R Retnakaran

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. ncbi request reprint C-reactive protein and gestational diabetes: the central role of maternal obesity
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
    J Clin Endocrinol Metab 88:3507-12. 2003
  2. doi request reprint Glycemic Variability in Patients With Early Type 2 Diabetes: The Impact of Improvement in β-Cell Function
    Caroline K Kramer
    Corresponding author Ravi Retnakaran
    Diabetes Care 37:1116-23. 2014
  3. ncbi request reprint Adiponectin in pregnancy: implications for health and disease
    A Retnakaran
    Great Lakes Forestry Centre, Canadian Forestry Service, Sault Ste Marie, Canada
    Curr Med Chem 19:5444-50. 2012
  4. pmc Determinants of insulin resistance in infants at age 1 year: impact of gestational diabetes mellitus
    Carla A Borgono
    Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:1795-7. 2012
  5. pmc Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus
    Robert J Goldberg
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1578-84. 2012
  6. ncbi request reprint Role of vitamin D in the pathophysiology and treatment of type 2 diabetes
    Erica Stivelman
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada M5T3L9
    Curr Diabetes Rev 8:42-7. 2012
  7. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
  8. pmc Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    BMC Public Health 10:590. 2010
  9. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
  10. pmc Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, and Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 34:1601-4. 2011

Collaborators

Detail Information

Publications70

  1. ncbi request reprint C-reactive protein and gestational diabetes: the central role of maternal obesity
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
    J Clin Endocrinol Metab 88:3507-12. 2003
    ..These data suggest a model in which obesity mediates a systemic inflammatory response, with possible downstream metabolic sequelae, including insulin resistance and glucose dysregulation...
  2. doi request reprint Glycemic Variability in Patients With Early Type 2 Diabetes: The Impact of Improvement in β-Cell Function
    Caroline K Kramer
    Corresponding author Ravi Retnakaran
    Diabetes Care 37:1116-23. 2014
    ..041 ± 0.06 vs. -0.0002 ± 0.04, respectively; P = 0.006). CONCLUSIONS In early T2DM, glycemic variability is a modifiable parameter that can be reduced by improving β-cell function with short-term IIT. ..
  3. ncbi request reprint Adiponectin in pregnancy: implications for health and disease
    A Retnakaran
    Great Lakes Forestry Centre, Canadian Forestry Service, Sault Ste Marie, Canada
    Curr Med Chem 19:5444-50. 2012
    ..Ultimately, elucidation of adiponectin physiology in the setting of both normal pregnancy and its pathologic conditions may provide unique insight into fundamental processes that are relevant to health and disease in mother and child...
  4. pmc Determinants of insulin resistance in infants at age 1 year: impact of gestational diabetes mellitus
    Carla A Borgono
    Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:1795-7. 2012
    ..Thus, we sought to identify early life determinants of insulin resistance in infants of women with and without GDM...
  5. pmc Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus
    Robert J Goldberg
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1578-84. 2012
    ..Thus, using their subsequent OGTT (performed in the morning), we sought to characterize the metabolic function of women with positive GCTs in relation to the timing of their test...
  6. ncbi request reprint Role of vitamin D in the pathophysiology and treatment of type 2 diabetes
    Erica Stivelman
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada M5T3L9
    Curr Diabetes Rev 8:42-7. 2012
    ..Nevertheless, in light of the widespread prevalence of both vitamin D insufficiency and T2DM, this potential relationship could hold enormous public health implications and hence demands further study to address its unresolved questions...
  7. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
    ..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
  8. pmc Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    BMC Public Health 10:590. 2010
    ..The objective of this report is to present the methodology and design of this study...
  9. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
    ..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
  10. pmc Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, and Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 34:1601-4. 2011
    ..9 years. We evaluate the temporal changes in glycemic control, insulin sensitivity, and β-cell function during this trial...
  11. pmc Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Toronto, Canada M5T3L9
    J Clin Endocrinol Metab 95:670-7. 2010
    ....
  12. doi request reprint The response to short-term intensive insulin therapy in type 2 diabetes
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Diabetes Obes Metab 12:65-71. 2010
    ..Thus, we sought to evaluate the effect of short-term IIT in patients with established T2DM...
  13. ncbi request reprint Glucose tolerance status in pregnancy: a window to the future risk of diabetes and cardiovascular disease in young women
    Ravi Retnakaran
    Department of Medicine, Division of Endocrinology, University of Toronto, Toronto, Canada
    Curr Diabetes Rev 5:239-44. 2009
    ..Ultimately, the insight so derived may inform strategies for postpartum surveillance, risk factor modification, and disease prevention that may eventually lead to a reduction in the burden of T2DM and CVD in women...
  14. doi request reprint Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Res Clin Pract 85:40-6. 2009
    ....
  15. pmc An abnormal screening glucose challenge test in pregnancy predicts postpartum metabolic dysfunction, even when the antepartum oral glucose tolerance test is normal
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Division of Endocrinology, University of Toronto, Toronto, Canada
    Clin Endocrinol (Oxf) 71:208-14. 2009
    ..Thus, we sought to characterize the obstetrical and postpartum metabolic significance of an abnormal GCT in women with normal glucose tolerance (NGT) on antepartum OGTT...
  16. pmc The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
    J Clin Endocrinol Metab 94:840-5. 2009
    ..Thus, to test this assumption, we sought to evaluate the predictive capacity of each glucose value on antepartum OGTT in relation to LGA and postpartum prediabetes/diabetes...
  17. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  18. pmc Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada
    Diabetologia 53:268-76. 2010
    ..Thus, we sought to determine whether adiponectin, leptin and CRP levels during pregnancy relate to the postpartum metabolic defects linking GDM with type 2 diabetes...
  19. doi request reprint Evaluation of proposed oral disposition index measures in relation to the actual disposition index
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Diabet Med 26:1198-203. 2009
    ..166, P = 0.015). Conclusions The OGTT-derived measures ISSI-2 and IGI/fasting insulin exhibit modest correlations with the disposition index. These relationships require further assessment in other patient populations...
  20. pmc Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 33:1798-804. 2010
    ..In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status...
  21. doi request reprint Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 73:476-83. 2010
    ..In this context, we sought to evaluate the risk of early progression to dysglycaemia in women with NGT at 3-month postpartum and identify predictors thereof...
  22. doi request reprint The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  23. pmc Postpartum metabolic function in women delivering a macrosomic infant in the absence of gestational diabetes mellitus
    Simone Kew
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 34:2608-13. 2011
    ..Thus, to test this hypothesis, we assessed metabolic function during and after pregnancy in a cohort of women stratified according to the presence/absence of GDM and LGA delivery, respectively...
  24. doi request reprint Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 12:909-15. 2010
    ..We applied this strategy to assess the effect of sitagliptin on beta-cell function...
  25. pmc Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 34:2431-4. 2011
    ..13 [95% CI 0.06-0.29]; P < 0.0001). CONCLUSIONS Hepatic insulin resistance is an early determinant of declining β-cell function after gestational dysglycemia...
  26. doi request reprint The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy
    R Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:706-12. 2011
    ....
  27. doi request reprint Discordant effects on central obesity, hepatic insulin resistance, and alanine aminotransferase of low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 14:91-3. 2012
    ..In contrast, Rosi/Met lowered ALT in year 1 and maintained this effect throughout the trial. Thus, low-dose Rosi/Met had no effect on central obesity, a transient effect on hepatic insulin sensitivity, and a sustained effect on ALT...
  28. doi request reprint Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 16:1901-7. 2008
    ..Based on these findings, the product of these two indices emerges as a potential OGTT-based measure of beta-cell function...
  29. pmc Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:1323-9. 2010
    ..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis...
  30. ncbi request reprint The impact of family history of diabetes on risk factors for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 67:754-60. 2007
    ..We thus hypothesized that the risk factors for gestational hyperglycaemia in women with FHD may differ from those in women without FHD...
  31. pmc Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 31:1275-81. 2008
    ..Thus, we hypothesized that 1-h GIGT would be associated with the same adverse outcomes as GDM, i.e., increased infant birth weight and postpartum metabolic dysfunction...
  32. ncbi request reprint Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Diabet Med 24:245-52. 2007
    ..e. representing an early stage in the natural history of the disease), we sought to determine if decreased HMW adiponectin is a feature of GDM...
  33. ncbi request reprint Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 48:993-1001. 2005
    ..We conducted the current investigation to determine whether adiponectin is associated with beta cell dysfunction in GDM...
  34. doi request reprint Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy, irrespective of gestational glucose tolerance status
    L Maple-Brown
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 025, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 97:4148-55. 2012
    ..However, these studies have yielded markedly conflicting results, including increased, decreased, and unchanged leptin levels in women with GDM as compared with their peers...
  35. doi request reprint Abnormal screening glucose challenge test in pregnancy and future risk of diabetes in young women
    R Retnakaran
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabet Med 26:474-7. 2009
    ..Thus, in this context, we sought to determine whether women who have a pregnancy complicated by an abnormal GCT, but who do not have GDM, are at increased risk of subsequent diabetes, compared with their peers with an abnormal GCT...
  36. ncbi request reprint Hypoadiponectinaemia in South Asian women during pregnancy: evidence of ethnic variation in adiponectin concentration
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabet Med 21:388-92. 2004
    ..Here, we report the impact of ethnicity on plasma adiponectin concentration in that study...
  37. ncbi request reprint Elevated C-reactive protein in Native Canadian children: an ominous early complication of childhood obesity
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:483-91. 2006
    ..Thus, we sought to determine whether subclinical inflammation is an early complication of obesity in Native children...
  38. doi request reprint Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
    Jill K Hamilton
    Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:340-6. 2010
    ..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
  39. pmc Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study
    Ravi Retnakaran
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    CMAJ 181:371-6. 2009
    ..Thus, we sought to determine whether pregnant women with an abnormal glucose challenge test result but without gestational diabetes have an increased risk of cardiovascular disease...
  40. pmc Area-under-the-HbA1c-curve above the normal range and the prediction of microvascular outcomes: an analysis of data from the Diabetes Control and Complications Trial
    L J Maple-Brown
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Diabet Med 30:95-9. 2013
    ....
  41. pmc Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 70:615-22. 2009
    ..Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function...
  42. ncbi request reprint The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 28:2710-5. 2005
    ..Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide ratio, an alternate measure of proinsulin secretion that is not affected by hepatic insulin extraction...
  43. doi request reprint Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 94:3824-32. 2009
    ....
  44. doi request reprint Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
    Phillip Segal
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Matern Fetal Neonatal Med 21:73-9. 2008
    ..We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population...
  45. doi request reprint Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Obes Metab 14:161-6. 2012
    ..In this report, we will review the rationale and evidence underlying this interesting therapeutic option, and its implications for both clinical research and the management of patients with T2DM...
  46. ncbi request reprint Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects
    Ying Liu
    Department of Biology, York University Toronto, M3J 1P3, Ontario, Canada
    J Clin Endocrinol Metab 92:4313-8. 2007
    ..Circulating levels of HMW, hexameric, and trimeric adiponectin were measured using a multimeric adiponectin ELISA based upon selective protease-mediated digestion...
  47. ncbi request reprint Nontraditional cardiovascular risk factors in pediatric metabolic syndrome
    Ravi Retnakaran
    Division of Endocrinology, The Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 148:176-82. 2006
    ..To study the relationships between nontraditional cardiovascular (CV) risk factors and components of the metabolic syndrome in Native Canadian children, a population at risk of future CV disease...
  48. ncbi request reprint Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Ontario, Canada
    Diabetes Care 29:57-62. 2006
    ..e., a single abnormal value on an OGTT), however, are not well established. We sought to evaluate the metabolic phenotype of pregnant women with IGT in relation to the timing of their isolated hyperglycemia...
  49. ncbi request reprint Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 91:93-7. 2006
    ..Nevertheless, there has been limited study of insulin action during pregnancy in these ethnic groups...
  50. doi request reprint Effect of maternal gestational diabetes on the cardiovascular risk factor profile of infants at 1 year of age
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada Division of Endocrinology, University of Toronto, Toronto, Canada Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nutr Metab Cardiovasc Dis 23:1175-81. 2013
    ..Thus, we sought to evaluate cardiovascular risk factors and determinants thereof in 1-year-old infants of women with and without GDM...
  51. doi request reprint Effect of subsequent pregnancies on the risk of developing diabetes following a first pregnancy complicated by gestational diabetes: a population-based study
    R Retnakaran
    Department of Medicine Institute of Medical Science, University of Toronto Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Diabet Med 28:287-92. 2011
    ..Thus, we sought to determine whether subsequent pregnancies are associated with the risk of developing diabetes following gestational diabetes...
  52. ncbi request reprint Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution
    Gabie K B Ong
    Faculty of Arts and Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 67:108-14. 2007
    ....
  53. pmc Increased risk of cardiovascular disease in young women following gestational diabetes mellitus
    Baiju R Shah
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:1668-9. 2008
    ..To determine whether women with gestational diabetes mellitus (GDM) have an increased risk of cardiovascular disease (CVD) following pregnancy...
  54. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
  55. pmc Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:1410-5. 2008
    ....
  56. ncbi request reprint Does hypoadiponectinemia explain the increased risk of diabetes and cardiovascular disease in South Asians?
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 29:1950-4. 2006
  57. ncbi request reprint Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:799-800. 2004
  58. doi request reprint Intensive insulin therapy in newly diagnosed type 2 diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ont, Canada M5G 1X5
    Lancet 371:1725-6. 2008
  59. ncbi request reprint Continuous subcutaneous insulin infusion versus multiple daily injections: the impact of baseline A1c
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:2590-6. 2004
    ..Thus, a comparison of efficacy between CSII and MDII should be undertaken only in studies that used rapid-acting analogs for both intensive regimens...
  60. pmc Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1379-81. 2010
    ..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
  61. doi request reprint Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 69:885-93. 2008
    ..Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters...
  62. doi request reprint Type 1 diabetes, hyperglycaemia, and the heart
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Lancet 371:1790-9. 2008
    ..We review current concepts in type 1 diabetes and the heart, focusing on recent insights into the central role of hyperglycaemia...
  63. ncbi request reprint Low serum levels of high-molecular weight adiponectin in Indo-Asian women during pregnancy: evidence of ethnic variation in adiponectin isoform distribution
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5
    Diabetes Care 29:1377-9. 2006
  64. ncbi request reprint Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Pediatr Nephrol 22:1007-13. 2007
    ..0072). In summary, increased cystatin C is associated with an enhanced CV risk factor profile in Aboriginal youth and may be an early event in the natural history of vascular disease...
  65. ncbi request reprint Unmasking of type III hyperlipoproteinemia by hypothyroidism: a dramatic illustration of altered lipoprotein metabolism in a postpartum woman
    Ravi Retnakaran
    Department of Medicine, Division of Endocrinology, St Michael s Hospital and Health Centre, 61 Queen Street East, Toronto, Ontario, Canada
    Endocr Pract 11:394-8. 2005
    ..To illustrate the potential abnormalities in lipoprotein metabolism associated with type III hyper-lipoproteinemia and the modulation of their clinical expression by thyroid hormone and estrogenic status...
  66. pmc Cigarette smoking and cardiovascular risk factors among Aboriginal Canadian youths
    Ravi Retnakaran
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 173:885-9. 2005
    ....
  67. ncbi request reprint Impact of the metabolic syndrome on macrovascular and microvascular outcomes in type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study 78
    Carole A Cull
    Diabetes Trial Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom, OX3 7LJ
    Circulation 116:2119-26. 2007
    ..We examined retrospectively the degree to which the presence of MetS in individuals with type 2 diabetes mellitus increased their risk of diabetic complications using United Kingdom Prospective Diabetes Study data...
  68. ncbi request reprint Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74
    Ravi Retnakaran
    Diabetes Trial Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Diabetes 55:1832-9. 2006
    ..Distinct sets of risk factors are associated with the development of these two outcomes, consistent with the concept that they are not linked inexorably in type 2 diabetes...
  69. ncbi request reprint Framingham, SCORE, and DECODE risk equations do not provide reliable cardiovascular risk estimates in type 2 diabetes
    Ruth L Coleman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, UK
    Diabetes Care 30:1292-3. 2007
  70. ncbi request reprint Continuous subcutaneous insulin infusion versus multiple daily injections: modeling predicted benefits in relationship to baseline A1c
    Ravi Retnakaran
    Diabetes Care 28:1835-6. 2005