M P Muller
Affiliation: Mount Sinai Hospital
- Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, CanadaMatthew P Muller
Department of Microbiology, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
Arch Intern Med 163:467-72. 2003..Progression is rapid despite appropriate therapy. The incidence is similar to, and the case fatality rate higher than, that of necrotizing fasciitis...
- Febrile respiratory illness in the intensive care unit setting: an infection control perspectiveMatthew P Muller
Department of Internal Medicine, Infectious Diseases Division, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Curr Opin Crit Care 12:37-42. 2006....
- Early diagnosis of SARS: lessons from the Toronto SARS outbreakM P Muller
Department of Microbiology, Mount Sinai Hospital, 600 University Avenue, M5G 1X5 Toronto, Canada
Eur J Clin Microbiol Infect Dis 25:230-7. 2006..Other clinical, laboratory and radiographic findings further raise or lower the likelihood of SARS and provide a rational basis for estimating the likelihood of SARS and directing initial management...
- Adverse events associated with high-dose ribavirin: evidence from the Toronto outbreak of severe acute respiratory syndromeMatthew P Muller
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Pharmacotherapy 27:494-503. 2007..To distinguish adverse events related to ribavirin therapy from those attributable to severe acute respiratory syndrome (SARS), and to determine the rate of potential ribavirin-related adverse events...
- Severe acute respiratory syndromeMichael D Christian
Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Clin Infect Dis 38:1420-7. 2004..We present an overview of the epidemiology, clinical presentation, diagnosis, and treatment of SARS based on the current state of knowledge derived from published studies and our own personal experience...
- Rapid control of a methicillin resistant Staphylococcus aureus (MRSA) outbreak in a medical surgical intensive care unit (ICU)Anjum Khan
St Michael s Hospital, Toronto, Ontario, Canada
Can J Infect Control 24:12-6. 2009..Complete cessation of transmission occurred after the initiation of decolonization for all positive patients...
- Clinical trials and novel pathogens: lessons learned from SARSMatthew P Muller
Mount Sinai Hospital, Toronto, Ontario, Canada
Emerg Infect Dis 10:389-94. 2004..Strategies to facilitate future clinical trials during outbreaks of unknown or novel pathogens are also presented...
- Severe acute respiratory syndrome (SARS) coronavirusMatthew P Muller
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
Semin Respir Crit Care Med 28:201-12. 2007..This review discusses the likelihood of another SARS pandemic and reviews the epidemiological and clinical features of the disease with an emphasis on the clinical presentation, diagnosis, and management of SARS...
- Impact of a mandatory infection control education program on nosocomial acquisition of methicillin-resistant Staphylococcus aureusTodd C Lee
University of Toronto, Canada
Infect Control Hosp Epidemiol 30:249-56. 2009..To assess the impact of an institution-wide infection control education program on the rate of transmission of methicillin-resistant Staphylococcus aureus (MRSA)...
- One-year outcomes and health care utilization in survivors of severe acute respiratory syndromeCatherine M Tansey
Department of Medicine, University Health Network, and Mount Sinai Hospital, Toronto, Ontario, Canada
Arch Intern Med 167:1312-20. 2007..Research conducted during the SARS outbreak may help inform research planning for future public health emergencies. The objective of this study was to evaluate the 1-year outcomes in survivors of SARS and their family caregivers...
- Human immunopathogenesis of severe acute respiratory syndrome (SARS)Mark J Cameron
University Health Network, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Virus Res 133:13-9. 2008..We contend that dysregulated type I and II interferon (IFN) responses during SARS may culminate in a failure of the switch from hyper-innate immunity to protective adaptive immune responses in the human host...
- Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndromeMark J Cameron
Division of Experimental Therapeutics, University Health Network, MaRS Centre, 3 916 TMDT, 101 College Street, Toronto, Ontario, Canada
J Virol 81:8692-706. 2007....
- Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia?Matthew P Muller
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Clin Infect Dis 40:1079-86. 2005..Hematological and biochemical abnormalities, particularly lymphopenia, are common in patients with SARS...
- Alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndromeBenjamin J Cowling
Department of Community Medicine, School of Public Health, University of Hong Kong, Pokfulam, Hong Kong
Epidemiology 18:253-9. 2007..Accurate and precise estimates of the incubation distribution of novel, emerging infectious diseases are vital to inform public health policy and to parameterize mathematical models...
- Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, CanadaDavid A Boyd
Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington St, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 48:3758-64. 2004..coli strain isolated in India in 1999, revealed that the plasmids had several features in common, including an R100 backbone and several of the resistance genes, including bla(CTX-M-15), bla(TEM-1), bla(OXA-1), tetA, and aac(6')-Ib...
- Clinical prognostic rules for severe acute respiratory syndrome in low- and high-resource settingsBenjamin J Cowling
Department of Community Medicine and School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong
Arch Intern Med 166:1505-11. 2006..877 and 0.892 in the derivation and validation cohorts, respectively. CONCLUSION: The model performs well and could be useful in assessing prognosis for patients who are infected with re-emergent SARS...
- Development of a triage protocol for critical care during an influenza pandemicMichael D Christian
Division of Infectious Diseases and Critical Care, Department of Postgraduate Medicine, McMaster University, Hamilton, Ont
CMAJ 175:1377-81. 2006..Of particular concern in this planning is the allocation of resources, such as ventilators and antiviral medications, which will likely become scarce during a pandemic...