Patrick S Parfrey

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. doi request reprint The clinical course of treated hyperparathyroidism among patients receiving hemodialysis and the effect of cinacalcet: the EVOLVE trial
    Patrick S Parfrey
    MD, Health Sciences Center, Memorial University, St John s, Newfoundland, Canada A1B 3V6
    J Clin Endocrinol Metab 98:4834-44. 2013
  2. doi request reprint Why does the treatment of anaemia not improve cardiac outcomes in CKD?
    Patrick S Parfrey
    Division of Nephrology, The Health Sciences Centre, Memorial University, St John s, NL A1B 3V6, Canada
    Nat Rev Nephrol 9:59-61. 2013
  3. ncbi request reprint The clinical epidemiology of contrast-induced nephropathy
    Patrick Parfrey
    Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Cardiovasc Intervent Radiol 28:S3-11. 2005
  4. ncbi request reprint An evaluation of acute care restructuring in Newfoundland and Labrador: conclusions
    Patrick Parfrey
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:71-3. 2005
  5. ncbi request reprint Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 16:2180-9. 2005
  6. ncbi request reprint Autosomal-recessive polycystic kidney disease
    Patrick S Parfrey
    Health Sciences Center, St Johns, Newfoundland, Canada
    Kidney Int 67:1638-48. 2005
  7. doi request reprint Critical appraisal of randomized controlled trials of anemia correction in patients with renal failure
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Centre, Memorial University, St John s, Newfoundland and Labrador, Canada
    Curr Opin Nephrol Hypertens 20:177-81. 2011
  8. pmc Erythropoietin therapy and left ventricular mass index in CKD and ESRD patients: a meta-analysis
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Clin J Am Soc Nephrol 4:755-62. 2009
  9. ncbi request reprint Clinical and genetic epidemiology of inherited renal disease in Newfoundland
    Patrick S Parfrey
    Department of Medicine and Biochemistry, Memorial University, St John s, Newfoundland, Canada
    Kidney Int 61:1925-34. 2002
  10. ncbi request reprint The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome
    Susan Stuckless
    Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Fam Cancer 6:1-12. 2007

Detail Information

Publications73

  1. doi request reprint The clinical course of treated hyperparathyroidism among patients receiving hemodialysis and the effect of cinacalcet: the EVOLVE trial
    Patrick S Parfrey
    MD, Health Sciences Center, Memorial University, St John s, Newfoundland, Canada A1B 3V6
    J Clin Endocrinol Metab 98:4834-44. 2013
    ..The clinical course of secondary hyperparathyroidism (sHPT) in patients on hemodialysis is not well described, and the effect of the calcimimetic cinacalcet on disease progression is uncertain...
  2. doi request reprint Why does the treatment of anaemia not improve cardiac outcomes in CKD?
    Patrick S Parfrey
    Division of Nephrology, The Health Sciences Centre, Memorial University, St John s, NL A1B 3V6, Canada
    Nat Rev Nephrol 9:59-61. 2013
    ....
  3. ncbi request reprint The clinical epidemiology of contrast-induced nephropathy
    Patrick Parfrey
    Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Cardiovasc Intervent Radiol 28:S3-11. 2005
    ..A review of the incidence, pathogenesis, and clinical consequences of CIN is provided...
  4. ncbi request reprint An evaluation of acute care restructuring in Newfoundland and Labrador: conclusions
    Patrick Parfrey
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:71-3. 2005
  5. ncbi request reprint Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 16:2180-9. 2005
    ..Normalization of hemoglobin in incident hemodialysis patients does not have a beneficial effect on cardiac structure, compared with partial correction...
  6. ncbi request reprint Autosomal-recessive polycystic kidney disease
    Patrick S Parfrey
    Health Sciences Center, St Johns, Newfoundland, Canada
    Kidney Int 67:1638-48. 2005
  7. doi request reprint Critical appraisal of randomized controlled trials of anemia correction in patients with renal failure
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Centre, Memorial University, St John s, Newfoundland and Labrador, Canada
    Curr Opin Nephrol Hypertens 20:177-81. 2011
    ..The purpose of this review is to critically appraise the RCTs most relevant to clinical decision-making...
  8. pmc Erythropoietin therapy and left ventricular mass index in CKD and ESRD patients: a meta-analysis
    Patrick S Parfrey
    Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Clin J Am Soc Nephrol 4:755-62. 2009
    ..The purpose was to evaluate changes in the left ventricular mass index (LVMi) among anemic chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients treated with recombinant human erythropoietin (EPO)...
  9. ncbi request reprint Clinical and genetic epidemiology of inherited renal disease in Newfoundland
    Patrick S Parfrey
    Department of Medicine and Biochemistry, Memorial University, St John s, Newfoundland, Canada
    Kidney Int 61:1925-34. 2002
    ..We conclude that collaborations between clinical epidemiologists and molecular geneticists, using the Newfoundland population, have provided important clinical and mechanistic insights into inherited renal diseases...
  10. ncbi request reprint The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome
    Susan Stuckless
    Department of Clinical Epidemiology, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Fam Cancer 6:1-12. 2007
    ..The incidence of CRC in MSH2 mutation carriers, exposed to the same environment, is not modified by the specific mutation, although there is a suggestion that type of mutation may influence development of some extracolonic cancers...
  11. doi request reprint Autosomal recessive Bardet-Biedl syndrome: first-degree relatives have no predisposition to metabolic and renal disorders
    Michael P Webb
    Clinical Epidemiology Unit, Department of Medicine, Memorial University, St John s, Newfoundland and Labrador, Canada
    Kidney Int 76:215-23. 2009
    ....
  12. pmc Interaction between alcohol drinking and obesity in relation to colorectal cancer risk: a case-control study in Newfoundland and Labrador, Canada
    Jinhui Zhao
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St, John s, NL, A1B 3V6, Canada
    BMC Public Health 12:94. 2012
    ..We used a case-control study to examine if alcohol drinking is associated with an increased risk of CRC and if such risk differs in people with and without obesity...
  13. ncbi request reprint Reported intake of selected micronutrients and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland, Labrador and Ontario, Canada
    Zhuoyu Sun
    Ph D Division of Community Health, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, NL, A1B 3V6, Canada
    Anticancer Res 32:687-96. 2012
    ..The objective of this study was to evaluate the associations of selected micronutrients with risk of incident CRC in study participants from Newfoundland, Labrador (NL) and Ontario (ON), Canada...
  14. doi request reprint Prediction of Lynch syndrome in consecutive patients with colorectal cancer
    Roger C Green
    Department of Genetics, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada A1B 3V6
    J Natl Cancer Inst 101:331-40. 2009
    ..We used data from such patients to test the ability of four models--Leiden, MMRpredict, PREMM(1,2), and MMRpro--to distinguish between those who did and did not carry DNA mismatch repair gene mutations...
  15. doi request reprint Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study
    Tyler A Wish
    Health Sciences Centre, 300 Prince Philip Drive, St John s, NL A1B3V6, Canada
    Cancer Epidemiol Biomarkers Prev 19:1831-9. 2010
    ..The objective of this study is to characterize the cancer family history and clinicopathologic features of colorectal cancer (CRC) patients according to the microsatellite instability (MSI) and BRAF mutation status of their tumors...
  16. pmc Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada
    Zhuoyu Sun
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St, John s, NL, Canada
    Nutr J 11:18. 2012
    ....
  17. ncbi request reprint Tobacco smoking and colorectal cancer: a population-based case-control study in Newfoundland and Labrador
    Jinhui Zhao
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL
    Can J Public Health 101:281-9. 2010
    ..Newfoundland and Labrador (NL) has the highest incidence rate of both colorectal cancer (CRC) and smoking prevalence in Canada. The objective of this study was to examine if CRC is associated with smoking in this population...
  18. pmc A nurse-coordinated model of care versus usual care for stage 3/4 chronic kidney disease in the community: a randomized controlled trial
    Brendan J Barrett
    Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Clin J Am Soc Nephrol 6:1241-7. 2011
    ..It is unclear how to optimally care for chronic kidney disease (CKD). This study compares a new coordinated model to usual care for CKD...
  19. ncbi request reprint Clinical research of kidney diseases II: problems of study design
    Pietro Ravani
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Canada
    Nephrol Dial Transplant 22:2785-94. 2007
  20. doi request reprint Pickled meat consumption and colorectal cancer (CRC): a case-control study in Newfoundland and Labrador, Canada
    Josh Squires
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Cancer Causes Control 21:1513-21. 2010
    ..The objective of this study was to assess whether an association exists between the intakes of total red meat and pickled red meat and the risk of colorectal cancer in study subjects residing in Newfoundland and Labrador...
  21. doi request reprint Dietary N-nitroso compounds and risk of colorectal cancer: a case-control study in Newfoundland and Labrador and Ontario, Canada
    Yun Zhu
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL A1B 3V6, Canada
    Br J Nutr 111:1109-17. 2014
    ..The present results support the hypothesis that NOC intake may be positively associated with CRC risk in humans. Vitamin E, which inhibits nitrosation, could modify the effect of NDMA on CRC risk. ..
  22. doi request reprint Predictors of perceived health care quality for registered nurses during and after health care reform
    Deborah M Gregory
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Canada
    Health Care Manage Rev 35:301-11. 2010
    ..Limited research has focused on the predictive nature of organizational culture and trust on registered nurses' perceived health care quality in reformed health care systems...
  23. ncbi request reprint Calcium and vitamin D and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland and Labrador and Ontario
    Zhuoyu Sun
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL
    Can J Public Health 102:382-9. 2011
    ..We conducted a large population-based comparison of such associations in Newfoundland and Labrador (NL) and Ontario (ON)...
  24. ncbi request reprint Incident renal events and risk factors in autosomal dominant polycystic kidney disease: a population and family-based cohort followed for 22 years
    Elizabeth Dicks
    Clinical Epidemiology Unit and Division of Nephrology, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Clin J Am Soc Nephrol 1:710-7. 2006
    ..Gender, gender of parent who transmitted PKD, family history of essential hypertension, multiparity, and use of the oral contraceptive pill were not identified as risk factors for renal events in ADPKD...
  25. ncbi request reprint Clinical research of kidney diseases 1: researchable questions and valid answers
    Pietro Ravani
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Canada
    Nephrol Dial Transplant 22:3681-90. 2007
  26. ncbi request reprint Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction
    Christopher Butt
    Discipline of Laboratory Medicine, Memorial University of Newfoundland, St John s, NF, Canada
    Blood 101:3037-41. 2003
    ....
  27. ncbi request reprint Health care quality from the perspective of health care providers and patients during and shortly after acute care restructuring in Newfoundland and Labrador
    Deborah Gregory
    Patient Research Centre, Health Care Corporation, St Johns, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:48-57. 2005
    ....
  28. pmc Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene
    Nancy D Merner
    Faculty of Medicine, Memorial University, St John s, Newfoundland and Labrador A1B 3V6, Canada
    Am J Hum Genet 82:809-21. 2008
    ....
  29. doi request reprint Inherited deleterious variants in GALNT12 are associated with CRC susceptibility
    Erica Clarke
    Discipline of Genetics, Memorial University, St John s, Newfoundland, Canada
    Hum Mutat 33:1056-8. 2012
    ....
  30. ncbi request reprint Quality of medical care during and shortly after acute care restructuring in Newfoundland and Labrador
    Bryan Curtis
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    J Health Serv Res Policy 10:S2:38-47. 2005
    ..To critically evaluate the quality of hospital medical care at the beginning, during and shortly after regionalization of health boards in Newfoundland and Labrador, and aggregation of hospitals in the St John's region...
  31. pmc Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study
    Susan J Moore
    Clinical Epidemiology Unit, Memorial University, St John s, Newfoundland, Canada
    Am J Med Genet A 132:352-60. 2005
    ..The features in this population do not support the notion that BBS and LMS are distinct. The lack of a genotype-phenotype correlation implies that BBS proteins interact and are necessary for the development of many organs...
  32. ncbi request reprint Familial risk of preeclampsia in Newfoundland: a population-based study
    Lesa M Dawson
    Department of Obstetrics, Memorial University Health Sciences Center, St John s, Newfoundland A1B 3V6, Canada
    J Am Soc Nephrol 13:1901-6. 2002
    ....
  33. ncbi request reprint High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes
    Michael O Woods
    Discipline of Genetics, Department of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Clin Cancer Res 11:6853-61. 2005
    ..Our purpose was to determine the proportion of hereditary colorectal cancer and to determine the genetic basis of disease in both population and clinically referred cohorts from Newfoundland...
  34. ncbi request reprint Acute care restructuring in Newfoundland and Labrador: the history and impact on expenditure
    Laurie Twells
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:4-11. 2005
    ....
  35. ncbi request reprint Clinical research of kidney diseases 1: researchable questions and valid answers
    Pietro Ravani
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Canada, and Divisione di Nefrologia, Azienda Istituti Ospitalieri di Cremona, Italy
    Nephrol Dial Transplant 22:2459-68. 2007
  36. ncbi request reprint Congestive heart failure in chronic kidney disease: disease-specific mechanisms of systolic and diastolic heart failure and management
    Bryan M Curtis
    Division of Nephrology and Clinical Epidemiology Unit Patient Research Centre, Health Sciences Centre, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    Cardiol Clin 23:275-84. 2005
    ..Nonetheless, interventions such as controlling hypertension, specific pharmacologic options, lifestyle modification, anemia management, and early nephrology referral are recommended when appropriate...
  37. ncbi request reprint The clinical epidemiology of cardiovascular disease in chronic kidney disease
    John Shik
    Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Curr Opin Nephrol Hypertens 14:550-7. 2005
    ..To review recent publications concerning the epidemiology and management of cardiovascular disease in the stages of chronic kidney disease...
  38. ncbi request reprint Clinical practice. Preventing nephropathy induced by contrast medium
    Brendan J Barrett
    Division of Nephrology, Memorial University of Newfoundland, St John s, Newf, Canada
    N Engl J Med 354:379-86. 2006
  39. pmc The impact of implantable cardioverter-defibrillator therapy on survival in autosomal-dominant arrhythmogenic right ventricular cardiomyopathy (ARVD5)
    Kathy A Hodgkinson
    Clinical Epidemiology Unit, Memorial University Health Sciences Centre, St John s, Newfoundland, Canada A1B 3V6
    J Am Coll Cardiol 45:400-8. 2005
    ..We sought to determine the impact of implantable cardioverter-defibrillator (ICD) therapy in patients with familial arrhythmogenic right ventricular cardiomyopathy (ARVC)...
  40. ncbi request reprint High incidence of childhood type 1 diabetes in the Avalon Peninsula, Newfoundland, Canada
    Leigh A Newhook
    Memorial University of Newfoundland, Medicine, St John s, Newfoundland, Canada
    Diabetes Care 27:885-8. 2004
    ..The aim of this study was to determine the incidence of type 1 diabetes among children aged 0-14 years in the Avalon Peninsula in the Canadian Province of Newfoundland...
  41. doi request reprint Variable neurologic phenotype in a GEFS+ family with a novel mutation in SCN1A
    Krista Mahoney
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University, St John s, NL, Canada
    Seizure 18:492-7. 2009
    ..To describe the spectrum of clinical disease in a mutliplex family with an autosomal dominant form of generalized epilepsy with febrile seizures plus (GEFS+) and determine its genetic etiology...
  42. doi request reprint Translation of research discoveries to clinical care in arrhythmogenic right ventricular cardiomyopathy in Newfoundland and Labrador: lessons for health policy in genetic disease
    Kathy Hodgkinson
    Clinical Epidemiology Unit, Memorial University, Newfoundland, Canada
    Genet Med 11:859-65. 2009
    ..Although yet to be fully effected in our setting, our discussion highlights both the ethical necessity as well as some practical barriers in realizing this outcome...
  43. ncbi request reprint Health care provider outcomes during and shortly after acute care restructuring in Newfoundland and Labrador
    Christine Way
    School of Nursing, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:58-67. 2005
    ....
  44. ncbi request reprint Hospital utilization, efficiency and access to care during and shortly after restructuring acute care in Newfoundland and Labrador
    Brendan Barrett
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:31-7. 2005
    ....
  45. ncbi request reprint Attitudes and perceptions of registered nurses during and shortly after acute care restructuring in Newfoundland and Labrador
    Christine Way
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    J Health Serv Res Policy 10:S2:22-30. 2005
    ....
  46. ncbi request reprint The impact of organizational culture on clinical managers' organizational commitment and turnover intentions
    Christine Way
    School of Nursing and Clinical Epidemiology, Memorial University of Newfoundland, St John s, NL, Canada
    J Nurs Adm 37:235-42. 2007
    ..The purpose was to investigate managers' perceptions of organizational culture and attitudinal and behavioral reactions during and after restructuring, and to test a model linking culture to outcome...
  47. pmc A Newfoundland cohort of familial and sporadic idiopathic pulmonary fibrosis patients: clinical and genetic features
    Bridget A Fernandez
    Discipline of Genetics, Memorial University of Newfoundland, St John s, NL, Canada
    Respir Res 13:64. 2012
    ..Individuals with Familial Pulmonary Fibrosis (FPF) have at least one affected first or second-degree relative and account for 0.5-20% of cases...
  48. ncbi request reprint The clinical epidemiology of cardiovascular disease in chronic kidney disease
    Patrick S Parfrey
    Department of Medicine, Division of Nephrology, Health Sciences Center, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Semin Dial 16:83-4. 2003
  49. doi request reprint The design of randomized controlled trials
    Bryan M Curtis
    Department of Medicine, Memorial University of Newfoundland, St John s, Canada
    Methods Mol Biol 473:95-111. 2009
    ..In addition, funding strategies and trial team composition are discussed...
  50. ncbi request reprint Multiple risk factor intervention in chronic kidney disease: management of cardiac disease in chronic kidney disease patients
    Bryan M Curtis
    Division of Nephrology and Clinical Epidemiology Unit, Patient Research Centre, Health Sciences Centre, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, NF A1B 3V6, Canada
    Med Clin North Am 89:511-23. 2005
    ..Appropriate use of ACE inhibitors, beta-blockers, and statins should be encouraged...
  51. doi request reprint Mechanisms of the cardiorenal syndromes
    M Khaled Shamseddin
    Division of Nephrology, Memorial University of Newfoundland, 300 Prince Phillip Drive, St John s, NL, Canada
    Nat Rev Nephrol 5:641-9. 2009
    ..These mechanisms provide a template that accounts for the heart-kidney interactions that occur in patients whose concomitant cardiac and renal conditions result from a third cause...
  52. ncbi request reprint Predictors of registered nurses' organizational commitment and intent to stay
    Deborah M Gregory
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Health Care Manage Rev 32:119-27. 2007
    ..Health care reform has significantly altered employment relations. Research findings suggest that the presence or absence of supportive work environments helps explain the differences observed in employee attitudes and turnover intentions...
  53. ncbi request reprint Impact of gender and parent of origin on the phenotypic expression of hereditary nonpolyposis colorectal cancer in a large Newfoundland kindred with a common MSH2 mutation
    Jane Green
    Medical Genetics Program, Memorial University, St John s, Newfoundland, Canada
    Dis Colon Rectum 45:1223-32. 2002
    ..This study was designed to provide precise estimates of death and cancer risks, by gender and parent of origin, in hereditary nonpolyposis colorectal cancer independent of mutation, geographic variation, and ascertainment bias...
  54. ncbi request reprint How can the cardiac death rate be reduced in dialysis patients?
    Bryan M Curtis
    Division of Nephrology and Clinical Epidemiology Unit, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Semin Dial 15:22-4. 2002
  55. pmc Lynch syndrome: barriers to and facilitators of screening and disease management
    Kathy E Watkins
    Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St, John s, NL, Canada
    Hered Cancer Clin Pract 9:8. 2011
    ..abstract:..
  56. doi request reprint Bias in clinical studies of genetic diseases
    Susan Stuckless
    Department of Medicine, Memorial University of Newfoundland, St John s, Canada
    Methods Mol Biol 473:171-86. 2009
    ..This chapter reviews the epidemiological concepts of selection bias, information bias, and confounding and discusses ways in which these sources of bias can be minimized...
  57. ncbi request reprint The restructuring of institutional long-term care in St. John's: impact of supply-induced demand on planning
    Robert C Wilson
    Clinical Epidemiology Unit, Health Sciences Centre, Memorial University, St John s, Newfoundland and Labrador, Canada
    Healthc Manage Forum 24:63-7. 2011
    ..Consequently, more appropriate housing and supervised care beds, and more limited downsizing of nursing homes will be required...
  58. ncbi request reprint Validity of random-digit-dialing in recruiting controls in a case-control study
    Peizhong Peter Wang
    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Am J Health Behav 33:513-20. 2009
    ..To evaluate whether the participating controls represented the underlying population in a colorectal cancer case-control study in a geographically isolated North American population...
  59. ncbi request reprint How to design a clinical trial
    Bryan M Curtis
    Patient Research Centre, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Methods Mol Med 86:475-89. 2003
  60. doi request reprint Sudden cardiac death in chronic kidney disease: epidemiology and prevention
    M Khaled Shamseddin
    Division of Nephrology, Memorial University of Newfoundland, Patient Research Centre, Health Science Centre, St John s, Canada
    Nat Rev Nephrol 7:145-54. 2011
    ..Cardioverter-defibrillator implantation decreases the risk of sudden death in patients with CKD. The decision to implant a cardioverter-defibrillator should be influenced by the patient's age and stage of CKD...
  61. ncbi request reprint The breast cancer hormone receptor retesting controversy in Newfoundland and Labrador, Canada: lessons for the health system
    Deborah M Gregory
    Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Healthc Manage Forum 23:114-8. 2010
    ....
  62. doi request reprint A histology-based model for predicting microsatellite instability in colorectal cancers
    Angela Hyde
    Discipline of Genetics, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Am J Surg Pathol 34:1820-9. 2010
    ..4% and a specificity of 53.9%. In the validation cohort, sensitivity was 96.9% and specificity 76.6%. We conclude that PREDICT is a good predictor of MSI-H CRC...
  63. pmc Unified criteria for ultrasonographic diagnosis of ADPKD
    York Pei
    Division of Nephrology, University of Toronto, 8N838, 585 University Avenue, Toronto, Ontario, Canada
    J Am Soc Nephrol 20:205-12. 2009
    ..These unified diagnostic criteria will be useful for testing individuals who are at risk for autosomal dominant polycystic kidney disease in the usual clinical setting in which molecular genotyping is seldom performed...
  64. ncbi request reprint Rationale--Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney disease
    T Christian H Mix
    Department of Development and Medical Affairs, Amgen Inc, Thousand Oaks, Calif, USA
    Am Heart J 149:408-13. 2005
    ....
  65. ncbi request reprint MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer
    Stavroula Raptis
    Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9
    J Natl Cancer Inst 99:463-74. 2007
    ..We investigated whether polymorphisms in DNA mismatch repair genes are associated with the risk of colorectal cancer...
  66. ncbi request reprint MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer
    Miralem Mrkonjic
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada
    Carcinogenesis 28:2575-80. 2007
    ..003 and P = 0.0001, respectively). The MSH2 -118T>C polymorphism was associated with strong family history of CRC in Ontario patients...
  67. ncbi request reprint Target hemoglobin level for EPO therapy in CKD
    Patrick S Parfrey
    Am J Kidney Dis 47:171-3. 2006
  68. ncbi request reprint Linkage disequilibrium mapping in the Newfoundland population: a re-evaluation of the refinement of the Bardet-Biedl syndrome 1 critical interval
    Yanli Fan
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
    Hum Genet 116:62-71. 2005
    ..Knowing the amount of genetic variation and its distribution in the Newfoundland population would be useful to maximize its potential for mapping hereditary disorders...
  69. ncbi request reprint Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
    Jin Billy Li
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 117:541-52. 2004
    ..We show that this novel protein localizes to basal bodies in mouse and C. elegans, is under the regulatory control of daf-19, and is necessary for the generation of both cilia and flagella...
  70. ncbi request reprint Long-term care in the St. John's region: impact of single entry and prediction of bed need
    Jacqueline McDonald
    Patient Research Centre, Eastern Health
    Healthc Manage Forum 18:6-12, 50-7. 2005
    ..However, there was a mismatch in need for and provision of institutional long-term care. Investment in the reconfiguration of long-term care beds by case mix and by geography is necessary...
  71. ncbi request reprint Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome
    Yanli Fan
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, B C V5A 1S6, Canada
    Nat Genet 36:989-93. 2004
    ..These findings implicate a small GTP-binding protein in ciliary transport and the pathogenesis of a pleiotropic disorder...
  72. ncbi request reprint Inhibitors of the renin angiotensin system: proven benefits, unproven safety
    Patrick S Parfrey
    Ann Intern Med 148:76-7. 2008
  73. ncbi request reprint In the literature: on clinical performance measures and outcomes among hemodialysis patients
    Patrick S Parfrey
    Am J Kidney Dis 49:352-5. 2007