D Low

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. pmc Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones
    Jeff Powis
    Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Antimicrob Agents Chemother 49:2130-2. 2005
  2. pmc Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling
    David N Fisman
    Dalla Lana School of Public Health, University of Toronto, Canada
    BMC Public Health 11:694. 2011
  3. pmc Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006
    Victoria Ng
    Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, Toronto, Canada
    BMC Infect Dis 9:68. 2009
  4. pmc Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae
    Dylan R Pillai
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    BMC Genomics 10:642. 2009
  5. pmc Characterization of the quinolone resistant determining regions in clinical isolates of pneumococci collected in Canada
    Samir N Patel
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Ann Clin Microbiol Antimicrob 9:3. 2010
  6. ncbi Activity of GAR-936 and other antimicrobial agents against North American isolates of Staphylococcus aureus
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, Room 1487, 600 University Avenue, Toronoto, Ont, Canada M5G 1X5
    Int J Antimicrob Agents 20:220-2. 2002
  7. ncbi Clinical and bacteriological efficacy of the ketolide telithromycin against isolates of key respiratory pathogens: a pooled analysis of phase III studies
    D E Low
    Mount Sinai Hospital, Department of Microbiology, University of Toronto, 600 University Avenue, Room 1487, Toronto, Ontario, Canada M5G 1X5
    Clin Microbiol Infect 10:27-36. 2004
  8. ncbi The era of antimicrobial resistance-implications for the clinical laboratory
    D E Low
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Microbiol Infect 8:9-20; discussion 33-5. 2002
  9. ncbi Changing trends in antimicrobial-resistant pneumococci: it's not all bad news
    Donald E Low
    Department of Microbiology, University Health Network Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 41:S228-33. 2005
  10. doi Pandemic planning: non-pharmaceutical interventions
    Donald E Low
    Department of Microbiology, Mt Sinai Hospital and the Ontario Central Public Health Laboratory, Toronto, Ontario, Canada
    Respirology 13:S44-8. 2008

Detail Information

Publications89

  1. pmc Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones
    Jeff Powis
    Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Antimicrob Agents Chemother 49:2130-2. 2005
    ..None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6...
  2. pmc Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling
    David N Fisman
    Dalla Lana School of Public Health, University of Toronto, Canada
    BMC Public Health 11:694. 2011
    ..We evaluated pertussis trends in Toronto using all available specimen data, which allowed us to control for changing testing patterns and practices...
  3. pmc Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006
    Victoria Ng
    Child Health Evaluative Sciences, Research Institute of the Hospital for Sick Children, Toronto, Canada
    BMC Infect Dis 9:68. 2009
    ..We sought to provide a laboratory-based review of the epidemiology of legionellosis in Ontario over the past 3 decades, with a focus on changing rates of disease and species associated with legionellosis during that time period...
  4. pmc Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae
    Dylan R Pillai
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    BMC Genomics 10:642. 2009
    ..Canadian SPN isolates (1993-2008, n = 11,083) were serotyped and in vitro susceptibility tested. A subset of MDR 19A were multi-locus sequence typed (MLST) and representative isolates' whole genomes sequenced...
  5. pmc Characterization of the quinolone resistant determining regions in clinical isolates of pneumococci collected in Canada
    Samir N Patel
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Ann Clin Microbiol Antimicrob 9:3. 2010
    ....
  6. ncbi Activity of GAR-936 and other antimicrobial agents against North American isolates of Staphylococcus aureus
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, Room 1487, 600 University Avenue, Toronoto, Ont, Canada M5G 1X5
    Int J Antimicrob Agents 20:220-2. 2002
    ..The GAR-936 MICs ranged from 0.06 to 1.0 mg/l. The MIC(50)s and MIC(90)s were 0.12 and 0.25 mg/l for MSSA and 0.25 and 0.5 mg/l for MRSA...
  7. ncbi Clinical and bacteriological efficacy of the ketolide telithromycin against isolates of key respiratory pathogens: a pooled analysis of phase III studies
    D E Low
    Mount Sinai Hospital, Department of Microbiology, University of Toronto, 600 University Avenue, Room 1487, Toronto, Ontario, Canada M5G 1X5
    Clin Microbiol Infect 10:27-36. 2004
    ..pneumoniae. The results suggest that telithromycin will provide effective empirical therapy for community-acquired upper and lower respiratory tract infections...
  8. ncbi The era of antimicrobial resistance-implications for the clinical laboratory
    D E Low
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Microbiol Infect 8:9-20; discussion 33-5. 2002
    ..Simple techniques for the clinical diagnostic laboratory to enable these first-step mutants to be detected are urgently required...
  9. ncbi Changing trends in antimicrobial-resistant pneumococci: it's not all bad news
    Donald E Low
    Department of Microbiology, University Health Network Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 41:S228-33. 2005
    ..This may well be a result of several initiatives to promote the judicious use of antimicrobials, as well as the introduction of the pneumococcal conjugate vaccine, suggesting that the fight against resistance is maybe not futile...
  10. doi Pandemic planning: non-pharmaceutical interventions
    Donald E Low
    Department of Microbiology, Mt Sinai Hospital and the Ontario Central Public Health Laboratory, Toronto, Ontario, Canada
    Respirology 13:S44-8. 2008
    ..These factors have focused attention on the use of non-pharmaceutical public health interventions to inhibit human-to-human transmission...
  11. ncbi Antimicrobial susceptibility among bacterial isolates from ICU and non-ICU setting and different age groups: results from the tigecycline evaluation and Surveillance trial in North America
    D E Low
    Department of Microbiology, Mount Sinai Hospital and University of Toronto, ON, Canada
    J Chemother 21:16-23. 2009
    ..Against eSbl-producing K. pneumoniae, imipenem (88.9%-96.4%) and tigecycline (85.1%-100%) demonstrated the highest rates of activity. tigecycline demonstrated excellent activity against clinically relevant resistant organisms...
  12. ncbi Progressive and nonresolving pneumonia
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Ontario, Canada
    Curr Opin Pulm Med 11:247-52. 2005
    ..It is critical to be able to identify patients at risk to institute early appropriate therapy. The purpose of this review is to summarise the most updated developments in this area...
  13. pmc Why SARS will not return: a polemic
    Donald E Low
    Department of Microbiology, University Health Network Mount Sinai Hospital, University of Toronto, Toronto, Ont
    CMAJ 170:68-9. 2004
  14. ncbi Resistance trends in Haemophilus influenzae (PROTEKT years 1-3 [1999-20021)
    D E Low
    Mount Sinai Hospital, Toronto, Canada
    J Chemother 16:49-61. 2004
  15. ncbi Activity of telithromycin against key pathogens associated with community-acquired respiratory tract infections
    Donald E Low
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ont, Canada
    J Infect 49:115-25. 2004
    ..To investigate the correlation between in vitro susceptibility of isolates and clinical outcomes with telithromycin in respiratory tract infections...
  16. pmc Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in Canada during 2000
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada
    Antimicrob Agents Chemother 46:1295-301. 2002
    ..The MIC of linezolid was <or=2 microg/ml for all isolates. Many of the new antimicrobial agents tested in this study appear to have potential for the treatment of multidrug-resistant strains of pneumococci...
  17. pmc Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance
    D E Low
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada
    Antimicrob Agents Chemother 46:1119-21. 2002
    ..For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively...
  18. ncbi Quinolone resistance among pneumococci: therapeutic and diagnostic implications
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Clin Infect Dis 38:S357-62. 2004
    ....
  19. doi FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia
    Donald E Low
    Mount Sinai Hospital University Health Network, Toronto, Ontario, Canada
    J Antimicrob Chemother 66:iii33-44. 2011
    ....
  20. ncbi Antimicrobial drug use and resistance among respiratory pathogens in the community
    D E Low
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Infect Dis 33:S206-13. 2001
    ....
  21. ncbi Reducing antibiotic use in influenza: challenges and rewards
    D Low
    Department of Microbiology, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Microbiol Infect 14:298-306. 2008
    ..The widespread adoption of these principles may have a significant effect on antimicrobial use and resistance...
  22. pmc Emergence of macrolide resistance in throat culture isolates of group a streptococci in Ontario, Canada, in 2001
    Kevin C Katz
    Toronto Medical Laboratories Mount Sinai Hospital Department of Microbiology University of Toronto, Toronto, Ontario, Canada
    Antimicrob Agents Chemother 47:2370-2. 2003
    ..3%) were of the MLS phenotype. Pulsed-field gel electrophoresis found that two clones, with patterns identical to those of serotypes M1 and M4, accounted for 19.4 and 68.1% of the macrolide-resistant isolates, respectively...
  23. pmc Activities of new fluoroquinolones, ketolides, and other antimicrobials against blood culture isolates of viridans group streptococci from across Canada, 2000
    Andrea S Gershon
    University of Toronto, Toronto, Canada
    Antimicrob Agents Chemother 46:1553-6. 2002
    ..06, 0.06, 0.12, and 0.03 microg/ml, respectively...
  24. ncbi A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance
    Jeffrey D Fuller
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Infect Dis 41:118-21. 2005
    ....
  25. ncbi A new twist on an old problem: a case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19A
    W Ciccotelli
    Department of Infectious Diseases and Medical Microbiology, McMaster University, Hamilton, Ontario, Canada
    Can Commun Dis Rep 34:1-6. 2008
    ..pneumoniae serotype 19A meningitis successfully treated with vancomycin and levofloxacin. This case reinforces the need for the empiric use of vancomycin in meningitis and the need for alternative treatments...
  26. ncbi The battle against emerging antibiotic resistance: should fluoroquinolones be used to treat children?
    Lionel A Mandell
    Division of Infectious Diseases, McMaster University School of Medicine, Hamilton, Ontario, Canada
    Clin Infect Dis 35:721-7. 2002
    ....
  27. ncbi Optimizing antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance
    Donald E Low
    Mount Sinai Hospital, Toronto, Canada
    Clin Pediatr (Phila) 43:135-51. 2004
    ..New antibacterials will continue to have a role in the treatment of RTIs in children, especially where resistance compromises existing therapies...
  28. pmc In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002
    Jeff Powis
    Department of Microbiology, Rm 1487, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5 Ontario, Canada
    Antimicrob Agents Chemother 48:3305-11. 2004
    ..Nonsusceptibility to amoxicillin and ceftriaxone remains uncommon. Newer antimicrobials such as telithromycin and respiratory fluoroquinolones have excellent in vitro activity...
  29. ncbi Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada
    Matthew P Muller
    Department of Microbiology, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Arch Intern Med 163:467-72. 2003
    ..During the past 2 decades there has been a resurgence of invasive GAS infection, but no large study of GAS pneumonia has been performed...
  30. ncbi Morbidity and mortality of patients with invasive group A streptococcal infections admitted to the ICU
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Ave, Suite 18 216, Toronto, Ontario, Canada M5G 1X5
    Chest 130:1679-86. 2006
    ..To describe the clinical features and outcome of patients with invasive group A streptococcal (GAS) infections admitted to the ICU...
  31. ncbi Empirical validation of guidelines for the management of pharyngitis in children and adults
    Warren J McIsaac
    Ray D Wolfe Department of Family Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    JAMA 291:1587-95. 2004
    ..Recent guidelines for management of pharyngitis vary in their recommendations concerning empirical antibiotic treatment and the need for laboratory confirmation of group A streptococcus (GAS)...
  32. ncbi The impact of empirical management of acute cystitis on unnecessary antibiotic use
    Warren J McIsaac
    Mt Sinai Family Medicine Centre, 600 University Ave, Room 413, Toronto, Ontario, Canada M5G 1X5
    Arch Intern Med 162:600-5. 2002
    ..Guidelines for the management of acute cystitis support empirical antibiotic treatment; however, up to half of symptomatic women have negative urine cultures...
  33. doi Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada
    Allison Mcgeer
    Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, ON M5G 1X5 Canada
    Clin Infect Dis 45:1568-75. 2007
    ..We conducted a prospective cohort study to assess the impact of antiviral therapy on outcomes of patients hospitalized with influenza in southern Ontario, Canada...
  34. ncbi Effect on antibiotic prescribing of repeated clinical prompts to use a sore throat score: lessons from a failed community intervention study
    Warren J McIsaac
    Mt Sinai Family Medicine Centre, 600 University Ave, Suite 413, Toronto, Ont, Canada M5G 1X5
    J Fam Pract 51:339-44. 2002
    ..This study sought to determine whether repeated clinical prompts to use a scoring approach could help family physicians lower antibiotic use in patients with a sore throat...
  35. ncbi Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance
    Darrin J Bast
    Toronto Centre for Antimicrobial Research and Evaluation ToCARE, Room 1483, Department of Microbiology, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada
    J Antimicrob Chemother 54:90-4. 2004
    ..To identify and characterize the mechanisms of high-level fluoroquinolone resistance in two strains of Bacillus anthracis following serial passage in increasing concentrations of fluoroquinolones...
  36. ncbi Risk factors for resistance to antimicrobial agents among nursing home residents
    Mark B Loeb
    Department of Pathology and Molecular Medicine, McMaster University and Hamilton Regional Laboratory Program, Hamilton, Ontario, Canada
    Am J Epidemiol 157:40-7. 2003
    ..08, 95% CI: 1.04, 1.11), respectively. These findings suggest that increased staffing, more hand-washing sinks, and use of antimicrobial soap may reduce resistance to antimicrobial agents in long-term care facilities...
  37. ncbi Canadian guidelines for the management of acute exacerbations of chronic bronchitis: executive summary
    Meyer S Balter
    University of Toronto, Mount Sinai Hospital, Toronto, Ontario
    Can Respir J 10:248-58. 2003
  38. ncbi Canadian guidelines for the management of acute exacerbations of chronic bronchitis
    Meyer S Balter
    University of Toronto, Mount Sinai Hospital, Toronto, Canada
    Can Respir J 10:3B-32B. 2003
    ..The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested...
  39. ncbi Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000
    Nick Daneman
    University of Toronto, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Intern Med 147:234-41. 2007
    ..Streptococcus pyogenes can cause severe disease in the individual patient and dramatic hospital outbreaks...
  40. ncbi A blinded comparison of three laboratory protocols for the identification of patients colonized with methicillin-resistant Staphylococcus aureus
    M Gardam
    Department of Microbiology, University Health Network, University of Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 22:152-6. 2001
    ..A broth-containing protocol should be considered the gold standard in future studies examining newer MRSA screening protocols..
  41. pmc Antimicrobial susceptibility breakpoints and first-step parC mutations in Streptococcus pneumoniae: redefining fluoroquinolone resistance
    Sue Lim
    Toronto Medical Laboratories Mount Sinai Hospital, Toronto, Ontario, Canada
    Emerg Infect Dis 9:833-7. 2003
    ..Whether surveillance programs that use levofloxacin data can effectively detect emerging resistance and whether fluoroquinolones can effectively treat infections caused by such isolates should be evaluated...
  42. ncbi Chest radiographic manifestations of severe acute respiratory syndrome in health care workers: the Toronto experience
    Richard Bitar
    Department of Medical Imaging, St Michael s Hospital, 60 Bond St, Toronto, ON M5B 1W8, Canada
    AJR Am J Roentgenol 182:45-8. 2004
    ..The purpose of this article is to describe the chest radiographic manifestations of severe acute respiratory syndrome (SARS) in previously uninfected health care workers during the early stages of an outbreak in Toronto, Canada...
  43. pmc Use of the Vitek-1 and Vitek-2 systems for detection of constitutive and inducible macrolide resistance in group B streptococci
    Patrick Tang
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, and University of Toronto, Ontario, Canada
    J Clin Microbiol 42:2282-4. 2004
    ..6 and 94.4%. In light of these results, we recommend that GBS be routinely tested using the double-disk diffusion method...
  44. ncbi SARS--one year later
    Donald E Low
    Department of Microbiology, University Health Network Mount Sinai Hospital and the University of Toronto, Toronto
    N Engl J Med 349:2381-2. 2003
  45. pmc Investigation of Staphylococcus aureus isolates identified as erythromycin intermediate by the Vitek-1 System: comparison with results obtained with the Vitek-2 and Phoenix systems
    Patrick Tang
    Department of Microbiology, Mount Sinai Hospital, and Toronto Medical Laboratories, Toronto, Ontario, Canada
    J Clin Microbiol 41:4823-5. 2003
    ..We recommend that all S. aureus strains determined as erythromycin intermediate by the Vitek-1 system be interpreted as resistant to erythromycin...
  46. ncbi Serotypes of respiratory tract isolates of Streptococcus pneumoniae from Jamaican children
    Upton D Allen
    Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Int J Infect Dis 7:29-35. 2003
    ..Data are lacking on the pneumococcal serotypes present in many developing regions, including the Caribbean. We examined the serotypes of nasopharyngeal (NP) isolates of pneumococci obtained from Jamaican children...
  47. ncbi Identification of severe acute respiratory syndrome in Canada
    Susan M Poutanen
    Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Canada
    N Engl J Med 348:1995-2005. 2003
    ..This report summarizes the initial epidemiologic findings, clinical description, and diagnostic findings that followed the identification of SARS in Canada...
  48. pmc Population-based surveillance for invasive pneumococcal disease in homeless adults in Toronto
    Agron Plevneshi
    Toronto Invasive Bacterial Diseases Network, Toronto, Ontario, Canada
    PLoS ONE 4:e7255. 2009
    ..Identification of high-risk populations for serious infection due to S. pneumoniae will permit appropriately targeted prevention programs...
  49. pmc Evaluation of coseasonality of influenza and invasive pneumococcal disease: results from prospective surveillance
    Stefan P Kuster
    Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS Med 8:e1001042. 2011
    ..We aimed to investigate the relationship between influenza infection and IPD in Ontario, Canada, using several complementary methodological tools...
  50. pmc Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience
    Patrick Tang
    University of Toronto, Ont
    CMAJ 170:47-54. 2004
    ..We describe how these tests were used during the first phase of the SARS outbreak in Toronto and offer some recommendations that may be useful if SARS returns...
  51. ncbi Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia?
    Matthew P Muller
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Infect Dis 40:1079-86. 2005
    ..Hematological and biochemical abnormalities, particularly lymphopenia, are common in patients with SARS...
  52. pmc West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario
    Caitlin Pepperell
    Divisions of Infectious Diseases, University of Toronto, Toronto, Ont, Canada
    CMAJ 168:1399-405. 2003
    ..We encountered a number of seriously ill patients at our hospitals. In this article we document the clinical characteristics of these cases...
  53. ncbi Facility-level correlates of antimicrobial use in nursing homes
    Mark Loeb
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Infect Control Hosp Epidemiol 25:173-6. 2004
    ....
  54. ncbi Severe acute respiratory syndrome
    Michael D Christian
    Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Clin Infect Dis 38:1420-7. 2004
    ..We present an overview of the epidemiology, clinical presentation, diagnosis, and treatment of SARS based on the current state of knowledge derived from published studies and our own personal experience...
  55. pmc Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel
    Beth A Hanselman
    Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Emerg Infect Dis 12:1933-8. 2006
    ..001) in the United States (n = 10), United Kingdom (n = 2), and Denmark (n = 1). MRSA colonization may be an occupational risk for veterinary professionals...
  56. ncbi Severe group a streptococcal soft-tissue infections in Ontario: 1992-1996
    Abdu Sharkawy
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5
    Clin Infect Dis 34:454-60. 2002
    ..Previously healthy patients without hypotension or NF may be considered for outpatient treatment...
  57. ncbi Pulmonary pathology of severe acute respiratory syndrome in Toronto
    David M Hwang
    Toronto Medical Laboratories, Toronto, Ontario, Canada
    Mod Pathol 18:1-10. 2005
    ..Cases of SARS may be complicated by coexistent infections and therapy-related lung injury...
  58. pmc Severe acute respiratory syndrome-associated coronavirus in lung tissue
    Tony Mazzulli
    Toronto Medical Labaratories Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada
    Emerg Infect Dis 10:20-4. 2004
    ..CoV was consistently identified in the lungs of all patients who died of SARS but not in control patients, supporting a primary role for CoV in deaths...
  59. ncbi Predicting antimicrobial resistance in invasive pneumococcal infections
    Otto G Vanderkooi
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Clin Infect Dis 40:1288-97. 2005
    ....
  60. doi Going with the flow: legionellosis risk in Toronto, Canada is strongly associated with local watershed hydrology
    Victoria Ng
    Research Institute of the Hospital for Sick Children, Toronto, Canada
    Ecohealth 5:482-90. 2008
    ..These observations suggest testable hypotheses for future empiric studies...
  61. ncbi Is surveillance for multidrug-resistant enterobacteriaceae an effective infection control strategy in the absence of an outbreak?
    Michael A Gardam
    Infection Prevention and Control Unit, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4
    J Infect Dis 186:1754-60. 2002
    ..The annual cost of a surveillance program was calculated at Canadian $1,130,184.44. Thus, the routine and costly use of MDRE surveillance and isolation precautions are not warranted in the absence of a clonal outbreak in this population...
  62. pmc Respiratory infection in institutions during early stages of pandemic (H1N1) 2009, Canada
    Alex Marchand-Austin
    Public Health Agency of Canada, Toronto, Ontario, Canada
    Emerg Infect Dis 15:2001-3. 2009
    ..Despite widespread presence of influenza in the general population, only 2 of 83 outbreaks evaluated by molecular methods were associated with pandemic (H1N1) 2009...
  63. pmc New endemic Legionella pneumophila serogroup I clones, Ontario, Canada
    Nathalie Tijet
    Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
    Emerg Infect Dis 16:447-54. 2010
    ..These findings have general clinical implications for the study of Lp1 molecular evolution and for the identification of Lp1 circulating strains in North America...
  64. ncbi Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study
    Donna O Lowe
    Department of Pharmacy Services, University Health Network, University of Toronto, ON, M5G 2C4, Canada
    Clin Infect Dis 43:1272-6. 2006
    ..Whether outpatient PPI use influences the risk of hospital admission for CDAD among older patients who have recently been treated with antibiotics is unknown...
  65. pmc Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease
    Jeffrey D Fuller
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Infect Immun 70:5730-9. 2002
    ..These studies demonstrated that S. iniae SLS expression is required for local tissue necrosis but does not contribute to the establishment of bacteremia or to resistance to phagocytic clearance...
  66. ncbi Severe acute respiratory syndrome: an update
    Susan M Poutanen
    Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada
    Curr Opin Infect Dis 17:287-94. 2004
    ..Since then, a large body of research on the syndrome has been published; the most updated developments are summarized here...
  67. pmc Possible SARS coronavirus transmission during cardiopulmonary resuscitation
    Michael D Christian
    Immunodeficiency Clinic, University Health Network, University of Toronto, Toronto, ON, Canada
    Emerg Infect Dis 10:287-93. 2004
    ....
  68. ncbi Resistance to antibiotics: administrative response to the challenge
    Deborah A Marshall
    Research and Development, Health Economics and Outcomes Research, Innovus Research Inc, Burlington, Ontario, Canada
    Manag Care Interface 17:20-9. 2004
    ....
  69. ncbi Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivo
    Jin Hwa Lee
    Department of Anaesthesia, St Michael s Hospital, Toronto, ON, M5B 1W8 Canada
    Am J Respir Crit Care Med 168:1462-70. 2003
    ..coli growth in vitro and in vivo. However, in vivo, this effect becomes only apparent in neutropenic animals. The relevance of these findings for immune compromised patients remains to be investigated...
  70. pmc Rhinovirus outbreaks in long-term care facilities, Ontario, Canada
    Jean Longtin
    Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada
    Emerg Infect Dis 16:1463-5. 2010
    ..Disease was sometimes severe. Molecular diagnostic testing can differentiate these outbreaks from other infections such as influenza...
  71. ncbi Outpatient gatifloxacin therapy and dysglycemia in older adults
    Laura Y Park-Wyllie
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, Toronto
    N Engl J Med 354:1352-61. 2006
    ..We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older...
  72. ncbi Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses
    J Scott Weese
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Am Vet Med Assoc 226:580-3. 2005
    ..To evaluate the prevalence of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) in horses and horse personnel...
  73. ncbi Severe acute respiratory syndrome (SARS): a year in review
    Danuta M Skowronski
    University of British Columbia Center for Disease Control, Vancouver, British Columbia, Canada V5Z 4R4
    Annu Rev Med 56:357-81. 2005
    ..This review synthesizes lessons learned from this remarkable achievement. These lessons can be applied to re-emergence of SARS or to the next pandemic threat to arise...
  74. ncbi Managing acute lower respiratory tract infections in an era of antibacterial resistance
    Gregory A Volturo
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Emerg Med 24:329-42. 2006
    ..Newer classes of antimicrobial agents, such as the oxazolidinones and ketolides, will likely play a significant role in this era of antimicrobial resistance...
  75. ncbi Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia
    Ross Davidson
    Queen Elizabeth Health Sciences Centre, Halifax, N S, Canada
    N Engl J Med 346:747-50. 2002
  76. ncbi Fluoroquinolone-resistant pneumococci: maybe resistance isn't futile?
    Donald E Low
    Clin Infect Dis 40:236-8. 2005
  77. pmc Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections
    Stephen B Beres
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:11833-8. 2004
    ..Genome-wide analysis of population-based strain samples cultured from clinically well defined patients is crucial for understanding the molecular events underlying bacterial epidemics...
  78. pmc Late recognition of SARS in nosocomial outbreak, Toronto
    Thomas Wong
    Public Health Agency of Canada, Room 3444, Building 6 AL 0603B, Tunney s Pasture, Ottawa, Ontario K1A OL2, Canada
    Emerg Infect Dis 11:322-5. 2005
    ..SARS is difficult to recognize in hospitalized patients with a variety of underlying conditions in the absence of epidemiologic links...
  79. ncbi Treatment and vaccines for severe acute respiratory syndrome
    David A Groneberg
    Department of Pneumology, Hannover Medical School, Hannover, Germany
    Lancet Infect Dis 5:147-55. 2005
    ..Efforts should be made to evaluate the most promising treatments and vaccines in controlled clinical trials, should another SARS outbreak occur...
  80. ncbi A comparison of bacteremic pneumococcal pneumonia with nonbacteremic community-acquired pneumonia of any etiology--results from a Canadian multicentre study
    Thomas J Marrie
    Department of Medicine, University of Alberta, Edmonton, Canada
    Can Respir J 10:368-74. 2003
    ..Bacteremic pneumococcal pneumonia has not been the subject of a multicentre Canadian Study...
  81. pmc High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae
    Nicole Wolter
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Johannesburg, South Africa
    Antimicrob Agents Chemother 51:1092-5. 2007
    ..By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4...
  82. pmc Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes
    Ramy K Aziz
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis 38163, USA
    J Bacteriol 187:3311-8. 2005
    ..Y, replacing it with a different module identical to that found on a related M3 phage. Taken together, the data demonstrate that mosaicism of the GAS prophages has contributed to the emergence and diversification of the M1T1 subclone...
  83. ncbi Clinical aspects and cost of invasive Streptococcus pneumoniae infections in children: resistant vs. susceptible strains
    Caroline Quach
    Department of Microbiology and Infectious Disease, Maisonneuve Rosemont Hospital, University of Montreal, 5415 L Assomption, Que, Canada H1T 2M4
    Int J Antimicrob Agents 20:113-8. 2002
    ..There were no differences between invasive infections caused by PRSP and PSSP in terms of clinical presentation, morbidity or mortality in a paediatric population...
  84. ncbi Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline
    Ralf Rene Reinert
    Institute for Medical Microbiology, National Reference Centre for Streptococci, Aachen, Germany
    J Antimicrob Chemother 60:1018-29. 2007
    ..To describe antimicrobial susceptibility among bacterial isolates associated with hospital infections collected from 266 centres in Asia/Pacific Rim (n = 1,947), North America (n = 24,283), Latin America (n = 1,957) and Europe (n = 8,796)...
  85. ncbi Emergence of levofloxacin-resistant pneumococci in immunocompromised adults after therapy for community-acquired pneumonia
    Kevin B Anderson
    Summa Health System, Akron, Ohio 44304, USA
    Clin Infect Dis 37:376-81. 2003
    ..In immunocompromised patients with suspected or proven pneumococcal infection, it may be prudent not to use fluoroquinolone monotherapy empirically when the patient has a history of fluoroquinolone therapy in at least the past 4 months...
  86. ncbi Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach
    Anna Norrby-Teglund
    Centre for Infectious Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Scand J Infect Dis 37:166-72. 2005
    ....
  87. ncbi Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units
    Timothy F Booth
    National Microbiology Laboratory, Public Health Agency of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada
    J Infect Dis 191:1472-7. 2005
    ....
  88. doi At the threshold: defining clinically meaningful resistance thresholds for antibiotic choice in community-acquired pneumonia
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, USA
    Clin Infect Dis 46:1131-8. 2008
    ..Guidelines suggest a 25% rate of high-level macrolide resistance in the community as the threshold beyond which macrolides should not be used. We evaluated the implications of this threshold for clinical failure rates...
  89. ncbi Interview with Donald E. Low, MD, Microbiologist-in-Chief, Mt. Sinai Hospital, Toronto, Ontario, Canada
    Donald E Low
    Biosecur Bioterror 2:1-6. 2004