Michael D Grant

Summary

Affiliation: Memorial University of Newfoundland
Country: Canada

Publications

  1. pmc The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces endotoxin tolerance
    Tigran K Davtyan
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St, John s, NL, Canada
    J Inflamm (Lond) 10:14. 2013
  2. pmc Responses to pandemic ASO3-adjuvanted A/California/07/09 H1N1 influenza vaccine in human immunodeficiency virus-infected individuals
    Deborah Kelly
    School of Pharmacy, Memorial University of Newfoundland and Labrador, NL, St John s, Canada
    BMC Immunol 13:49. 2012
  3. pmc Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment
    Mahdis Monajemi
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada
    Retrovirology 9:35. 2012
  4. pmc Enhanced IL-10 production in response to hepatitis C virus proteins by peripheral blood mononuclear cells from human immunodeficiency virus-monoinfected individuals
    Lisa Barrett
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St, John s, Canada
    BMC Immunol 9:28. 2008
  5. ncbi request reprint Antibody convergence along a common idiotypic axis in immunodeficiency virus and hepatitis C virus infections
    Michael D Grant
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NF Canada
    J Med Virol 66:13-21. 2002
  6. ncbi request reprint Secondary persistent infection with hepatitis C virus: a challenge for adaptive immunity
    Michael Grant
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of St john s, Newfoundland, NF A1B 3V6, Canada
    Lancet 359:1452. 2002
  7. ncbi request reprint A therapy-related point mutation changes the HLA restriction of an HIV-1 Pol epitope from A2 to B57 and enhances its recognition
    Rosemarie D Mason
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    AIDS 19:981-4. 2005
  8. doi request reprint Hepatitis C virus-infected cells downregulate NKp30 and inhibit ex vivo NK cell functions
    Kayla A Holder
    Division of Biomedical Sciences, Immunology and Infectious Diseases Program, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    J Immunol 191:3308-18. 2013
  9. doi request reprint Heteroclitic peptides enhance human immunodeficiency virus-specific CD8(+) T cell responses
    Krista H Gladney
    Division of Biomedical Sciences, Memorial University of Newfoundland and Labrador, St John s, NL, Canada A1B 3V6
    Vaccine 30:6997-7004. 2012
  10. ncbi request reprint Immune reconstitution and viral stimulation are required to restore HIV-specific CD8 T cell responses following advanced infection
    Jane Gamberg
    Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Clin Immunol 24:115-24. 2004

Collaborators

Detail Information

Publications15

  1. pmc The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces endotoxin tolerance
    Tigran K Davtyan
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St, John s, NL, Canada
    J Inflamm (Lond) 10:14. 2013
    ..In this study, we investigated direct effects of the 1F7 mAb itself on peripheral blood mononuclear cells (PBMC)...
  2. pmc Responses to pandemic ASO3-adjuvanted A/California/07/09 H1N1 influenza vaccine in human immunodeficiency virus-infected individuals
    Deborah Kelly
    School of Pharmacy, Memorial University of Newfoundland and Labrador, NL, St John s, Canada
    BMC Immunol 13:49. 2012
    ....
  3. pmc Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment
    Mahdis Monajemi
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada
    Retrovirology 9:35. 2012
    ..We discuss the limitations of experimental systems used to assess its activities as well as caveats in data interpretation...
  4. pmc Enhanced IL-10 production in response to hepatitis C virus proteins by peripheral blood mononuclear cells from human immunodeficiency virus-monoinfected individuals
    Lisa Barrett
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St, John s, Canada
    BMC Immunol 9:28. 2008
    ..Therefore, we investigated in vitro cytokine responses to HCV structural and non-structural proteins in peripheral blood mononuclear cells (PBMC) from uninfected, HIV-infected, HCV-infected and HIV/HCV-coinfected individuals...
  5. ncbi request reprint Antibody convergence along a common idiotypic axis in immunodeficiency virus and hepatitis C virus infections
    Michael D Grant
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NF Canada
    J Med Virol 66:13-21. 2002
    ..Thus, distinct pathogens establishing chronic infection in the face of strong humoral immune responses select antibodies along a common idiotypic axis of the immune network...
  6. ncbi request reprint Secondary persistent infection with hepatitis C virus: a challenge for adaptive immunity
    Michael Grant
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of St john s, Newfoundland, NF A1B 3V6, Canada
    Lancet 359:1452. 2002
  7. ncbi request reprint A therapy-related point mutation changes the HLA restriction of an HIV-1 Pol epitope from A2 to B57 and enhances its recognition
    Rosemarie D Mason
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada A1B 3V6
    AIDS 19:981-4. 2005
    ..An antiretroviral therapy-associated mutation thus alters the HLA restriction of a weak Pol epitope, potentially enhancing CD8 T-cell recognition of HIV...
  8. doi request reprint Hepatitis C virus-infected cells downregulate NKp30 and inhibit ex vivo NK cell functions
    Kayla A Holder
    Division of Biomedical Sciences, Immunology and Infectious Diseases Program, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    J Immunol 191:3308-18. 2013
    ..Similar localized effects in vivo may contribute to establishment of chronic HCV infection and associated phenotypic and functional changes in the NK population...
  9. doi request reprint Heteroclitic peptides enhance human immunodeficiency virus-specific CD8(+) T cell responses
    Krista H Gladney
    Division of Biomedical Sciences, Memorial University of Newfoundland and Labrador, St John s, NL, Canada A1B 3V6
    Vaccine 30:6997-7004. 2012
    ....
  10. ncbi request reprint Immune reconstitution and viral stimulation are required to restore HIV-specific CD8 T cell responses following advanced infection
    Jane Gamberg
    Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Clin Immunol 24:115-24. 2004
    ..However, the transient nature of these responses suggests failure to generate stable long-lived memory cells in the absence of HIV-specific helper T cell responses...
  11. pmc Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells
    Mahdis Monajemi
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    PLoS ONE 9:e93428. 2014
    ....
  12. pmc Human immunodeficiency virus type I-specific CD8+ T cell subset abnormalities in chronic infection persist through effective antiretroviral therapy
    Julia Pohling
    Immunology and Infectious Diseases Program, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St, John s NL, Canada
    BMC Infect Dis 10:129. 2010
    ....
  13. ncbi request reprint Antiretroviral drug resistance mutations sustain or enhance CTL recognition of common HIV-1 Pol epitopes
    Rosemarie D Mason
    Immunology Program, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Immunol 172:7212-9. 2004
    ..Thus, drug-resistant variants of HIV are susceptible to immune selective pressure that could be applied to combat transmission or emergence of antiretroviral drug-resistant HIV strains and to enhance the immune response against HIV...
  14. ncbi request reprint Factors related to loss of HIV-specific cytotoxic T lymphocyte activity
    Jane Gamberg
    Immunology Program, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland, Canada A1B 3V6
    AIDS 18:597-604. 2004
    ..To identify factors associated with loss of in vitro stimulated anti-HIV cytotoxic T lymphocyte (CTL) activity...
  15. ncbi request reprint The T cell receptor V beta repertoire shows little change during treatment interruption-related viral rebound in chronic HIV infection
    Michael Grant
    Immunology Program, Memorial University of Newfoundland, St John s, Canada
    AIDS 16:287-90. 2002
    ..The magnitude of associated T cell repertoire perturbation thus contrasts with that observed during primary HIV infection...