Brosseau C, Moffett P. Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Plant Cell. 2015;27:1742-54 pubmed publisher
..In agreement with functional assays, we show that Potexvirus infection induces AGO5 expression and that both AGO2 and AGO5 are required for full restriction of PVX infection in systemic tissues of Arabidopsis. ..
Moffett P. Using Decoys to Detect Pathogens: An Integrated Approach. Trends Plant Sci. 2016;21:369-370 pubmed publisher
..In certain examples such decoys are integrated as fusions into their cognate NLR. Two new studies have analysed thousands of predicted NLRs to address how commonly plants use this 'integrated decoy' strategy. ..
Moffett P. Transfer and modification of NLR proteins for virus resistance in plants. Curr Opin Virol. 2017;26:43-48 pubmed publisher
Ma X, Nicole M, Meteignier L, Hong N, Wang G, Moffett P. Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants. J Exp Bot. 2015;66:919-32 pubmed publisher
..Consistent with this, we found that viral recovery induced increased PB formation and that a decapping mutant (DCP2) showed increased VIGS and virus RNA accumulation, indicating an important role for PBs in eliminating viral RNA. ..
Meteignier L, Zhou J, Cohen M, Bhattacharjee S, Brosseau C, Chan M, et al
. NB-LRR signaling induces translational repression of viral transcripts and the formation of RNA processing bodies through mechanisms differing from those activated by UV stress and RNAi. J Exp Bot. 2016;67:2353-66 pubmed publisher
Hamel L, Sekine K, Wallon T, Sugiwaka Y, Kobayashi K, Moffett P. The Chloroplastic Protein THF1 Interacts with the Coiled-Coil Domain of the Disease Resistance Protein N' and Regulates Light-Dependent Cell Death. Plant Physiol. 2016;171:658-74 pubmed publisher
..Together, our results define, to our knowledge, novel molecular mechanisms linking light and chloroplasts to the induction of cell death by a subgroup of NB-LRR proteins. ..
Carpentier J, Grenier E, Esquibet M, Hamel L, Moffett P, Manzanares Dauleux M, et al
. Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1. BMC Evol Biol. 2013;13:87 pubmed publisher
..From a mechanistic point of view these results are in accordance with a physical interaction of RanGAP2 with GPA2 and suggest that RBP-1 would rather bind the RanGAP2-GPA2 complex than the RanGAP2 protein alone. ..