Simon de Denus

Summary

Affiliation: Montreal Heart Institute
Country: Canada

Publications

  1. ncbi request reprint Key articles and guidelines in the management of hypertension
    Simon de Denus
    Montreal Heart Institute and the Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Pharmacotherapy 24:1385-99. 2004
  2. doi request reprint An evaluation of pharmacists' expectations towards pharmacogenomics
    Simon de Denus
    Universite de Montreal, Montreal, Canada
    Pharmacogenomics 14:165-75. 2013
  3. doi request reprint Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Heart Lung Transplant 30:326-31. 2011
  4. ncbi request reprint Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
  5. ncbi request reprint Mineralocorticoid receptor antagonists and cardiovascular mortality in patients with atrial fibrillation and left ventricular dysfunction: insights from the Atrial Fibrillation and Congestive Heart Failure Trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal Heart Institute Coordinating Center, and Université de Montréal, Montreal, QC, Canada
    Circ Heart Fail 5:586-93. 2012
  6. doi request reprint PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients
    Kim Lachance
    University of Montreal, Quebec, Canada
    Pharmacogenet Genomics 22:336-43. 2012
  7. pmc Temporal variations in hematocrit values in patients with left ventricular dysfunction: Relationship with cause-specific mortality and morbidity and optimal monitoring--further insights from SOLVD
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    Can J Cardiol 24:45-8. 2008
  8. ncbi request reprint Quantification of the risk and predictors of hyperkalemia in patients with left ventricular dysfunction: a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trials
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Am Heart J 152:705-12. 2006
  9. doi request reprint Differences in biomarkers in patients with heart failure with a reduced vs a preserved left ventricular ejection fraction
    Simon de Denus
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 28:62-8. 2012
  10. ncbi request reprint Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure
    Michel White
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Card Fail 13:86-94. 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Key articles and guidelines in the management of hypertension
    Simon de Denus
    Montreal Heart Institute and the Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Pharmacotherapy 24:1385-99. 2004
    ..We present a list of publications, clinical trials, meta-analyses, and clinical practice guidelines that we believe are essential in defining the current practice standards in the management of hypertension...
  2. doi request reprint An evaluation of pharmacists' expectations towards pharmacogenomics
    Simon de Denus
    Universite de Montreal, Montreal, Canada
    Pharmacogenomics 14:165-75. 2013
    ..However, little is known about the opinions of pharmacists towards pharmacogenomics or their willingness to integrate this new field in their practice...
  3. doi request reprint Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Heart Lung Transplant 30:326-31. 2011
    ..The aim of this study was to evaluate the association between polymorphisms of the genes encoding these proteins and the long-term renal function of heart transplant recipients treated with calcineurin inhibitors...
  4. ncbi request reprint Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
    ..It is currently impossible to determine which patient will benefit from the addition of an ARB...
  5. ncbi request reprint Mineralocorticoid receptor antagonists and cardiovascular mortality in patients with atrial fibrillation and left ventricular dysfunction: insights from the Atrial Fibrillation and Congestive Heart Failure Trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal Heart Institute Coordinating Center, and Université de Montréal, Montreal, QC, Canada
    Circ Heart Fail 5:586-93. 2012
    ..Our primary objective was to assess the impact of mineralocorticoid receptor antagonists on cardiovascular mortality in patients with AF and HF enrolled in the Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial...
  6. doi request reprint PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients
    Kim Lachance
    University of Montreal, Quebec, Canada
    Pharmacogenet Genomics 22:336-43. 2012
    ..The secondary objective was to investigate the effect of candidate genes related to the RAAS, natriuretic peptides, and other elements involved in the intracellular signaling of these pathways...
  7. pmc Temporal variations in hematocrit values in patients with left ventricular dysfunction: Relationship with cause-specific mortality and morbidity and optimal monitoring--further insights from SOLVD
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    Can J Cardiol 24:45-8. 2008
    ..Currently, the relationship between temporal variations in hematocrit and specific causes of mortality and morbidity, as well as the most appropriate way to monitor changes in hematocrit, is unknown...
  8. ncbi request reprint Quantification of the risk and predictors of hyperkalemia in patients with left ventricular dysfunction: a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trials
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    Am Heart J 152:705-12. 2006
    ..Limited data are available to predict the occurrence of hyperkalemia. Risk assessment is complicated by the lack of consistency of definition between trials...
  9. doi request reprint Differences in biomarkers in patients with heart failure with a reduced vs a preserved left ventricular ejection fraction
    Simon de Denus
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Can J Cardiol 28:62-8. 2012
    ..The objectives of this study were to compare the concentrations and correlation of biomarkers of inflammation, extracellular matrix (ECM) turnover and neurohormonal activation between these populations...
  10. ncbi request reprint Effects of combined candesartan and ACE inhibitors on BNP, markers of inflammation and oxidative stress, and glucose regulation in patients with symptomatic heart failure
    Michel White
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Card Fail 13:86-94. 2007
    ....
  11. pmc Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure
    Marcin Zakrzewski-Jakubiak
    Universite de Montreal, Montreal, Canada
    Br J Clin Pharmacol 65:742-51. 2008
    ..It is also acknowledged that the genotype frequency of certain gene polymorphisms varies across different ethnic groups and that a difference in gene polymorphism frequencies between healthy and heart failure patients seems to exist...
  12. pmc Bucindolol, systolic blood pressure, and outcomes in systolic heart failure: a prespecified post hoc analysis of BEST
    Michel White
    Montreal Heart Institute, Montreal, Quebec, Canada
    Can J Cardiol 28:354-9. 2012
    ..Because SBP is an important predictor of response to β-blocker therapy, the BEST protocol prespecified a post hoc analysis to determine whether the effect of bucindolol varied by baseline SBP...
  13. doi request reprint Oral ferrous sulfate does not increase preoperative hemoglobin in patients scheduled for hip or knee arthroplasty
    Kim Lachance
    University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    Ann Pharmacother 45:764-70. 2011
    ..To optimize preoperative Hb, blood conservation protocols often recommend oral iron supplements, even in nonanemic patients...
  14. doi request reprint Disclosure of individual pharmacogenomic results in research projects: when and what kind of information to return to research participants
    Sandra Korol
    Faculty of Pharmacy, Universite de Montreal, Montreal, Canada
    Pharmacogenomics 14:675-88. 2013
    ..This review aims to describe the conditions in which disclosure of pharmacogenomic results is appropriate...
  15. doi request reprint Systematic review of pharmacoeconomic studies of pharmacogenomic tests
    Mathieu Beaulieu
    Faculte de Pharmacie, Universite de Montreal, PO Box 6128, Succ Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    Pharmacogenomics 11:1573-90. 2010
    ..In order to fully assess all aspects of pharmacogenomic testing, future pharmacoeconomic assessments should include every specific component that has an impact on the incremental cost-effectiveness ratio...
  16. doi request reprint Pharmacogenomics and heart failure in congenital heart disease
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    Can J Cardiol 29:779-85. 2013
    ....
  17. doi request reprint Impact of a pharmacist-led warfarin self-management program on quality of life and anticoagulation control: a randomized trial
    Lucie Verret
    Department of Pharmacy, Montreal Heart Institute Université de Montréal, Montreal, Quebec, Canada
    Pharmacotherapy 32:871-9. 2012
    ..To evaluate the impact of a pharmacist-led warfarin patient self-management program on quality of life and anticoagulation control compared with management in a physician-led specialized anticoagulation clinic...
  18. ncbi request reprint Temporal increases in subclinical levels of inflammation are associated with adverse clinical outcomes in patients with left ventricular dysfunction
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Card Fail 12:353-9. 2006
    ..The role of temporal changes of more conventional markers of inflammation, such as the white blood cell (WBC) count, on clinical outcomes remains largely unknown...