Affiliation: Mount Sinai Hospital
- Postasphyxial hypoxic-ischemic encephalopathy in neonates: outcome prediction rule within 4 hours of birthPrakesh S Shah
Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 160:729-36. 2006..To construct and validate a model and derive a simple rule that is usable in any birth location for the prediction of outcome of term infants with severe asphyxia...
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infantsArne Ohlsson
Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, University ofToronto, Toronto, Canada
Cochrane Database Syst Rev 4:CD003481. 2013..Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer side effects...
- NIDCAP: a systematic review and meta-analyses of randomized controlled trialsArne Ohlsson
Department of Paediatrics, University of Toronto, Ontario, Canada
Pediatrics 131:e881-93. 2013..Our objective was to assess the effectiveness of NIDCAP in improving outcomes in preterm infants...
- Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infantsArne Ohlsson
Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, University ofToronto, Toronto, Canada
Cochrane Database Syst Rev 9:CD004863. 2012..Low plasma levels of erythropoietin (EPO) in preterm infants provide a rationale for the use of EPO to prevent or treat anaemia...
- Actuarial survival of a large Canadian cohort of preterm infantsHuw P Jones
Department of Pediatrics, St Mary s Hospital, Portsmouth, UK
BMC Pediatr 5:40. 2005....
- Healthcare professionals' perceptions of pain in infants at risk for neurological impairmentLynn M Breau
Pediatric Pain Service, IWK Health Centre, 5850 University Ave, P, O, Box 9700, Halifax, Nova Scotia, B3K 6R8, Canada
BMC Pediatr 4:23. 2004..To determine whether healthcare professionals perceive the pain of infants differently due to their understanding of that infant's level of risk for neurological impairment...
- Identification of pain indicators for infants at risk for neurological impairment: a Delphi consensus studyBonnie Stevens
Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
BMC Pediatr 6:1. 2006..The objective of this study was to establish consensus about which behavioural, physiologic and contextual indicators best characterize pain in infants at high, moderate and low levels of risk for NI...
- Knowledge translation and evidence-based perinatal/neonatal health careArne Ohlsson
University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Neonatal Netw 21:69-74. 2002..Consumers of perinatal/neonatal health care or their ombudsmen should be encouraged to take part in setting the agenda and defining important outcomes for such research...
- [Meta-regression can indicate if further NIDCAP studies are justified]Arne Ohlsson
Department of Paediatrics, Obstetrics and Gynaecology, University of Toronto, Ontario, Canada
Lakartidningen 104:134-7. 2007
- Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infantsA Ohlsson
Mount Sinai Hospital, Department of Paediatrics, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
Cochrane Database Syst Rev 3:CD004863. 2006..Hematocrit falls after birth in preterm infants due to physiological factors and blood letting. Low plasma levels of erythropoietin (EPO) in preterm infants provide a rationale for the use of EPO to prevent or treat anemia...
- Effects of the September 11, 2001 disaster on pregnancy outcomes: a systematic reviewArne Ohlsson
Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Canada
Acta Obstet Gynecol Scand 90:6-18. 2011..Pregnant women and their offspring are especially vulnerable during and after such a terrorist attack. The objective was to systematically review the risks of adverse pregnancy outcomes after the terrorist attacks on Sept 11, 2001...
- Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomesElizabeth V Asztalos
Department of Newborn and Developmental Paediatrics, Centre for Mother, Infant, and Child Research, Sunnybrook Health Sciences Centre, M4 233 2075 Bayview Ave Toronto, Ontario, M4N 3M5, Canada
Pediatrics 126:e1045-55. 2010....
- Outcomes of preterm infants <29 weeks gestation over 10-year period in Canada: a cause for concern?P S Shah
Division of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada
J Perinatol 32:132-8. 2012..To compare risk-adjusted changes in outcomes of preterm infants <29 weeks gestation born in 1996 to 1997 with those born in 2006 to 2007...
- Variations in practice and outcomes in the Canadian NICU network: 1996-1997S K Lee
Department of Pediatrics, University of British Columbia, British Columbia, Canada
Pediatrics 106:1070-9. 2000..Previous reports of variations in outcomes among neonatal intensive care units (NICUs) examined only specific subpopulations of interest (eg, very low birth weight [VLBW] infants <1500 g of birth weight [BW])...
- The outcome of triplet, quadruplet, and quintuplet pregnancies managed in a perinatal unit: obstetric, neonatal, and follow-up dataR Gonen
Regional Perinatal Unit, Women s College Hospital, Toronto, Ontario, Canada
Am J Obstet Gynecol 162:454-9. 1990....
- Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infantsB Schmidt
Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 344:1966-72. 2001..Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known...
- The Early External Cephalic Version (ECV) 2 Trial: an international multicentre randomised controlled trial of timing of ECV for breech pregnanciesE K Hutton
Department of Obstetrics and Gynecology Midwifery, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
BJOG 118:564-77. 2011....
- Prediction of perinatal outcome in fetuses suspected to have intrauterine growth restriction: Doppler US study of fetal cerebral, renal, and umbilical arteriesK W Fong
Dept of Medical Imaging, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Radiology 213:681-9. 1999....
- Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trialKellie E Murphy
Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Lancet 372:2143-51. 2008..We aimed to find out whether multiple courses of antenatal corticosteroids would reduce neonatal morbidity and mortality without adversely affecting fetal growth...
- Survival, morbidity, and resource use of infants of 25 weeks' gestational age or lessK Chan
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Am J Obstet Gynecol 185:220-6. 2001..CONCLUSION: Extremely preterm infants have a high incidence of mortality and morbidity and consume disproportionate amounts of neonatal intensive care unit resources...
- Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infectionDirk Bassler
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Pediatrics 123:313-8. 2009..Neonatal infection has also been linked with later impairment. We examined whether the addition of infection to the count of 3 neonatal morbidities further improves the prediction of poor outcome...
- Multiple courses of antenatal corticosteroids: a systematic review and meta-analysisF Aghajafari
Institute of Medical Sciences, Center for Research in Women s Health, University of Toronto, Ontario, Canada
Am J Obstet Gynecol 185:1073-80. 2001..To assess the effects of multiple courses of antenatal corticosteroids on perinatal and neonatal death and neonatal, infant, and maternal disease...
- Effect of epidural vs parenteral opioid analgesia on the progress of labor: a meta-analysisS H Halpern
Department of Anaesthesia, University of Toronto and Women s College Hospital, Ontario, Canada
JAMA 280:2105-10. 1998..Epidural labor analgesia, if selected by the patient, is associated with high cesarean delivery rates. Results of randomized trials comparing rates of cesarean delivery using epidural anesthesia vs parenteral opioids are inconsistent...
- A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) studyPrakesh S Shah
Department of Pediatrics, Mount Sinai Hospital, 775A, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
Pediatrics 119:e284-91. 2007..Heparin use to prevent such complications and prolong the usability of peripherally inserted central venous catheters is inconclusive...
- No indications of increased quiet sleep in infants who receive care based on the Newborn Individualized Care and Assessment Program (NIDCAP)Arne Ohlsson
Acta Paediatr 91:262-263.. 2002
- The effectiveness of premedication for endotracheal intubation in mechanically ventilated neonates. A systematic reviewVibhuti Shah
Department of Paediatrics, Mount Sinai Hospital, Faculty of Medicine, University of Toronto, 600 University Avenue, Toronto, ON M5G 1X5, Canada
Clin Perinatol 29:535-54. 2002..Adequately skilled staff who have a full understanding of the potential benefits and harms of the interventions used should perform intubation and the administration of premedication in neonates...
- Determining the structure of acute pain responses in vulnerable neonatesBonnie Stevens
Lawrence Bloomberg Faculty of Nursing, University of Toronto, Canada
Can J Nurs Res 39:32-47. 2007..Physiological indicators explained 8 to 26% additional variance. There were no consistent differences in the factor structures when contextual factors were explored...
- Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic reviewPrakesh S Shah
Department of Paediatrics, Mount Sinai Hospital, and University of Toronto, Ontario, M5G 1X5, Canada
Arch Pediatr Adolesc Med 161:951-8. 2007..0-33.5 degrees C] or mild [>or=33.6 degrees C])...
- Long-term effects of caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
N Engl J Med 357:1893-902. 2007..Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth...
- The Newborn Individualized Developmental Care and Assessment Program is not supported by meta-analyses of the dataSusan E Jacobs
Division of Neonatology, Department of Pediatrics, the Hospital for Sick Children and Mount Sinai Hospital, University of Toronto, Ontario, Canada
J Pediatr 140:699-706. 2002..Neurodevelopmental outcome was improved at 9 or 12 months but not at 2 years. CONCLUSIONS: There is insufficient evidence to support the NIDCAP to improve medical and neurodevelopmental outcomes of preterm infants...
- Efficacy and safety of sucrose for procedural pain relief in preterm and term neonatesSharyn Gibbins
Faculty of Nursing, Health Scoences Center, Sunnybrook and Women s College Hospital, 76 Grenville Street, Rm 445, Toronto, Ontario, Canada M5A 1B2
Nurs Res 51:375-82. 2002....
- Caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 354:2112-21. 2006..It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight...
- Comparison of pain responses in infants of different gestational agesSharyn Gibbins
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Neonatology 93:10-8. 2008..Using physiological or behavioral pain indicators derived from more mature infants may lead to inaccurate assessments and management...
- Procedural pain in newborns at risk for neurologic impairmentBonnie Stevens
Faculties of Nursing and Medicine, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Room 4734c, Toronto, Ontario, Canada M5G 1X8
Pain 105:27-35. 2003..As these infants are vulnerable to pain and its consequences, the rational underlying health professional strategies regarding painful procedures and analgesic use for procedural pain in this population urgently awaits exploration...
- Judgments of pain in the neonatal intensive care setting: a survey of direct care staffs' perceptions of pain in infants at risk for neurological impairmentLynn M Breau
Pediatric Pain Service, IWK Health Centre, Halifax, Nova Scotia, Canada
Clin J Pain 22:122-9. 2006..To determine whether healthcare professionals believe the pain of infants at risk for neurologic impairment differs from that of typical infants...
- Variations in antenatal corticosteroid therapy: a persistent problem despite 30 years of evidenceLi-Yin Chien
Institute of Community Health Nursing, School of Nursing, National Yang-Ming University, Taipei, Taiwan
Obstet Gynecol 99:401-8. 2002..Increased use of antenatal corticosteroids for preterm deliveries can reduce neonatal mortality in Canada by up to 10%...
- Repeated doses of antenatal corticosteroids in animals: a systematic reviewFariba Aghajafari
Institute of Medical Sciences, Maternal, Infant and Reproductive Health Research Unit, Center for Research in Women's Health, Department of Obstetrics and Gynecology, Sunnybrook and Women's College Health Sciences Center, University of Toronto, Ontario
Am J Obstet Gynecol 186:843-9. 2002....
- Variations in mortality rates among Canadian neonatal intensive care unitsKoravangattu Sankaran
Department of Pediatrics, University of Saskatchewan, Saskatoon
CMAJ 166:173-8. 2002..The significant variation in risk-adjusted mortality rates emphasizes the importance of risk adjustment for valid comparison of NICU outcomes...
- Preterm birth, stillbirth and infant mortality among triplet births in Canada, 1985-96K S Joseph
Department of Obstetrics and Gyneacology, Halifax, Nova Scotia, Canada
Paediatr Perinat Epidemiol 16:141-8. 2002..In spite of temporal reductions in infant mortality, triplet births continue to be associated with very high rates of preterm birth and fetal and infant mortality. Fetal mortality among triplets has not changed over the last ten years...
- Male/female differences in indomethacin effects in preterm infantsArne Ohlsson
University of Toronto, Toronto, McMaster University, Hamilton, Ontario, Canada
J Pediatr 147:860-2. 2005..A secondary analysis was performed in the entire "Trial of Indomethacin Prophylaxis in Preterms study" cohort. The results suggest a weak differential treatment effect of indomethacin by sex...
- Perinatal outcomes of in vitro fertilization twins: a systematic review and meta-analysesSarah McDonald
Department of Obstetrics and Gynecology, Ottawa Hospital, University of Ottawa, Ontario, Canada
Am J Obstet Gynecol 193:141-52. 2005..The objective of this meta-analysis was to determine whether the incidence of poor obstetric outcomes is higher for in vitro fertilization twins than for spontaneously conceived twins who were matched for maternal age...
- Improved outcomes of outborn preterm infants if admitted to perinatal centers versus freestanding pediatric hospitalsPrakesh S Shah
Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
J Pediatr 146:626-31. 2005..CONCLUSIONS: After adjustment for perinatal risks and admission illness severity, outborn infants had better outcomes if they were admitted to perinatal centers compared with freestanding pediatric hospitals...
- Multiple versus single courses of antenatal corticosteroids for preterm birth: a pilot studyFariba Aghajafari
Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada
J Obstet Gynaecol Can 24:321-9. 2002..If the study protocols are supported by physicians and their patients, a multicentre randomized controlled trial is feasible...
- Perinatel outcomes of singleton pregnancies achieved by in vitro fertilization: a systematic review and meta-analysisSarah D McDonald
Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, Ontario, Canada
J Obstet Gynaecol Can 27:449-59. 2005..59; 95% CI 1.20-2.11), and congenital malformations (OR 1.41; CI 1.06-1.88). CONCLUSIONS: IVF singleton pregnancies have increased rates of poor obstetric outcome, compared with spontaneously conceived singletons matched for maternal age...
- Hydralazine for treatment of severe hypertension in pregnancy: meta-analysisLaura A Magee
University of British Columbia, BC Women s Hospital and Health Centre, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
BMJ 327:955-60. 2003..To review outcomes in randomised controlled trials comparing hydralazine against other antihypertensives for severe hypertension in pregnancy...
- Perinatal and neurodevelopmental outcome with isolated fetal ventriculomegaly: a systematic reviewMatthew D Laskin
Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Canada
J Matern Fetal Neonatal Med 18:289-98. 2005..We recommend prospective cohort studies with new diagnostic modalities to better identify the underlying conditions relating to moderate/severe impairments in the remaining cases...
- Economics of home vs. hospital breastfeeding support for newbornsBonnie Stevens
Faculties of Nursing and Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
J Adv Nurs 53:233-43. 2006..hospital-based support for breastfeeding by nurse lactation consultants for term and near-term neonates during the first week of life...
- Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm laborGraeme N Smith
Queen s Perinatal Research Unit, Department of Obstetrics and Gynecology, Kingston General Hospital, Queen s University, Kingston, Ontario, Canada
Am J Obstet Gynecol 196:37.e1-8. 2007..The objective of this randomized placebo-controlled trial was to determine the effect of transdermal nitroglycerin on neonatal outcomes in women who present in preterm labor...
- Determining behavioural and physiological responses to pain in infants at risk for neurological impairmentBonnie Stevens
Faculty of Nursing, University of Toronto, Toronto, Ont, Canada
Pain 127:94-102. 2007..All infants responded to the most painful phase of the heel lance; however, infants at moderate and highest risk for NI exhibited decreased responses in some indicators...
- Neonatal intensive care unit characteristics affect the incidence of severe intraventricular hemorrhageAnne R Synnes
Department of Pediatrics, University of British Columbia, Canada
Med Care 44:754-9. 2006..CONCLUSIONS: The incidence of severe IVH is affected by NICU characteristics, suggesting important new strategies to reduce this important adverse outcome...
- The benefit of preterm birth at tertiary care centers is related to gestational ageShoo K Lee
Department of Pediatrics, University of British Columbia, Vancouver, Canada
Am J Obstet Gynecol 188:617-22. 2003..CONCLUSION: The short-term benefit of preterm birth at tertiary centers is related inversely to gestational age and may not extend beyond 29 weeks of gestation...
- Doppler ultrasonography versus amniocentesis to predict fetal anemiaDick Oepkes
Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
N Engl J Med 355:156-64. 2006..CONCLUSIONS: Doppler measurement of the peak velocity of systolic blood flow in the middle cerebral artery can safely replace invasive testing in the management of Rh-alloimmunized pregnancies. (ClinicalTrials.gov number, NCT00295516.)...
- Antibiotics for sore throat to prevent rheumatic fever: yes or no? How the Cochrane Library can helpArne Ohlsson
Department of Paediatrics, University of Toronto, Ont
CMAJ 171:721-3. 2004