Sevtap Savas

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. pmc Special considerations in prognostic research in cancer involving genetic polymorphisms
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St, John s, Newfoundland, Canada
    BMC Med 11:149. 2013
  2. pmc Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    PLoS ONE 7:e38953. 2012
  3. doi request reprint A curated database of genetic markers from the angiogenesis/VEGF pathway and their relation to clinical outcome in human cancers
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Acta Oncol 51:243-6. 2012
  4. doi request reprint Useful genetic variation databases for oncologists investigating the genetic basis of variable treatment response and survival in cancer
    Sevtap Savas
    Memorial University of Newfoundland, St John s, NL, Canada
    Acta Oncol 49:1217-26. 2010
  5. doi request reprint dbCPCO: a database of genetic markers tested for their predictive and prognostic value in colorectal cancer
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    Hum Mutat 31:901-7. 2010
  6. doi request reprint Genetic variations as cancer prognostic markers: review and update
    Sevtap Savas
    Department of Medical Biophysics, Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Hum Mutat 30:1369-77. 2009
  7. doi request reprint Studying genetic variations in cancer prognosis (and risk): a primer for clinicians
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    Oncologist 14:657-66. 2009
  8. doi request reprint A comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario, Canada
    Int J Cancer 125:1257-65. 2009
  9. doi request reprint Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers
    Abul Kalam Azad
    Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer 118:1554-65. 2012
  10. ncbi request reprint Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Proteins 58:697-705. 2005

Collaborators

Detail Information

Publications25

  1. pmc Special considerations in prognostic research in cancer involving genetic polymorphisms
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St, John s, Newfoundland, Canada
    BMC Med 11:149. 2013
    ..In this article, we review these and other considerations specific to genetic polymorphism by focusing on genetic prognostic studies in cancer. ..
  2. pmc Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    PLoS ONE 7:e38953. 2012
    ..While our results remain to be replicated in other patient cohorts, we suggest that the genetic variations in the SLC6A4 gene contribute to poor survival in colorectal cancer patients...
  3. doi request reprint A curated database of genetic markers from the angiogenesis/VEGF pathway and their relation to clinical outcome in human cancers
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Acta Oncol 51:243-6. 2012
    ..Genes and genetic variations in angiogenesis/VEGF pathway thus may be correlated with clinical outcome in cancer patients...
  4. doi request reprint Useful genetic variation databases for oncologists investigating the genetic basis of variable treatment response and survival in cancer
    Sevtap Savas
    Memorial University of Newfoundland, St John s, NL, Canada
    Acta Oncol 49:1217-26. 2010
    ..Utilization of these databases can assist clinicians in their studies related to treatment response and prognosis in cancer patients...
  5. doi request reprint dbCPCO: a database of genetic markers tested for their predictive and prognostic value in colorectal cancer
    Sevtap Savas
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    Hum Mutat 31:901-7. 2010
    ..The dbCPCO is periodically updated and freely available for the scientific and medical community at http://www.med.mun.ca/cpco...
  6. doi request reprint Genetic variations as cancer prognostic markers: review and update
    Sevtap Savas
    Department of Medical Biophysics, Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Hum Mutat 30:1369-77. 2009
    ..We discuss the interrelatedness among the disease susceptibility, treatment response, and prognosis at the genetic level and focus on how the emerging technologies and approaches can uniquely benefit the genetic prognosis studies...
  7. doi request reprint Studying genetic variations in cancer prognosis (and risk): a primer for clinicians
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    Oncologist 14:657-66. 2009
    ..In this review, we summarize the current knowledge on how candidate genes and genetic variations are selected to evaluate gene-outcome, gene-prognosis, and gene-treatment response relationships as applicable to the practicing oncologist...
  8. doi request reprint A comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research
    Sevtap Savas
    Division of Applied Molecular Oncology, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario, Canada
    Int J Cancer 125:1257-65. 2009
    ..The genes and their SNPs identified in the network-based analysis represent potential candidates for gene-gene and SNP-SNP interaction studies in cancer research...
  9. doi request reprint Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers
    Abul Kalam Azad
    Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer 118:1554-65. 2012
    ..We thus hypothesized that the same sequence variants associated with HNC survival can also be associated with SPC...
  10. ncbi request reprint Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Proteins 58:697-705. 2005
    ..Our study strongly suggests the presence of naturally occurring genetic variations in the cell cycle proteins that may affect their interactions and functions with possible roles in complex human diseases, such as cancer...
  11. pmc Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines
    Lawson Eng
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada
    BMC Med Genomics 4:18. 2011
    ..Ingenuity Pathway Analysis software helped us understand how our identified genes may alter the cellular response to paclitaxel...
  12. pmc Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs
    Sevtap Savas
    Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, ON, Canada
    BMC Cancer 5:107. 2005
    ..Non-synonymous single nucleotide polymorphisms (nsSNPs) result in the substitution of the encoded amino acids and thus are likely to alter the phosphorylation motifs in the proteins...
  13. doi request reprint Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine
    Hamdi Jarjanazi
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Hum Mutat 29:461-7. 2008
    ..The results obtained using this novel methodology can be used to better design the clinical trials for effective study of the chemotherapeutic agents and thus provide a basis for individualized chemotherapy...
  14. ncbi request reprint Human non-synonymous single nucleotide polymorphisms can influence ubiquitin-mediated protein degradation
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    OMICS 11:200-8. 2007
    ..Although experimental analyses are required to confirm these results, they suggest that nsSNPs can induce changes in ubiquitin-mediated protein degradation...
  15. ncbi request reprint Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Physiol Genomics 29:109-17. 2007
    ..The nsSNPs reported in here can be characterized by experimental approaches to elucidate their exact biological roles and whether they are related to human disease...
  16. pmc Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2
    Eric Tram
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    PLoS ONE 8:e62468. 2013
    ..We propose that rare VUS affecting phosphorylation may be a novel and important mechanism for which BRCA1 and BRCA2 functions are disrupted in breast cancer...
  17. pmc MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland
    Amit A Negandhi
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    PLoS ONE 8:e61469. 2013
    ....
  18. pmc NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    PLoS ONE 6:e18306. 2011
    ..Our results indicated genes involved in the cellular response to these statins and siRNA studies confirmed the role of the EAF2 in response to these drugs in HCT-116 colon cancer cells...
  19. ncbi request reprint Identifying functional genetic variants in DNA repair pathway using protein conservation analysis
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Avenue Room 992A, Toronto, ON M5G 1X5, Canada
    Cancer Epidemiol Biomarkers Prev 13:801-7. 2004
    ..The strategy developed and applied in this study has the potential to identify functional protein variants of DNA repair pathway that may be associated with cancer predisposition...
  20. pmc A whole-genome SNP association study of NCI60 cell line panel indicates a role of Ca2+ signaling in selenium resistance
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 5:e12601. 2010
    ....
  21. pmc Human SNPs resulting in premature stop codons and protein truncation
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Hum Genomics 2:274-86. 2006
    ..We believe that the SNPs reported here are likely to affect gene/protein function, although their biological and evolutionary roles need to be further investigated...
  22. pmc Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:99. 2007
    ..In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry...
  23. ncbi request reprint Biological implications of SNPs in signal peptide domains of human proteins
    Hamdi Jarjanazi
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Proteins 70:394-403. 2008
    ..Functional evaluation of candidates identified herein may reveal effects on major cellular processes including immune cell function, cell recognition and adhesion, and signal transduction...
  24. pmc Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Hum Genomics 2:287-96. 2006
    ....
  25. doi request reprint Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival
    Abul Kalam Azad
    Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 18:196-206. 2012
    ..The purpose of this study was to validate the role of these 23 sequence variants for overall (OS) and disease-free survival (DFS) in a large, comprehensive, well-annotated data set of patients with head and neck cancer...