Tom Moss

Summary

Country: Canada

Publications

  1. ncbi request reprint At the center of eukaryotic life
    Tom Moss
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, Quebec, Canada
    Cell 109:545-8. 2002
  2. ncbi request reprint Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
    G Pelletier
    Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
    Mol Cell 6:1059-66. 2000
  3. ncbi request reprint An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6, Quebec, Canada
    Mol Cell 8:1063-73. 2001
  4. ncbi request reprint A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis
    T Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ HDQ, Pavillon St Patrick, 9 rue McMahon, Québec G1R 3S3, Canada
    Cell Mol Life Sci 64:29-49. 2007
  5. ncbi request reprint At the crossroads of growth control; making ribosomal RNA
    Tom Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 9 rue McMahon, G1R 2J6 Québec, Canada
    Curr Opin Genet Dev 14:210-7. 2004
  6. ncbi request reprint A new paradigm for the regulation of the mammalian ribosomal RNA genes
    T Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ HDQ, Pavillon St Patrick, 9 rue McMahon, QC, Canada G1R 3S3
    Biochem Soc Trans 34:1079-81. 2006
  7. pmc DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis
    Tom Moss
    Cancer Research Centre and Dept of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, Canada
    Epigenetics 6:128-33. 2011
  8. doi request reprint Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing
    Thérèse Gagnon-Kugler
    Cancer Research Centre, CHUQ HDQ Research Centre, Pavillon St Patrick, 9 rue McMahon, Quebec, QC G1R 3S3, Canada
    Mol Cell 35:414-25. 2009
  9. doi request reprint Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo
    Steve Jean
    Cancer Research Centre and Department of Medical Biology, Medical Biochemistry and Pathology, Laval University, Hotel Dieu de Quebec, 9 rue McMahon, G1R 2J6 Québec, Canada
    Dev Cell 19:426-39. 2010
  10. pmc The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation
    Frédéric Lessard
    Cancer Research Centre and Department of Molecular Biology, Medical Biochemistry and Pathology of Laval University, CHUQ Research Centre, Pavillon St Patrick, 9 rue McMahon, Quebec, G1R 3S3 Québec, Canada
    Nucleic Acids Res 40:5357-67. 2012

Collaborators

  • Steve Jean
  • Doris Wedlich
  • David R Kaplan
  • Victor Stefanovsky
  • Nicolas Bisson
  • Victor Y Stefanovsky
  • Frédéric Lessard
  • Frédéric Langlois
  • Alexander Mikryukov
  • V Y Stefanovsky
  • Thérèse Gagnon-Kugler
  • G Pelletier
  • Michel Tremblay
  • Katherine M Hannan
  • Michel G Tremblay
  • L I Rothblum
  • James Rutka
  • Stacey Ivanchuk
  • Françoise Morin
  • Fiona Robinson
  • Steven P Trusko
  • Luc Poitras
  • Guillaume Pelletier
  • David Bazett-Jones
  • Larry I Rothblum
  • Anna Jenkins
  • Gretchen Poortinga
  • Lawrence Rothblum
  • Yves Brandenburger
  • Ross D Hannan
  • Kerith Sharkey
  • Richard B Pearson
  • Grant A McArthur
  • Alice Cavanaugh
  • P Levac
  • D P Bazett-Jones
  • T Gagnon-Kugler
  • C Crane-Robinson
  • R Hannan
  • M Faubladier
  • I Hirschler-Laszkiewicz
  • J Cote
  • J Savard
  • D Bachvarov
  • M Normandeau

Detail Information

Publications26

  1. ncbi request reprint At the center of eukaryotic life
    Tom Moss
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, Quebec, Canada
    Cell 109:545-8. 2002
    ..The ribosomal RNA genes encode the enzymatic scaffold of the ribosome and thereby perform perhaps the most basic of all housekeeping functions. However, recent data suggests that they might also control important aspects of cell behavior...
  2. ncbi request reprint Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
    G Pelletier
    Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
    Mol Cell 6:1059-66. 2000
    ..quot; Thus, PolI transcription is regulated by protein acetylation, and the competitive recruitment of CBP and Rb...
  3. ncbi request reprint An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6, Quebec, Canada
    Mol Cell 8:1063-73. 2001
    ..Thus, growth factor regulation of ribosomal transcription likely acts by a cyclic modulation of DNA architecture. The data suggest a central role for ribosome biogenesis in growth regulation...
  4. ncbi request reprint A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis
    T Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ HDQ, Pavillon St Patrick, 9 rue McMahon, Québec G1R 3S3, Canada
    Cell Mol Life Sci 64:29-49. 2007
    ..It is argued that transcription elongation is a key mechanism regulating rRNA gene transcription. This unorthodox view provides a logical framework to explain the co-transcriptional phase of ribosome biogenesis...
  5. ncbi request reprint At the crossroads of growth control; making ribosomal RNA
    Tom Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 9 rue McMahon, G1R 2J6 Québec, Canada
    Curr Opin Genet Dev 14:210-7. 2004
    ..In the past few years we have begun to penetrate the network linking rRNA gene transcription to growth...
  6. ncbi request reprint A new paradigm for the regulation of the mammalian ribosomal RNA genes
    T Moss
    Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ HDQ, Pavillon St Patrick, 9 rue McMahon, QC, Canada G1R 3S3
    Biochem Soc Trans 34:1079-81. 2006
    ..Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly...
  7. pmc DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis
    Tom Moss
    Cancer Research Centre and Dept of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, Canada
    Epigenetics 6:128-33. 2011
    ..As such, the data provide an unforeseen explanation of the action of DNA methylation inhibitors in restricting cancer cell growth...
  8. doi request reprint Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing
    Thérèse Gagnon-Kugler
    Cancer Research Centre, CHUQ HDQ Research Centre, Pavillon St Patrick, 9 rue McMahon, Quebec, QC G1R 3S3, Canada
    Mol Cell 35:414-25. 2009
    ..Lack of silencing leads to the partial disruption of rRNA synthesis and rRNA processing, providing an explanation for the cytotoxic effects of loss of CpG methylation...
  9. doi request reprint Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo
    Steve Jean
    Cancer Research Centre and Department of Medical Biology, Medical Biochemistry and Pathology, Laval University, Hotel Dieu de Quebec, 9 rue McMahon, G1R 2J6 Québec, Canada
    Dev Cell 19:426-39. 2010
    ..The data identify E-Syt2 as an endocytic adaptor for the clathrin-mediated pathway whose function is conserved in human and suggest a broader role for the E-Syt subfamily in growth factor signaling...
  10. pmc The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation
    Frédéric Lessard
    Cancer Research Centre and Department of Molecular Biology, Medical Biochemistry and Pathology of Laval University, CHUQ Research Centre, Pavillon St Patrick, 9 rue McMahon, Quebec, G1R 3S3 Québec, Canada
    Nucleic Acids Res 40:5357-67. 2012
    ..Thus, both the sub-nuclear localization and the abundance of TTF-I are key regulators of ribosome biogenesis...
  11. pmc The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
    Victor Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, 9 rue McMahon, G1R 3S3 Québec, QC, Canada
    Nucleic Acids Res 36:5093-101. 2008
    ..Thus, UBF2 functionally simulates a hemi-phosphorylated UBF whose expression may provide a means by which to tune the response of the ribosomal RNA genes to growth factor stimulation...
  12. doi request reprint The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I
    Frédéric Lessard
    Cancer Research Centre, Department of Molecular Biology, Medical Biochemistry, and Pathology of Laval University, CHUQ Research Centre, Quebec, Quebec, Canada
    Mol Cell 38:539-50. 2010
    ..Thus, our data delineate the pathway by which ARF regulates ribosomal RNA synthesis and provide a compelling explanation for the role of NPM...
  13. pmc Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling
    Alexander Mikryukov
    Laboratory of Growth and Development, Cancer Research Centre, Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e43330. 2012
    ..Our data suggest that the proteolytic cleavage of xTNIK and xMINK determines their respective activities and is an important factor in controlling the balance between canonical and non-canonical Wnt signalling in vivo...
  14. ncbi request reprint ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF
    Victor Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, 9 rue McMahon G1R 2J6 Québec, QC, Canada
    Biochemistry 45:3626-34. 2006
    ..The data demonstrate that ERK phosphorylation of UBF prevents DNA bending by its first two HMG boxes, leading to a cooperative unfolding of the enhancesome...
  15. ncbi request reprint Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count
    Victor Stefanovsky
    Cancer Research Centre, Department of Medical Biology, Laval University, Quebec, Canada
    Cell Cycle 5:735-9. 2006
    ..Since ERK and the acetyltransferase CBP both bind the architectural factor UBF, this suggests a mechanism for targeting active CBP to the rRNA genes...
  16. ncbi request reprint Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype
    Nicolas Bisson
    Cancer Research Centre and Department of Medical Biology, Laval University, Quebec, Quebec, Canada
    Cell Cycle 7:909-16. 2008
    ..Our results suggest that there is extensive functional redundancy between MLK1/MLK2 and the other member of the family, MLK3, which is also not required for survival in mouse...
  17. ncbi request reprint Inactivation of topoisomerase I or II may lead to recombination or to aberrant replication termination on both SV40 and yeast 2 micron DNA
    P Levac
    Centre de Recherche en Cancérologie et Département de Biochimie, Universite Laval, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6 Québec, Canada
    Chromosoma 105:250-60. 1996
    ..The data suggest that inactivation of topoisomerase I or II either stimulates recombination or, by differentially affecting replication fork progression, leads to aberrant replication termination...
  18. doi request reprint The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus
    Nicolas Bisson
    Laboratory of Signal Network Dynamics, Cancer Research Centre and Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine Laval University, Quebec, QC, Canada
    Cell Cycle 11:1316-24. 2012
    ..Our results also represent the first evidence that Pak1 links extracellular signals to the genetic cascade of transcription factors necessary for CNC specification...
  19. doi request reprint The cruciform DNA mobility shift assay: a tool to study proteins that recognize bent DNA
    Victor Y Stefanovsky
    Department of Medical Biology, Cancer Research Centre, Hotel Dieu de Quebec, 9 rue McMahon Québec, QC, Canada G1R 2J6
    Methods Mol Biol 543:537-46. 2009
    ..A synthetic cruciform DNA structure will often provide an ideal binding site for such proteins, allowing their affinities for both bent and linear DNAs to be directly and simply determined by a modified form of EMSA...
  20. ncbi request reprint Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
    Victor Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6 Québec, Canada
    Mol Cell 21:629-39. 2006
    ..The data suggest a mechanism for coordinating the cotranscriptional assembly of preribosomal particles...
  21. pmc DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, , , , Canada
    Nucleic Acids Res 29:3241-7. 2001
    ..We use this and previous data to refine the existing enhancesome model and show that HMG boxes 1 and 2 of UBF lie head-to-head along the DNA...
  22. ncbi request reprint A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus
    Steve Jean
    Department of Medical Biology, Cancer Research Centre, Laval University, CHUQ HDQ, Pavillon St Patrick, 9 rue McMahon, Quebec, Canada G1R 3S3
    Differentiation 76:431-41. 2008
    ..Because ube2d3.2 is also shown to limit accumulation of xMLK2, it is likely that this effect is direct, although other explanations are possible. Ube2d3.2 is thus probably an endogenous regulator of xMLK2, and hence of JNK activity...
  23. pmc EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function
    Nicolas Bisson
    Cancer Research Centre, Department of Medical Biology, Laval University, Hotel Dieu de Quebec, Quebec, G1R 2J6 Québec, Canada
    Mol Biol Cell 18:1030-43. 2007
    ..Together, the data suggest that EphA4 activation sequesters active Cdc42 and in this way down-regulates cell-cell adhesion. This novel signaling pathway suggests a mechanism for EphA4-guided migration...
  24. ncbi request reprint Heterogeneity in the Xenopus ribosomal transcription factor xUBF has a molecular basis distinct from that in mammals
    D Bachvarov
    Centre de recherche en cancérologie de l Université Laval, Hotel Dieu de Quebec, Canada
    FEBS Lett 288:55-9. 1991
    ..It is also shown that the Xenopus laevis genome contains 3 or 4 distinct loci which hybridise with xUBF coding sequences, leaving open the possibility of yet further unrecognised heterogeneity in xUBF...
  25. pmc The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes
    D Bachvarov
    Centre de recherche en cancérologie de l Université Laval, Quebec, Canada
    Nucleic Acids Res 19:2331-5. 1991
    ..laevis and human proteins and may well explain their different transcriptional specificities. It is shown that xUBF contains 5 tandemly repeated HMG-boxes and that by analogy the human protein contains 6...
  26. pmc mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    Katherine M Hannan
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, USA
    Mol Cell Biol 23:8862-77. 2003
    ..Thus, mTOR plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 activation and phosphorylation of UBF...