R Kandel

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. ncbi request reprint Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors
    R Kandel
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, 600 University Avenue, Suite 600, Toronto, Ontario M5X 1G5 Canada
    J Orthop Res 24:428-37. 2006
  2. pmc An in vitro tissue model to study the effect of age on nucleus pulposus cells
    R A Kandel
    CIHR BioEngineering of Skeletal Tissues Team, Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 6 500, M5X 1G5, Toronto, ON, Canada
    Eur Spine J 16:2166-73. 2007
  3. pmc Tissue engineering and the intervertebral disc: the challenges
    Rita Kandel
    CIHR BioEngineering of Skeletal Tissues Team, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Eur Spine J 17:480-91. 2008
  4. ncbi request reprint Cyclin D1 protein overexpression and gene amplification in benign breast tissue and breast cancer risk
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Canada
    Eur J Cancer Prev 10:43-51. 2001
  5. ncbi request reprint Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model
    R A Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Biomaterials 27:4120-31. 2006
  6. ncbi request reprint p53 protein accumulation and mutations in normal and benign breast tissue
    R Kandel
    Department of Pathology and Laboratory Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 87:73-8. 2000
  7. ncbi request reprint Characterization of the mineral in calcified articular cartilagenous tissue formed in vitro
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Tissue Eng 5:25-34. 1999
  8. ncbi request reprint The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro study
    Y Gortzak
    Mount Sinai Hospital, Toronto, Canada
    J Bone Joint Surg Br 92:1475-9. 2010
  9. pmc Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes
    L Ho
    1 Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada 2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Oncogene 32:5388-96. 2013
  10. ncbi request reprint A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage
    S D Waldman
    Department of Mechanical and Materials Engineering, Queen s University, Kingston, Ontario, Canada
    Osteoarthritis Cartilage 14:323-30. 2006

Research Grants

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors
    R Kandel
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, 600 University Avenue, Suite 600, Toronto, Ontario M5X 1G5 Canada
    J Orthop Res 24:428-37. 2006
    ..Additional studies are required to confirm the role of p21 in the pathogenesis of these tumors...
  2. pmc An in vitro tissue model to study the effect of age on nucleus pulposus cells
    R A Kandel
    CIHR BioEngineering of Skeletal Tissues Team, Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 6 500, M5X 1G5, Toronto, ON, Canada
    Eur Spine J 16:2166-73. 2007
    ..This suggests that this in vitro NP tissue model will be suitable to determine the mechanism(s) regulating age-induced changes...
  3. pmc Tissue engineering and the intervertebral disc: the challenges
    Rita Kandel
    CIHR BioEngineering of Skeletal Tissues Team, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Eur Spine J 17:480-91. 2008
    ..This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration...
  4. ncbi request reprint Cyclin D1 protein overexpression and gene amplification in benign breast tissue and breast cancer risk
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Canada
    Eur J Cancer Prev 10:43-51. 2001
    ....
  5. ncbi request reprint Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model
    R A Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Biomaterials 27:4120-31. 2006
    ..The results indicate that further study of this treatment approach is warranted to attempt to overcome the technical surgical difficulties identified in this study...
  6. ncbi request reprint p53 protein accumulation and mutations in normal and benign breast tissue
    R Kandel
    Department of Pathology and Laboratory Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 87:73-8. 2000
    ....
  7. ncbi request reprint Characterization of the mineral in calcified articular cartilagenous tissue formed in vitro
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Tissue Eng 5:25-34. 1999
    ..The crystals were similar in size (16.0 +/- 5.5 nm) and appearance to the crystals in the in vivo calcified cartilage. This data suggests that the mineralization that occurs in vitro is similar to the in vivo cartilage...
  8. ncbi request reprint The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro study
    Y Gortzak
    Mount Sinai Hospital, Toronto, Canada
    J Bone Joint Surg Br 92:1475-9. 2010
    ..No multinucleated cell formation was seen in these cultures. These results suggest that the use of chemical adjuvants other than water could help improve local control in the treatment of GCT of bone...
  9. pmc Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes
    L Ho
    1 Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada 2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Oncogene 32:5388-96. 2013
    ..Moreover, as primary cilia suppress Hh pathway activation in chondrosarcoma, cellular mechanisms inhibiting proper cilia function may be important in maintaining the neoplastic phenotype. ..
  10. ncbi request reprint A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage
    S D Waldman
    Department of Mechanical and Materials Engineering, Queen s University, Kingston, Ontario, Canada
    Osteoarthritis Cartilage 14:323-30. 2006
    ..Thus, the purpose of this study was to investigate the effect of a single application of cyclic loading to chondrocytes on the formation and properties of in vitro-formed tissue...
  11. ncbi request reprint Chondrocyte interactions with porous titanium alloy and calcium polyphosphate substrates
    V J D Ciolfi
    Institute of Biomaterials and Bioengineering, Mount Sinai Hospital, University of Toronto, Ontario M5G 1X5, Canada
    Biomaterials 24:4761-70. 2003
    ..The data suggests that CPP and titanium alloy may mediate their effect by limiting cell spreading in part by favoring the maintenance of a ring-like actin distribution...
  12. ncbi request reprint Characterisation of reconstituted equine cartilage formed in vitro
    Y Sun
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Equine Vet J 34:373-7. 2002
    ..This tissue may be useful in the management of chondral injuries in the horse in a scenario where the patient donates cells, the cells are propagated under laboratory conditions and the resulting tissue becomes the therapeutic agent...
  13. ncbi request reprint Periosteal chondroid tumors: radiologic evaluation with pathologic correlation
    P Robinson
    Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    AJR Am J Roentgenol 177:1183-8. 2001
    ..This and the fact that histologic differentiation of the entities can be difficult, suggests that surgical wide excision may be the most appropriate procedure in treating patients with lesions greater than 3 cm...
  14. ncbi request reprint Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database
    J A Crosby
    Department of Surgical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Ann Surg Oncol 8:50-9. 2001
    ..Localized and locally advanced M-GIST of the small intestine have a mean OS > 5 years. Complete resection should be the goal of initial surgical treatment...
  15. pmc Porous silk scaffolds can be used for tissue engineering annulus fibrosus
    G Chang
    CIHR BioEngineering of Skeletal Tissues Team, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Eur Spine J 16:1848-57. 2007
    ....
  16. ncbi request reprint Effect of material geometry on cartilagenous tissue formation in vitro
    T Bhardwaj
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    J Biomed Mater Res 57:190-9. 2001
    ..56 +/- 0.2; 43 microm = 2.19 +/- 0.2; 68 microm = 2.3 +/- 0.3]. These results suggest that material geometry, as defined by pore size, can affect the amount and composition of the cartilagenous tissue that forms...
  17. ncbi request reprint Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation
    J N A De Croos
    CIHR BioEngineering of Skeletal Tissues Team, Mount Sinai Hospital, Canada
    Matrix Biol 25:323-31. 2006
    ..Given the sequence of changes, cyclic compressive loading appears to initiate a remodelling effect involving MAPK and AP-1 signalling resulting in improved in vitro formation of cartilage...
  18. ncbi request reprint The clinical status of cartilage tissue regeneration in humans
    B Mollon
    Department of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada Electronic address
    Osteoarthritis Cartilage 21:1824-33. 2013
    ..To provide a comprehensive overview of the basic science and clinical evidence behind cartilage regeneration techniques as they relate to surgical management of chondral lesions in humans...
  19. ncbi request reprint Formation of biphasic constructs containing cartilage with a calcified zone interface
    K S Allan
    CIHR BioEngineering of Skeletal Tissues Team, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada
    Tissue Eng 13:167-77. 2007
    ..Because failure due to shear occurred at the cartilage-CPP interface instead of the tidemark, as occurs with osteochondral tissue, further study is required to optimize this system so that it more closely mimics the native tissue...
  20. ncbi request reprint Characterization of nucleus pulposus-like tissue formed in vitro
    Y Sun
    Department of Pathology and Laboratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    J Orthop Res 19:1078-84. 2001
    ..NP cells grown on filters generate tissue similar in composition to the in vivo tissue, for the characteristics examined to date, and should be a suitable model to use to study NP metabolism and extracellular matrix turnover...
  21. ncbi request reprint Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression
    T L Willett
    Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Ontario, Canada
    Osteoarthritis Cartilage 20:736-44. 2012
    ..To test the hypothesis that heightened advanced glycation endproducts (AGEs) content in cartilage accelerates the progression of spontaneous osteoarthritis (OA) in the Hartley guinea pig (HGP) model...
  22. ncbi request reprint Transarticular invasion of bone tumours across the sacroiliac joint
    S Chhaya
    Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, Toronto, Canada
    Skeletal Radiol 34:771-7. 2005
    ....
  23. ncbi request reprint Osteochondral defect repair using a novel tissue engineering approach: sheep model study
    R M Pilliar
    Faculty of Dentistry, University of Toronto, Institute of Biomaterials and Biomedical Engineering, Toronto, Canada
    Technol Health Care 15:47-56. 2007
    ..The properties and characteristics of the as-in vitro-formed, short- and long-term implanted tissues were compared. The results indicated that such implants might be useful for repair of small subchondral defects...
  24. pmc Surgical margins and handling of soft-tissue sarcoma in extremities: a clinical practice guideline
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON
    Curr Oncol 20:e247-54. 2013
    ..extremity soft-tissue sarcoma (sts), what is an adequate surgical margin?What is the appropriate number of samples to take from the margins of a surgical resection specimen?What is the appropriate handling of surgical resection specimens?..
  25. ncbi request reprint Value of electron microscopy and immunohistochemistry in the diagnosis of soft tissue tumors
    R Kandel
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Ultrastruct Pathol 22:141-6. 1998
    ..These findings suggest that both IHC and EM are necessary to properly evaluate soft tissue tumors...
  26. ncbi request reprint Association between fluoride, magnesium, aluminum and bone quality in renal osteodystrophy
    A H M Ng
    Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada
    Bone 34:216-24. 2004
    ..Bone quality encompasses parameters that contribute to the mechanical integrity of the bone...
  27. pmc Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma
    H Al-Hussaini
    Division of Medical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9
    Sarcoma 2011:231789. 2011
    ..Conclusions. Patients with localized SS have a good chance of cure with surgery and RT. Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive...
  28. ncbi request reprint Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies
    M D Grynpas
    Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada
    Biomaterials 23:2063-70. 2002
    ..In conclusion, this material seems to promote rapid bone ingrowth and can be tailored to degrade at a given rate in vivo to some degree through appropriate selection of the starting particle size...
  29. ncbi request reprint Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice
    J M Lee
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Oncogene 9:3731-6. 1994
    ..Taken together, these observations suggest that p53 acts to suppress tumour formation in vivo by preventing the accumulation of cells that have sustained radiation-induced DNA damage...
  30. ncbi request reprint Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization
    R M Pilliar
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, ON
    Biomaterials 22:963-72. 2001
    ..The observed structures, strengths and in vitro degradation characteristics of the porous CPP samples suggested their potential usefulness as bone substitute materials pending subsequent in vivo behaviour assessment...
  31. ncbi request reprint Membrane type-1 matrix metalloproteinase is induced following cyclic compression of in vitro grown bovine chondrocytes
    J N A De Croos
    CIHR BioEngineering of Skeletal Tissues Team, Mount Sinai Hospital, Canada
    Osteoarthritis Cartilage 15:1301-10. 2007
    ..To determine if membrane type-1 matrix metalloproteinase (MT1-MMP) will respond to cyclic compression of chondrocytes grown in vitro and the regulatory mechanisms underlying this response...
  32. ncbi request reprint Substrate porosity enhances chondrocyte attachment, spreading, and cartilage tissue formation in vitro
    C G Spiteri
    BioEngineering of Skeletal Tissues Team, Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Suite 600 9, Toronto, Ontario, Canada M5G 1X5
    J Biomed Mater Res A 78:676-83. 2006
    ..Understanding how substrate porosity influences chondrocyte behavior may help identify methods to further enhance cartilage tissue formation in vitro...
  33. ncbi request reprint Effect of zoledronate on bone quality in the treatment of aseptic loosening of hip arthroplasty in the dog
    L M Wise
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Calcif Tissue Int 77:367-75. 2005
    ..We conclude that ZLN affects some of the material properties of cortical bone and allows the newly formed subperiosteal bone to remain and therefore affect the overall quality of the bone...

Research Grants1

  1. Bioengineering Annulus Fibrosus using Silk Scaffold
    Rita Kandel; Fiscal Year: 2006
    ..The viability and mechanical properties of the tissue will be evaluated. ..