R C Green
Affiliation: Memorial University of Newfoundland
- SISE matters: the sum of information on seventy-yr-old equivalents measures pedigree information content when assessing the risk of HNPCC in a familyR C Green
Faculty of Medicine, Memorial University, St John s, Newfoundland, A1B 3V6 Canada
Fam Cancer 4:169-75. 2005..001). Using a cumulative binomial distribution function, we estimated the likelihood of observing multiple cancers in families of different SISE coefficients...
- Germline hMLH1 promoter mutation in a Newfoundland HNPCC kindredR C Green
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Clin Genet 64:220-7. 2003..This is consistent with a substantial decrease, but not total elimination, of mismatch repair function in affected members of this family. This is the first report of a heritable hMLH1 promoter mutation in any HNPCC family...
- Prediction of Lynch syndrome in consecutive patients with colorectal cancerRoger C Green
Department of Genetics, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada A1B 3V6
J Natl Cancer Inst 101:331-40. 2009..We used data from such patients to test the ability of four models--Leiden, MMRpredict, PREMM(1,2), and MMRpro--to distinguish between those who did and did not carry DNA mismatch repair gene mutations...
- Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studiesR C Green
Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Fam Cancer 6:53-62. 2007..We conclude that the high incidence of CRC in Newfoundland may be attributable to genetic, or at least familial, factors. In the high-risk families we provide evidence for the involvement of founder mutations in the APC and MSH2 genes...
- The genetic basis of colorectal cancer in a population-based incident cohort with a high rate of familial diseaseM O Woods
Discipline of Genetics, Health Sciences Centre, St John s, Newfoundland, Canada
Gut 59:1369-77. 2010....
- Impact of colonoscopic screening in male and female Lynch syndrome carriers with an MSH2 mutationS Stuckless
Department of Clinical Epidemiology Department of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Clin Genet 82:439-45. 2012..CRC development may be further reduced by decreasing the screening interval to 1 year and improving quality of colonoscopy...
- Vascular factors predict rate of progression in Alzheimer diseaseM M Mielke
Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
Neurology 69:1850-8. 2007..While there is considerable epidemiologic evidence that cardiovascular risk factors increase risk of incident Alzheimer disease (AD), few studies have examined their effect on progression after an established AD diagnosis...
- Conversion to dementia from mild cognitive disorder: the Cache County StudyJ T Tschanz
Department of Psychology, Utah State University, Logan, USA
Neurology 67:229-34. 2006..To examine 3-year rates of conversion to dementia, and risk factors for such conversion, in a population-based sample with diverse types of cognitive impairment...
- APOE, vascular pathology, and the AD brainA G Yip
Department of Medicine, Boston University School of Medicine, Bedford, MA, USA
Neurology 65:259-65. 2005..To use neuropathologic data to examine the association between APOE genotype and cerebrovascular lesions commonly found in Alzheimer disease (AD), as well as neuritic senile plaque (SP) and neurofibrillary tangle (NFT) burden...
- Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with ageV W Henderson
Stanford University School of Medicine, 259 Campus Drive, HRP Redwood Building, Stanford University, Stanford, CA 94305 5405, USA
J Neurol Neurosurg Psychiatry 76:103-5. 2005..However, our observational findings are consistent with the view that HT may protect younger women from AD or reduce the risk of early onset forms of AD, or that HT used during the early postmenopause may reduce AD risk...
- Comparison of Alzheimer's disease risk factors in white and African American familiesD L Bachman
Department of Medicine, Medical University of South Carolina, Charleston, USA
Neurology 60:1372-4. 2003..88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE epsilon4 allele...