Genomes and Genes
Affiliation: Mount Sinai Hospital
- Prediction of neonatal outcomes in extremely preterm neonatesWen J Ge
Maternal Infant Care MiCare Research Centre, Mount Sinai Hospital, 700 University Ave, Suite 8 500, Toronto, Ontario M5G 1X6
Pediatrics 132:e876-85. 2013..To develop and validate a statistical prediction model spanning the severity range of neonatal outcomes in infants born at ≤ 30 weeks' gestation...
- Treatment of patent ductus arteriosus and neonatal mortality/morbidities: adjustment for treatment selection biasLucia Mirea
Maternal Infant Care MiCare Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada
J Pediatr 161:689-94.e1. 2012..To examine the association between treatment for patent ductus arteriosus (PDA) and neonatal outcomes in preterm infants, after adjustment for treatment selection bias...
- Strategies for genetic association analyses combining unrelated case-control individuals and family triosLucia Mirea
Maternal Infant Care Research Centre, Mount Sinai Hospital, 700 University Avenue, Suite 8 500, Toronto, Ontario M5G 1X6, Canada
Am J Epidemiol 176:70-9. 2012..The statistical methods are evaluated using simulations and applied to a candidate gene study of childhood leukemia (Quebec Childhood Leukemia Study, 1980-2000)...
- Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications GHussam Al-Kateb
Program in Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building East Tower, Rm 15 707, 101 College St, Toronto, Ontario, Canada
Diabetes 57:218-28. 2008..Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes...
- Beliefs about optimal age and screening frequency predict breast screening adherence in a prospective study of female relatives from the Ontario site of the Breast Cancer Family RegistryPaul Ritvo
Research, Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON M5G 2L7, Canada
BMC Public Health 12:518. 2012..Although few studies have linked cognitive variables with adherence to mammography screening in women with family histories of breast and/or ovarian cancer, research studies suggest cognitive phenomena can be powerful adherence predictors...
- Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectinAndrew D Paterson
Hospital for Sick Children, Toronto, Ontario, Canada
Arterioscler Thromb Vasc Biol 29:1958-67. 2009..Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype...
- Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traitsLucia Mirea
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Genet Epidemiol 34:502-11. 2010....
- Perceived risk and adherence to breast cancer screening guidelines among women with a familial history of breast cancer: a review of the literatureMeghan J Walker
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
Breast 22:395-404. 2013..A small positive association has been consistently demonstrated between perceived breast cancer risk and mammography use. Evidence specific to women with familial breast cancer risk has not been previously reviewed...
- Adherence to breast and ovarian cancer screening recommendations for female relatives from the Ontario site of the Breast Cancer Family RegistryMichael A Campitelli
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada
Eur J Cancer Prev 20:492-500. 2011..76-4.05). Although the overall level of adherence among high-risk women is suboptimal in the community, women at a higher familial risk are adhering more often to cancer screening recommendations than women at a lower familial risk...
- Does perceived risk predict breast cancer screening use? Findings from a prospective cohort study of female relatives from the Ontario site of the breast cancer family registryMeghan J Walker
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada Division of Epidemiology, Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
Breast 23:482-8. 2014..Results may inform risk education and management strategies for women with varying levels of familial breast cancer risk...
- Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics studyHussam Al-Kateb
Program in Genetics and Genome Biology, Hospital of Sick Children Research Institute, Toronto, ON, Canada
Diabetes 56:2161-8. 2007..We sought to determine if any common variants in the gene for vascular endothelial growth factor (VEGFA) are associated with long-term renal and retinal complications in type 1 diabetes...
- Association between congenital anomalies and area-level deprivation among infants in neonatal intensive care unitsKate L Bassil
Maternal Infant Care Research Centre MiCare, Mount Sinai Hospital, Toronto, Canada
Am J Perinatol 30:225-32. 2013..To examine the relationship between area-level material deprivation and the risk of congenital anomalies in infants admitted to neonatal intensive care units (NICUs) across Canada...
- Worry is good for breast cancer screening: a study of female relatives from the ontario site of the breast cancer family registryLi Rita Zhang
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9
J Cancer Epidemiol 2012:545062. 2012..Conclusions. Medium levels of cancer worries predicted higher rates of screening mammography and CBE among high-risk women...
- Impact of familial risk and mammography screening on prognostic indicators of breast disease among women from the Ontario site of the Breast Cancer Family RegistryMeghan J Walker
Division of Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, ON, M5G 2L7, Canada
Fam Cancer 13:163-72. 2014..80, 95 % CI 1.18-51.50) compared with screen-detected cancers. Screening mammography may be effective for women with a first-degree family history of breast cancer, irrespective of level of familial risk...
- Relationship of mode of conception and sex concordance with mortality/morbidity in preterm twinsLucia Mirea
Maternal Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada
Twin Res Hum Genet 16:985-93. 2013..To assess the association of mode of conception and sex concordance with neonatal outcomes in very preterm twins...
- Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics StudyAndrew P Boright
Department of Medicine, University Health Network, University of Toronto, Toronto, Canada
Diabetes 54:1238-44. 2005..41 [0.22-0.78], P = 0.006). Our findings in the DCCT/EDIC cohort provide strong evidence that genetic variation at the ACE gene is associated with the development of nephropathy in patients with type 1 diabetes...
- Tests for covariate-associated heterogeneity in IBD allele sharing of affected relativesLucia Mirea
Prosserman Centre for Studies of Complex Diseases in Human Populations, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Genet Epidemiol 26:44-60. 2004..Application of these tests for heterogeneity detected significant differences in allele sharing between subgroups of families with inflammatory bowel disease...
- Favourable prognostic factors of subsequent screen-detected breast cancers among women aged 50-69Anna M Chiarelli
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
Eur J Cancer Prev 21:499-506. 2012..As long-term mortality reduction for breast screening may depend on subsequent screens, our study indicates that mammography screening can be effective in women aged 50-69...
- Passive cigarette smoke exposure during various periods of life, genetic variants, and breast cancer risk among never smokersLaura N Anderson
Department of Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
Am J Epidemiol 175:289-301. 2012..Although the results of this study were largely null, it is possible that premenopausal women exposed to passive smoke or carrying certain genetic variants may be at higher risk of breast cancer...
- Active cigarette smoking, variants in carcinogen metabolism genes and breast cancer risk among pre- and postmenopausal women in Ontario, CanadaMichelle Cotterchio
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Breast J 20:468-80. 2014..0) making interpretations difficult. Active smoking was not associated with breast cancer risk, although several significant interactions were observed between smoking, carcinogen-metabolizing genetic variants, and breast cancer risk...
- Influence of perceived breast cancer risk on screening behaviors of female relatives from the Ontario site of the Breast Cancer Family RegistryLi Rita Zhang
Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 2L7, Canada
Eur J Cancer Prev 20:255-62. 2011..These findings may inform educational messages for improving risk communication of women at elevated familial breast cancer risk...
- Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressureLucia Mirea
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
BMC Genet 4:S23. 2003....
- Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relativesShelley B Bull
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
Hum Hered 56:94-106. 2003..In this report, we highlight issues that arise in studies of families with affected relatives...
- The International Network for Evaluating Outcomes of very low birth weight, very preterm neonates (iNeo): a protocol for collaborative comparisons of international health services for quality improvement in neonatal carePrakesh S Shah
Canadian Neonatal Network, Maternal Infant Care Research Centre, Mount Sinai Hospital, 700 University Avenue, Toronto, Ontario M5G 1X6, Canada
BMC Pediatr 14:110. 2014....
- A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel diseaseMark S Silverberg
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Inflamm Bowel Dis 9:1-9. 2003....
- Model-free linkage analysis of a binary traitWei Xu
Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada
Methods Mol Biol 850:317-45. 2012..In Subheading 2, we work through the methods on a rich example providing sample software code and output. Subheading 3 contains notes with additional details on various topics that may need further consideration during analysis...