Research Topics
Genomes and Genes | Guang SunSummaryAffiliation: Memorial University of Newfoundland Country: Canada Publications
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Detail Information
Publications
Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malariaGuang Sun
Departments of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Infect Immun 71:6553-61. 2003..CD41 is not an adhesion molecule for parasitized erythrocytes, these findings support the hypothesis that inhibition of platelet adhesion to the brain microvasculature protects against development of malarial pathogenesis...
Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young menGuang Sun
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Am J Clin Nutr 85:399-404. 2007..Visfatin is an insulin-mimicking adipokine. Visfatin is elevated in obesity and type 2 diabetes. However, its role in glucose and lipid metabolism in healthy humans is unclear...- Application of DNA microarrays in the study of human obesity and type 2 diabetesGuang Sun
Discipline of Genetics, Memorial University of Newfoundland, St John s, NL A1B 3V6, Canada
OMICS 11:25-40. 2007..The problems and challenges are summarized under eight categories and suggestions for the future direction of research in this area are proposed... - Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland populationGuang Sun
Discipline of Genetics, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Diabetes 54:3336-9. 2005..Our results suggest that alteration of serum calcium homeostasis is significantly correlated with the abnormality of glucose level, insulin resistance, and beta-cell function... - Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy populationGuang Sun
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada, and Newlab Clinical Genetics, St John s, Canada
Am J Clin Nutr 81:74-8. 2005..However, the results of BIA validation with reference methods are contradictory, and few data are available on the influence of adiposity on the measurement of body composition by BIA... 
Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese menJennifer Shea
Discipline of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Am J Clin Nutr 89:407-15. 2009..Little is known regarding the molecular mechanisms involved in the response to an energy surplus in human adipose tissue at the genomic level...- Serum peptide YY in response to short-term overfeeding in young menFarrell Cahill
Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
Am J Clin Nutr 93:741-7. 2011..Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity... - Serum acylated ghrelin concentrations in response to short-term overfeeding in normal weight, overweight, and obese menDanny Wadden
Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
PLoS ONE 7:e45748. 2012..Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity... - Association of RBP4 gene variants and serum HDL cholesterol levels in the Newfoundland populationJennifer L Shea
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Obesity (Silver Spring) 18:1393-7. 2010..We also found no significant association between any variant sites and markers of insulin resistance. Our results suggest that genetic variations in RBP4 may play a role in the differences in serum HDL-C levels in the NL population... - Relationship between serum magnesium values, lipids and anthropometric risk factorsEdward W Randell
Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Nfld A1B 3V6, Canada
Atherosclerosis 196:413-9. 2008..This study examines whether the relationships between SMg levels and biochemical and anthropometric risk factors for these conditions are also present in the general adult population... - Comparison of the classification of obesity by BMI vs. dual-energy X-ray absorptiometry in the Newfoundland populationAaron P Kennedy
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Obesity (Silver Spring) 17:2094-9. 2009..In conclusion, BMI misclassified adiposity status in approximately one-third of women and men compared with DXA. Caution should be taken when BMI is used in clinical and scientific research as well as clinical practice... - The prevalence of metabolically healthy obese subjects defined by BMI and dual-energy X-ray absorptiometryJennifer L Shea
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Obesity (Silver Spring) 19:624-30. 2011..Caution should therefore be taken when making inferences about the metabolic health of an OB population depending on the method used to measure adiposity... - Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese menJennifer Shea
Discipline of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
Am J Clin Nutr 86:1310-5. 2007..Studies in humans have shown a correlation between serum RBP4 and insulin resistance in obese subjects and in subjects with type 2 diabetes. Few data are available regarding the nutritional regulation of RBP4... - Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same populationJianxun Cui
Discipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Am Heart J 152:543.e1-5. 2006..To validate this sex-dependent association with the THBS-4 variant, we analyzed an additional 532 patients and 514 controls from the same population and the combined cohort consisting of 1032 patients and 1014 controls... - Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profilesGlynn R Martin
Discipline of Genetics, Faculty of Medicine, Memorial University, St John s, Newfoundland and Labrador, Canada
Obesity (Silver Spring) 16:908-12. 2008..In summary, the results of our study do not support a significant role for genetic variations in GHRL in the differences of body fat and serum lipid profiles in the NL population... - Serum acylated ghrelin is negatively correlated with the insulin resistance in the CODING studyPeyvand Amini
Division of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
PLoS ONE 7:e45657. 2012..The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study... - Relationship between serum butyrylcholinesterase and the metabolic syndromeEdward W Randell
Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
Clin Biochem 38:799-805. 2005..To identify independent predictors of serum butyrylcholinesterase (BuChE) activity and examine its relationship with the metabolic syndrome... - Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokinesHenri C van der Heyde
La Jolla Bioengineering Institute and Targeted Molecules Corporation, 505 Coast Blvd, Suite 405, San Diego, CA 92037, USA
Blood 105:1956-63. 2005.... - Regulation of endothelial cell adhesion molecule expression in an experimental model of cerebral malariaPhillipe R Bauer
Departments of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA
Microcirculation 9:463-70. 2002..CONCLUSIONS: These findings indicate that vascular endothelial cells in most regional circulations assume an inflammatory phenotype and that cytokines and immune cells mediate this response in a tissue-specific manner... - P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculatureWun Ling Chang
Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
Infect Immun 71:1911-8. 2003..berghei malaria was similar to that observed in control mice. Collectively, these results indicate that P-selectin is important for the development of malarial pathogenesis but is not required for leukocyte adhesion in brain... - Global gene expression profile of Saccharomyces cerevisiae induced by dictamnineNa Guo
College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People s Republic of China
Yeast 25:631-41. 2008..Furthermore, morphological transitions during dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy... - Intercellular adhesion molecule 1 is important for the development of severe experimental malaria but is not required for leukocyte adhesion in the brainJie Li
Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, USA
J Investig Med 51:128-40. 2003..berghei malaria. Leukocyte rolling and adhesion in the brain vasculature during P. berghei malaria use different ligands than observed during inflammation in other vascular beds... - Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young menGuang Sun
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Metabolism 51:451-6. 2002..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...