Research Topics
Species | Kelly S MacDonaldSummaryAffiliation: Mount Sinai Hospital Country: Canada Publications
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Detail Information
Publications
Mother-child class I HLA concordance increases perinatal human immunodeficiency virus type 1 transmissionK S MacDonald
Department of Medical Microbiology, University of Nairobi, Kenya
J Infect Dis 177:551-6. 1998..63; 95% confidence interval, 1.36-5.07; P = .003). Thus, discordant HLA may provide infants with a means of protection against HIV-1 as a result of allogeneic infant anti-maternal MHC immune responses...- Human leucocyte antigen supertypes and immune susceptibility to HIV-1, implications for vaccine designK S MacDonald
Department of Microbiology, Mount Sinai Hospital, Room 1484, 600 University Avenue, Toronto, Ont, M5G 1X5 Canada
Immunol Lett 79:151-7. 2001..The identification of HIV-1 supertopes, which are associated with protection from HIV-1 infection, has important implications for the application of epitope-based HIV-l vaccines in a variety of racial groups... - Vitamin A and risk of HIV-1 seroconversion among Kenyan men with genital ulcersK S MacDonald
Department of Microbiology, Mount Sinai Hospital, Toronto, Canada
AIDS 15:635-9. 2001..Vitamin A is involved in normal immune function and the maintenance of mucosal integrity through complex effects on cellular differentiation... - The HLA A2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmissionK S MacDonald
Departments of Immunology and Medicine, University of Toronto, and Department of Microbiology, Mount Sinai Hospital, Toronto, Canada
J Infect Dis 183:503-6. 2001..03-0.54; P=.006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission... - Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infectionK S MacDonald
Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
J Infect Dis 181:1581-9. 2000..These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated... - Prevalent herpes simplex virus type 2 infection is associated with altered vaginal flora and an increased susceptibility to multiple sexually transmitted infectionsRupert Kaul
Department of Medical Microbiology, University of Nairobi, Kenya
J Infect Dis 196:1692-7. 2007..We hypothesized that HSV-2 infection might also predispose individuals to acquire other common sexually transmitted infections (STIs)... 
Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activationPrameet M Sheth
Department of Medicine, University of Toronto, Toronto, Canada
J Infect Dis 197:1394-401. 2008....- Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex workers predating population declines in HIV prevalenceJoshua Kimani
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
AIDS 22:131-7. 2008..We examined temporal trends in HIV prevalence and per-act incidence, adjusted for behavioral and other variables, in FSWs from Nairobi, Kenya... - Sustained changes in sexual behavior by female sex workers after completion of a randomized HIV prevention trialElizabeth N Ngugi
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Acquir Immune Defic Syndr 45:588-94. 2007..Behavioral interventions in female sex workers (FSWs) are associated with changes in sexual behavior and reduced rates of sexually transmitted infections (STIs) and HIV We examined the sustainability of such interventions... - Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responsesAnthony Sheung
Department of Medicine, University of Toronto, Ontario, Canada
AIDS 22:1729-37. 2008..As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, we hypothesized that coinfection during HIV acquisition would impair subsequent systemic T-cell responses... - HIV viral set point and host immune control in individuals with HIV-specific CD8+ T-cell responses prior to HIV acquisitionRupert Kaul
Department of Medicine, University of Toronto, Toronto, ON, Canada
AIDS 24:1449-54. 2010..We examined the impact of pre-existing CD8(+) T-cell responses on post-acquisition outcomes... - Associations of sexual risk taking among Kenyan female sex workers after enrollment in an HIV-1 prevention trialGeeta Yadav
Faculty of Arts and Sciences, University of Toronto, Toronto, Ontario, Canada
J Acquir Immune Defic Syndr 38:329-34. 2005..Potential response heterogeneity in FSW subgroups should be considered in the design of HIV-1 prevention programs... - Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trialRupert Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
JAMA 291:2555-62. 2004..Sexually transmitted infections (STIs) are common in female sex workers (FSWs) and may enhance susceptibility to infection with human immunodeficiency virus type 1 (HIV-1)... 
Evaluation of cynomolgus macaque (Macaca fascicularis) endogenous retrovirus expression following simian immunodeficiency virus infectionAngie K Marsh
Department of Immunology, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 7:e40158. 2012....- Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing responseJason Ho
Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Vaccine 23:1559-73. 2005..While HIV-1 gp160 cross-reactive antibodies were induced, virus neutralization was not detected. Thus, factors other than 2F5 binding affinity may have a critical role to play in the design of a 2F5-based vaccine... - Genomic sequencing and characterization of cynomolgus macaque cytomegalovirusAngie K Marsh
Department of Microbiology, Mount Sinai Hospital, Room 1484, 600 University Avenue, Toronto, ON, Canada
J Virol 85:12995-3009. 2011..Similar to HCMV, CyCMV does not produce the RhCMV-specific viral homologue of cyclooxygenase-2. This newly characterized CMV may provide a novel model in which to study CMV biology and HCMV vaccine development... - Sequence and peptide-binding motif for a variant of HLA-A*0214 (A*02142) in an HIV-1-resistant individual from the Nairobi Sex Worker cohortM A Luscher
Department of Medicine, University of Toronto, Canada
Immunogenetics 53:10-4. 2001..The data complement available information on the peptide-binding characteristics of this molecule, and will be of use in identifying antigenic peptides from HIV-1 and other pathogens... - CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjectsR Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Clin Invest 107:1303-10. 2001..The association between differential recognition of distinct CTL epitopes and protection from HIV-1 infection may have significant implications for vaccine design... - Experimental infection of Cynomolgus Macaques (Macaca fascicularis) with human varicella-zoster virusDavid O Willer
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
J Virol 86:3626-34. 2012.... - Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutationsR Brad Jones
Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada
J Virol 83:8722-32. 2009.... - Isolation and characterization of cynomolgus macaque (Macaca fascicularis) cytomegalovirus (CyCMV)Aruna P N Ambagala
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
Virology 412:125-35. 2011..CyCMV down-regulates MHC class I expression on infected cells and we show that the colony-bred cynomolgus macaques have detectable CyCMV-specific humoral and cell-mediated immune responses... - Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responsesR Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Clin Invest 107:341-9. 2001..Seroconversion generally occurs in the absence of detectable CTL escape mutations and may relate to the waning of HIV-specific CD8+ responses due to reduced antigenic exposure... - Multi-low-dose mucosal simian immunodeficiency virus SIVmac239 challenge of cynomolgus macaques immunized with "hyperattenuated" SIV constructsDavid O Willer
Department of Microbiology, Mt Sinai Hospital, Ontario, Canada
J Virol 84:2304-17. 2010..Prior immunization with hyperattenuated SIVmac239, even if sterilizing immunity is not achieved, may allow a more advantageous host response... - Sequence of beta(2)-microglobulin from rhesus macaque ( Macaca mulatta) includes an allelic variation in the 3'-untranslated regionJin Su
Department of Medicine, University of Toronto, Toronto, Canada
Immunogenetics 55:873-7. 2004..Our findings contribute to the growing understanding of rhesus macaque histocompatibility antigens and antigen presentation, and to the phylogeny of beta(2)m in primates... - Assessing human alloimmunization as a strategy for inducing HIV type 1 neutralizing anti-HLA responsesJonathan G Leith
Department of Immunology, University of Toronto, Toronto, Canada
AIDS Res Hum Retroviruses 19:957-65. 2003.... - Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137LJacob Bukczynski
Department of Immunology, University of Toronto, Toronto, Canada
J Immunol 175:6378-89. 2005..Taken together, these data suggest that 4-1BBL and B7.1 have additive or synergistic effects on HIV-specific CD8 T cell responses and represent a promising combination for therapeutic vaccination for HIV... - HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV sheddingPrameet M Sheth
Department of Medicine, University of Toronto, Ontario, Canada
J Immunol 175:4789-96. 2005..6; p = 0.03) and of several proinflammatory cytokines. Neither the presence nor the frequency of semen HIV-specific CD8+ T cell IFN-gamma responses in semen correlated with reduced levels of HIV RNA in semen... - New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workersR Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
Immunol Lett 79:3-13. 2001..These findings suggest that vaccine-induced protective HIV immunity is a realistic goal, but that vaccine strategies of boosting or persistent antigen may be necessary for long-lived protection... - Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaquesJin Su
Department of Medicine, University of Toronto, Toronto, Canada
Int Immunol 17:637-48. 2005..It may thus help increase the supply of rhesus macaques in which epitope-specific immunity can be studied in the context of SIV vaccine design... - Reduced HIV risk-taking and low HIV incidence after enrollment and risk-reduction counseling in a sexually transmitted disease prevention trial in Nairobi, KenyaRupert Kaul
Department of Medical Microbiology, University of Nairobi, Kenya
J Acquir Immune Defic Syndr 30:69-72. 2002..This finding should be considered in the design of clinical trials with an endpoint of HIV incidence, in particular HIV preventive vaccine trials... - Molecular characterization of a nosocomial outbreak of human respiratory syncytial virus on an adult leukemia/lymphoma wardT Mazzulli
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
J Infect Dis 180:1686-9. 1999..Instead of a single nosocomial outbreak of HRSV, multiple introductions of HRSV likely occurred with distinct lines of nosocomial transmission... - HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in NairobiR Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Immunol 164:1602-11. 2000..HIV-specific CD8+ T cell responses in the absence of detectable HIV infection in the genital mucosa of HIV-1-resistant sex workers may be playing an important part in protective immunity against heterosexual HIV-1 transmission... - Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cell immunity to gag in HIV-1-infected individuals with differential disease progression: reciprocal interferon-gamma and interleukin-10 responsesM A Ostrowski
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Infect Dis 184:1268-78. 2001..The detection of HIV-1-specific IL-10-inducing CD4(+) T cells in HIV-1-infected individuals suggests that HIV-1 may directly subvert specific immune responses by IL-10 induction... - Construction of recombinant targeting immunogens incorporating an HIV-1 neutralizing epitope into sites of differing conformational constraintJason Ho
Department of Immunology, Medical Sciences Building, 1 Kings College Circle, University of Toronto, Ont, M5S 1A8, Toronto, Canada
Vaccine 20:1169-80. 2002..Importantly, with respect to vaccine development, the 2F5-reactive antibody constructs represent candidate immunogens for the adjuvant-independent induction of an HIV-1, neutralizing 2F5-like antibody response in humans... - Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1N M Christie
Department of Immunology, University of Toronto, Toronto, ON, Canada
Virology 388:137-46. 2009..In light of this data, assumptions regarding the balance of immune and viral selective pressures on this immunodominant epitope sequence need to be reassessed...