R Retnakaran

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. request reprint
    Retnakaran R, Connelly P, Maguire G, Sermer M, Zinman B, Hanley A. Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. Diabet Med. 2007;24:245-52 pubmed
    ..HMW adiponectin is significantly decreased in women with GDM. Deficiency of HMW adiponectin may be an early event in the natural history of T2DM. ..
  2. Retnakaran R, Qi Y, Connelly P, Sermer M, Zinman B, Hanley A. Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women. J Clin Endocrinol Metab. 2010;95:670-7 pubmed publisher
  3. Retnakaran R, Qi Y, Connelly P, Sermer M, Hanley A, Zinman B. Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia. Diabetologia. 2010;53:268-76 pubmed publisher
    ..01, p = 0.0027). Hypoadiponectinaemia during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia, and hence may be relevant to the pathophysiology relating GDM with type 2 diabetes. ..
  4. request reprint
    Retnakaran R. Glucose tolerance status in pregnancy: a window to the future risk of diabetes and cardiovascular disease in young women. Curr Diabetes Rev. 2009;5:239-44 pubmed
    ..Ultimately, the insight so derived may inform strategies for postpartum surveillance, risk factor modification, and disease prevention that may eventually lead to a reduction in the burden of T2DM and CVD in women. ..
  5. Retnakaran R, Qi Y, Sermer M, Connelly P, Hanley A, Zinman B. Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes. Diabetes Care. 2008;31:2026-31 pubmed publisher
    ..0001). Any degree of abnormal glucose homeostasis in pregnancy independently predicts an increased risk of glucose intolerance postpartum. ..
  6. Retnakaran R, Qi Y, Sermer M, Connelly P, Hanley A, Zinman B. An abnormal screening glucose challenge test in pregnancy predicts postpartum metabolic dysfunction, even when the antepartum oral glucose tolerance test is normal. Clin Endocrinol (Oxf). 2009;71:208-14 pubmed publisher
    ..754). An abnormal antepartum GCT, even when followed by a normal OGTT, is associated with postpartum glycaemia and beta-cell dysfunction, factors that may portend an increased future risk of diabetes in this patient population. ..
  7. Eng C, Kramer C, Zinman B, Retnakaran R. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Lancet. 2014;384:2228-34 pubmed publisher
    ..This combination is thus a potential therapeutic strategy that could improve the management of patients with type 2 diabetes. None. ..
  8. Retnakaran R, Kramer C, Choi H, Swaminathan B, Zinman B. Liraglutide and the preservation of pancreatic β-cell function in early type 2 diabetes: the LIBRA trial. Diabetes Care. 2014;37:3270-8 pubmed publisher
    ..9 ± 24.7 vs. 238.1 ± 25.2, P = 0.20). Liraglutide provides robust enhancement of β-cell function that is sustained over 48 weeks in early T2DM but lost upon cessation of therapy. ..
  9. Retnakaran R, Qi Y, Sermer M, Connelly P, Hanley A, Zinman B. The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes. J Clin Endocrinol Metab. 2009;94:840-5 pubmed publisher
    ..These relationships may have implications for the glycemic thresholds that define obstetrical and metabolic risk. ..

More Information

Publications15

  1. Kramer C, Swaminathan B, Hanley A, Connelly P, Sermer M, Zinman B, et al. Each degree of glucose intolerance in pregnancy predicts distinct trajectories of β-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum. Diabetes Care. 2014;37:3262-9 pubmed publisher
    ..Each degree of gestational glucose intolerance predicts distinct trajectories of β-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum that drive their differential risk of future T2DM. ..
  2. Retnakaran R, Qi Y, Connelly P, Sermer M, Hanley A, Zinman B. The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk. J Clin Endocrinol Metab. 2010;95:4345-53 pubmed publisher
    ..0239), apoB (t = 2.04, P = 0.0416), and apoB to apoA1 ratio (t = 1.97, P = 0.049). Compared with their peers, women with GDM and GIGT have a more atherogenic lipid profile by 3 months postpartum, characterized by increased LDL and apoB. ..
  3. Shah R, Ye C, Woo M, Connelly P, Hanley A, Sermer M, et al. Erythropoietin and glucose homeostasis in women at varying degrees of future diabetic risk. J Diabetes Complications. 2015;29:26-31 pubmed publisher
    ..003) and diastolic blood pressure (beta=0.3321, p=0.01) at 12-months. Endogenous erythropoietin is not associated with glucose homeostasis early in the natural history of metabolic disease, but may be relevant to vascular health. ..
  4. Retnakaran R, Kramer C, Ye C, Kew S, Hanley A, Connelly P, et al. Fetal sex and maternal risk of gestational diabetes mellitus: the impact of having a boy. Diabetes Care. 2015;38:844-51 pubmed publisher
    ..Male fetus is associated with poorer β-cell function, higher postprandial glycemia, and an increased risk of GDM in the mother. Thus, fetal sex potentially may influence maternal glucose metabolism in pregnancy. ..
  5. Retnakaran R, Qi Y, Sermer M, Connelly P, Zinman B, Hanley A. Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery. Obesity (Silver Spring). 2010;18:1323-9 pubmed publisher
    ..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis. ..
  6. Retnakaran R, Ye C, Kramer C, Connelly P, Hanley A, Sermer M, et al. Maternal Serum Prolactin and Prediction of Postpartum ?-Cell Function and Risk of Prediabetes/Diabetes. Diabetes Care. 2016;39:1250-8 pubmed publisher
    ..50, 95% CI 0.35-0.72, P = 0.0002). Serum prolactin in pregnancy predicts postpartum ?-cell function and risk of prediabetes/diabetes. ..