J Montplaisir

Summary

Country: Canada

Publications

  1. ncbi Abnormal motor behavior during sleep
    Jacques Montplaisir
    Sleep Disorders Centre, University of Montreal, Montreal, Canada
    Sleep Med 5:S31-4. 2004
  2. ncbi Ropinirole is effective in the long-term management of restless legs syndrome: a randomized controlled trial
    Jacques Montplaisir
    Sleep Disorders Clinic, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Mov Disord 21:1627-35. 2006
  3. ncbi Slow-wave sleep and delta power in rapid eye movement sleep behavior disorder
    Jessica Massicotte-Marquez
    Sleep Disorders Center Sacred Heart Hospital of Montreal, Quebec, Canada
    Ann Neurol 57:277-82. 2005
  4. ncbi Pramipexole in the treatment of restless legs syndrome: a follow-up study
    J Montplaisir
    Centre d Etude du Sommeil, Hopital du Sacre Coeur de Montreal, Department of Psychiatry, Universite de Montreal, Montreal, Quebec, Canada
    Eur J Neurol 7:27-31. 2000
  5. ncbi Sleep disturbances and eeg slowing in alzheimer's disease
    J Montplaisir
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, D 79104, Germany
    Sleep Res Online 1:147-51. 1998
  6. doi Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder
    J Massicotte-Marquez
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest Montréal, Quebec, Canada
    Neurology 70:1250-7. 2008
  7. ncbi Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Canada
    Neurology 62:401-6. 2004
  8. ncbi REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
    M Vendette
    CRCPC, Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, Canada
    Neurology 69:1843-9. 2007
  9. pmc Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
    R B Postuma
    Department of Neurology, L7 305 Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada
    Neurology 72:1296-300. 2009
  10. ncbi Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation
    M L Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Neurology 59:1889-94. 2002

Detail Information

Publications91

  1. ncbi Abnormal motor behavior during sleep
    Jacques Montplaisir
    Sleep Disorders Centre, University of Montreal, Montreal, Canada
    Sleep Med 5:S31-4. 2004
    ..Understanding the underlying pathophysiology of abnormal sleep motor behaviors may prove useful in the management of insomnia...
  2. ncbi Ropinirole is effective in the long-term management of restless legs syndrome: a randomized controlled trial
    Jacques Montplaisir
    Sleep Disorders Clinic, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Mov Disord 21:1627-35. 2006
    ..Ropinirole was well tolerated; adverse events were typical for dopamine agonists. Ropinirole was highly effective and well tolerated in the long-term management of RLS, with pharmacological effect over 36 weeks...
  3. ncbi Slow-wave sleep and delta power in rapid eye movement sleep behavior disorder
    Jessica Massicotte-Marquez
    Sleep Disorders Center Sacred Heart Hospital of Montreal, Quebec, Canada
    Ann Neurol 57:277-82. 2005
    ..Results are discussed about the possible nigrostriatal dopaminergic impairment in RBD patients and the association between RBD and neurodegenerative disorders...
  4. ncbi Pramipexole in the treatment of restless legs syndrome: a follow-up study
    J Montplaisir
    Centre d Etude du Sommeil, Hopital du Sacre Coeur de Montreal, Department of Psychiatry, Universite de Montreal, Montreal, Quebec, Canada
    Eur J Neurol 7:27-31. 2000
    ..The remarkable efficacy of pramipexole raises the possibility that the D3 receptors of the mesolimbic system may be more specifically involved in the physiopathology of RLS...
  5. ncbi Sleep disturbances and eeg slowing in alzheimer's disease
    J Montplaisir
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, D 79104, Germany
    Sleep Res Online 1:147-51. 1998
    ..After six months on a placebo, there was only a decrease in alpha activity in wakefulness over all regions studied. No changes were observed for REM sleep...
  6. doi Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder
    J Massicotte-Marquez
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest Montréal, Quebec, Canada
    Neurology 70:1250-7. 2008
    ..Recent studies showing a slowing of waking EEG in iRBD suggest that iRBD is associated with cognitive impairment...
  7. ncbi Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Canada
    Neurology 62:401-6. 2004
    ..To compare nondemented patients with Parkinson's disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep...
  8. ncbi REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
    M Vendette
    CRCPC, Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, Canada
    Neurology 69:1843-9. 2007
    ..To assess the relationship between the presence of REM sleep behavior disorder (RBD) and the cognitive profile of nondemented patients with Parkinson disease (PD)...
  9. pmc Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
    R B Postuma
    Department of Neurology, L7 305 Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada
    Neurology 72:1296-300. 2009
    ..Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies...
  10. ncbi Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation
    M L Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Neurology 59:1889-94. 2002
    ..To assess the frequency of periodic leg movements (PLM) in idiopathic REM sleep behavior disorder (RBD) and to analyze their polysomnographic characteristics and associated autonomic and cortical activation...
  11. ncbi REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Neurology 59:585-9. 2002
    ..To determine the frequency of REM sleep behavior disorder (RBD) among patients with PD using both history and polysomnography (PSG) recordings and to further study REM sleep muscle atonia in PD...
  12. ncbi Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
    S Mazza
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, Canada, H4J 1C5
    Neurology 67:1618-22. 2006
    ..To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved...
  13. ncbi The effect of gender on autonomic and respiratory responses during sleep among both young and middle-aged subjects
    M Richard
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Que, Canada
    Sleep Med 8:760-7. 2007
    ..We investigated whether gender affects sleep-related cardiovascular and respiratory responses and whether these vary according to healthy subjects being young or middle-aged...
  14. doi REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    J Neurol Neurosurg Psychiatry 79:1117-21. 2008
    ..However, it is unclear whether the association of RBD in PD has implications for motor manifestations of the disease...
  15. ncbi The effects of pramipexole in REM sleep behavior disorder
    M L Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Montreal, Canada
    Neurology 61:1418-20. 2003
    ..Surprisingly, a decrease in the percentage of time spent with REM sleep muscle atonia was observed with treatment. The treatment did not modify the indexes of periodic leg movements...
  16. ncbi Effects of obstructive sleep apnea on cognitive function: a comparison between younger and older OSAS patients
    A Mathieu
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Que, Canada H4J 1C5
    Sleep Med 9:112-20. 2008
    ..The aim of the study was to assess the effects of age on cognitive functions in OSAS patients. It was hypothesized that older OSAS patients will exhibit significant cognitive dysfunction relative to younger OSAS patients and controls...
  17. ncbi [Restless leg syndrome: clinical aspects, etiology and genetic factors]
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Caeur de Montréal, Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Canada
    Rev Neurol (Paris) 158:1225-31. 2002
  18. ncbi Canadian restless legs syndrome twin study
    L Xiong
    Center for the Study of Brain Diseases, CHUM Research Center Notre Dame Hospital, University of Montreal, Montreal, Quebec, Canada
    Neurology 68:1631-3. 2007
  19. ncbi Long-term treatment with pramipexole in restless legs syndrome
    J Montplaisir
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Universite de Montreal, QC, Canada
    Eur J Neurol 13:1306-11. 2006
    ..None of the adverse effects occurred in more than 5% of patients at follow-up. The present study confirms, in a large cohort of unselected patients, that pramipexole is effective and safe in the long-term treatment of RLS...
  20. pmc Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Montreal, Quebec, Canada
    Am J Hum Genet 69:1266-70. 2001
    ..59. Haplotype analysis refined the genetic interval, positioning the RLS-predisposing gene in a 14.71-cM region between D12S1044 and D12S78. These findings represent the first mapping of a locus conferring susceptibility to RLS...
  21. ncbi Age-at-onset in restless legs syndrome: a clinical and polysomnographic study
    S Whittom
    Sleep Disorders Center, Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Que, Canada H4J 1C5
    Sleep Med 9:54-9. 2007
    ..To determine the distribution of age-at-onset in a large cohort of patients with restless legs syndrome (RLS) and to compare clinical and polysomnographic characteristics of patients with early and late age-at-onset of RLS...
  22. ncbi Age and gender effects on heart rate activation associated with periodic leg movements in patients with restless legs syndrome
    N Gosselin
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boulevard Gouin Ouest, Montreal, Quebec, Canada H4J 1C5
    Clin Neurophysiol 114:2188-95. 2003
    ..The aim of the present study was to evaluate the effects of age and gender on HR changes associated with PLMS in restless legs syndrome (RLS) patients...
  23. doi Predicting Parkinson's disease - why, when, and how?
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Parkinsonism Relat Disord 15:S105-9. 2009
    ..This provides an unprecedented opportunity to test potential predictive markers before clinical disease onset. The results of marker testing in idiopathic RBD with its implications for disease prediction will be detailed...
  24. doi Effects of melatonin and bright light administration on motor and sensory symptoms of RLS
    S Whittom
    Sleep Disorders Center, Sacre Coeur Hospital, Montreal, Canada Department of Psychology, Universite de Montreal, Canada
    Sleep Med 11:351-5. 2010
    ..To test this hypothesis we studied the effects of the administration of exogenous melatonin and, conversely, the suppression of endogenous melatonin secretion by bright light exposure on the severity of RLS symptoms...
  25. pmc Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder
    Paola A Lanfranchi
    Department of Medicine, Cardiology Division, Hopital du Sacre Coeur de Montreal, Montreal, Canada
    Sleep 30:1019-25. 2007
    ..We tested the hypothesis that REM-related cardiorespiratory activation is altered in subjects with RBD...
  26. ncbi Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery
    A Decary
    Centre d Etude du Sommeil, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Sleep 23:369-81. 2000
    ..In addition to providing a comprehensive neuropsychological evaluation of OSAS patients, the proposed test battery should facilitate the comparison of results from different laboratories...
  27. ncbi Nocturnal blood pressure changes in patients with restless legs syndrome
    M H Pennestri
    Sleep Disorders Center, Hôpital du Sacré Coeur, University of Montreal, Montreal, Quebec, Canada
    Neurology 68:1213-8. 2007
    ..To assess heart rate (HR) and blood pressure (BP) changes associated with periodic leg movements during sleep (PLMS) with or without EEG signs of arousal in subjects with primary restless legs syndrome (RLS)...
  28. ncbi Neurobiology of sleep disturbances in neurodegenerative disorders
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, H4J 1C5, Canada
    Curr Pharm Des 14:3430-45. 2008
    ..The cause of sleep disturbances in neurodegenerative disorders may be attributed to several factors, including age-related modifications, symptoms of the disease, comorbid conditions and the neurodegenerative process itself...
  29. ncbi Circadian rhythm of restless legs syndrome: relationship with biological markers
    Martin Michaud
    Sleep Disorders Center, Sacre Coeur Hospital, 5400 Boulevard Gouin Ouest, Montreal, Quebec, Canada
    Ann Neurol 55:372-80. 2004
    ..This result and those of others studies showing that melatonin exerts an inhibitory effect on central dopamine secretion suggest that melatonin might be implicated in the worsening of RLS symptoms in the evening and during the night...
  30. ncbi Hypersynchronous delta waves and somnambulism: brain topography and effect of sleep deprivation
    Mathieu Pilon
    Centre d tude du sommeil, Hôpital du Sacré Coeur, Universite de Montreal, Montreal, Quebec, Canada
    Sleep 29:77-84. 2006
    ....
  31. ncbi [Rapid-eye-movement sleep disorders in Parkinson's disease]
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Rev Neurol (Paris) 158:135-52. 2002
    ..Finally, future research directions are proposed...
  32. doi Clinical prediction of Parkinson's disease: planning for the age of neuroprotection
    R B Postuma
    Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada
    J Neurol Neurosurg Psychiatry 81:1008-13. 2010
    ....
  33. doi Manifestations of Parkinson disease differ in association with REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 23:1665-72. 2008
    ..These findings suggest that the pathophysiology of RBD and nonmotor manifestations of PD, particularly autonomic dysfunction, are linked...
  34. ncbi Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Ann Neurol 66:39-47. 2009
    ..To investigate the frequency and subtypes of mild cognitive impairment (MCI) in idiopathic rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) in association with RBD...
  35. doi Changes in rapid eye movement sleep associated with placebo-induced expectations and analgesia
    Danièle Laverdure-Dupont
    Department of Physiology, University of Montreal, Quebec, Canada
    J Neurosci 29:11745-52. 2009
    ..However, equivocal previous experience with treatments may significantly alter the relationship between relief expectation, REM sleep, and placebo effects...
  36. ncbi Precipitating factors of somnambulism: impact of sleep deprivation and forced arousals
    Mathieu Pilon
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur, Department of Psychology, Universite de Montreal, Quebec, Canada
    Neurology 70:2284-90. 2008
    ..The main goal of this study was to assess the effects of forced arousals from auditory stimuli (AS) in adult sleepwalkers and control subjects during normal sleep and following post-sleep deprivation recovery sleep...
  37. ncbi Relief expectation and sleep
    Danièle Laverdure-Dupont
    Department of Physiology, Faculty of Medicine, University de Montreal, Montreal, Canada
    Rev Neurosci 21:381-95. 2010
    ....
  38. ncbi Menopause, hormone replacement and RR and QT modulation during sleep
    Paola A Lanfranchi
    Centre de Recherche, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Que, Canada H4J 1C5
    Sleep Med 6:561-6. 2005
    ..The aim of the present study was to evaluate sleep-related RR and QT changes: (1) with the physiological decline in female hormones occurring with menopause, and (2) after hormone replacement therapy with estrogen and progesterone (HRT)...
  39. ncbi Circadian variation of the effects of immobility on symptoms of restless legs syndrome
    Martin Michaud
    Sleep Disorders Center, Sacré Coeur Hospital Montreal, Quebec, Canada
    Sleep 28:843-6. 2005
    ..However, no study has ever attempted to dissociate these two effects. The objective of this study was to evaluate the nycthemeral variations in the effects of duration of immobility on symptoms of RLS...
  40. doi Polysomnographic diagnosis of idiopathic REM sleep behavior disorder
    Jacques Montplaisir
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Mov Disord 25:2044-51. 2010
    ..For the five RBD patients who did not show chin EMG abnormalities, it cannot be excluded that they had increased phasic EMG activity in the upper limbs and presented visible motor activity...
  41. ncbi Polysomnographic diagnosis of sleepwalking: effects of sleep deprivation
    Antonio Zadra
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur, Universite de Montreal, Montreal, Quebec, Canada
    Ann Neurol 63:513-9. 2008
    ..Because sleep deprivation can precipitate sleepwalking, we aimed to determine the effects of 25 hours of sleep deprivation on the frequency and complexity of somnambulistic episodes recorded in the laboratory...
  42. pmc Nighttime blood pressure in normotensive subjects with chronic insomnia: implications for cardiovascular risk
    Paola A Lanfranchi
    Department of Medicine, Division of Cardiology, Hôpital du Sacré Coeur de Montréal and Université de Montréal, Quebec, Canada
    Sleep 32:760-6. 2009
    ..To assess as whether insomniacs have higher nighttime blood pressure (BP) and a blunted day-to-night BP reduction, recognized markers of increased risk of cardiovascular morbidity and mortality...
  43. ncbi A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy
    Mortimer Mamelak
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Sleep 27:1327-34. 2004
    ..To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy...
  44. ncbi Analysis of postarousal EEG activity during somnambulistic episodes
    Antonio Zadra
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
    J Sleep Res 13:279-84. 2004
    ..The results support the view of somnambulism as a disorder of arousal and suggest that sleepwalkers' atypical arousal reactions can manifest themselves in stage 2 sleep in addition to SWS...
  45. ncbi Effects of periodic leg movements during sleep in middle-aged subjects without sleep complaints
    Julie Carrier
    Centre du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Province of Quebec, Canada
    Mov Disord 20:1127-32. 2005
    ....
  46. ncbi Age difference in heart rate changes associated with micro-arousals in humans
    N Gosselin
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Quebec, Montreal, Canada
    Clin Neurophysiol 113:1517-21. 2002
    ..Heart rate (HR) is known to change in association to micro-arousals (MA) during sleep. The aim of the present study was to evaluate the effect of age on HR variations associated with MA...
  47. ncbi Alexithymia and impoverished dream recall in asthmatic patients: evidence from self-report measures
    T Nielsen
    Department of Psychiatry and Sleep Research Center, Hopital du Sacre Coeur de Montreal, Montreal, QC, Canada
    J Psychosom Res 42:53-9. 1997
    ....
  48. ncbi Development of disturbing dreams during adolescence and their relation to anxiety symptoms
    T A Nielsen
    , , , Quebec, Canada
    Sleep 23:727-36. 2000
    ..Further study of disturbing dreams may contribute to understanding of associated pathophysiological factors which, too, vary by sex (e.g., PTSD, insomnia, depression)...
  49. ncbi Sleep laboratory diagnosis of restless legs syndrome
    Martin Michaud
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Que, Canada
    Eur Neurol 48:108-13. 2002
    ..The combination of these 2 parameters correctly classified 88% of all subjects with a sensitivity of 82% and a specificity of 100%...
  50. ncbi Electroencephalography during sleep of patients with nocturnal panic disorder
    Pierre Landry
    Department of Psychiatry, Hopital Louis H Lafontaine, University of Montreal, Canada
    J Nerv Ment Dis 190:559-62. 2002
  51. doi Sleep following sport-related concussions
    Nadia Gosselin
    Research Center on Sleep and Biological Rhythms, Sacre Coeur Hospital, 5400 Boul Gouin Ouest, Montreal, Que, Canada
    Sleep Med 10:35-46. 2009
    ..Sleep and vigilance disorders are among the most commonly reported symptoms following a concussion. The aim of the study was thus to investigate the effects of sport-related concussions on subjective and objective sleep quality...
  52. ncbi Is interhemispheric connectivity reduced after callosotomy? A critique
    T A Nielsen
    Hôpital du Sacré Coeur de Montréal Departement de psychiatrie, Universite de Montreal, Quebec
    Percept Mot Skills 83:348-50. 1996
    ..In view of these two shortcomings, the authors' conclusion concerning callosal function may be premature...
  53. ncbi Sleep complaints in patients with myotonic dystrophy
    Luc Laberge
    Clinical Research Unit, Chicoutimi Hospital and Université du Québec à Chicoutimi, Saguenay, Quebec, Canada
    J Sleep Res 13:95-100. 2004
    ..The severity of daytime sleepiness is weakly related to the extent of muscular impairment but not to CTG repeat...
  54. ncbi Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Lancet Neurol 5:424-32. 2006
    ..RBD might be a stage in the development of neurodegenerative disorders and increased awareness of this could lead to substantial advances in knowledge of mechanisms, diagnosis, and treatment of neurodegenerative disorders...
  55. ncbi Neurophysiological anomalies in symptomatic and asymptomatic concussed athletes
    Nadia Gosselin
    Research Center in Neuropsychology and Cognition, Department of Psychology, University of Montreal, Montreal, Canada
    Neurosurgery 58:1151-61; discussion 1151-61. 2006
    ..The aim of the present study was to investigate the effect of concussion on event-related potentials, in symptomatic as well as in asymptomatic athletes...
  56. ncbi Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 66:845-51. 2006
    ..Several potential early diagnostic markers of PD have been proposed, but they have generally not been tested in presymptomatic PD. The authors hypothesized that these markers may be abnormal in idiopathic RBD...
  57. ncbi Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians
    Lan Xiong
    Center for the Study of Brain Diseases, CHUM Research Center Notre Dame Hospital, University of Montreal, Bureau Y 3616 2, 1560, rue Sherbrooke Est, Montreal, Que, Canada H2L 4MI
    Sleep Med 9:273-82. 2008
    ..The purpose of the current study is to further explore the NTS gene for potential functional variant(s) in its entire genomic and potential regulatory regions and their possible association with RLS symptoms...
  58. ncbi Does age worsen EEG slowing and attention deficits in obstructive sleep apnea syndrome?
    Annie Mathieu
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Que, Canada
    Clin Neurophysiol 118:1538-44. 2007
    ....
  59. ncbi Slowing of electroencephalogram in rapid eye movement sleep behavior disorder
    Maria Livia Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Quebec, Canada
    Ann Neurol 53:774-80. 2003
    ..The topographical distribution of EEG slowing and possible pathophysiological mechanisms are discussed in light of the known association between RBD and neurodegenerative disorders...
  60. ncbi Evidence for a genetic association between monoamine oxidase A and restless legs syndrome
    A Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    Neurology 59:215-9. 2002
    ..Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS)...
  61. ncbi Zopiclone and zaleplon vs benzodiazepines in the treatment of insomnia: Canadian consensus statement
    J Montplaisir
    Department of Psychiatry, University of Toronto, ECW 3D Bathurst Street, Toronto, Ontario M5T 2SB, Canada
    Hum Psychopharmacol 18:29-38. 2003
  62. ncbi Analysis of CAG repeat expansions in restless legs syndrome
    Alex Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Caeur de Montréal, Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Quebec, Canada
    Sleep 26:1055-7. 2003
    ..Our aim was to investigate whether there is a common genetic etiology between restless legs syndrome and spinocerebellar ataxia type 3...
  63. ncbi Effects of immobility on sensory and motor symptoms of restless legs syndrome
    Martin Michaud
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Montreal, Canada
    Mov Disord 17:112-5. 2002
    ..6; P < 0.00004) than control subjects. These results further validate the use of the SIT as a diagnostic and research tool for RLS and confirm the contention of the International RLS study group that RLS symptoms worsen at rest...
  64. pmc MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels
    Lan Xiong
    Centre of Excellence in Neuromics of University of Montreal, CHUM Research Center, University of Montreal, Montreal, Quebec, Canada
    Hum Mol Genet 18:1065-74. 2009
    ..Therefore, these data suggest that reduced expression of the MEIS1 gene, possibly through intronic cis-regulatory element(s), predisposes to RLS...
  65. ncbi Deficits in involuntary attention switching in obstructive sleep apnea syndrome
    Nadia Gosselin
    Sleep Disorder Center, Sacre Coeur Hospital and University of Montreal, Montreal, Canada
    Neurosci Lett 408:73-8. 2006
    ..In conclusion, patients with OSAS have specific alterations of the P3a component that reflects involuntary attention switching, but automatic auditory processing assessed by MMN appears to be preserved...
  66. ncbi Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families
    Lan Xiong
    Laboratoire d étude des maladies du cerveau, Centre de Recherche du CHUM, Hopital Notre Dame, Universite de Montreal, 1560 rue Sherbrooke Est, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:911-7. 2007
    ..Finally, two DMT1 intronic SNPs showed positive association with RLS in patients with a history of anemia, when compared to RLS patients without anemia...
  67. ncbi PLMS and PLMW in healthy subjects as a function of age: prevalence and interval distribution
    Marie Hélène Pennestri
    Sleep Disorders Center, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Sleep 29:1183-7. 2006
    ..The aim of the present study was to look at the prevalence and interval distribution of PLMS and PLMW in relationship with age in a population of healthy subjects...
  68. ncbi Idiopathic REM sleep behavior disorder: toward a better nosologic definition
    Maria Livia Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Montreal, Canada
    Neurology 64:780-6. 2005
    ..Identifying subjects with a high risk of developing a neurodegenerative process may be crucial in order to develop early intervention strategies...
  69. ncbi Increased frequency of restless legs syndrome in a French-Canadian population with multiple sclerosis
    Chantale Auger
    Centre Hospitalier, Universite de Montreal, Montreal, Quebec, Canada
    Neurology 65:1652-3. 2005
    ..They found that 37.5% of MS patients, 31% of RA patients, and 16% of controls fulfilled the criteria for RLS. MS can cause RLS, or MS and RLS may have common susceptibility factors...
  70. ncbi Nocturnal breathing in cyanotic congenital heart disease
    Sylvie Legault
    Adult Congenital Heart Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Int J Cardiol 128:197-200. 2008
    ..Sleep aggravated hypoxia has been observed in many such patients, but it remains to be determined whether sleep disordered breathing is contributory. We, therefore, sought to assess sleep-related breathing pattern in patients with CCHD...
  71. ncbi Update on the pharmacology of REM sleep behavior disorder
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Neurology 67:742-7. 2006
    ..When these agents are prescribed to patients with neurodegenerative disorders or narcolepsy who are at risk of developing RBD, systematic follow-up may be warranted to detect the emergence of RBD symptoms...
  72. ncbi Mutational analysis of neurotensin in familial restless legs syndrome
    Alex Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    Mov Disord 19:90-4. 2004
    ..Based on these results, it is unlikely that NTS is the gene responsible for RLS in chromosome 12-linked families...
  73. ncbi Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases
    Lan Xiong
    Center of Excellence in Neuromics, Research Centre of the University of Montreal Hospital Centre, and the Department of Medicine, University of Montreal, Montreal, Quebec Canada
    Arch Neurol 67:617-22. 2010
    ..To fully ascertain the familial aggregation of restless legs syndrome (RLS) and to characterize the clinical features of familial RLS (fRLS) cases...
  74. ncbi Sleep and quantitative EEG in neurodegenerative disorders
    Dominique Petit
    Centre d étude du sommeil et des rythmes diologiques, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
    J Psychosom Res 56:487-96. 2004
    ..The study of sleep variables and that of the spectral composition of the EEG can provide valuable information for understanding the pathophysiology and for assisting the diagnosis of neurodegenerative diseases...
  75. ncbi The value of sleep deprivation as a diagnostic tool in adult sleepwalkers
    Steve Joncas
    Centre d Etude du Sommeil, Hopital du Sacre Coeur de Montreal, Canada
    Neurology 58:936-40. 2002
    ..Therefore, the effects of 38 hours of sleep deprivation in adult sleepwalkers and control subjects were investigated...
  76. ncbi REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Qudbec, Canada
    Sleep 29:1321-5. 2006
    ..To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects...
  77. ncbi Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder
    Maria Livia Fantini
    Sleep Disorders Center, Department of Neurology, Universita Vita Salute San Raffaele, via Stamira d Ancona n 20, 20127 Milan, Italy
    Brain Res Bull 70:386-90. 2006
    ..Pathological changes in the anterior olfactory nucleus and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to assess olfactory function in a large group of idiopathic RBD patients...
  78. ncbi Periodic leg movements during sleep and wakefulness in narcolepsy
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, INSERM U888, Universite de Montpellier, Montpellier, France
    J Sleep Res 16:333-9. 2007
    ..These results suggest that PLMS represent an intrinsic feature of narcolepsy...
  79. pmc REM sleep characteristics in narcolepsy and REM sleep behavior disorder
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, INSERM, U888, Universite de Montpellier 1, Montpellier, France
    Sleep 30:844-9. 2007
    ....
  80. ncbi Neuroimaging in sleep medicine
    Thien Thanh Dang-Vu
    Cyclotron Research Centre B30, University of Liege Sart Tilman, 4000 Liege, Belgium
    Sleep Med 8:349-72. 2007
    ..This may finally offer the opportunity to use neuroimaging, in addition to the clinical and electrophysiological assessments, as a helpful tool in the diagnosis, classification, treatment and monitoring of sleep disorders in humans...
  81. ncbi Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study
    Wayne Hening
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
    Sleep Med 5:237-46. 2004
    ..To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population...
  82. ncbi SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep
    Martin Michaud
    Département de Psychiatrie Faculté de Médecine Université de Montréal, Canada
    J Neurol 249:164-70. 2002
    ....
  83. ncbi Diagnostic indicators of restless legs syndrome in primary care consultations: the DESYR study
    Anne Crochard
    Laboratoire GlaxoSmithKline, Marly le Roi, France
    Mov Disord 22:791-7; quiz 907. 2007
    ..7% a hypnotic, and 41.5% an anxiolytic. Complaints of sleep or leg symptoms are frequently associated with a diagnosis of RLS, and their presence should alert the physician to the possibility of a differential diagnosis of RLS...
  84. ncbi Potential early markers of Parkinson's disease in idiopathic rapid-eye-movement sleep behaviour disorder
    Ronald B Postuma
    Lancet Neurol 5:552-3. 2006
  85. ncbi New trends in restless legs syndrome research
    Jacques Montplaisir
    Sleep Med Rev 10:147-51. 2006
  86. ncbi Month of birth as a risk factor for narcolepsy
    Yves Dauvilliers
    Service de Neurologie B, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France
    Sleep 26:663-5. 2003
    ..The aim of the study was to find out whether there is a seasonality of month of birth in narcoleptic patients...
  87. ncbi Procedural skill learning in obstructive sleep apnea syndrome
    Isabelle Rouleau
    Departement de Psychologie, Universite du Quebec a Montreal, Canada
    Sleep 25:401-11. 2002
    ..To better characterize the cognitive deficits observed in obstructive sleep apnea syndrome (OSAS) by examining procedural skill learning abilities...
  88. ncbi Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center of Environment and Health, D 85764 Neuherberg, Munich, Germany
    Nat Genet 39:1000-6. 2007
    ..MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder...
  89. ncbi Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity
    Alex Desautels
    Centre d Etude du Sommeil, Hopital du Sacre Coeur de Montreal, Canada
    Arch Neurol 62:591-6. 2005
    ..Genes are involved in the etiology of restless legs syndrome, a common sensorimotor disorder...
  90. ncbi PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
    Barbara Schormair
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg 85764, Germany
    Nat Genet 40:946-8. 2008
    ..91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS...
  91. ncbi Restless legs syndrome prevalence and impact: REST general population study
    Richard P Allen
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21224, USA
    Arch Intern Med 165:1286-92. 2005
    ..Previous epidemiological studies, however, have failed to determine the prevalence of those with clinically significant RLS symptoms and to examine the life effects and medical experiences of this group...