Guang Sun

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. pmc Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria
    Guang Sun
    Departments of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Infect Immun 71:6553-61. 2003
  2. pmc Higher Dietary Protein Intake is Associated with Lower Body Fat in the Newfoundland Population
    Kristian K Green
    Discipline of Genetics
    Clin Med Insights Endocrinol Diabetes 3:25-35. 2010
  3. doi request reprint Concordance of BAI and BMI with DXA in the Newfoundland population
    Guang Sun
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 21:499-503. 2013
  4. pmc Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men
    Danny Wadden
    Division of Medicine, Faculty of Medicine, Health Sciences Center, Memorial University of Newfoundland, 300 Prince Phillip Drive, St, John s, NL, A1B 3V6, Canada
    Nutr Metab (Lond) 10:33. 2013
  5. ncbi request reprint Application of DNA microarrays in the study of human obesity and type 2 diabetes
    Guang Sun
    Discipline of Genetics, Memorial University of Newfoundland, St John s, NL A1B 3V6, Canada
    OMICS 11:25-40. 2007
  6. ncbi request reprint Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men
    Guang Sun
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Am J Clin Nutr 85:399-404. 2007
  7. ncbi request reprint Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland population
    Guang Sun
    Discipline of Genetics, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Diabetes 54:3336-9. 2005
  8. ncbi request reprint Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population
    Guang Sun
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada, and Newlab Clinical Genetics, St John s, Canada
    Am J Clin Nutr 81:74-8. 2005
  9. pmc High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population
    Farrell Cahill
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    PLoS ONE 8:e58278. 2013
  10. pmc Serum acylated ghrelin concentrations in response to short-term overfeeding in normal weight, overweight, and obese men
    Danny Wadden
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    PLoS ONE 7:e45748. 2012

Collaborators

  • Guangju Zhai
  • Yuhua Zhang
  • Weizhen Zhang
  • David Pace
  • Edward W Randell
  • Peizhong Peter Wang
  • Tracey Bridger
  • Ana M Valdes
  • Lin Liu
  • Jing Zhao
  • Tim D Spector
  • Xian Wang
  • S Vasdev
  • M Mathews
  • C Bouchard
  • Olavi Ukkola
  • T Rankinen
  • D Neil Granger
  • Farrell Cahill
  • Danny Wadden
  • Peyvand Amini
  • Jennifer L Shea
  • Wayne Gulliver
  • Pardis Pedram
  • Jennifer Shea
  • Henri C van der Heyde
  • Yanqing Yi
  • Bénédicte Fontaine-Bisson
  • Erfan Aref-Eshghi
  • Matthew B Miller
  • Yunqi Ji
  • Xinxin Xiang
  • Hongwei Zhang
  • Glynn Martin
  • Kristian K Green
  • Wun Ling Chang
  • Jie Li
  • Robert D Specian
  • Aaron P Kennedy
  • Na Guo
  • Barbara Roebothan
  • Glynn R Martin
  • Jianxun Cui
  • Hong Li Chen
  • Seth Mark Berney
  • Deborah Hart
  • Gregory E P Pearcey
  • Phillipe R Bauer
  • Andrew Furey
  • Anne Gregory
  • Proton Rahman
  • James Thorburn
  • Duane C Button
  • Fabien A Basset
  • Nigel Arden
  • Steven Buckle
  • Shane B D Stratton
  • HEATHER MCCARTHY
  • Jennifer C Noftall
  • Yin Li
  • Changtao Jiang
  • Sammy Khalili
  • Mariam Shahidi
  • Jacqueline C Carter
  • Alan Goodridge
  • Wenjiao An
  • Jon Church
  • Xihua Chen
  • J Concepcion Loredo-Osti
  • Jessica Bishop
  • Donald Fitzpatrick
  • Curtis R French
  • Xuming Deng
  • Dacheng Wang
  • Lu Yu
  • J C Loredo
  • Rizeng Meng
  • Junwen Fan
  • Roger Green
  • Ya Gang Xie
  • James Renouf
  • Fei Yu Han
  • Irene Gramaglia
  • Catherine Woods
  • Donald Kimpel

Detail Information

Publications38

  1. pmc Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria
    Guang Sun
    Departments of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Infect Immun 71:6553-61. 2003
    ..CD41 is not an adhesion molecule for parasitized erythrocytes, these findings support the hypothesis that inhibition of platelet adhesion to the brain microvasculature protects against development of malarial pathogenesis...
  2. pmc Higher Dietary Protein Intake is Associated with Lower Body Fat in the Newfoundland Population
    Kristian K Green
    Discipline of Genetics
    Clin Med Insights Endocrinol Diabetes 3:25-35. 2010
    ..It is not known if the beneficial effect of dietary protein exists in the general population under normal living conditions without a negative energy balance...
  3. doi request reprint Concordance of BAI and BMI with DXA in the Newfoundland population
    Guang Sun
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 21:499-503. 2013
    ..Body adiposity index (BAI), indirect method proposed to predict adiposity, was developed using Mexican Americans and very little data are available regarding its validation in Caucasian populations to date...
  4. pmc Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men
    Danny Wadden
    Division of Medicine, Faculty of Medicine, Health Sciences Center, Memorial University of Newfoundland, 300 Prince Phillip Drive, St, John s, NL, A1B 3V6, Canada
    Nutr Metab (Lond) 10:33. 2013
    ..Currently little is known about GLP-1's responsiveness to an energy surplus, a fundamental cause of obesity and diabetes. Our objective was to examine the response of serum GLP-1 to short-term (7 day) overfeeding in young men...
  5. ncbi request reprint Application of DNA microarrays in the study of human obesity and type 2 diabetes
    Guang Sun
    Discipline of Genetics, Memorial University of Newfoundland, St John s, NL A1B 3V6, Canada
    OMICS 11:25-40. 2007
    ..The problems and challenges are summarized under eight categories and suggestions for the future direction of research in this area are proposed...
  6. ncbi request reprint Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men
    Guang Sun
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Am J Clin Nutr 85:399-404. 2007
    ..Visfatin is an insulin-mimicking adipokine. Visfatin is elevated in obesity and type 2 diabetes. However, its role in glucose and lipid metabolism in healthy humans is unclear...
  7. ncbi request reprint Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland population
    Guang Sun
    Discipline of Genetics, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Diabetes 54:3336-9. 2005
    ..Our results suggest that alteration of serum calcium homeostasis is significantly correlated with the abnormality of glucose level, insulin resistance, and beta-cell function...
  8. ncbi request reprint Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population
    Guang Sun
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada, and Newlab Clinical Genetics, St John s, Canada
    Am J Clin Nutr 81:74-8. 2005
    ..However, the results of BIA validation with reference methods are contradictory, and few data are available on the influence of adiposity on the measurement of body composition by BIA...
  9. pmc High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population
    Farrell Cahill
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    PLoS ONE 8:e58278. 2013
    ..However, data is inconsistent and most studies have not adequately controlled for critical confounding factors...
  10. pmc Serum acylated ghrelin concentrations in response to short-term overfeeding in normal weight, overweight, and obese men
    Danny Wadden
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    PLoS ONE 7:e45748. 2012
    ..Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity...
  11. pmc Short-term overfeeding increases circulating adiponectin independent of obesity status
    Farrell Cahill
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    PLoS ONE 8:e74215. 2013
    ..However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response...
  12. doi request reprint Serum peptide YY in response to short-term overfeeding in young men
    Farrell Cahill
    Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Am J Clin Nutr 93:741-7. 2011
    ..Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity...
  13. pmc Serum acylated ghrelin is negatively correlated with the insulin resistance in the CODING study
    Peyvand Amini
    Division of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    PLoS ONE 7:e45657. 2012
    ..The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study...
  14. doi request reprint Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men
    Jennifer Shea
    Discipline of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Am J Clin Nutr 89:407-15. 2009
    ..Little is known regarding the molecular mechanisms involved in the response to an energy surplus in human adipose tissue at the genomic level...
  15. doi request reprint Relationship between blood plasma and synovial fluid metabolite concentrations in patients with osteoarthritis
    Weidong Zhang
    From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland MUN, St John s, Newfoundland, Canada Department of Twin Research and Genetic Epidemiology, King s College London, London, UK W Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics S Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine E Aref Eshghi, MD, PhD student Y Zhang, MSc, Statistician P E Harper, Bsc, MSc Student, Discipline of Genetics E Randell, PhD, Associate Professor, Department of Laboratory Medicine R Green, PhD, Professor, Discipline of Genetics G Martin, MD, Orthopedic Fellow A Furey, MD, Associate Professor, Department of Surgery G Sun, PhD, Professor P Rahman, Department of Pathology
    J Rheumatol 42:859-65. 2015
    ..To investigate the relationship between plasma and synovial fluid (SF) metabolite concentrations in patients with osteoarthritis (OA)...
  16. ncbi request reprint Relationship between serum magnesium values, lipids and anthropometric risk factors
    Edward W Randell
    Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Nfld A1B 3V6, Canada
    Atherosclerosis 196:413-9. 2008
    ..This study examines whether the relationships between SMg levels and biochemical and anthropometric risk factors for these conditions are also present in the general adult population...
  17. doi request reprint Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study
    Bénédicte Fontaine-Bisson
    Nutrition Sciences Program, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada BF B, and the Discipline of Medicine, Faculty of Medicine, Memorial University, St John s, Canada JT, AG, hz, and GS
    Am J Clin Nutr 99:384-91. 2014
    ..Inconsistent effects of MCHR1 polymorphisms on energy homeostasis in humans may partly be attributable to environmental factors...
  18. pmc Food addiction: its prevalence and significant association with obesity in the general population
    Pardis Pedram
    Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    PLoS ONE 8:e74832. 2013
    ..Food addiction' shares a similar neurobiological and behavioral framework with substance addiction. However whether, and to what degree, 'food addiction' contributes to obesity in the general population is unknown...
  19. doi request reprint Comparison of the classification of obesity by BMI vs. dual-energy X-ray absorptiometry in the Newfoundland population
    Aaron P Kennedy
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 17:2094-9. 2009
    ..In conclusion, BMI misclassified adiposity status in approximately one-third of women and men compared with DXA. Caution should be taken when BMI is used in clinical and scientific research as well as clinical practice...
  20. doi request reprint Association of RBP4 gene variants and serum HDL cholesterol levels in the Newfoundland population
    Jennifer L Shea
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 18:1393-7. 2010
    ..We also found no significant association between any variant sites and markers of insulin resistance. Our results suggest that genetic variations in RBP4 may play a role in the differences in serum HDL-C levels in the NL population...
  21. pmc Classification of osteoarthritis phenotypes by metabolomics analysis
    Weidong Zhang
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    BMJ Open 4:e006286. 2014
    ..To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups...
  22. pmc The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study
    Farrell Cahill
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    PLoS ONE 9:e95235. 2014
    ..PYY is an appetite suppressing hormone. Low circulating PYY has been linked to greater BMI. However data is controversial and this association has not been verified in large human populations...
  23. ncbi request reprint Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese men
    Jennifer Shea
    Discipline of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Am J Clin Nutr 86:1310-5. 2007
    ..Studies in humans have shown a correlation between serum RBP4 and insulin resistance in obese subjects and in subjects with type 2 diabetes. Few data are available regarding the nutritional regulation of RBP4...
  24. doi request reprint The prevalence of metabolically healthy obese subjects defined by BMI and dual-energy X-ray absorptiometry
    Jennifer L Shea
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 19:624-30. 2011
    ..Caution should therefore be taken when making inferences about the metabolic health of an OB population depending on the method used to measure adiposity...
  25. doi request reprint Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles
    Glynn R Martin
    Discipline of Genetics, Faculty of Medicine, Memorial University, St John s, Newfoundland and Labrador, Canada
    Obesity (Silver Spring) 16:908-12. 2008
    ..In summary, the results of our study do not support a significant role for genetic variations in GHRL in the differences of body fat and serum lipid profiles in the NL population...
  26. ncbi request reprint Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population
    Jianxun Cui
    Discipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Am Heart J 152:543.e1-5. 2006
    ..To validate this sex-dependent association with the THBS-4 variant, we analyzed an additional 532 patients and 514 controls from the same population and the combined cohort consisting of 1032 patients and 1014 controls...
  27. pmc Assessing the validity of a self-administered food-frequency questionnaire (FFQ) in the adult population of Newfoundland and Labrador, Canada
    Lin Liu
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St John s, NL A1B 3V6, Canada
    Nutr J 12:49. 2013
    ..The goal of the present study is to validate a self-administered version of the Hawaii FFQ modified for use in the general adult population of Newfoundland and Labrador (NL)...
  28. doi request reprint Lipopolysaccharide inhibits the expression of resistin in adipocytes
    Xinxin Xiang
    Department of Physiology and Pathophysiology, Peking University Health Science Center Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China Department of Pathology, Central Hospital of Zibo, Zibo 255000, China Division of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Mol Endocrinol 51:287-99. 2013
    ..Taken together, these results suggest that LPS inhibits resistin expression through a unique signaling pathway involving toll-like receptor 4, JNK, CHOP-10 and C/EBP-α/PPAR-γ. ..
  29. pmc Hormonal and dietary characteristics in obese human subjects with and without food addiction
    Pardis Pedram
    Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St John s, NL A1B3V6, Canada
    Nutrients 7:223-38. 2015
    ..The findings provide insights into the mechanisms by which FA could contribute to obesity. ..
  30. pmc SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study
    Erfan Aref-Eshghi
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    PLoS ONE 9:e97786. 2014
    ..Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with GOA and tested the hypothesis in a population-based cohort...
  31. pmc The effect of a short-term high-intensity circuit training program on work capacity, body composition, and blood profiles in sedentary obese men: a pilot study
    Matthew B Miller
    School of Human Kinetics and Recreation, Memorial University of Newfoundland, St John s, NL, Canada A1C 5S7
    Biomed Res Int 2014:191797. 2014
    ..Overall, sedentary obese males experienced a significant improvement in biochemical, physical, and body composition characteristics from a HICT program that was only 6 hours of the total exercise. ..
  32. ncbi request reprint Relationship between serum butyrylcholinesterase and the metabolic syndrome
    Edward W Randell
    Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    Clin Biochem 38:799-805. 2005
    ..To identify independent predictors of serum butyrylcholinesterase (BuChE) activity and examine its relationship with the metabolic syndrome...
  33. ncbi request reprint Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines
    Henri C van der Heyde
    La Jolla Bioengineering Institute and Targeted Molecules Corporation, 505 Coast Blvd, Suite 405, San Diego, CA 92037, USA
    Blood 105:1956-63. 2005
    ....
  34. ncbi request reprint Regulation of endothelial cell adhesion molecule expression in an experimental model of cerebral malaria
    Phillipe R Bauer
    Departments of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 9:463-70. 2002
    ....
  35. pmc P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature
    Wun Ling Chang
    Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Infect Immun 71:1911-8. 2003
    ..berghei malaria was similar to that observed in control mice. Collectively, these results indicate that P-selectin is important for the development of malarial pathogenesis but is not required for leukocyte adhesion in brain...
  36. ncbi request reprint Intercellular adhesion molecule 1 is important for the development of severe experimental malaria but is not required for leukocyte adhesion in the brain
    Jie Li
    Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, USA
    J Investig Med 51:128-40. 2003
    ..berghei malaria. Leukocyte rolling and adhesion in the brain vasculature during P. berghei malaria use different ligands than observed during inflammation in other vascular beds...
  37. doi request reprint Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine
    Na Guo
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People s Republic of China
    Yeast 25:631-41. 2008
    ..Furthermore, morphological transitions during dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy...
  38. ncbi request reprint Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men
    Guang Sun
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Metabolism 51:451-6. 2002
    ..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...