Laetitia Michou

Summary

Country: Canada

Publications

  1. ncbi Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, CHUQ CHUL Research centre and Division of Rheumatology, CHUQ CHUL, Quebec City, QC, Canada
    Bone 51:720-8. 2012
  2. ncbi Epidemiogenetic study of French families with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, and Division of Rheumatology, CHUQ CHUL, Quebec City, Quebec, Canada
    Joint Bone Spine 79:393-8. 2012
  3. ncbi Genetics of Dupuytren's disease
    Laetitia Michou
    Service de rhumatologie du CHUQ CHUL, Centre de Recherche du CHUQ CHUL, Departement de Medecine, Universite Laval, 2705 Boulevard Laurier, G1V4G2 Québec, Canada
    Joint Bone Spine 79:7-12. 2012
  4. ncbi Genetics of bone diseases: Paget's disease, fibrous dysplasia, osteopetrosis, and osteogenesis imperfecta
    Laetitia Michou
    Service de rhumatologie du CHUQ CHUL H1365, Departement de Medecine, Centre de Recherche du CHUQ CHUL, Universite Laval, 2705, boulevard Laurier, G1V 4G2, Quebec, Canada
    Joint Bone Spine 78:252-8. 2011
  5. ncbi Genetics of digital osteoarthritis
    Laetitia Michou
    Department of Medicine, CHUQ CHUL Research Center, Laval University, Canada
    Joint Bone Spine 78:347-51. 2011
  6. ncbi Novel SQSTM1 mutations in patients with Paget's disease of bone in an unrelated multiethnic American population
    Laetitia Michou
    Department of Medicine, Laval University, CHUQ CHUL Research centre and Division of Rheumatology, CHUQ CHUL, Quebec City, QC, Canada
    Bone 48:456-60. 2011
  7. ncbi Emerging strategies and therapies for treatment of Paget's disease of bone
    Laetitia Michou
    Department of Medicine, CHUQ CHUL, Research Centre and Division of Rheumatology, Laval University, Quebec City, QC, Canada
    Drug Des Devel Ther 5:225-39. 2011
  8. ncbi Gene expression profile in osteoclasts from patients with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, Canada G1V 4G2
    Bone 46:598-603. 2010

Detail Information

Publications8

  1. ncbi Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, CHUQ CHUL Research centre and Division of Rheumatology, CHUQ CHUL, Quebec City, QC, Canada
    Bone 51:720-8. 2012
    ..We also identified a very rare variant in the promoter of OPTN, and through bioinformatic analysis, identified putative transcription factor binding sites likely to affect OPTN gene transcription...
  2. ncbi Epidemiogenetic study of French families with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, and Division of Rheumatology, CHUQ CHUL, Quebec City, Quebec, Canada
    Joint Bone Spine 79:393-8. 2012
    ..To search for association with environmental factors and to determine SQSTM1/p62 mutations prevalence in French families with Paget's disease of bone (PDB)...
  3. ncbi Genetics of Dupuytren's disease
    Laetitia Michou
    Service de rhumatologie du CHUQ CHUL, Centre de Recherche du CHUQ CHUL, Departement de Medecine, Universite Laval, 2705 Boulevard Laurier, G1V4G2 Québec, Canada
    Joint Bone Spine 79:7-12. 2012
    ..Pathophysiology of DD involves mainly myofibroblasts and the extracellular matrix of collagen. Gene and protein expression studies have confirmed the central role of the β catenin of the TGFβ pathways in the pathogenesis of DD...
  4. ncbi Genetics of bone diseases: Paget's disease, fibrous dysplasia, osteopetrosis, and osteogenesis imperfecta
    Laetitia Michou
    Service de rhumatologie du CHUQ CHUL H1365, Departement de Medecine, Centre de Recherche du CHUQ CHUL, Universite Laval, 2705, boulevard Laurier, G1V 4G2, Quebec, Canada
    Joint Bone Spine 78:252-8. 2011
    ..The recent identification of mutations in the CRTAP, LEPRE1, and PPIB genes in recessive forms has radically changed the classification of osteogenesis imperfecta and generated new pathophysiological hypotheses...
  5. ncbi Genetics of digital osteoarthritis
    Laetitia Michou
    Department of Medicine, CHUQ CHUL Research Center, Laval University, Canada
    Joint Bone Spine 78:347-51. 2011
    ..In one study, women with hand osteoarthritis had significant telomere shortening. Telomere shortening has also been reported in other age-related conditions...
  6. ncbi Novel SQSTM1 mutations in patients with Paget's disease of bone in an unrelated multiethnic American population
    Laetitia Michou
    Department of Medicine, Laval University, CHUQ CHUL Research centre and Division of Rheumatology, CHUQ CHUL, Quebec City, QC, Canada
    Bone 48:456-60. 2011
    ..The SQSTM1 mutation rate in unrelated American patients described in the present study was similar to that reported in European populations...
  7. ncbi Emerging strategies and therapies for treatment of Paget's disease of bone
    Laetitia Michou
    Department of Medicine, CHUQ CHUL, Research Centre and Division of Rheumatology, Laval University, Quebec City, QC, Canada
    Drug Des Devel Ther 5:225-39. 2011
    ....
  8. ncbi Gene expression profile in osteoclasts from patients with Paget's disease of bone
    Laetitia Michou
    Department of Medicine, Laval University, Canada G1V 4G2
    Bone 46:598-603. 2010
    ..They also suggest that the SQSTM1 P392L mutation plays a role in PDB pathogenesis, even at early preclinical stages in healthy carriers of the P392L mutation...