Jean Francois Tanguay

Summary

Affiliation: Montreal Heart Institute
Country: Canada

Publications

  1. pmc Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein
    Emilie Cossette
    Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada
    Mol Cell Biochem 373:137-47. 2013
  2. doi Focused 2012 update of the Canadian Cardiovascular Society guidelines for the use of antiplatelet therapy
    Jean Francois Tanguay
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Quebec, Canada Electronic address
    Can J Cardiol 29:1334-45. 2013
  3. doi Antiplatelet therapy in acute coronary syndrome and atrial fibrillation: aspirin
    Jean Francois Tanguay
    Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Adv Cardiol 47:20-30. 2012
  4. pmc Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice
    Souhad El Akoum
    Montreal Heart Institute, 5000 Belanger, Montréal QC H1T 1C8, Canada
    Diabetol Metab Syndr 3:34. 2011
  5. ncbi Estrogen regulation of endothelial and smooth muscle cell migration and proliferation: role of p38 and p42/44 mitogen-activated protein kinase
    Pedro Geraldes
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 22:1585-90. 2002
  6. ncbi Lower incidence of thrombus formation with cryoenergy versus radiofrequency catheter ablation
    Paul Khairy
    Department of Electrophysiology, Montreal Heart Institute, Quebec, Canada
    Circulation 107:2045-50. 2003
  7. ncbi Estradiol blocks the induction of CD40 and CD40L expression on endothelial cells and prevents neutrophil adhesion: an ERalpha-mediated pathway
    Pedro Geraldes
    Research Center of Montreal Heart Institute, Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 71:566-73. 2006
  8. ncbi Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand-1
    Jean Francois Tanguay
    Research Center, Montreal Heart Institute, and University of Montreal, Quebec, Canada
    Thromb Haemost 91:1186-93. 2004
  9. doi Differential 1-year clinical outcomes for ST-segment elevation myocardial infarction related to stent thrombosis or saphenous vein graft thrombosis
    Dabit Arzamendi
    Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, QC H1T 1C8, Canada
    Catheter Cardiovasc Interv 82:193-200. 2013
  10. doi Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models
    Kunihiro Nishida
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1168-75. 2012

Collaborators

Detail Information

Publications49

  1. pmc Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein
    Emilie Cossette
    Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC H1T 1C8, Canada
    Mol Cell Biochem 373:137-47. 2013
    ..These findings suggest that E2 can interfere with CRP pro-inflammatory effects via activation signals using its rapid, non-genomic pathway that may provide a new mechanism to improve vascular repair...
  2. doi Focused 2012 update of the Canadian Cardiovascular Society guidelines for the use of antiplatelet therapy
    Jean Francois Tanguay
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Quebec, Canada Electronic address
    Can J Cardiol 29:1334-45. 2013
    ....
  3. doi Antiplatelet therapy in acute coronary syndrome and atrial fibrillation: aspirin
    Jean Francois Tanguay
    Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Adv Cardiol 47:20-30. 2012
    ..This chapter provides a comprehensive overview of the clinical utility of aspirin in the setting of acute coronary syndrome and atrial fibrillation...
  4. pmc Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice
    Souhad El Akoum
    Montreal Heart Institute, 5000 Belanger, Montréal QC H1T 1C8, Canada
    Diabetol Metab Syndr 3:34. 2011
    ..abstract:..
  5. ncbi Estrogen regulation of endothelial and smooth muscle cell migration and proliferation: role of p38 and p42/44 mitogen-activated protein kinase
    Pedro Geraldes
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 22:1585-90. 2002
    ..The cardioprotection of estrogen is well recognized, but the intracellular mechanisms related to these beneficial effects are not completely understood...
  6. ncbi Lower incidence of thrombus formation with cryoenergy versus radiofrequency catheter ablation
    Paul Khairy
    Department of Electrophysiology, Montreal Heart Institute, Quebec, Canada
    Circulation 107:2045-50. 2003
    ..The objective of this study was to compare the incidence and characteristics of thrombi complicating RF and cryoenergy ablation, a novel technology for the catheter-based treatment of arrhythmias...
  7. ncbi Estradiol blocks the induction of CD40 and CD40L expression on endothelial cells and prevents neutrophil adhesion: an ERalpha-mediated pathway
    Pedro Geraldes
    Research Center of Montreal Heart Institute, Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 71:566-73. 2006
    ..The pro- and anti-inflammatory effects of estrogens are well recognized but their role on the regulation of CD40 and CD40L expression on ECs remains undefined...
  8. ncbi Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand-1
    Jean Francois Tanguay
    Research Center, Montreal Heart Institute, and University of Montreal, Quebec, Canada
    Thromb Haemost 91:1186-93. 2004
    ..In conclusion, pretreatment with rPSGL-Ig reduces thrombo-inflammatory responses, neointimal proliferation, and in-stent restenosis. P-selectin antagonism offers a promising therapy to improve clinical outcomes of coronary stenting...
  9. doi Differential 1-year clinical outcomes for ST-segment elevation myocardial infarction related to stent thrombosis or saphenous vein graft thrombosis
    Dabit Arzamendi
    Interventional Cardiology Division, Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, QC H1T 1C8, Canada
    Catheter Cardiovasc Interv 82:193-200. 2013
    ..The aim of this longitudinal cohort study was to compare the 1-year clinical outcomes among STEMI patients requiring primary PCI due to stent thrombosis and graft occlusion presenting with STEMI...
  10. doi Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models
    Kunihiro Nishida
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1168-75. 2012
    ..This study assessed effects of AF-related remodeling on the atrial thrombogenic milieu by using radiofrequency ablation (RFA) to create a quantifiable prothrombotic nidus...
  11. ncbi Local delivery of 17beta-estradiol improves reendothelialization and decreases inflammation after coronary stenting in a porcine model
    Baskaran Chandrasekar
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Thromb Haemost 94:1042-7. 2005
    ..Together, these data demonstrate the potential clinical application of 17beta-estradiol to improve vascular healing and prevent in-stent restenosis...
  12. doi Cardiac resident nestin(+) cells participate in reparative vascularisation
    Vivianne El-Helou
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Cell Physiol 228:1844-53. 2013
    ..Increasing the population of nestin((+)) cells via the transplantation of skin-derived cells represents a potential approach to limit ischemic damage to the heart...
  13. ncbi Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model
    Olivier Malo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 59:501-11. 2003
    ..The objective of this study was to assess the effect of L-arginine, BH(4) and the combination of two antioxidants, superoxide dismutase and catalase, on endothelium-dependent relaxations in a swine left ventricular hypertrophy model...
  14. ncbi Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation
    Pedro Geraldes
    Research Center, Montreal Heart Institute, Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Circ Res 93:399-405. 2003
    ....
  15. doi Cardiovascular effects of oxytocin infusion in a porcine model of myocardial infarct
    Simon Authier
    GREPAQ Department Of Veterinary Biomedicine, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    J Cardiovasc Pharmacol 55:74-82. 2010
    ..Pretreatment endogenous OT levels and timing of OT administration post MI seem to impact outcome in this porcine model, and further investigations are warranted to define potential role of OT in cardiac regenerative therapy...
  16. doi Tuning the properties and functions of 17β-estradiol-polysaccharide conjugates in thin films: impact of sample history
    Zhimei Miao
    Faculté de Pharmacie and Département de Chimie, Universite de Montreal, CP 6128 Succursale Centre Ville, Montreal, QC, H3C 3J7, Canada
    Biomacromolecules 13:4098-108. 2012
    ..The structural analysis presented offers useful guidelines for the study of amphiphilic biomacromolecules designed for therapeutic use as thin films...
  17. ncbi Percutaneous endoluminal arterial cryoenergy improves vascular remodelling after angioplasty
    Jean Francois Tanguay
    Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Thromb Haemost 92:1114-21. 2004
    ..The increased synthesis of collagen III appears to be involved in this phenomenon and could be a potential method of stabilizing the vulnerable plaque...
  18. doi Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors
    Ba Khoi Nguyen
    Cardiac Surgery, Montreal University Hospital Centre CHUM, Montreal, QC, Canada
    J Cardiovasc Transl Res 3:547-58. 2010
    ..MSC-derived growth factors injection (rather than MSC themselves) should be evaluated as a novel therapy to treat ischemic heart disease, avoiding many practical and technical issues of cell therapy...
  19. doi Group V secreted phospholipase A2 contributes to LPS-induced leukocyte recruitment
    Stéphanie Lapointe
    Research Centre, Montreal Heart Institute, Universite de Montreal, Montreal, QC, Canada
    J Cell Physiol 224:127-34. 2010
    ..Together, our data demonstrate the role of sPLA(2)-V in LPS-induced ICAM-1 and VCAM-1 protein overexpression and leukocyte recruitment, supporting the contribution of sPLA(2)-V in the development of inflammatory innate immune responses...
  20. doi Enlargement of catheter ablation lesions in infant hearts with cryothermal versus radiofrequency energy: an animal study
    Paul Khairy
    Electrophysiology Service and Research Center, Montreal Heart Institute, Universite de Montreal, Canada
    Circ Arrhythm Electrophysiol 4:211-7. 2011
    ..It remains unknown whether cryothermal ablation lesions display a similar pattern of growth...
  21. doi An anti-von Willebrand factor aptamer reduces platelet adhesion among patients receiving aspirin and clopidogrel in an ex vivo shear-induced arterial thrombosis
    Dabit Arzamendi
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Canada
    Clin Appl Thromb Hemost 17:E70-8. 2011
    ..These proof-of-concept data may constitute the framework for randomized clinical investigations of this novel antiplatelet therapy among patients with CAD...
  22. doi A phosphorylcholine-modified chitosan polymer as an endothelial progenitor cell supporting matrix
    Kim Tardif
    Department of Biomedical Sciences, Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada
    Biomaterials 32:5046-55. 2011
    ..07 ± 0.01%, FN: 0.55 ± 0.22%). Polymeric substrate CH-PC might provide a suitable surface to promote the amplification of EPC for future vascular therapeutic applications...
  23. ncbi Specific alterations of endothelial signal transduction pathways of porcine epicardial coronary arteries in left ventricular hypertrophy
    Olivier Malo
    Research Center, Department of Pharmacology, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    J Cardiovasc Pharmacol 42:275-86. 2003
    ..8% +/- 0.2% to 1.2% +/- 0.1% (P < 0.05 versus control). Chronic pressure-overload LVH is associated with an endothelial dysfunction involving both Gi and Gq protein-mediated relaxations in coronary arteries as well as the EDHF pathway...
  24. doi Effect on bleeding, time to revascularization, and one-year clinical outcomes of the radial approach during primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
    Dabit Arzamendi
    Division of Interventional Cardiology, Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Am J Cardiol 106:148-54. 2010
    ..Moreover, the radial approach was associated with a significant reduction in major adverse cardiac events at 12 months...
  25. ncbi Chronic platelet and neutrophil adhesion: a causal role for neointimal hyperplasia in in-stent restenosis
    Jean Francois Tanguay
    Experimental Interventional Laboratory, Montreal Heart Institute and University of Montreal, Quebec, Canada
    J Endovasc Ther 10:968-77. 2003
    ..To investigate the relationship between platelets and neutrophils and the progression of neointimal hyperplasia after angioplasty versus stenting of porcine coronary arteries...
  26. ncbi Blockade of in vivo VEGF-mediated angiogenesis by antisense gene therapy: role of Flk-1 and Flt-1 receptors
    Geneviève S Marchand
    Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, Canada H1T 1C8
    Am J Physiol Heart Circ Physiol 282:H194-204. 2002
    ..These data demonstrate the therapeutical potential of AS-Flk-1 or AS-Flt-1 to prevent VEGF-mediated angiogenesis in vivo...
  27. ncbi Endovascular cryotherapy accentuates the accumulation of the fibrillar collagen types I and III after percutaneous transluminal angioplasty in pigs
    Jean Francois Dorval
    Research Center and Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    J Endovasc Ther 13:104-10. 2006
    ....
  28. ncbi Stent implantation in coronary porcine arteries is associated with early activation of TNFalpha and TNFalpha receptor II expression
    Sofiane Hadjadj
    Research Center, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 192:25-32. 2007
    ..These results implicate TNFalpha and TNFalpha-RII as important actors in both the acute and the chronic phases of inflammation following stent implantation...
  29. ncbi Estrogen-induced gene expression in bone marrow c-kit+ stem cells and stromal cells: identification of specific biological processes involved in the functional organization of the stem cell niche
    Caroline Lemieux
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
    Stem Cells Dev 17:1153-63. 2008
    ....
  30. doi Nestin (+) stem cells independently contribute to neural remodelling of the ischemic heart
    Pauline C Beguin
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 226:1157-65. 2011
    ....
  31. ncbi Key fatty acid combinations define vascular smooth muscle cell proliferation and viability
    Corinne St-Denis
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada
    Lipids 47:1073-84. 2012
    ..monounsaturated) and on insulinemia. They also underline the importance of the presence of MUFA such as OLA in diets containing high proportions of SFA...
  32. ncbi Tamoxifen treatment of myocardial infarcted female rats exacerbates scar formation
    Pedro Geraldes
    Research Centre, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Pflugers Arch 454:385-93. 2007
    ..These data have demonstrated that TAM treatment of post-MI female rats exacerbated scar formation and may have occurred at least in part via the attenuation of new vessel formation in the infarct region...
  33. doi Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial
    Jean Claude Tardif
    Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 61:2048-55. 2013
    ..The study aimed to evaluate inclacumab for the reduction of myocardial damage during a percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction...
  34. pmc Demographics, treatment and outcome of acute coronary syndromes: 17 years of experience in a specialized cardiac centre
    Jean Pierre S Awaida
    Research Centre, Montreal Heart Institute, and Department of Medicine, University of Montreal, Quebec, Canada
    Can J Cardiol 22:121-4. 2006
    ..Epidemiological information on patients with acute coronary syndromes managed in specialized cardiac centres is limited...
  35. doi Effectiveness of percutaneous coronary intervention in patients with silent myocardial ischemia (post hoc analysis of the COURAGE trial)
    Gilbert Gosselin
    Montreal Heart Institute, Quebec, Canada
    Am J Cardiol 109:954-9. 2012
    ..Although underpowered, given similar outcomes in other small studies, these findings suggest the need for an adequately powered trial of revascularization versus OMT in SMI patients...
  36. doi Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties
    Ian B Copland
    Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Cardiovasc Res 79:405-15. 2008
    ..In this work, we tested whether genetically engineering MSCs to secrete erythropoietin (Epo) could represent a better therapeutic platform than MSCs in their native form...
  37. doi Local delivery of 17-beta-estradiol modulates collagen content in coronary porcine arteries after PTCA and stent implantation
    Pedro Geraldes
    Research Center, Montreal Heart Institute, Montreal, Que, Canada
    J Vasc Res 45:503-11. 2008
    ..Because estrogens decreased type I and type III collagen synthesis in vitro, we hypothesized that local delivery of 17betaE may influence intimal hyperplasia formation by modulating ECM expression...
  38. ncbi Vascular smooth muscle cell alterations triggered by mice adipocytes: role of high-fat diet
    Souhad El Akoum
    Montreal Heart Institute, Montreal, Canada
    J Atheroscler Thromb 19:1128-41. 2012
    ..This study evaluates the impact of supernatant of adipocytes extracted from mice fed high-fat-diets (HFD) on the proliferation and apoptosis of VSMC...
  39. ncbi Antiplatelet therapy in the era of drug-eluting stents: current and future perspectives
    Gregory Ducrocq
    Universite de Montreal, Institut de Cardiologie de Montreal, Research Centre, Department of Medicine, 5000, rue Belanger, Montreal, QC H1T 1C8, Canada
    Expert Rev Cardiovasc Ther 5:939-53. 2007
    ....
  40. ncbi 2-Dioleoyl-sn-glycero-3-phosphocholine-based nanoliposomes as an effective delivery platform for 17β-estradiol
    Kristen Bowey
    Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
    Eur J Pharm Biopharm 86:369-75. 2014
    ....
  41. ncbi Vascular healing after stenting: the role of 17-beta-estradiol in improving re-endothelialization and reducing restenosis
    Jean Francois Tanguay
    Institut de Cardiologie de Montreal, Research Centre, Montreal Heart Institute, Department of Medicine, Quebec
    Can J Cardiol 21:1025-30. 2005
    ..The present article reviews the scientific rationale, experimental data and early clinical results of 17-beta-estradiol and its role in the acceleration of endothelial recovery in vivo after PCI...
  42. ncbi Immediate vs. delayed stenting in acute myocardial infarction: a systematic review and meta-analysis
    Xavier Freixa
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Quebec, Canada
    EuroIntervention 8:1207-16. 2013
    ..To conduct a meta-analysis of studies comparing immediate versus delayed stenting in populations where primary percutaneous coronary intervention (PCI) or early invasive revascularisation was the initial mode of reperfusion...
  43. doi Increase in sudden death from coronary artery disease in young adults
    Dabit Arzamendi
    Montreal Heart Institute, University of Montreal, Canada
    Am Heart J 161:574-80. 2011
    ..The aim of the study was to assess the prevalence of CAD among autopsies of young individuals (<40 years) who had sudden death (SD)...
  44. ncbi A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation
    Simon Authier
    LAB Research Inc, 445 Armand Frappier, Laval, Quebec, Canada
    J Pharmacol Toxicol Methods 56:122-30. 2007
    ..This project addresses the validation study design of a test system using a telemetered non-human primate model for cardiovascular safety pharmacology evaluation...
  45. ncbi A novel hybrid transcatheter ablation system that combines radiofrequency and cryoenergy
    Paul Khairy
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Canada
    J Cardiovasc Electrophysiol 19:188-93. 2008
    ..There are numerous theoretical advantages to engineering a system capable of delivering both energy forms...
  46. ncbi Role of rheolytic thrombectomy in massive pulmonary embolism with contraindication to systemic thrombolytic therapy
    Dabit Arzamendi
    Montreal Heart Institute, Montreal, Canada
    EuroIntervention 5:716-21. 2010
    ..Our objective was to assess the efficacy of rheolytic thrombectomy in the specific treatment of massive pulmonary embolism with contraindication to systemic thrombolytic therapy...
  47. ncbi A cardiovascular monitoring system in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 1: Non-pharmacological validation
    Simon Authier
    LAB Research Inc, 445 Armand Frappier, Laval, Quebec, Canada
    J Pharmacol Toxicol Methods 56:115-21. 2007
    ..This project addresses the validation study design of a test system using a telemetered non-human primate model for cardiovascular safety pharmacology evaluation...
  48. ncbi Menstrual cycle influences endothelial progenitor cell regulation: a link to gender differences in vascular protection?
    Caroline Lemieux
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, QC, Canada
    Int J Cardiol 136:200-10. 2009
    ..We thus evaluated if menstrual cycle influences circulating levels of EPC subpopulations in normally menstruating women and if this could underline gender differences...
  49. doi Liposome technology for cardiovascular disease treatment and diagnosis
    Kristen Bowey
    McGill University, Department of Biomedical Engineering, Montreal, Quebec, H3A 1A4, Canada
    Expert Opin Drug Deliv 9:249-65. 2012
    ..It is for these reasons that liposomes have been applied as carriers for a multitude of drugs and genetic material, and as contrast agents, aimed to treat and diagnose cardiovascular diseases...