Jean Claude Tardif

Summary

Affiliation: Montreal Heart Institute
Country: Canada

Publications

  1. pmc Ivabradine: the evidence of its therapeutic impact in angina
    Guillaume Marquis-Gravel
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Core Evid 3:1-12. 2008
  2. ncbi request reprint Optimisation of reference genes for gene-expression analysis in a rabbit model of left ventricular diastolic dysfunction
    Walid Nachar
    Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 9:e89331. 2014
  3. ncbi request reprint Effects of ivabradine in patients with stable angina receiving β-blockers according to baseline heart rate: an analysis of the ASSOCIATE study
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada Electronic address
    Int J Cardiol 168:789-94. 2013
  4. ncbi request reprint Emerging anti-inflammatory therapies for atherosclerosis
    Francois Roubille
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ H1T 1C8, Canada
    Curr Pharm Des 19:5840-9. 2013
  5. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
  6. pmc Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT)
    Georg M Schuetz
    Department of Radiology, Charité Universitätsmedizin Berlin Campus Mitte, Humboldt Universitat zu Berlin, Freie Universitat Berlin, Chariteplatz 1, Berlin 10117, Germany
    Syst Rev 2:13. 2013
  7. doi request reprint Inflammation and the heart - prime time for new therapeutic approaches
    Francois Roubille
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada 514 376 3330, ext 3612 514 593 2500
    Expert Opin Emerg Drugs 18:259-61. 2013
  8. doi request reprint Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 61:2048-55. 2013
  9. ncbi request reprint Apolipoprotein B antisense inhibition--update on mipomersen
    Catherine Gebhard
    Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Curr Pharm Des 19:3132-42. 2013
  10. doi request reprint Atherosclerosis imaging and the Canadian Atherosclerosis Imaging Network
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 29:297-303. 2013

Collaborators

Detail Information

Publications149 found, 100 shown here

  1. pmc Ivabradine: the evidence of its therapeutic impact in angina
    Guillaume Marquis-Gravel
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Core Evid 3:1-12. 2008
    ..Ongoing studies will determine the potential of ivabradine to improve morbidity and mortality in coronary artery disease and heart failure...
  2. ncbi request reprint Optimisation of reference genes for gene-expression analysis in a rabbit model of left ventricular diastolic dysfunction
    Walid Nachar
    Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 9:e89331. 2014
    ..This is the first study emphasizing the selection of stable reference genes for RT-PCR normalization in a rabbit model of LVDD. ..
  3. ncbi request reprint Effects of ivabradine in patients with stable angina receiving β-blockers according to baseline heart rate: an analysis of the ASSOCIATE study
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada Electronic address
    Int J Cardiol 168:789-94. 2013
    ..This analysis of the ASSOCIATE trial assessed whether the anti-ischemic efficacy and safety of ivabradine were comparable in patients with baseline resting HRs above and below the median...
  4. ncbi request reprint Emerging anti-inflammatory therapies for atherosclerosis
    Francois Roubille
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ H1T 1C8, Canada
    Curr Pharm Des 19:5840-9. 2013
    ....
  5. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
    ....
  6. pmc Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT)
    Georg M Schuetz
    Department of Radiology, Charité Universitätsmedizin Berlin Campus Mitte, Humboldt Universitat zu Berlin, Freie Universitat Berlin, Chariteplatz 1, Berlin 10117, Germany
    Syst Rev 2:13. 2013
    ..The individual patient data meta-analysis is registered with the PROSPERO database (CoMe-CCT, CRD42012002780)...
  7. doi request reprint Inflammation and the heart - prime time for new therapeutic approaches
    Francois Roubille
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada 514 376 3330, ext 3612 514 593 2500
    Expert Opin Emerg Drugs 18:259-61. 2013
    ..Expert opinion: Indeed, recent data from clinical trials on anti-inflammatory drugs in coronary artery disease highlight the potential of such therapies. ..
  8. doi request reprint Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 61:2048-55. 2013
    ..The study aimed to evaluate inclacumab for the reduction of myocardial damage during a percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction...
  9. ncbi request reprint Apolipoprotein B antisense inhibition--update on mipomersen
    Catherine Gebhard
    Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Curr Pharm Des 19:3132-42. 2013
    ..If future studies continue to show such promising results, mipomersen would likely be a viable additional lipid-lowering therapy for high-risk populations...
  10. doi request reprint Atherosclerosis imaging and the Canadian Atherosclerosis Imaging Network
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 29:297-303. 2013
    ..The benefits are expected to appear in the next 2 to 3 years. CAIN will drive innovation in imaging technology within the field of cardiology and neurology and improve health outcomes in Canada and worldwide...
  11. doi request reprint An update on the clinical development of dalcetrapib (RO4607381), a cholesteryl ester transfer protein modulator that increases HDL cholesterol levels
    David Rhainds
    Atherosclerosis Research Group, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, Canada
    Future Cardiol 8:513-31. 2012
    ....
  12. pmc Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
    Andrew Mk Brown
    Universite de Montreal, Montreal, Quebec, Canada
    BMC Res Notes 3:185. 2010
    ....
  13. ncbi request reprint Imaging biomarkers of atherosclerosis
    Stephane Noble
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Biomark Med 2:555-65. 2008
    ..These technologies include traditional imaging such as angiography, as well as advanced imaging techniques using both invasive and noninvasive approaches...
  14. doi request reprint Heart rate as a treatable cardiovascular risk factor
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, QC, Canada H1T 1C8
    Br Med Bull 90:71-84. 2009
    ..Although several epidemiological studies demonstrate the association between resting heart rate (HR) and cardiovascular morbidity and mortality, an elevated HR remains a neglected cardiovascular risk factor...
  15. pmc Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Eur Heart J 30:540-8. 2009
    ..To evaluate the anti-anginal and anti-ischaemic efficacy of the selective I(f) current inhibitor ivabradine in patients with chronic stable angina pectoris receiving beta-blocker therapy...
  16. doi request reprint Ivabradine: I(f) inhibition in the management of stable angina pectoris and other cardiovascular diseases
    Jean Claude Tardif
    Montreal Heart Institute, University of Montreal, Montreal, QC, Canada
    Drugs Today (Barc) 44:171-81. 2008
    ..Ongoing studies will determine the potential of pure heart rate reduction with ivabradine to improve morbidity and mortality...
  17. ncbi request reprint Atherosclerosis imaging
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Quebec
    Can J Cardiol 21:1035-9. 2005
    ..IVUS can also help to determine dose-response relationships in the development of novel pharmacological agents. IVUS is currently the ideal imaging modality for clinical trials examining the progression or regression of atherosclerosis...
  18. ncbi request reprint Reaching the therapeutic goal in hypertension: results from the Canadian valsartan observational study. (Diovantage 4)
    Jean Claude Tardif
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Can J Clin Pharmacol 15:e177-87. 2008
    ..Hypertension is a leading cause of death worldwide, and a major public health problem in Canada. Despite treatment guidelines and availability of therapies for blood pressure (BP) management, treatment of hypertension remains sub-optimal...
  19. ncbi request reprint Antioxidants and atherosclerosis: emerging drug therapies
    Jean Claude Tardif
    MHI Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Curr Atheroscler Rep 7:71-7. 2005
    ....
  20. doi request reprint Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial
    Jean Claude Tardif
    Montreal Heart Institute, University of Montreal, Montreal, Canada
    Lancet 371:1761-8. 2008
    ..Our aim was to assess the effects of the antioxidant succinobucol (AGI-1067) on cardiovascular outcomes in patients with recent acute coronary syndromes already managed with conventional treatments...
  21. ncbi request reprint Clinical results of I(f) current inhibition by ivabradine
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    Drugs 67:35-41. 2007
    ....
  22. ncbi request reprint Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial
    Jean Claude Tardif
    Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 197:480-6. 2008
    ..The present study originally intended to study restenosis as a primary endpoint but was subsequently modified to primarily investigate the effects of AGI-1067 on coronary atherosclerosis...
  23. pmc Prevention challenges: the era of atherosclerosis regression
    Jean Claude Tardif
    Montreal Heart Institute, and Université de Montréal, Montreal, Quebec
    Can J Cardiol 22:27C-30C. 2006
    ..The additional cardiovascular protection required for patients with atherosclerosis or risk equivalents will likely be provided by therapies that go beyond LDL reduction...
  24. ncbi request reprint Vascular biomarkers and surrogates in cardiovascular disease
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 113:2936-42. 2006
    ..The information presented in the present report summarizes the authors' perspective distilled from these proceedings...
  25. ncbi request reprint Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial
    Jean Claude Tardif
    Montreal Heart Institute and the Montreal Heart Institute Coordinating Center, Universite de Montreal, Montreal, Quebec, Canada
    JAMA 297:1675-82. 2007
    ..High-density lipoprotein (HDL) cholesterol is an inverse predictor of coronary atherosclerotic disease. Preliminary data have suggested that HDL infusions can induce atherosclerosis regression...
  26. ncbi request reprint Effect of atherosclerotic regression on total luminal size of coronary arteries as determined by intravascular ultrasound
    Jean Claude Tardif
    Department of Medicine and Research Center of the Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Am J Cardiol 98:23-7. 2006
    ..This reverse vascular remodeling may be responsible for the "regression paradox," whereby secondary prevention is associated with clinical benefits despite minimal improvement in coronary lumen dimensions...
  27. ncbi request reprint Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    J Thorac Cardiovasc Surg 133:1604-11. 2007
    ..The MEND-CABG trial tested the hypothesis that MC-1 reduces cardiovascular morbidity and mortality after coronary artery bypass graft...
  28. pmc Antioxidants: the good, the bad and the ugly
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec
    Can J Cardiol 22:61B-65B. 2006
    ....
  29. ncbi request reprint Cardiac investigation in patients with diabetes
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec
    Can J Cardiol 22:38A-40A. 2006
    ..Official guidelines for appropriate and cost-effective cardiac investigation should help physicians manage diabetic patients...
  30. ncbi request reprint Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
    ..The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis. This study was designed to investigate the effects of avasimibe on human coronary atherosclerosis...
  31. doi request reprint Emerging high-density lipoprotein infusion therapies: fulfilling the promise of epidemiology?
    Jean Claude Tardif
    Department of Medicine, Research Centre, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T1C8, Canada
    J Clin Lipidol 4:399-404. 2010
    ..Taken together, this evidence suggests that infusions of HDL or apoA-1 may reduce events, particularly among patients with ACS...
  32. ncbi request reprint Retrospective longitudinal cohort study comparing the effects of angiotensin-converting enzyme inhibitors and long-acting calcium channel blockers on total and cardiovascular mortality in patients with hypertension
    Jean Claude Tardif
    Montreal Heart Institute, Montreal H1T IC8, Canada
    Clin Ther 26:1073-83. 2004
    ..There is controversy regarding the impact that different antihypertensive regimens, including modern combination therapy, have on the incidence of myocardial infarction, other cardiovascular events, and mortality...
  33. pmc Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, Canada H1T 1C8
    Eur Heart J 32:2507-15. 2011
    ..The SHIFT echocardiographic substudy evaluated the effects of ivabradine on left ventricular (LV) remodelling in heart failure (HF)...
  34. doi request reprint A randomized controlled, phase 2 trial of the viral serpin Serp-1 in patients with acute coronary syndromes undergoing percutaneous coronary intervention
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Cardiovasc Interv 3:543-8. 2010
    ..Our objective was to evaluate the safety and efficacy of Serp-1 in patients with ACS undergoing percutaneous coronary intervention...
  35. ncbi request reprint Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression
    Colin Berry
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Circulation 115:1851-7. 2007
    ..To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical trial population...
  36. ncbi request reprint Quantification of the risk and predictors of hyperkalemia in patients with left ventricular dysfunction: a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trials
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Am Heart J 152:705-12. 2006
    ..Limited data are available to predict the occurrence of hyperkalemia. Risk assessment is complicated by the lack of consistency of definition between trials...
  37. ncbi request reprint Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction: insight from the Studies Of Left Ventricular Dysfunction (SOLVD) trials
    Emmanuelle Vermes
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Circulation 107:2926-31. 2003
    ....
  38. doi request reprint Perioperative intravenous amiodarone does not reduce the burden of atrial fibrillation in patients undergoing cardiac valvular surgery
    Yanick Beaulieu
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Anesthesiology 112:128-37. 2010
    ....
  39. ncbi request reprint Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy
    Marie Claude Aubin
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 47:702-10. 2006
    ..In conclusion, the antioxidant probucol limited the development and induced the regression of LVH and the associated coronary endothelial dysfunction...
  40. ncbi request reprint Effects of AGI-1067 and probucol after percutaneous coronary interventions
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    Circulation 107:552-8. 2003
    ..In a multicenter trial, we studied whether AGI-1067 reduces restenosis assessed by intravascular ultrasound (IVUS) after percutaneous coronary intervention (PCI) compared with placebo and probucol used as a positive control...
  41. ncbi request reprint Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model
    Olivier Malo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 59:501-11. 2003
    ..The objective of this study was to assess the effect of L-arginine, BH(4) and the combination of two antioxidants, superoxide dismutase and catalase, on endothelium-dependent relaxations in a swine left ventricular hypertrophy model...
  42. ncbi request reprint Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease
    Anil Nigam
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 92:395-9. 2003
    ..An increase in large conduit vessel stiffness may represent either a cause or consequence of endothelial dysfunction and may explain why elevated pulse pressure is a new cardiovascular risk factor...
  43. ncbi request reprint Incidence and significance of abnormal hepatic venous Doppler flow velocities before cardiac surgery
    Maïté Carricart
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 19:751-8. 2005
    ..The purpose of this study was to determine the incidence and significance of abnormal hepatic Doppler venous flow velocities as signs of an abnormal right ventricular filling pattern before cardiac surgery...
  44. pmc Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice
    Virginie Bolduc
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 301:H2081-92. 2011
    ..In conclusion, HR-dependent mechanical stress contributes to carotid artery wall stiffening in severely dyslipidemic mice while cerebrovascular compliance is mostly regulated by the endothelium...
  45. ncbi request reprint Mineralocorticoid receptor antagonists and cardiovascular mortality in patients with atrial fibrillation and left ventricular dysfunction: insights from the Atrial Fibrillation and Congestive Heart Failure Trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal Heart Institute Coordinating Center, and Université de Montréal, Montreal, QC, Canada
    Circ Heart Fail 5:586-93. 2012
    ..Our primary objective was to assess the impact of mineralocorticoid receptor antagonists on cardiovascular mortality in patients with AF and HF enrolled in the Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial...
  46. doi request reprint Unique quantitative trait loci in synergy permanently improve diastolic dysfunction
    Cristina Chauvet
    Research Centre, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 29:1302-9. 2013
    ..We previously demonstrated that diastolic dysfunction and left ventricular hypertrophy (LVH) in Dahl salt-sensitive rats can be ameliorated by quantitative trait loci (QTLs)...
  47. ncbi request reprint Identification of atrial tissue in pulmonary veins using intravascular ultrasound
    Peter G Guerra
    Department of Medicine, Montreal Heart Institute
    J Am Soc Echocardiogr 16:982-7. 2003
    ..Ectopic beats initiating AF always originated from these areas. PVs without thickening on IVUS did not have these potentials...
  48. ncbi request reprint Left and right ventricular diastolic dysfunction as predictors of difficult separation from cardiopulmonary bypass
    Andre Y Denault
    Department of Anesthesia, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    Can J Anaesth 53:1020-9. 2006
    ....
  49. ncbi request reprint Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs
    Kaori Shinagawa
    Department of Medicine, Montreal Heart Institute, and University of Montreal, Montreal, Canada
    Circulation 105:2672-8. 2002
    ..Clinical atrial fibrillation (AF) often results from pathologies that cause atrial structural remodeling. The reversibility of arrhythmogenic structural remodeling on removal of the underlying stimulus has not been studied systematically...
  50. ncbi request reprint Angiotensin-converting enzyme inhibition in hypertensive patients is associated with a reduction in the occurrence of atrial fibrillation
    Philippe L L'Allier
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Coll Cardiol 44:159-64. 2004
    ..The objective of this study was to determine the effects of angiotensin-converting enzyme inhibition (ACEI) versus long-acting calcium-channel blockade (CCB) on atrial fibrillation (AF) in patients with hypertension...
  51. ncbi request reprint Effects of angiotensin-converting enzyme inhibitor plus irbesartan on maximal and submaximal exercise capacity and neurohumoral activation in patients with congestive heart failure
    Martine Blanchet
    Department of Medicine, Division of Cardiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 149:938.e1-7. 2005
    ....
  52. doi request reprint Atorvastatin worsens left ventricular diastolic dysfunction and endothelial dysfunction of epicardial coronary arteries in normocholesterolemic porcine with left ventricular hypertrophy
    Jessica Forcillo
    Cardiac Surgery, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 58:295-306. 2011
    ..05). In this swine model of LVH, atorvastatin did not prevent LVH development or coronary endothelial dysfunction and resulted in worsening of the LV diastolic dysfunction...
  53. doi request reprint Preliminary experience in the use of preoperative echo-guided left stellate ganglion block in patients undergoing cardiac surgery
    Sébastien Y Garneau
    Department of Anesthesiology, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 25:78-84. 2011
    ..Thus, the goal of the study was to test the hypothesis that echo-guided left SGB, performed before the induction of general anesthesia, could prevent PA pressure increases during CPB weaning...
  54. doi request reprint Cardiac remodeling with rhythm versus rate control strategies for atrial fibrillation in patients with heart failure: insights from the AF-CHF echocardiographic sub-study
    Valérie Henrard
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Int J Cardiol 165:430-6. 2013
    ..This echocardiographic sub-study was designed to compare the effects of the two treatment strategies on LV ejection fraction (LVEF), chamber volumes and dimensions, valvular regurgitation and functional status...
  55. doi request reprint T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice
    Khai Le Quang
    Department of Medicine and Research Centre, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 6:799-808. 2013
    ..The role of T-type Ca(2+) channels in pacemaking outside the sinus node is unknown. We investigated the role of T-type Ca(2+) channels in escape rhythms and bradycardia-related ventricular tachyarrhythmias after AVB in mice...
  56. ncbi request reprint Milrinone enhances systolic, but not diastolic function during coronary artery bypass grafting surgery
    Pierre Couture
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Can J Anaesth 54:509-22. 2007
    ..To evaluate the effect of milrinone on diastolic function during coronary artery bypass grafting surgery (CABG)...
  57. ncbi request reprint Sustained elevation of serum CD40 ligand levels one month after coronary angioplasty predicts angiographic restenosis
    Philippe L L'Allier
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Can J Cardiol 21:495-500. 2005
    ..The intensity of such a reaction as measured by high-sensitivity C-reactive protein has been correlated with recurrent ischemic events, but its association with restenosis remains uncertain...
  58. ncbi request reprint Effects of plaque composition on vascular remodelling after angioplasty in the MultiVitamins and Probucol (MVP) trial
    Hai Shiang Lee
    Department of Medicine, Montreal Heart Institute, Quebec
    Can J Cardiol 18:271-5. 2002
    ..The antioxidant probucol reduced coronary restenosis in the MultiVitamins and Probucol (MVP) trial by improving vascular remodelling. Whether calcification limits the extent of adaptive vessel enlargement is not known...
  59. ncbi request reprint Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Curr Opin Lipidol 14:615-20. 2003
    ....
  60. ncbi request reprint Two-year angiographic follow-up of intracoronary Sr90 therapy for restenosis prevention after balloon angioplasty
    David Meerkin
    Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 106:539-43. 2002
    ..Postcoronary angioplasty vascular brachytherapy (VBT) has emerged as a successful intervention for restenosis prevention in some clinical scenarios. Longer-term follow-up after VBT in de novo nonstented lesions has not been reported...
  61. ncbi request reprint Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure
    Yanfen Shi
    Montreal Heart Institute, Research Center and Department of Medicine, 5000 Belanger Street East, Montreal HlT 1C8 Quebec, Canada
    Cardiovasc Res 54:456-61. 2002
    ..There have been no studies performed to assess the effects of ACE inhibitors on atrial dimensions and emptying function in relationship to vulnerability to AF in the setting of experimental CHF...
  62. ncbi request reprint Design features of the Avasimibe and Progression of coronary Lesions assessed by intravascular UltraSound (A-PLUS) clinical trial
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Quebec, Canada
    Am Heart J 144:589-96. 2002
    ..In addition to ACAT inhibitor monotherapy, combination of a statin with an ACAT inhibitor may be a promising approach to further prevent the progression of atherosclerosis...
  63. ncbi request reprint Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts
    Mona Aflaki
    From the Department of Medicine, Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada M A, X Y Q, L X, B O, A T, X L, A M, Y S, J C T, S N and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada M A, S N
    Circ Res 114:993-1003. 2014
    ..Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs)...
  64. doi request reprint Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure
    Sophie Cardin
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1027-35. 2012
    ..The present study examined the potential role of miR-21 in the atrial AF substrate resulting from experimental heart failure after myocardial infarction (MI)...
  65. ncbi request reprint Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD)
    Emmanuelle Vermes
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Circulation 107:1291-6. 2003
    ....
  66. ncbi request reprint Temporal increases in subclinical levels of inflammation are associated with adverse clinical outcomes in patients with left ventricular dysfunction
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Card Fail 12:353-9. 2006
    ..The role of temporal changes of more conventional markers of inflammation, such as the white blood cell (WBC) count, on clinical outcomes remains largely unknown...
  67. ncbi request reprint Absence of association between infectious agents and endothelial function in healthy young men
    Paul Khairy
    Department of Medicine, Montreal Heart Institute, University of Montreal, Quebec, Canada
    Circulation 107:1966-71. 2003
    ..This study assessed whether infection with Chlamydia pneumoniae (CP), cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Helicobacter pylori (HP) is associated with decreased endothelial function...
  68. doi request reprint Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome
    Jean Claude Tardif
    Department of Medicine, Radiology, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Cardiovasc Imaging 3:298-307. 2010
    ..Production of leukotrienes by 5-lipoxygenase (5-LO) has been linked to unstable atherosclerotic plaques and cardiovascular events. VIA-2291 is a potent 5-LO inhibitor...
  69. pmc Critical appraisal of C-reactive protein throughout the spectrum of cardiovascular disease
    Raed Osman
    Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Vasc Health Risk Manag 2:221-37. 2006
    ..Therapeutic interventions to decrease circulating levels of CRP are also reviewed...
  70. doi request reprint Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis
    David Busseuil
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Cardiology 117:234-42. 2010
    ..To determine if heart rate (HR) reduction with ivabradine (IVA), a selective inhibitor of the pacemaker I(f) current, prevents cardiac dysfunction associated with dyslipidemia...
  71. doi request reprint Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy
    Kimberley Crespo
    Research Centre, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Hypertens 31:927-35. 2013
    ..We previously showed in principle that diastolic function in Dahl salt-sensitive rats (DSS) can be genetically determined by quantitative trait loci (QTLs) that also modulate blood pressure (BP)...
  72. ncbi request reprint Specific alterations of endothelial signal transduction pathways of porcine epicardial coronary arteries in left ventricular hypertrophy
    Olivier Malo
    Research Center, Department of Pharmacology, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    J Cardiovasc Pharmacol 42:275-86. 2003
    ..8% +/- 0.2% to 1.2% +/- 0.1% (P < 0.05 versus control). Chronic pressure-overload LVH is associated with an endothelial dysfunction involving both Gi and Gq protein-mediated relaxations in coronary arteries as well as the EDHF pathway...
  73. ncbi request reprint Biventricular diastolic filling patterns after coronary artery bypass graft surgery
    Yanfen Shi
    Department of Medicine, Montreal Heart Institute, and University of Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 131:1080-6. 2006
    ..We sought to study the evolution of biventricular filling properties after coronary artery bypass grafting...
  74. ncbi request reprint Right ventricular myocardial performance index predicts perioperative mortality or circulatory failure in high-risk valvular surgery
    Francois Haddad
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Soc Echocardiogr 20:1065-72. 2007
    ..The main objective of this study is to assess the prognostic value of RVMPI and RVFAC in predicting postoperative mortality or circulatory failure...
  75. ncbi request reprint Mitral Doppler indices are superior to two-dimensional echocardiographic and hemodynamic variables in predicting responsiveness of cardiac output to a rapid intravenous infusion of colloid
    Robert Lattik
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Anesth Analg 94:1092-9, table of contents. 2002
    ..We conclude that the MF Doppler filling pattern is an important factor to predict the increase in CO after intravascular fluid challenge in patients undergoing coronary artery bypass grafting...
  76. doi request reprint Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models
    Kunihiro Nishida
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1168-75. 2012
    ..This study assessed effects of AF-related remodeling on the atrial thrombogenic milieu by using radiofrequency ablation (RFA) to create a quantifiable prothrombotic nidus...
  77. ncbi request reprint Prevention of restenosis with antioxidants: mechanisms and implications
    Jean Claude Tardif
    Department of Medicine, Montreal Heart Institute, Montreal, Canada
    Am J Cardiovasc Drugs 2:323-34. 2002
    ....
  78. doi request reprint Enlargement of catheter ablation lesions in infant hearts with cryothermal versus radiofrequency energy: an animal study
    Paul Khairy
    Electrophysiology Service and Research Center, Montreal Heart Institute, Universite de Montreal, Canada
    Circ Arrhythm Electrophysiol 4:211-7. 2011
    ..It remains unknown whether cryothermal ablation lesions display a similar pattern of growth...
  79. ncbi request reprint Inhaled milrinone: a new alternative in cardiac surgery?
    Andre Y Denault
    Department of Cardiac Anesthesiology, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Semin Cardiothorac Vasc Anesth 10:346-60. 2006
    ..Therefore, this approach could represent an alternative to nitric oxide. This current state of knowledge of intravenous and inhaled milrinone is presented and summarized...
  80. ncbi request reprint Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Eur Heart J 26:2529-36. 2005
    ..Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic effects of ivabradine and the beta-blocker atenolol...
  81. ncbi request reprint Effect of intravenous nitroglycerin on cerebral saturation in high-risk cardiac surgery
    Dominique Piquette
    Department of Anesthesiology and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Can J Anaesth 54:718-27. 2007
    ..To determine whether or not intravenous nitroglycerin (IV NTG) can prevent a decrease in near-infrared spectroscopy (NIRS) values during cardiopulmonary bypass (CPB)...
  82. ncbi request reprint Coronary heart disease in patients with diabetes: part I: recent advances in prevention and noninvasive management
    Colin Berry
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 49:631-42. 2007
    ..Noncompliance, particularly with lifestyle measures, and underprescription of evidence-based therapies remain important unsolved problems...
  83. ncbi request reprint Vascular protectants for the treatment of atherosclerosis
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger Street, Montreal, PQ, H1T 1C8, Canada
    Expert Rev Cardiovasc Ther 1:385-92. 2003
    ....
  84. ncbi request reprint Poor correlation between hemodynamic and echocardiographic indexes of left ventricular performance in the operating room and intensive care unit
    Marie Josée Bouchard
    Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Crit Care Med 32:644-8. 2004
    ..To compare hemodynamic and echocardiographic indexes of left ventricular performance...
  85. ncbi request reprint Long-term safety of intravascular ultrasound in nontransplant, nonintervened, atherosclerotic coronary arteries
    Antoine Guédès
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Am Coll Cardiol 45:559-64. 2005
    ..The goal of this study was to demonstrate that intravascular ultrasound (IVUS) examination of native coronary arteries does not result in an acceleration of the atherosclerotic process...
  86. doi request reprint Heart rate recovery after exercise and long-term prognosis in patients with coronary artery disease
    Mathieu Gayda
    Montreal Heart Institute Cardiovascular and Prevention Centre Centre ÉPIC, Montreal, Quebec, Canada
    Can J Cardiol 28:201-7. 2012
    ..The long-term prognostic value of heart rate recovery (HRR) has been incompletely documented in patients with coronary artery disease (CAD). We sought to confirm the prognostic value of HRR in a large cohort with stable CAD...
  87. pmc Temporal variations in hematocrit values in patients with left ventricular dysfunction: Relationship with cause-specific mortality and morbidity and optimal monitoring--further insights from SOLVD
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    Can J Cardiol 24:45-8. 2008
    ..Currently, the relationship between temporal variations in hematocrit and specific causes of mortality and morbidity, as well as the most appropriate way to monitor changes in hematocrit, is unknown...
  88. ncbi request reprint Intensity of lipid lowering with statins and brachial artery vascular endothelium reactivity after acute coronary syndromes (from the BRAVER trial)
    Jocelyn Dupuis
    The Research Center of the Montreal Heart Institute and the Department of Medicine of the University of Montreal, Montreal, Quebec, Canada
    Am J Cardiol 96:1207-13. 2005
    ..140) and NMD (p = 0.129). In conclusion, initiation of statin therapy soon after ACS is associated with improvements in endothelium-dependent and independent vascular reactivities after 4 months...
  89. doi request reprint Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice
    Khai Le Quang
    Research Center and Departments of Medicine, Université de Montréal and Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, Canada
    Cardiovasc Res 91:420-8. 2011
    ..To clarify the role of I(CaT) in cardiac remodelling, we studied mice with either of the principal cardiac I(CaT)-subunits (Cav3.1 or Cav3.2) knocked out...
  90. doi request reprint Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors
    Ba Khoi Nguyen
    Cardiac Surgery, Montreal University Hospital Centre CHUM, Montreal, QC, Canada
    J Cardiovasc Transl Res 3:547-58. 2010
    ..MSC-derived growth factors injection (rather than MSC themselves) should be evaluated as a novel therapy to treat ischemic heart disease, avoiding many practical and technical issues of cell therapy...
  91. ncbi request reprint Intravascular ultrasound assessment of atherosclerosis
    Antoine Guédès
    Department of Medicine, Montreal Heart Institute, 5000 Belanger Street, Montreal H1T 1C8, Canada
    Curr Atheroscler Rep 6:219-24. 2004
    ..IVUS can also help to determine dose-response relationships in the development of novel pharmacologic agents. IVUS is currently the ideal imaging modality for clinical trials of atherosclerosis progression/regression...
  92. doi request reprint Effectiveness and safety of glycoprotein IIb/IIIa inhibitors in patients with myocardial infarction undergoing primary percutaneous coronary intervention: a meta-analysis of observational studies
    Remi Kouz
    University of Montreal, Canada
    Int J Cardiol 153:249-55. 2011
    ..The objective of this study is to evaluate the effectiveness and safety of GPI, as adjuvant therapy for primary PCI in real-life patients with myocardial infarction with ST segment elevation (STEMI) from the general population...
  93. pmc Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure
    Andreanne Chabot
    Research Center, Montreal Heart Institute Université de Montréal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8, Canada
    BMC Cardiovasc Disord 11:72. 2011
    ..We hypothesized that aldosterone contributes to pulmonary remodelling and right ventricular (RV) dysfunction associated with CHF by stimulation of lung myofibroblasts (MYFs) proliferation...
  94. ncbi request reprint Dynamic right ventricular outflow tract obstruction in cardiac surgery
    Andre Y Denault
    Department of Anesthesiology, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 132:43-9. 2006
    ..Right ventricular outflow tract obstruction can be a cause of hemodynamic instability but it has not been described in non-congenital cardiac surgery...
  95. ncbi request reprint Coronary heart disease in patients with diabetes: part II: recent advances in coronary revascularization
    Colin Berry
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 49:643-56. 2007
    ..Improvements in PCI and coronary artery bypass graft surgery are leading to better results in diabetic patients, and clinical trials are presently comparing contemporary PCI with surgery...
  96. doi request reprint Single measurement of troponin T for early prediction of infarct size, congestive heart failure, and pulmonary hypertension in an animal model of myocardial infarction
    Bao Hua Jiang
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Pathol 20:e85-9. 2011
    ..Early prediction of infarct size and of the subsequent development of congestive heart failure (CHF) and pulmonary hypertension (PH) would be useful in therapeutic trials using the rat myocardial infarction (MI) model...
  97. doi request reprint Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model
    Eduard Guasch
    Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 62:68-77. 2013
    ..The goal of this study was to assess mechanisms underlying atrial fibrillation (AF) promotion by exercise training in an animal model...
  98. doi request reprint Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians
    Melissa Beaudoin
    Montreal Heart Institute, 5000 rue Belanger, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 5:547-54. 2012
    ..Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated...
  99. doi request reprint Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea
    Yu Ki Iwasaki
    Department of Medicine and Research Center, Montreal Heart Institute, Quebec, Canada
    Heart Rhythm 9:1409-16.e1. 2012
    ..Obesity and obstructive sleep apnea (OSA) are risk factors for atrial fibrillation (AF), but the underlying mechanisms are poorly understood...
  100. doi request reprint Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress
    Joanna Rossi
    Dept of Chemical Engineering, McGill University, 3610 University Street, Montreal, QC, Canada
    Life Sci 87:92-9. 2010
    ..In this study, we investigated the combined effect of laminar shear stress (LSS) and statins on endothelial cell gene expression...
  101. doi request reprint Remodeling is a more important determinant of lumen size than atheroma burden in left main coronary artery disease
    Colin Berry
    Department of Medicine, Montreal Heart Institute Université de Montréal, Montreal, Quebec, Canada
    Am Heart J 160:188-194.e1. 2010
    ..Left main coronary artery (LMCA) disease influences survival; however, the predictors of LMCA changes over time are incompletely understood...