (pANCA) demarcates subtypes which differ with respect to psychobiological interactions...
  19. ncbi Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
    Amir S Karban
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Room B136, Baltimore, MD 21231, USA
    Hum Mol Genet 13:35-45. 2004
    ..Therefore, we have identified the first potentially functional polymorphism of NFKB1 and demonstrated its genetic association with a common human disease, ulcerative colitis...
  20. ncbi The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction
    Marie Pierik
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 11:1-7. 2005
    ..To further characterize this locus, we assessed gene-environment interaction (IBD4 x smoking) and phenotypic heterogeneity in a large cohort of IBD-affected sibling pairs as part of an ongoing international collaborative effort...
  21. ncbi Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Gastroenterol 101:572-80. 2006
    ..The purpose of this study was to assess phenotypic subsets that contribute to the major IBD susceptibility loci...
  22. ncbi Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort
    Geoffrey C Nguyen
    Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 101:1012-23. 2006
    ..This study was undertaken to characterize racial differences in disease phenotype in a predominantly adult population...
  23. ncbi A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  24. doi Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis
    Roman Kotlowski
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 14:1112-7. 2008
    ..Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the digestive tract. Genetic factors and an abnormal immune response to infections are suspected to be involved in inflammatory bowel diseases...
  25. ncbi Association between the C3435T polymorphism of the MDR1 gene and Crohn's disease
    Simon Lal
    Inflamm Bowel Dis 12:1006-7. 2006
  26. ncbi Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC)
    Themistocles Dassopoulos
    Johns Hopkins University Meyerhoff Inflammatory Bowel Disease Center, Baltimore MD, USA
    Inflamm Bowel Dis 13:975-83. 2007
    ..Our aim was to determine the reliability and validity of these phenotypic assessments...
  27. ncbi Genetic variation in myosin IXB is associated with ulcerative colitis
    Adriaan A van Bodegraven
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Gastroenterology 131:1768-74. 2006
    ..These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease...
  28. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  29. pmc Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    John D Rioux
    Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
    Nat Genet 39:596-604. 2007
    ..Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease...
  30. ncbi Prevalence of CARD15/NOD2 mutations in Caucasian healthy people
    Jean Pierre Hugot
    INSERM Avenir U763 AP HP Université Paris 7, Hopital Robert Debre, Paris, France
    Am J Gastroenterol 102:1259-67. 2007
    ..This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels...

Research Grants2

  1. Identification of IBD Susceptibility Genes
    Mark Silverberg; Fiscal Year: 2007
    ..Advances in IBD gene identification and methodologic approaches may also be applicable to other complex genetic disorders. ..