Research Topics
Species | John T WeberSummaryAffiliation: Memorial University of Newfoundland Country: Canada Publications
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Detail Information
Publications
Cell death, glial protein alterations and elevated S-100 beta release in cerebellar cell cultures following mechanically induced traumaJennifer E Slemmer
Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
Neurobiol Dis 15:563-72. 2004..Lastly, the addition of exogenous S-100 beta to uninjured cerebellar cells caused no overt change in cell viability or overall neuronal number; there were, however, fewer calbindin-positive PNs, similar to findings after stretch injury...- Calcium homeostasis following traumatic neuronal injuryJohn T Weber
Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Curr Neurovasc Res 1:151-71. 2004..While the focus is on alterations in neuronal calcium homeostasis following mechanical injury, these findings may have implications for other pathological states of the brain, such as ischaemia and neurodegenerative disease... - Potential neuroprotective effects of oxyresveratrol against traumatic injuryJohn T Weber
School of Pharmacy, Health Sciences Centre, 300 Prince Philip Drive, Memorial University of Newfoundland, St John s, NL, Canada, A1B 3V6
Eur J Pharmacol 680:55-62. 2012..Further studies using oxyresveratrol in trauma models are warranted, as toxicity to glia could be beneficial by inhibiting reactive gliosis, which often occurs after trauma... - Experimental models of repetitive brain injuriesJohn T Weber
Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
Prog Brain Res 161:253-61. 2007..It will also be essential to combine, and compare, data derived from in vitro experiments with those conducted with animals in vivo. These issues, as well as a summary of findings from repeated TBI research, are discussed in this review... - Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agentsDoortje C Engel
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
Neuropharmacology 49:985-95. 2005.... 
Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapseAmor Belmeguenai
Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
J Neurophysiol 100:3167-74. 2008....
The role of calcium in synaptic plasticity and motor learning in the cerebellar cortexMatthew G Lamont
School of Pharmacy and Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Neurosci Biobehav Rev 36:1153-62. 2012..In the current review we discuss various types of synaptic plasticity in the cerebellar cortex and the role of calcium in these forms of plasticity...- Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber controlMichiel Coesmans
Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Neuron 44:691-700. 2004.... - Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicityJennifer E Slemmer
Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
Eur J Neurosci 26:649-56. 2007..The results from the present study indicate that aldolase C provides marked neuroprotection to PCs after trauma and excitotoxicity... - Don't get too excited: mechanisms of glutamate-mediated Purkinje cell deathJennifer E Slemmer
Department of Neuroscience, Erasmus Medical Center, Dr. Molenwaterplein 50, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
Prog Brain Res 148:367-90. 2005.... - The extent of damage following repeated injury to cultured hippocampal cells is dependent on the severity of insult and inter-injury intervalJennifer E Slemmer
Department of Neuroscience, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Neurobiol Dis 18:421-31. 2005..These results suggest cumulative damage is dependent on injury severity and inter-injury interval, and that neurons and glia react differently to various injury paradigms... - Long-term depression of climbing fiber-evoked calcium transients in Purkinje cell dendritesJohn T Weber
Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands
Proc Natl Acad Sci U S A 100:2878-83. 2003.... - Calcium responses to caffeine and muscarinic receptor agonists are altered in traumatically injured neuronsJohn T Weber
Department of Neuroscience, Erasmus University Rotterdam, Rotterdam, The Netherlands
J Neurotrauma 19:1433-43. 2002..These alterations could affect normal neurotransmission in the brain and may contribute to some of the pathology of TBI... - The making of a complex spike: ionic composition and plasticityMatthew T Schmolesky
Department of Neuroscience, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Ann N Y Acad Sci 978:359-90. 2002..In addition, we discuss which properties CF-LTD might add to the circuitry of the cerebellar cortex... - Repeated mild injury causes cumulative damage to hippocampal cellsJennifer E Slemmer
Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Brain 125:2699-709. 2002.... - Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocolDoortje C Engel
Department of Neurosurgery, University of Munich Medical Center, Munich, Germany
J Neurotrauma 25:739-53. 2008..3 to 25.1 mm3). The current data therefore suggest that the delayed secondary expansion of a cortical contusion following traumatic brain injury may not be caused by a reduction of CBF alone...