P Rahman

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. pmc TNFalpha polymorphisms and risk of psoriatic arthritis
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, 1 South 154 LeMarchant Rd, St John s, Newfoundland, Canada A1C 5B8
    Ann Rheum Dis 65:919-23. 2006
  2. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
  3. ncbi request reprint Association between the interleukin-1 family gene cluster and psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    Arthritis Rheum 54:2321-5. 2006
  4. ncbi request reprint Genetics of ankylosing spondylitis: an update
    Proton Rahman
    154 Le Marchant Road, St Clare s Mercy Hospital, St John s, NL, A1C 5B8, Canada
    Curr Rheumatol Rep 9:383-9. 2007
  5. doi request reprint A variant of the IL4 I50V single-nucleotide polymorphism is associated with erosive joint disease in psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St John s, Newfoundland
    Arthritis Rheum 58:2207-8. 2008
  6. pmc Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies
    Darren D O'Rielly
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Pharmgenomics Pers Med 3:15-31. 2010
  7. pmc Genome-wide signatures of 'rearrangement hotspots' within segmental duplications in humans
    Mohammed Uddin
    Faculty of Medicine, Discipline of Medicine and Genetics, Memorial University, St John s, Newfoundland, Canada
    PLoS ONE 6:e28853. 2011
  8. pmc Adult siblings with homozygous G6PC3 mutations expand our understanding of the severe congenital neutropenia type 4 (SCN4) phenotype
    Bridget A Fernandez
    Discipline of Genetics, Memorial University of Newfoundland, Health Sciences Centre, St John s, Newfoundland and Labrador, Canada
    BMC Med Genet 13:111. 2012
  9. pmc UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family
    Mohammed Uddin
    Faculty of Medicine, Memorial University of Newfoundland, St John s, NF, Canada
    BMC Genet 14:67. 2013
  10. pmc Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting
    Proton Rahman
    Memorial University, St John s, Newfoundland, Canada
    J Rheumatol 39:431-3. 2012

Collaborators

Detail Information

Publications52

  1. pmc TNFalpha polymorphisms and risk of psoriatic arthritis
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, 1 South 154 LeMarchant Rd, St John s, Newfoundland, Canada A1C 5B8
    Ann Rheum Dis 65:919-23. 2006
    ..Tumour necrosis factor alpha (TNFalpha) is a cytokine of critical importance in psoriatic arthritis...
  2. ncbi request reprint Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arthritis Rheum 54:524-32. 2006
    ..To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee...
  3. ncbi request reprint Association between the interleukin-1 family gene cluster and psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    Arthritis Rheum 54:2321-5. 2006
    ....
  4. ncbi request reprint Genetics of ankylosing spondylitis: an update
    Proton Rahman
    154 Le Marchant Road, St Clare s Mercy Hospital, St John s, NL, A1C 5B8, Canada
    Curr Rheumatol Rep 9:383-9. 2007
    ..This article reviews the current evidence regarding the genetics of AS, with an emphasis on the recent major advances, and it discusses the challenges and limitations in interpreting these studies...
  5. doi request reprint A variant of the IL4 I50V single-nucleotide polymorphism is associated with erosive joint disease in psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St John s, Newfoundland
    Arthritis Rheum 58:2207-8. 2008
  6. pmc Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies
    Darren D O'Rielly
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Pharmgenomics Pers Med 3:15-31. 2010
    ..We will also review the therapeutic agents that are currently being utilized or presently being evaluated in the treatment of RA, along with potential pharmacogenetic markers that have been proposed for such medications...
  7. pmc Genome-wide signatures of 'rearrangement hotspots' within segmental duplications in humans
    Mohammed Uddin
    Faculty of Medicine, Discipline of Medicine and Genetics, Memorial University, St John s, Newfoundland, Canada
    PLoS ONE 6:e28853. 2011
    ....
  8. pmc Adult siblings with homozygous G6PC3 mutations expand our understanding of the severe congenital neutropenia type 4 (SCN4) phenotype
    Bridget A Fernandez
    Discipline of Genetics, Memorial University of Newfoundland, Health Sciences Centre, St John s, Newfoundland and Labrador, Canada
    BMC Med Genet 13:111. 2012
    ..Its core features are congenital neutropenia and a prominent venous skin pattern, and affected individuals have variable birth defects. Oculocutaneous albinism type 4 (OCA4) is caused by autosomal recessive mutations in SLC45A2...
  9. pmc UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family
    Mohammed Uddin
    Faculty of Medicine, Memorial University of Newfoundland, St John s, NF, Canada
    BMC Genet 14:67. 2013
    ..The frequency of copy number variation for the UGT2B17 gene was then performed on two well-defined AS cohorts. Fisher exact test was performed to quantify the association...
  10. pmc Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting
    Proton Rahman
    Memorial University, St John s, Newfoundland, Canada
    J Rheumatol 39:431-3. 2012
    ..Further development of a global genetic risk score and inclusion of potential gene/gene and gene/environment interactions will likely enhance the predictive value of recently identified genetic variants...
  11. pmc VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis
    Christopher Butt
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    BMC Musculoskelet Disord 8:1. 2007
    ..As these diseases share common susceptibility associations with PsA, investigation of these angiogenic factors is warranted...
  12. pmc Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study
    Christopher Butt
    Memorial University of Newfoundland, Hospital for Sick Children, Department of Public Health Sciences, University of Toronto, Toronto, Canada
    Arthritis Res Ther 8:R27. 2006
    ..Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted...
  13. doi request reprint Psoriatic arthritis: genetic susceptibility and pharmacogenetics
    Proton Rahman
    Memorial University, Discipline of Rheumatology, School of Pharmacy and Faculty of Medicine, Health Science Centre, 300 Prince Philip Drive, St John s, NL, A1B 3V6, Canada
    Pharmacogenomics 9:195-205. 2008
    ..To date, only the -308 variant of the TNF-alpha promoter gene has been shown to be important in predicting response to TNF-alpha blockade in inflammatory arthritis...
  14. doi request reprint Pathophysiology and pathogenesis of immune-mediated inflammatory diseases: commonalities and differences
    Proton Rahman
    St Clare s Mercy Hospital, Memorial University, St John s, Newfoundland, Canada
    J Rheumatol Suppl 85:11-26. 2010
    ..Insights relating to a specific immune pathway could provide targets for therapeutic interventions...
  15. doi request reprint Association of interleukin 23 receptor variants with psoriatic arthritis
    Proton Rahman
    Department of Medicine, Memorial University, 154 Le Marchant Road, St John s, NL, Canada, A1C 5B8
    J Rheumatol 36:137-40. 2009
    ..Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA)...
  16. pmc Genetic epidemiology of psoriasis and psoriatic arthritis
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, Newfoundland, Canada A1C 5B8
    Ann Rheum Dis 64:ii37-9; discussion ii40-1. 2005
    ..Thus, exploration of the genetic basis of psoriasis will likely strengthen the contention of an underlying genetic susceptibility for PsA and vice versa...
  17. pmc Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, 1 South 154 LeMarchant Rd, St John s, Newfoundland, Canada A1C 5B8
    Ann Rheum Dis 64:1370-2. 2005
    ..To examine the relationship between SNP +39604 in SEEK1 and psoriatic arthritis (PsA) in two distinct Canadian populations...
  18. pmc CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1C 5B8
    Am J Hum Genet 73:677-81. 2003
    ..57%, and 0.37%, respectively, in the control patients. CARD15 conferred susceptibility to PsA independent of HLA-Cw*0602. Thus, CARD15 represents a pleiotropic autoimmune gene and is the first non-MHC gene to be associated with PsA...
  19. ncbi request reprint The Newfoundland population: a unique resource for genetic investigation of complex diseases
    Proton Rahman
    Department of Medicine, Memorial University of Newfoundland, St Johns, Newfoundland, Canada
    Hum Mol Genet 12:R167-72. 2003
    ..Based on these factors, we propose that the population of Newfoundland offers many advantages for genetic mapping of common diseases, compared with admixed populations, and even compared with other isolates...
  20. doi request reprint Association of interleukin-23 receptor variants with ankylosing spondylitis
    Proton Rahman
    Memorial University, St John s, Newfoundland, Canada
    Arthritis Rheum 58:1020-5. 2008
    ....
  21. doi request reprint Current challenges in the genetics of psoriatic arthritis: a report from the GRAPPA 2009 annual meeting
    Proton Rahman
    St Clare s Mercy Hospital, St John s, Newfoundland A1C 5B8, Canada
    J Rheumatol 38:564-6. 2011
    ....
  22. doi request reprint TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis
    D D O'Rielly
    Department of Rheumatology, Memorial University of Newfoundland, Newfoundland, Canada
    Pharmacogenomics J 9:161-7. 2009
    ..The clinical utility of prospectively genotyping for this variant when initiating anti-TNF-alpha therapy for RA should now be formally assessed...
  23. doi request reprint Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
    W P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 60:1317-23. 2009
    ....
  24. ncbi request reprint Association of SEEK1 polymorphisms in Crohn's disease
    Lynette Peddle
    Newfound Genomics, Memorial University of Newfoundland, Nefoundland A1C 5B8, Canada
    Hum Immunol 65:706-9. 2004
    ..There was no statistical difference in any of the variants between patients with CD and controls. The SEEK1polymorphisms +39604, +39709, and +26680 are not associated with CD in the Newfoundland population...
  25. ncbi request reprint Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study
    Tara Snelgrove
    Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Rheumatol 34:368-70. 2007
    ..TLR4 is in proximity to a genome-wide linkage peak in 9q32-33. Given the proposed function and location of TLR4, we examined the association of 2 functional variants of TLR4 in patients with ankylosing spondylitis (AS) in Newfoundland...
  26. ncbi request reprint PPAR-gamma gene polymorphisms and psoriatic arthritis
    Christopher Butt
    St Clare s Mercy Hospital, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Rheumatol 33:1631-3. 2006
    ..Given the potential physiological role for PPAR-gamma in PsA, we examined known coding polymorphisms in the PPAR-gamma gene in a Caucasian population...
  27. ncbi request reprint Association of TNF-alpha polymorphisms in Crohn disease
    Katrin Zipperlen
    Newfound Genomics, Memorial University of Newfoundland, Newfoundland, Canada
    Hum Immunol 66:56-9. 2005
    ..In conclusion, there was no significant association for any of the TNF-alpha promoter polymorphism tested and CD in the Newfoundland population...
  28. ncbi request reprint Comparative immune responses to candidate arthritogenic bacteria do not confirm a dominant role for Klebsiella pneumonia in the pathogenesis of familial ankylosing spondylitis
    M A Stone
    Toronto Western Research Institute, University Health Network, Newfoundland, Canada
    Rheumatology (Oxford) 43:148-55. 2004
    ..pneumoniae...
  29. ncbi request reprint HLA is a candidate region for psoriatic arthritis. evidence for excessive HLA sharing in sibling pairs
    Dafna D Gladman
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Hum Immunol 64:887-9. 2003
    ..04); whereas the haplotype sharing for the Ps affected sibling pairs was 12, 26, and 10, respectively (p = 0.38). In conclusion, the human leukocyte antigen region on chromosome 6p is implicated as one of the candidate regions in PsA...
  30. ncbi request reprint Divergent effects of infliximab and anakinra therapies on macrophage phenotype from patients with refractory rheumatoid arthritis
    T N Q Pham
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    Int J Immunopathol Pharmacol 23:491-501. 2010
    ....
  31. ncbi request reprint Spinal hyperostosis--a rare skeletal manifestation of psoriasis vulgaris
    P Rahman
    Department of Medicine, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    J Rheumatol 27:2513-5. 2000
    ..We review the association between uncomplicated psoriasis vulgaris and skeletal involvement...
  32. doi request reprint Autosome-wide copy number variation association analysis for rheumatoid arthritis using the WTCCC high-density SNP genotype data
    Mohammed Uddin
    St Clare s Mercy Hospital, 154 LeMarchant Road, St John s, Newfoundland, Canada
    J Rheumatol 38:797-801. 2011
    ..We set out to identify genes affected by CNV that are associated with RA at a genome-wide level...
  33. doi request reprint Genetic epidemiology of complex phenotypes
    Lynette Peddle
    Newfound Genomics, St John s, Canada
    Methods Mol Biol 473:187-201. 2009
    ..Therefore, it is important to understand the design as well as the technical and statistical issues of the two most common approaches for gene identification: linkage and association...
  34. doi request reprint Low-dose infliximab (3 mg/kg) significantly reduces spinal inflammation on magnetic resonance imaging in patients with ankylosing spondylitis: a randomized placebo-controlled study
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 37:1728-34. 2010
    ..The dose recommended for rheumatoid arthritis (3 mg/kg) is also clinically effective for ankylosing spondylitis (AS), although effects on spinal inflammation as defined by MRI have yet to be described in a placebo-controlled trial...
  35. ncbi request reprint Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 35:2030-7. 2008
    ..We analyzed the effects of adalimumab on biomarkers predictive of structural damage in inflammatory arthritis...
  36. ncbi request reprint Analysis of CARD15 polymorphisms in Korean patients with ankylosing spondylitis reveals absence of common variants seen in western populations
    Tae Hwan Kim
    Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    J Rheumatol 31:1959-61. 2004
    ..However, a homogenous population has yet to be studied. We investigated the prevalence of the 3 common CARD15 variants in a homogenous Korean population with AS...
  37. ncbi request reprint Association of nuclear factor-kappaB in psoriatic arthritis
    Christopher Butt
    Department of Statistics, University of Toronto, Ontario, Canada
    J Rheumatol 32:1742-4. 2005
    ..To examine the association of single nucleotide polymorphisms (SNP) in the NFKB1 gene, as well as 2 genes in the nuclear factor (NF)-kappaB functional complex (RelA and NFKBIA), in patients with psoriatic arthritis (PsA) from Newfoundland...
  38. ncbi request reprint Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea
    Tae Hwan Kim
    Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    J Rheumatol 32:1907-10. 2005
    ..To date there have been no reports examining an association between NFKB1 and AS. We investigated polymorphisms of IL-1 complex and NF-kappaB1 with 2 genetically and geographically different populations...
  39. ncbi request reprint Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 54:974-85. 2006
    ..To examine the association between the IL1 gene cluster and susceptibility to ankylosing spondylitis (AS) in 3 independent case-control cohorts...
  40. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1740-5. 2007
    ..To determine whether the assessments of peripheral joints and enthesitis were reproducible for both AS and PsA with axial disease, and whether dactylitis assessment is reproducible in patients with PsA...
  41. ncbi request reprint Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population
    Kyoung Sun Na
    The Hospital for Rheumatic Diseases, Hanyang University, Seoul 133 792, South Korea
    Rheumatol Int 28:627-30. 2008
    ..Our findings indicate that the polymorphisms in the TLR4 gene cannot be regarded as major contributors to AS susceptibility in the Korean population...
  42. ncbi request reprint Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies
    Susan Service
    Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA
    Nat Genet 38:556-60. 2006
    ..Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping...
  43. ncbi request reprint Role of specialty care in the management of patients with systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:1207-10. 2002
    ..To determine the role of rheumatologists in the management of systemic lupus erythematosus (SLE)...
  44. ncbi request reprint Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages
    Tram N Q Pham
    Faculty of Medicine, Memorial University of Newfoundland and Rheumatology Research, St Clare s Mercy Hospital, St John s, Newfoundland A1B 3V6, Canada
    J Rheumatol 30:2529-34. 2003
    ....
  45. ncbi request reprint Issues in investigating the genetic epidemiology of disease expression
    Proton Rahman
    J Rheumatol 31:1680-2. 2004
  46. ncbi request reprint Detailing ethnicity and phenotypes is critical for pooling association studies: comment on the article by Huizinga et al
    Proton Rahman
    Arthritis Rheum 52:676; author reply 676. 2005
  47. ncbi request reprint Accrual of organ damage over time in patients with systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1955-9. 2003
    ....
  48. ncbi request reprint Value of homogenous populations for gene identification in complex rheumatic diseases
    Proton Rahman
    J Rheumatol 32:971-3. 2005
  49. ncbi request reprint Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study
    Robert G W Lambert
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 56:4005-14. 2007
    ..To compare the efficacy of adalimumab versus placebo in reducing spinal and sacroiliac (SI) joint inflammation, by magnetic resonance imaging (MRI) in patients with active ankylosing spondylitis (AS)...
  50. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: I. Assessment of spinal measures
    Dafna D Gladman
    Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1733-9. 2007
    ..To determine whether the axial measures used in primary ankylosing spondylitis (AS) were reproducible for both AS and psoriatic arthritis (PsA) with axial disease...
  51. ncbi request reprint The apolipoprotein E2 isoform is associated with accelerated onset of coronary artery disease in systemic lupus erythematosus
    Antonio Orlacchio
    Laboratorio di Neurogenetica, CERC IRCCS Santa Lucia, Rome, Italy and Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Med Sci Monit 14:CR233-237. 2008
    ..It is hypothesized that apolipoprotein E (Apo E), which is involved in cholesterol metabolism, might play a role in this process...
  52. ncbi request reprint The Canadian Rheumatology Association/ Spondyloarthritis Research Consortium of Canada treatment recommendations for the management of spondyloarthritis: a national multidisciplinary stakeholder project
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 34:2273-84. 2007
    ..2) To generate a procedural template for the multidisciplinary development of treatment recommendations...