Pamela Goodwin

Summary

Affiliation: Mount Sinai Hospital
Country: Canada

Publications

  1. ncbi request reprint Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 20:42-51. 2002
  2. ncbi request reprint Diabetes mellitus and breast cancer: a retrospective population-based cohort study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, M4N 3M5, Toronto, Ontario, Canada
    Breast Cancer Res Treat 98:349-56. 2006
  3. pmc 25-Hydroxy vitamin-D, obesity, and associated variables as predictors of breast cancer risk and tamoxifen benefit in NSABP-P1
    Eitan Amir
    Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 133:1077-88. 2012
  4. pmc Understanding the benefit of metformin use in cancer treatment
    Ryan J O Dowling
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    BMC Med 9:33. 2011
  5. pmc Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:99. 2007
  6. doi request reprint Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 30:164-71. 2012
  7. ncbi request reprint Is leptin a mediator of adverse prognostic effects of obesity in breast cancer?
    Pamela J Goodwin
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Oncol 23:6037-42. 2005
  8. ncbi request reprint Support groups in advanced breast cancer
    Pamela J Goodwin
    Department of Medicine, Division of Epidemiology, Marvelle Koffler Breast Center, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Cancer 104:2596-601. 2005
  9. doi request reprint Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 126:215-20. 2011
  10. doi request reprint High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 1284 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Breast Cancer Res Treat 114:517-25. 2009

Research Grants

  1. Prognosis in BRCA1 Associated Breast Cancer
    Pamela Goodwin; Fiscal Year: 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 20:42-51. 2002
    ..Because of this and because of its recognized association with obesity, an adverse prognostic factor in breast cancer, we examined the prognostic associations of insulin in early-stage breast cancer...
  2. ncbi request reprint Diabetes mellitus and breast cancer: a retrospective population-based cohort study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, M4N 3M5, Toronto, Ontario, Canada
    Breast Cancer Res Treat 98:349-56. 2006
    ..The purpose of this study was to compare the incidence of breast cancer in postmenopausal women with and without diabetes...
  3. pmc 25-Hydroxy vitamin-D, obesity, and associated variables as predictors of breast cancer risk and tamoxifen benefit in NSABP-P1
    Eitan Amir
    Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 133:1077-88. 2012
    ..34). In this high risk population, higher BMI was associated with a greater breast cancer risk. Serum levels of 25OHD, insulin, CRP, and leptin were not independent predictors of either breast cancer risk or tamoxifen benefit...
  4. pmc Understanding the benefit of metformin use in cancer treatment
    Ryan J O Dowling
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    BMC Med 9:33. 2011
    ..The evidence supporting a role for metformin in cancer therapy and its potential molecular mechanisms of action are discussed...
  5. pmc Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:99. 2007
    ..In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry...
  6. doi request reprint Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 30:164-71. 2012
    ....
  7. ncbi request reprint Is leptin a mediator of adverse prognostic effects of obesity in breast cancer?
    Pamela J Goodwin
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Oncol 23:6037-42. 2005
    ..It has been suggested that leptin may mediate adverse prognostic effects of obesity in breast cancer...
  8. ncbi request reprint Support groups in advanced breast cancer
    Pamela J Goodwin
    Department of Medicine, Division of Epidemiology, Marvelle Koffler Breast Center, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Cancer 104:2596-601. 2005
    ..There was good evidence that support groups in metastatic breast cancer lead to improved psychologic outcomes. Evidence of beneficial survival effects was not convincing...
  9. doi request reprint Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 126:215-20. 2011
    ..32) that has recently been initiated...
  10. doi request reprint High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 1284 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Breast Cancer Res Treat 114:517-25. 2009
    ....
  11. doi request reprint Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    ..Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity...
  12. doi request reprint Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Princess Margaret Hospital, University of Toronto Mount Sinai Hospital, 1284 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Breast 20:S31-5. 2011
    ..Clinical studies in the neoadjuvant and adjuvant settings are ongoing; additional Phase 2 trials in the metastatic setting and proof of principle studies in the prevention setting are planned...
  13. doi request reprint Breast cancer prognosis in BRCA1 and BRCA2 mutation carriers: an International Prospective Breast Cancer Family Registry population-based cohort study
    Pamela J Goodwin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario
    J Clin Oncol 30:19-26. 2012
    ..To compare breast cancer prognosis in BRCA1 and BRCA2 mutation carriers with that in patients with sporadic disease...
  14. ncbi request reprint Health-related quality of life and psychosocial status in breast cancer prognosis: analysis of multiple variables
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Avenue, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 22:4184-92. 2004
    ..Evidence that psychosocial status and health-related quality of life (HRQOL) are associated with breast cancer (BC) outcomes is weak and inconsistent. We examined prognostic effects of these factors in a prospective cohort study...
  15. ncbi request reprint Diet and breast cancer: evidence that extremes in diet are associated with poor survival
    Pamela J Goodwin
    Department of Medicine, Sam Lunenfeld Research Institute Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Oncol 21:2500-7. 2003
    ..Because of a U-shaped association of body mass index (BMI) with survival in breast cancer, we hypothesized that a nonlinear association also existed for dietary variables...
  16. ncbi request reprint Lessons learned from enrollment in the BEST study--a multicenter, randomized trial of group psychosocial support in metastatic breast cancer
    P J Goodwin
    Department of Medicine, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada
    J Clin Epidemiol 53:47-55. 2000
    ....
  17. ncbi request reprint Management of familial breast cancer risk
    P J Goodwin
    Marvelle Koffler Breast Centre, Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Breast Cancer Res Treat 62:19-33. 2000
    ..An explicit examination of different time-frames (1, 5, 10 years) is recommended given the rapid evolution of knowledge in this area...
  18. ncbi request reprint Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes
    Pamela J Goodwin
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Breast Cancer Res Treat 74:65-76. 2002
    ..The adverse effect of IGFBP-3 on distant recurrence in postmenopausal women with estrogen receptor positive breast cancer should be further investigated...
  19. ncbi request reprint The effect of group psychosocial support on survival in metastatic breast cancer
    P J Goodwin
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    N Engl J Med 345:1719-26. 2001
    ..Supportive-expressive group therapy has been reported to prolong survival among women with metastatic breast cancer. However, in recent studies, various psychosocial interventions have not prolonged survival...
  20. ncbi request reprint Risk of menopause during the first year after breast cancer diagnosis
    P J Goodwin
    Departments of Medicine and Clinical Epidemiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
    J Clin Oncol 17:2365-70. 1999
    ..Adjuvant therapy is believed to contribute to this early menopause...
  21. ncbi request reprint Health-related quality-of-life measurement in randomized clinical trials in breast cancer--taking stock
    Pamela J Goodwin
    Department of Medicine, Division of Clinical Epidemiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 1284 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Natl Cancer Inst 95:263-81. 2003
    ....
  22. ncbi request reprint Economic issues in lung cancer: a review
    P J Goodwin
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Oncol 16:3900-12. 1998
    ..It is estimated that lung cancer is responsible for 20% of all cancer care costs. Concerns exist that this expenditure is associated with questionable benefits...
  23. ncbi request reprint Serum lipids and outcome of early-stage breast cancer: results of a prospective cohort study
    Mala Bahl
    The Samuel Lunenfeld Research Institute and Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Breast Cancer Res Treat 94:135-44. 2005
    ..Here, we examine whether serum levels of total cholesterol (TC) and triglycerides (TG) influence breast cancer outcome...
  24. ncbi request reprint Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer
    Anna Marie Mulligan
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Breast Cancer Res Treat 106:39-47. 2007
    ..Furthermore, high expression of IR is independently and significantly associated with more favorable clinical outcomes. Follow-up intervention research is recommended...
  25. ncbi request reprint Quality of life in a randomized trial of group psychosocial support in metastatic breast cancer: overall effects of the intervention and an exploration of missing data
    Louise Bordeleau
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    J Clin Oncol 21:1944-51. 2003
    ..To evaluate the effect of a standardized group psychosocial intervention on health-related quality of life (HrQOL) in women with metastatic breast cancer and to explore the effect of missing data in HrQOL analyses...
  26. doi request reprint Insulin-lowering effects of metformin in women with early breast cancer
    Pamela J Goodwin
    Department of Medicine, University of Toronto, Division of Clinical Epidemiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Breast Cancer 8:501-5. 2008
    ..If metformin lowers insulin levels in women with breast cancer, it may also improve breast cancer outcomes...
  27. ncbi request reprint Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review
    Louise Bordeleau
    Department of Medical Oncology, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:230-41. 2007
    ..Because of the contribution of sex hormones to breast cancer, the use of hormonal agents for the control of hot flashes is problematic in these women. Safer nonhormonal alternatives are recommended for this patient group...
  28. ncbi request reprint Economic analysis of psychosocial group therapy in women with metastatic breast cancer
    Julie Lemieux
    Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, University of Toronto, 1284 600 University Ave, M5G 1X5 Toronto, ON, Canada
    Breast Cancer Res Treat 100:183-90. 2006
    ..Psychosocial interventions have been shown to reduce psychological distress in these patients. In other diseases, depression and anxiety have been associated with higher health care system resource utilization...
  29. doi request reprint Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis
    Sarah Khalid
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 122:647-59. 2010
    ..These data indicate that HFD, in the absence of significant insulin resistance, mediates a tumor promoting, but not a tumor growth effect in this model of mammary carcinogenesis...
  30. ncbi request reprint Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada, M5T 3L9
    Breast Cancer Res Treat 105:69-80. 2007
    ....
  31. ncbi request reprint Increased prevalence of prior breast cancer in women with newly diagnosed diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Breast Cancer Res Treat 98:303-9. 2006
    ..Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period...
  32. ncbi request reprint HER-2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry
    Louise A Quenneville
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 95:2068-75. 2002
    ..The Ontario Familial Breast Cancer Registry collects clinical and family history data in familial breast carcinoma cases, and unselected Ashkenazi breast carcinomas, and acts as a tumor tissue repository...
  33. pmc Breast self-examination: resistance to change
    M Elisabeth Del Giudice
    Department of Family and Community Medicine, University of Toronto, Ontario
    Can Fam Physician 51:698-9. 2005
    ....
  34. ncbi request reprint Reliability and validity of the body image after breast cancer questionnaire
    Nancy N Baxter
    Department of Surgery, University of Toronto, Canada
    Breast J 12:221-32. 2006
    ..The BIBCQ provides a reliable and valid assessment of the long-term impact of breast cancer on body image. It is suitable for use in research focusing on this issue...
  35. ncbi request reprint The impact of diabetes on survival following breast cancer
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Breast Cancer Res Treat 109:389-95. 2008
    ..The purpose of this study was to examine the impact of diabetes on survival following breast cancer...
  36. ncbi request reprint Economic analysis of the TAX 317 trial: docetaxel versus best supportive care as second-line therapy of advanced non-small-cell lung cancer
    Natasha B Leighl
    Department of Medical Oncology, Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 20:1344-52. 2002
    ..To determine the cost-effectiveness (CE) of second-line docetaxel compared with best supportive care (BSC) in the TAX 317 trial, a randomized clinical trial of second-line chemotherapy in non-small-cell lung cancer...
  37. ncbi request reprint Reversible ovarian ablation or chemotherapy: are we ready for quality of life to guide adjuvant treatment decisions in breast cancer?
    Pamela J Goodwin
    J Clin Oncol 21:4474-5. 2003
  38. doi request reprint Identification of cancer care and protocol characteristics associated with recruitment in breast cancer clinical trials
    Julie Lemieux
    Unité de recherche en santé des populations, Centre des Maladies du Sein Deschênes Fabia, Hôpital St Sacrement, Quebec, Canada
    J Clin Oncol 26:4458-65. 2008
    ..Barriers to participation may relate to available protocols, physicians, and patients, but few data exist on barriers related to cancer care environments and protocol characteristics...
  39. ncbi request reprint Insulin in the adjuvant breast cancer setting: a novel therapeutic target for lifestyle and pharmacologic interventions?
    Pamela J Goodwin
    J Clin Oncol 26:833-4. 2008
  40. ncbi request reprint Responsiveness to change [corrected] due to supportive-expressive group therapy, improvement in mood and disease progression in women with metastatic breast cancer
    Julie Lemieux
    Departement d Hematologie, Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, pavillon St Sacrement, Quebec, Canada
    Qual Life Res 16:1007-17. 2007
    ..2) on Profile of Mood States (POMS) Total Mood Disturbance score and (iii) progression of disease...
  41. ncbi request reprint Three methods for minimally important difference: no relationship was found with the net proportion of patients improving
    Julie Lemieux
    Unité de recherche en santé des populations, Centre de Recherche, Hôpital du Saint Sacrement, Quebec, Canada
    J Clin Epidemiol 60:448-55. 2007
    ..To determine the impact on a responder type analysis of using three published methods to obtain the minimally important difference (MID) on the conclusion of a randomized controlled trial (RCT)...
  42. ncbi request reprint Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations
    Pamela J Goodwin
    N Engl J Med 357:1555; author reply 1556. 2007
  43. ncbi request reprint Group support in breast cancer: realistic hope, realistic benefits
    Pamela J Goodwin
    Expert Rev Anticancer Ther 2:135-6. 2002
  44. ncbi request reprint Options for preservation of fertility in women
    Pamela J Goodwin
    N Engl J Med 353:1418-20; author reply 1418-20. 2005
  45. ncbi request reprint Support groups in breast cancer: when a negative result is positive
    Pamela J Goodwin
    J Clin Oncol 22:4244-6. 2004
  46. ncbi request reprint Host-related factors in breast cancer: an underappreciated piece of the puzzle?
    Pamela J Goodwin
    J Clin Oncol 26:3299-300. 2008

Research Grants3

  1. Prognosis in BRCA1 Associated Breast Cancer
    Pamela Goodwin; Fiscal Year: 2007
    ..Because this research is nested within the CFRBCS, the objectives can be addressed in a timely and cost effective manner. ..