John T Weber

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. ncbi request reprint Cell death, glial protein alterations and elevated S-100 beta release in cerebellar cell cultures following mechanically induced trauma
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Neurobiol Dis 15:563-72. 2004
  2. ncbi request reprint Calcium homeostasis following traumatic neuronal injury
    John T Weber
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Neurovasc Res 1:151-71. 2004
  3. ncbi request reprint Potential neuroprotective effects of oxyresveratrol against traumatic injury
    John T Weber
    School of Pharmacy, Health Sciences Centre, 300 Prince Philip Drive, Memorial University of Newfoundland, St John s, NL, Canada, A1B 3V6
    Eur J Pharmacol 680:55-62. 2012
  4. ncbi request reprint Experimental models of repetitive brain injuries
    John T Weber
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    Prog Brain Res 161:253-61. 2007
  5. ncbi request reprint Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents
    Doortje C Engel
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Neuropharmacology 49:985-95. 2005
  6. pmc Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 100:3167-74. 2008
  7. doi request reprint The role of calcium in synaptic plasticity and motor learning in the cerebellar cortex
    Matthew G Lamont
    School of Pharmacy and Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Neurosci Biobehav Rev 36:1153-62. 2012
  8. ncbi request reprint Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control
    Michiel Coesmans
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Neuron 44:691-700. 2004
  9. ncbi request reprint Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    Eur J Neurosci 26:649-56. 2007
  10. doi request reprint Effects of intermittent binge alcohol exposure on long-term motor function in young rats
    Ashley Forbes
    Department of Psychology, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    Alcohol 47:95-102. 2013

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Cell death, glial protein alterations and elevated S-100 beta release in cerebellar cell cultures following mechanically induced trauma
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Neurobiol Dis 15:563-72. 2004
    ..Lastly, the addition of exogenous S-100 beta to uninjured cerebellar cells caused no overt change in cell viability or overall neuronal number; there were, however, fewer calbindin-positive PNs, similar to findings after stretch injury...
  2. ncbi request reprint Calcium homeostasis following traumatic neuronal injury
    John T Weber
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Neurovasc Res 1:151-71. 2004
    ..While the focus is on alterations in neuronal calcium homeostasis following mechanical injury, these findings may have implications for other pathological states of the brain, such as ischaemia and neurodegenerative disease...
  3. ncbi request reprint Potential neuroprotective effects of oxyresveratrol against traumatic injury
    John T Weber
    School of Pharmacy, Health Sciences Centre, 300 Prince Philip Drive, Memorial University of Newfoundland, St John s, NL, Canada, A1B 3V6
    Eur J Pharmacol 680:55-62. 2012
    ..Further studies using oxyresveratrol in trauma models are warranted, as toxicity to glia could be beneficial by inhibiting reactive gliosis, which often occurs after trauma...
  4. ncbi request reprint Experimental models of repetitive brain injuries
    John T Weber
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    Prog Brain Res 161:253-61. 2007
    ..It will also be essential to combine, and compare, data derived from in vitro experiments with those conducted with animals in vivo. These issues, as well as a summary of findings from repeated TBI research, are discussed in this review...
  5. ncbi request reprint Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents
    Doortje C Engel
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Neuropharmacology 49:985-95. 2005
    ....
  6. pmc Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 100:3167-74. 2008
    ....
  7. doi request reprint The role of calcium in synaptic plasticity and motor learning in the cerebellar cortex
    Matthew G Lamont
    School of Pharmacy and Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Neurosci Biobehav Rev 36:1153-62. 2012
    ..In the current review we discuss various types of synaptic plasticity in the cerebellar cortex and the role of calcium in these forms of plasticity...
  8. ncbi request reprint Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control
    Michiel Coesmans
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Neuron 44:691-700. 2004
    ....
  9. ncbi request reprint Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    Eur J Neurosci 26:649-56. 2007
    ..The results from the present study indicate that aldolase C provides marked neuroprotection to PCs after trauma and excitotoxicity...
  10. doi request reprint Effects of intermittent binge alcohol exposure on long-term motor function in young rats
    Ashley Forbes
    Department of Psychology, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    Alcohol 47:95-102. 2013
    ..Altered motor function suggests a possible neurodegenerative effect in the cerebellum initiated by adolescent ethanol exposure, and may depend on the extent of exposure during the preadolescent and/or adolescent brain periods...
  11. ncbi request reprint Don't get too excited: mechanisms of glutamate-mediated Purkinje cell death
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus Medical Center, Dr Molenwaterplein 50, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Prog Brain Res 148:367-90. 2005
    ....
  12. ncbi request reprint The extent of damage following repeated injury to cultured hippocampal cells is dependent on the severity of insult and inter-injury interval
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurobiol Dis 18:421-31. 2005
    ..These results suggest cumulative damage is dependent on injury severity and inter-injury interval, and that neurons and glia react differently to various injury paradigms...
  13. pmc Long-term depression of climbing fiber-evoked calcium transients in Purkinje cell dendrites
    John T Weber
    Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:2878-83. 2003
    ....
  14. ncbi request reprint Calcium responses to caffeine and muscarinic receptor agonists are altered in traumatically injured neurons
    John T Weber
    Department of Neuroscience, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 19:1433-43. 2002
    ..These alterations could affect normal neurotransmission in the brain and may contribute to some of the pathology of TBI...
  15. ncbi request reprint The making of a complex spike: ionic composition and plasticity
    Matthew T Schmolesky
    Department of Neuroscience, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Ann N Y Acad Sci 978:359-90. 2002
    ..In addition, we discuss which properties CF-LTD might add to the circuitry of the cerebellar cortex...
  16. ncbi request reprint Repeated mild injury causes cumulative damage to hippocampal cells
    Jennifer E Slemmer
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 125:2699-709. 2002
    ....
  17. doi request reprint Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol
    Doortje C Engel
    Department of Neurosurgery, University of Munich Medical Center, Munich, Germany
    J Neurotrauma 25:739-53. 2008
    ..3 to 25.1 mm3). The current data therefore suggest that the delayed secondary expansion of a cortical contusion following traumatic brain injury may not be caused by a reduction of CBF alone...